Details for: STAT6

Gene ID: 6778

Symbol: STAT6

Ensembl ID: ENSG00000166888

Description: signal transducer and activator of transcription 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 180.8799
    Cell Significance Index: -28.1400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 103.8860
    Cell Significance Index: -26.3500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 66.3742
    Cell Significance Index: -26.9700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 65.6397
    Cell Significance Index: -30.9900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 58.6623
    Cell Significance Index: -30.1800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 46.3696
    Cell Significance Index: -31.1200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 28.3322
    Cell Significance Index: -27.0500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.4721
    Cell Significance Index: -28.9400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.3533
    Cell Significance Index: -27.7400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.2359
    Cell Significance Index: -18.0300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.8432
    Cell Significance Index: -24.0900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.4860
    Cell Significance Index: -29.5400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 3.2858
    Cell Significance Index: 52.7200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.4665
    Cell Significance Index: 66.0900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.4547
    Cell Significance Index: 68.6000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.2483
    Cell Significance Index: 41.5600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.4565
    Cell Significance Index: 39.6500
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.2291
    Cell Significance Index: 10.9100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2195
    Cell Significance Index: 55.2800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1745
    Cell Significance Index: 70.5100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1188
    Cell Significance Index: 58.1200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.1047
    Cell Significance Index: 21.5600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0733
    Cell Significance Index: 30.9300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8515
    Cell Significance Index: 168.9800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.8074
    Cell Significance Index: 13.6000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7368
    Cell Significance Index: 50.9600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7367
    Cell Significance Index: 86.8800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.7233
    Cell Significance Index: 36.5500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.7134
    Cell Significance Index: 10.6900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6854
    Cell Significance Index: 123.5500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.6250
    Cell Significance Index: 5.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6126
    Cell Significance Index: 75.3200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5928
    Cell Significance Index: 38.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5262
    Cell Significance Index: 72.2600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5211
    Cell Significance Index: 51.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4833
    Cell Significance Index: 22.7200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4274
    Cell Significance Index: 54.7900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3690
    Cell Significance Index: 19.2200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3641
    Cell Significance Index: 73.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3104
    Cell Significance Index: 169.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2992
    Cell Significance Index: 132.3000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2346
    Cell Significance Index: 211.8500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2316
    Cell Significance Index: 5.7900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1572
    Cell Significance Index: 25.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1225
    Cell Significance Index: 5.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1079
    Cell Significance Index: 13.9500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1055
    Cell Significance Index: 20.0800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1042
    Cell Significance Index: 2.2200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0799
    Cell Significance Index: 2.2900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0738
    Cell Significance Index: 1.0600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0627
    Cell Significance Index: 1.0500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0557
    Cell Significance Index: 38.5100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0416
    Cell Significance Index: 7.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0368
    Cell Significance Index: 69.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0204
    Cell Significance Index: 12.9700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0138
    Cell Significance Index: 25.4800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0078
    Cell Significance Index: 3.5400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0026
    Cell Significance Index: 1.9900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0010
    Cell Significance Index: -1.5800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0080
    Cell Significance Index: -4.9900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0123
    Cell Significance Index: -16.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0126
    Cell Significance Index: -1.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0149
    Cell Significance Index: -11.0200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0231
    Cell Significance Index: -16.9500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0325
    Cell Significance Index: -11.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0362
    Cell Significance Index: -20.4100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0433
    Cell Significance Index: -3.2300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0450
    Cell Significance Index: -3.4500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0506
    Cell Significance Index: -10.6600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0738
    Cell Significance Index: -1.0900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0747
    Cell Significance Index: -1.5500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0763
    Cell Significance Index: -21.9500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0777
    Cell Significance Index: -4.3600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0820
    Cell Significance Index: -5.8000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0826
    Cell Significance Index: -9.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0876
    Cell Significance Index: -12.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0896
    Cell Significance Index: -10.4400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1116
    Cell Significance Index: -12.7800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1173
    Cell Significance Index: -1.6000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1357
    Cell Significance Index: -2.9400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1387
    Cell Significance Index: -3.7100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1830
    Cell Significance Index: -5.8600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2297
    Cell Significance Index: -14.1200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2299
    Cell Significance Index: -6.1400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2348
    Cell Significance Index: -24.4500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2380
    Cell Significance Index: -6.9900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2740
    Cell Significance Index: -12.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2820
    Cell Significance Index: -7.4100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2956
    Cell Significance Index: -6.8300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3364
    Cell Significance Index: -26.6400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3689
    Cell Significance Index: -13.9700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3822
    Cell Significance Index: -23.4300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3875
    Cell Significance Index: -9.9000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3933
    Cell Significance Index: -2.6700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3956
    Cell Significance Index: -26.6000
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.4360
    Cell Significance Index: -2.6900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5044
    Cell Significance Index: -31.7900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5468
    Cell Significance Index: -28.7100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5723
    Cell Significance Index: -20.0500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.6068
    Cell Significance Index: -6.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** STAT6 is a member of the STAT family of transcription factors, which are involved in signaling pathways that regulate cell growth, differentiation, and survival. STAT6 is specifically activated by the cytokines IL-4 and IL-13, which are key players in the regulation of the immune response, particularly in the context of allergic inflammation and asthma. STAT6 is also activated by the growth factor PDGF, which is involved in cell proliferation and differentiation. **Pathways and Functions** STAT6 is involved in several signaling pathways, including: 1. **Cytokine-mediated signaling pathway**: STAT6 is activated by the cytokines IL-4 and IL-13, which are produced by Th2 cells and mast cells in response to allergens. This leads to the transcriptional activation of genes involved in the regulation of immune responses, such as the expression of IgE and eosinophilic cytokines. 2. **Growth hormone receptor signaling pathway via JAK-STAT**: STAT6 is activated by the growth factor PDGF, which is involved in cell proliferation and differentiation. This pathway is also involved in the regulation of immune responses, particularly in the context of allergic inflammation. 3. **Interleukin-4 and interleukin-13 signaling**: STAT6 is activated by IL-4 and IL-13, which are key players in the regulation of the immune response, particularly in the context of allergic inflammation and asthma. 4. **Regulation of cell population proliferation**: STAT6 is involved in the regulation of cell proliferation, particularly in the context of mast cell and eosinophilic cell growth. **Clinical Significance** STAT6 has been implicated in various diseases, including: 1. **Asthma**: STAT6 is involved in the regulation of the immune response in asthma, particularly in the context of Th2 cell and mast cell activation. 2. **Allergic inflammation**: STAT6 is activated by IL-4 and IL-13, which are key players in the regulation of allergic inflammation. 3. **Cancer**: STAT6 has been implicated in the regulation of cell proliferation and survival in various types of cancer, including breast and lung cancer. 4. **Autoimmune diseases**: STAT6 has been implicated in the regulation of immune responses in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. In conclusion, STAT6 is a transcription factor that plays a crucial role in various biological processes, including immune responses, cell proliferation, and differentiation. Its activation by IL-4 and IL-13, as well as PDGF, has significant implications for our understanding of allergic inflammation, asthma, and other diseases. Further research is needed to fully elucidate the mechanisms of STAT6 and its role in human disease. **Significantly expressed cells** * Nasal mucosa goblet cell * CD14-positive, CD16-negative classical monocyte * Basal epithelial cell of tracheobronchial tree * CD14-positive, CD16-positive monocyte * CD14-positive monocyte * Bladder urothelial cell * Ciliated cell * Blood cell * Lung goblet cell * Conjunctival epithelial cell **Proteins** * STAT6_HUMAN (Signal transducer and activator of transcription 6) * B4DQB3_HUMAN * A8K4S9_HUMAN

