Details for: SRD5A1

Gene ID: 6715

Symbol: SRD5A1

Ensembl ID: ENSG00000145545

Description: steroid 5 alpha-reductase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 95.4706
    Cell Significance Index: -14.8500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 58.1919
    Cell Significance Index: -14.7600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 33.3070
    Cell Significance Index: -15.7300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 30.3469
    Cell Significance Index: -15.6100
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 20.5439
    Cell Significance Index: 26.5800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.4011
    Cell Significance Index: -15.2900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.4538
    Cell Significance Index: -14.6100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.9407
    Cell Significance Index: -15.5500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.4511
    Cell Significance Index: -10.6000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.5447
    Cell Significance Index: 42.8700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.1351
    Cell Significance Index: 59.6700
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.8497
    Cell Significance Index: 4.1700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8275
    Cell Significance Index: 81.8600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7016
    Cell Significance Index: 76.3100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7014
    Cell Significance Index: 140.7000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.6521
    Cell Significance Index: 10.4600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6192
    Cell Significance Index: 559.1300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6168
    Cell Significance Index: 426.5900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5504
    Cell Significance Index: 109.2300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5236
    Cell Significance Index: 32.1800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4825
    Cell Significance Index: 173.0600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4589
    Cell Significance Index: 53.4800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4446
    Cell Significance Index: 72.3100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.4316
    Cell Significance Index: 10.3500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.3969
    Cell Significance Index: 5.6500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3429
    Cell Significance Index: 23.7200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3315
    Cell Significance Index: 146.5600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3047
    Cell Significance Index: 21.5500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2583
    Cell Significance Index: 11.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2326
    Cell Significance Index: 5.0400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2251
    Cell Significance Index: 12.6300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.2232
    Cell Significance Index: 4.1300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2092
    Cell Significance Index: 39.8200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1972
    Cell Significance Index: 2.6900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1682
    Cell Significance Index: 4.8000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1429
    Cell Significance Index: 78.0600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1425
    Cell Significance Index: 3.1200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1131
    Cell Significance Index: 1.6700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0993
    Cell Significance Index: 11.7100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0953
    Cell Significance Index: 3.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0743
    Cell Significance Index: 13.4000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0653
    Cell Significance Index: 1.3900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0623
    Cell Significance Index: 3.9300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0447
    Cell Significance Index: 6.1400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0333
    Cell Significance Index: 0.5700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0330
    Cell Significance Index: 5.6300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0327
    Cell Significance Index: 1.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0262
    Cell Significance Index: 49.2500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0170
    Cell Significance Index: 2.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0111
    Cell Significance Index: 1.3600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0100
    Cell Significance Index: 13.6400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0077
    Cell Significance Index: 11.8000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0063
    Cell Significance Index: 11.5900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0036
    Cell Significance Index: 0.0900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0034
    Cell Significance Index: 1.9300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0022
    Cell Significance Index: 0.1500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0030
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0036
    Cell Significance Index: -2.6600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0052
    Cell Significance Index: -3.3200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0067
    Cell Significance Index: -4.2000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0119
    Cell Significance Index: -0.2500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0122
    Cell Significance Index: -8.9100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0165
    Cell Significance Index: -0.6300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0179
    Cell Significance Index: -13.5400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0188
    Cell Significance Index: -0.8300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0195
    Cell Significance Index: -1.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0202
    Cell Significance Index: -2.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0204
    Cell Significance Index: -9.2500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0331
    Cell Significance Index: -2.5400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0341
    Cell Significance Index: -4.9500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0387
    Cell Significance Index: -8.1500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0389
    Cell Significance Index: -11.1900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0428
    Cell Significance Index: -1.3700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0445
    Cell Significance Index: -5.7000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0615
    Cell Significance Index: -1.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0636
    Cell Significance Index: -7.2900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0691
    Cell Significance Index: -3.6300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0764
    Cell Significance Index: -4.9300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0773
    Cell Significance Index: -4.7400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0800
    Cell Significance Index: -3.7600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0837
    Cell Significance Index: -1.2000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1023
    Cell Significance Index: -2.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1035
    Cell Significance Index: -10.7800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1151
    Cell Significance Index: -13.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1165
    Cell Significance Index: -8.6800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1481
    Cell Significance Index: -4.0300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1560
    Cell Significance Index: -3.3100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1602
    Cell Significance Index: -2.4000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1640
    Cell Significance Index: -5.3700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1715
    Cell Significance Index: -13.5800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1881
    Cell Significance Index: -5.5400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1887
    Cell Significance Index: -6.0100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2034
    Cell Significance Index: -5.9800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2043
    Cell Significance Index: -5.8900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2367
    Cell Significance Index: -2.1800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2466
    Cell Significance Index: -4.9500
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2535
    Cell Significance Index: -2.1600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2550
    Cell Significance Index: -6.8200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2554
    Cell Significance Index: -13.3100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2613
    Cell Significance Index: -5.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SRD5A1 is a type II membrane-bound enzyme that catalyzes the conversion of 5-alpha-androstan-3-β-ol to 5-alpha-androstan-17β-ol, a key step in the biosynthesis of androgens. The enzyme exhibits high specificity and is highly expressed in tissues involved in androgen production, such as the testes, prostate, and adrenal glands. SRD5A1 is also present in various non-reproductive tissues, including the brain, where it plays a role in regulating androgen-dependent behaviors. **Pathways and Functions:** SRD5A1 is involved in the following pathways: 1. **Androgen biosynthesis:** SRD5A1 catalyzes the conversion of 5-alpha-androstan-3-β-ol to 5-alpha-androstan-17β-ol, which is then converted to testosterone and dihydrotestosterone (DHT) by other enzymes. 2. **Cellular differentiation:** Androgens, produced in part through SRD5A1-mediated conversion, play critical roles in regulating cellular differentiation, particularly in tissues such as the prostate and bone. 3. **Bone development:** Androgens, particularly DHT, are essential for maintaining bone density and regulating osteoblast activity. **Clinical Significance:** SRD5A1 has significant implications in various clinical contexts: 1. **Androgen insensitivity syndrome (AIS):** Mutations in the SRD5A1 gene can lead to AIS, a condition characterized by impaired androgen production and sensitivity. 2. **Hypogonadism:** SRD5A1 mutations can also contribute to hypogonadism, a condition characterized by reduced androgen production. 3. **Prostate cancer:** Elevated SRD5A1 expression has been linked to prostate cancer progression, suggesting a potential role for the enzyme in tumor growth and development. 4. **Neurological disorders:** SRD5A1 has also been implicated in neurological disorders, such as autism and schizophrenia, where androgens play a crucial role in regulating brain development and function. In conclusion, SRD5A1 is a critical enzyme in the biosynthesis of androgens, with significant implications for various physiological processes, including male reproductive development, bone density, and cellular differentiation. Understanding the role of SRD5A1 in these contexts can provide valuable insights into the pathogenesis of androgen-related disorders and inform the development of novel therapeutic strategies.

