Details for: SPTB

Gene ID: 6710

Symbol: SPTB

Ensembl ID: ENSG00000070182

Description: spectrin beta, erythrocytic

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 52.7907
    Cell Significance Index: -13.3900
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 35.4238
    Cell Significance Index: -5.5100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.3353
    Cell Significance Index: -11.5100
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 6.1010
    Cell Significance Index: 98.4400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 5.2428
    Cell Significance Index: 127.9200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.2338
    Cell Significance Index: 83.1300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.6131
    Cell Significance Index: 123.7900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.5191
    Cell Significance Index: 48.6600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.4980
    Cell Significance Index: 66.2600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.4535
    Cell Significance Index: 55.0400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.8847
    Cell Significance Index: 59.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8445
    Cell Significance Index: 169.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5606
    Cell Significance Index: 201.0600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5335
    Cell Significance Index: 369.0200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.4471
    Cell Significance Index: 3.8000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3498
    Cell Significance Index: 7.6600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.2222
    Cell Significance Index: 3.2800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1815
    Cell Significance Index: 5.1800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1488
    Cell Significance Index: 2.5500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0402
    Cell Significance Index: 36.2800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0391
    Cell Significance Index: 0.4900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0318
    Cell Significance Index: 1.6700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0304
    Cell Significance Index: 57.2900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0187
    Cell Significance Index: 8.4900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0143
    Cell Significance Index: 2.7300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0139
    Cell Significance Index: 21.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0139
    Cell Significance Index: 18.8800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0085
    Cell Significance Index: 15.7000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0035
    Cell Significance Index: 0.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0021
    Cell Significance Index: 0.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0010
    Cell Significance Index: 0.5800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0005
    Cell Significance Index: -0.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0010
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0015
    Cell Significance Index: -1.1200
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0054
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0055
    Cell Significance Index: -3.4500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0067
    Cell Significance Index: -2.9600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0077
    Cell Significance Index: -1.2500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0100
    Cell Significance Index: -5.4700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0120
    Cell Significance Index: -1.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0179
    Cell Significance Index: -3.5500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0190
    Cell Significance Index: -14.4000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0226
    Cell Significance Index: -0.4800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0253
    Cell Significance Index: -0.3200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0262
    Cell Significance Index: -4.7300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0265
    Cell Significance Index: -4.5300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0299
    Cell Significance Index: -0.6400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0329
    Cell Significance Index: -6.9400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0348
    Cell Significance Index: -10.0200
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0399
    Cell Significance Index: -0.3800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0477
    Cell Significance Index: -0.9900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0496
    Cell Significance Index: -6.1000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0630
    Cell Significance Index: -1.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0800
    Cell Significance Index: -10.9900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0822
    Cell Significance Index: -5.0400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0828
    Cell Significance Index: -9.6500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0832
    Cell Significance Index: -9.0500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0842
    Cell Significance Index: -1.6900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0868
    Cell Significance Index: -9.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0922
    Cell Significance Index: -9.6000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0950
    Cell Significance Index: -10.8500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0990
    Cell Significance Index: -12.8000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1006
    Cell Significance Index: -4.5600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1030
    Cell Significance Index: -1.3000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1066
    Cell Significance Index: -4.6400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1070
    Cell Significance Index: -2.9900
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1072
    Cell Significance Index: -0.8900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1103
    Cell Significance Index: -2.1800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1212
    Cell Significance Index: -2.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1264
    Cell Significance Index: -12.9200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1323
    Cell Significance Index: -9.3600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1364
    Cell Significance Index: -6.3600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1387
    Cell Significance Index: -3.3600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1415
    Cell Significance Index: -2.0100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1432
    Cell Significance Index: -4.1300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1525
    Cell Significance Index: -12.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1602
    Cell Significance Index: -8.9900
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.1650
    Cell Significance Index: -1.9000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1661
    Cell Significance Index: -5.2900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1689
    Cell Significance Index: -12.5900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1710
    Cell Significance Index: -10.7800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1780
    Cell Significance Index: -12.3100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1798
    Cell Significance Index: -9.3400
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1871
    Cell Significance Index: -2.4500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1894
    Cell Significance Index: -6.2000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1951
    Cell Significance Index: -12.5900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1987
    Cell Significance Index: -12.2100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2039
    Cell Significance Index: -12.2400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2060
    Cell Significance Index: -10.7300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.2152
    Cell Significance Index: -2.7600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2157
    Cell Significance Index: -5.3800
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.2189
    Cell Significance Index: -3.3300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2304
    Cell Significance Index: -8.0700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2345
    Cell Significance Index: -8.1500
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.2366
    Cell Significance Index: -3.5400
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.2526
    Cell Significance Index: -2.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2557
    Cell Significance Index: -12.0200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2711
    Cell Significance Index: -7.3800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2717
    Cell Significance Index: -5.8700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2947
    Cell Significance Index: -9.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural role:** SPTB is a component of the spectrin-actin cytoskeleton complex, which provides mechanical strength and stability to cells. 2. **Cell-type specificity:** SPTB is expressed in various cell types, including erythrocytes, neurons, and muscle fibers. 3. **Phosphorylation:** SPTB undergoes phosphorylation, which regulates its interactions with other cytoskeletal proteins and modulates its function. 4. **Glycosylation:** SPTB is subject to asparagine n-linked glycosylation, which affects its stability and function. **Pathways and Functions:** 1. **Actin cytoskeleton organization:** SPTB plays a crucial role in organizing and maintaining the actin cytoskeleton, which is essential for cell shape, movement, and division. 2. **Cell junction and adhesion:** SPTB interacts with ankyrin and L1cam, which are involved in cell junction and adhesion processes. 3. **Protein binding:** SPTB binds to various proteins, including spectrin, actin, and ankyrin, to regulate their interactions and function. 4. **Signaling pathways:** SPTB is involved in multiple signaling pathways, including MAPK1/3 and RAF/MAPK cascades, which regulate cell growth, differentiation, and survival. **Clinical Significance:** 1. **Sickle cell disease:** Mutations in the SPTB gene have been associated with sickle cell disease, a genetic disorder characterized by abnormal hemoglobin and erythrocyte morphology. 2. **Muscle disorders:** Dysregulation of SPTB has been implicated in various muscle disorders, including muscular dystrophy and myasthenia gravis. 3. **Neurological disorders:** SPTB has been linked to neurological disorders, including autism spectrum disorder and schizophrenia, although the exact mechanisms are not fully understood. 4. **Cancer:** Alterations in SPTB expression and function have been observed in various types of cancer, including breast and colon cancer. In conclusion, SPTB is a critical gene that plays a vital role in maintaining cellular integrity and function. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of SPTB and its potential therapeutic applications.

Genular Protein ID: 2890702858

Symbol: SPTB1_HUMAN

Name: Spectrin beta chain, erythrocytic

UniProtKB Accession Codes:

P11277 Q15510 Q15519

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CTD 1 CarbonylDB 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PIRSF 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 4 RefSeq 5 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2195026

Title: Full-length sequence of the cDNA for human erythroid beta-spectrin.

PubMed ID: 2195026

DOI: 10.1016/s0021-9258(19)38473-x

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 2056132

Title: Spectrin Rouen (beta 220-218), a novel shortened beta-chain variant in a kindred with hereditary elliptocytosis. Characterization of the molecular defect as exon skipping due to a splice site mutation.

PubMed ID: 2056132

DOI: 10.1172/jci115307

PubMed ID: 2243099

Title: Beta spectrin in human skeletal muscle. Tissue-specific differential processing of 3' beta spectrin pre-mRNA generates a beta spectrin isoform with a unique carboxyl terminus.

PubMed ID: 2243099

DOI: 10.1016/s0021-9258(17)30525-2

PubMed ID: 1840591

Title: A splice site mutation of the beta-spectrin gene causing exon skipping in hereditary elliptocytosis associated with a truncated beta-spectrin chain.

PubMed ID: 1840591

DOI: 10.1016/s0021-9258(18)98598-4

PubMed ID: 1976574

Title: Identification of an unusual deletion within homologous repeats of human reticulocyte beta-spectrin and probable peptide polymorphism.

PubMed ID: 1976574

DOI: 10.1016/0378-1119(90)90104-y

PubMed ID: 3390609

Title: Molecular cloning of the cDNA for human erythrocyte beta-spectrin.