Genular Protein ID: 2237908148

Symbol: S5A1_HUMAN

Name: 3-oxo-5-alpha-steroid 4-dehydrogenase 1

UniProtKB Accession Codes:

P18405 B2R7Q1 Q9UHY4 Q9UP36 Q9UP37

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 20 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 10 DrugCentral 1 EC 3 EMBL 18 Ensembl 1 ExpressionAtlas 1 GO 43 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 7 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2339109

Title: Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases.

PubMed ID: 2339109

DOI: 10.1073/pnas.87.10.3640

PubMed ID: 1686016

Title: Characterization and chromosomal mapping of a human steroid 5 alpha-reductase gene and pseudogene and mapping of the mouse homologue.

PubMed ID: 1686016

DOI: 10.1016/0888-7543(91)90038-g

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11678334

Title: New steroid 5alpha-reductase type I (SRD5A1) homologous sequences on human chromosomes 6 and 8.

PubMed ID: 11678334

DOI: 10.1007/s004240100019

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 259
  • Mass: 29459
  • Checksum: AEF9FD5521E43AC4
  • Sequence:
    • MATATGVAEE RLLAALAYLQ CAVGCAVFAR NRQTNSVYGR HALPSHRLRV PARAAWVVQE 
LPSLALPLYQ YASESAPRLR SAPNCILLAM FLVHYGHRCL IYPFLMRGGK PMPLLACTMA 
IMFCTCNGYL QSRYLSHCAV YADDWVTDPR FLIGFGLWLT GMLINIHSDH ILRNLRKPGD 
TGYKIPRGGL FEYVTAANYF GEIMEWCGYA LASWSVQGAA FAFFTFCFLS GRAKEHHEWY 
LRKFEEYPKF RKIIIPFLF

Genular Protein ID: 2722894854

Symbol: B7Z4D8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z4D8

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 NCBI Taxonomy 1 OrthoDB 1 ProteomicsDB 1 RefSeq 1

Sequence Information:

  • Length: 194
  • Mass: 21299
  • Checksum: 27CA9BCFEEBCA041
  • Sequence:
    • MEHAAQPWRW QRRRGWRRSA CWPRSPTCSA PWAARSSRAI VRRTQCTAAT RCPATGSECR 
RGPPGWCRSC PRWPCRSTST PASPPRVSAA RPTASSWPCS SSTTGIGNVG MQALAVCLHP 
KCQPMVPIVC PDLNHDSKTQ REIAGIRCSY SLLGNTAASR RIPTSLMTQH LNAHLLANTC 
FAVNQYEVFL GVLA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.