PubMed ID: 3390609

PubMed ID: 3478706

Title: Isolation and characterization of cDNA clones for human erythrocyte beta-spectrin.

PubMed ID: 3478706

DOI: 10.1073/pnas.84.21.7468

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 6472478

Title: Erythrocyte spectrin is comprised of many homologous triple helical segments.

PubMed ID: 6472478

DOI: 10.1038/311177a0

PubMed ID: 15065869

Title: In vivo phosphorylation of human erythrocyte spectrin occurs in a sequential manner.

PubMed ID: 15065869

DOI: 10.1021/bi036092x

PubMed ID: 19538529

Title: Novel beta-spectrin mutations in hereditary spherocytosis associated with decreased levels of mRNA.

PubMed ID: 19538529

DOI: 10.1111/j.1365-2141.2009.07759.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29459732

Title: A protease cascade regulates release of the human malaria parasite Plasmodium falciparum from host red blood cells.

PubMed ID: 29459732

DOI: 10.1038/s41564-018-0111-0

PubMed ID: 15062087

Title: Structural insights into the stability and flexibility of unusual erythroid spectrin repeats.

PubMed ID: 15062087

DOI: 10.1016/j.str.2004.02.022

PubMed ID: 8844207

Title: Spectrin mutations in hereditary elliptocytosis and hereditary spherocytosis.

PubMed ID: 8844207

DOI: 10.1002/(sici)1098-1004(1996)8:2<97::aid-humu1>3.0.co;2-m

PubMed ID: 1975598

Title: Point mutation in the beta-spectrin gene associated with alpha I/74 hereditary elliptocytosis. Implications for the mechanism of spectrin dimer self-association.

PubMed ID: 1975598

DOI: 10.1172/jci114792

PubMed ID: 8226774

Title: Spectrin Cagliari: an Ala-->Gly substitution in helix 1 of beta spectrin repeat 17 that severely disrupts the structure and self-association of the erythrocyte spectrin heterodimer.

PubMed ID: 8226774

DOI: 10.1016/s0021-9258(18)41578-5

PubMed ID: 8102379

Title: Beta spectrin Kissimmee: a spectrin variant associated with autosomal dominant hereditary spherocytosis and defective binding to protein 4.1.

PubMed ID: 8102379

DOI: 10.1172/jci116628

PubMed ID: 8018926

Title: Identification of three novel spectrin alpha I/74 mutations in hereditary elliptocytosis: further support for a triple-stranded folding unit model of the spectrin heterodimer contact site.

PubMed ID: 8018926

PubMed ID: 7883966

Title: Recurrent fatal hydrops fetalis associated with a nucleotide substitution in the erythrocyte beta-spectrin gene.

PubMed ID: 7883966

DOI: 10.1172/jci117766

PubMed ID: 9005995

Title: Mutation of a highly conserved residue of betaI spectrin associated with fatal and near-fatal neonatal hemolytic anemia.

PubMed ID: 9005995

DOI: 10.1172/jci119155

Sequence Information:

  • Length: 2137
  • Mass: 246468
  • Checksum: 311AE5CD53237610
  • Sequence:
    • MTSATEFENV GNQPPYSRIN ARWDAPDDEL DNDNSSARLF ERSRIKALAD EREVVQKKTF 
TKWVNSHLAR VSCRITDLYK DLRDGRMLIK LLEVLSGEML PKPTKGKMRI HCLENVDKAL 
QFLKEQRVHL ENMGSHDIVD GNHRLVLGLI WTIILRFQIQ DIVVQTQEGR ETRSAKDALL 
LWCQMKTAGY PHVNVTNFTS SWKDGLAFNA LIHKHRPDLI DFDKLKDSNA RHNLEHAFNV 
AERQLGIIPL LDPEDVFTEN PDEKSIITYV VAFYHYFSKM KVLAVEGKRV GKVIDHAIET 
EKMIEKYSGL ASDLLTWIEQ TITVLNSRKF ANSLTGVQQQ LQAFSTYRTV EKPPKFQEKG 
NLEVLLFTIQ SRMRANNQKV YTPHDGKLVS DINRAWESLE EAEYRRELAL RNELIRQEKL 
EQLARRFDRK AAMRETWLSE NQRLVAQDNF GYDLAAVEAA KKKHEAIETD TAAYEERVRA 
LEDLAQELEK ENYHDQKRIT ARKDNILRLW SYLQELLQSR RQRLETTLAL QKLFQDMLHS 
IDWMDEIKAH LLSAEFGKHL LEVEDLLQKH KLMEADIAIQ GDKVKAITAA TLKFTEGKGY 
QPCDPQVIQD RISHLEQCFE ELSNMAAGRK AQLEQSKRLW KFFWEMDEAE SWIKEKEQIY 
SSLDYGKDLT SVLILQRKHK AFEDELRGLD AHLEQIFQEA HGMVARKQFG HPQIEARIKE 
VSAQWDQLKD LAAFCKKNLQ DAENFFQFQG DADDLKAWLQ DAHRLLSGED VGQDEGATRA 
LGKKHKDFLE ELEESRGVME HLEQQAQGFP EEFRDSPDVT HRLQALRELY QQVVAQADLR 
QQRLQEALDL YTVFGETDAC ELWMGEKEKW LAEMEMPDTL EDLEVVQHRF DILDQEMKTL 
MTQIDGVNLA ANSLVESGHP RSREVKQYQD HLNTRWQAFQ TLVSERREAV DSALRVHNYC 
VDCEETSKWI TDKTKVVEST KDLGRDLAGI IAIQRKLSGL ERDVAAIQAR VDALERESQQ 
LMDSHPEQKE DIGQRQKHLE ELWQGLQQSL QGQEDLLGEV SQLQAFLQDL DDFQAWLSIT 
QKAVASEDMP ESLPEAEQLL QQHAGIKDEI DGHQDSYQRV KESGEKVIQG QTDPEYLLLG 
QRLEGLDTGW NALGRMWESR SHTLAQCLGF QEFQKDAKQA EAILSNQEYT LAHLEPPDSL 
EAAEAGIRKF EDFLGSMENN RDKVLSPVDS GNKLVAEGNL YSDKIKEKVQ LIEDRHRKNN 
EKAQEASVLL RDNLELQNFL QNCQELTLWI NDKLLTSQDV SYDEARNLHN KWLKHQAFVA 
ELASHEGWLE NIDAEGKQLM DEKPQFTALV SQKLEALHRL WDELQATTKE KTQHLSAARS 
SDLRLQTHAD LNKWISAMED QLRSDDPGKD LTSVNRMLAK LKRVEDQVNV RKEELGELFA 
QVPSMGEEGG DADLSIEKRF LDLLEPLGRR KKQLESSRAK LQISRDLEDE TLWVEERLPL 
AQSADYGTNL QTVQLFMKKN QTLQNEILGH TPRVEDVLQR GQQLVEAAEI DCQDLEERLG 
HLQSSWDRLR EAAAGRLQRL RDANEAQQYY LDADEAEAWI GEQELYVISD EIPKDEEGAI 
VMLKRHLRQQ RAVEDYGRNI KQLASRAQGL LSAGHPEGEQ IIRLQGQVDK HYAGLKDVAE 
ERKRKLENMY HLFQLKRETD DLEQWISEKE LVASSPEMGQ DFDHVTLLRD KFRDFARETG 
AIGQERVDNV NAFIERLIDA GHSEAATIAE WKDGLNEMWA DLLELIDTRM QLLAASYDLH 
RYFYTGAEIL GLIDEKHREL PEDVGLDAST AESFHRVHTA FERELHLLGV QVQQFQDVAT 
RLQTAYAGEK AEAIQNKEQE VSAAWQALLD ACAGRRTQLV DTADKFRFFS MARDLLSWME 
SIIRQIETQE RPRDVSSVEL LMKYHQGINA EIETRSKNFS ACLELGESLL QRQHQASEEI 
REKLQQVMSR RKEMNEKWEA RWERLRMLLE VCQFSRDASV AEAWLIAQEP YLASGDFGHT 
VDSVEKLIKR HEAFEKSTAS WAERFAALEK PTTLELKERQ IAERPAEETG PQEEEGETAG 
EAPVSHHAAT ERTSPVSLWS RLSSSWESLQ PEPSHPY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.