Genular Protein ID: 1141136395

Symbol: STAT6_HUMAN

Name: Signal transducer and activator of transcription 6

UniProtKB Accession Codes:

P42226 A8K316 B7ZA27 F5GXI9 Q5FBW5 Q71UP4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CORUM 1 CPTAC 2 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 10 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 35 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 3 RefSeq 5 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8085155

Title: An interleukin-4-induced transcription factor: IL-4 Stat.

PubMed ID: 8085155

DOI: 10.1126/science.8085155

PubMed ID: 9782085

Title: Localization of the human stat6 gene to chromosome 12q13.3-q14.1, a region implicated in multiple solid tumors.

PubMed ID: 9782085

DOI: 10.1006/geno.1998.5436

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12138096

Title: An LXXLL motif in the transactivation domain of STAT6 mediates recruitment of NCoA-1/SRC-1.

PubMed ID: 12138096

DOI: 10.1074/jbc.m203556200

PubMed ID: 17210636

Title: T-cell protein tyrosine phosphatase, distinctively expressed in activated-B-cell-like diffuse large B-cell lymphomas, is the nuclear phosphatase of STAT6.

PubMed ID: 17210636

DOI: 10.1128/mcb.01234-06

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 27796300

Title: PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation.

PubMed ID: 27796300

DOI: 10.1038/ncomms12849

PubMed ID: 14757047

Title: Structure of the NCoA-1/SRC-1 PAS-B domain bound to the LXXLL motif of the STAT6 transactivation domain.

PubMed ID: 14757047

DOI: 10.1016/j.jmb.2003.12.057

PubMed ID: 36758835

Title: Severe allergic dysregulation due to a gain of function mutation in the transcription factor STAT6.

PubMed ID: 36758835

DOI: 10.1016/j.jaci.2023.01.023

PubMed ID: 37316763

Title: Autosomal Dominant STAT6 Gain of Function Causes Severe Atopy Associated with Lymphoma.

PubMed ID: 37316763

DOI: 10.1007/s10875-023-01530-7

PubMed ID: 36884218

Title: Human germline heterozygous gain-of-function STAT6 variants cause severe allergic disease.

PubMed ID: 36884218

DOI: 10.1084/jem.20221755

Sequence Information:

  • Length: 847
  • Mass: 94135
  • Checksum: F35075F1C1F2A677
  • Sequence:
    • MSLWGLVSKM PPEKVQRLYV DFPQHLRHLL GDWLESQPWE FLVGSDAFCC NLASALLSDT 
VQHLQASVGE QGEGSTILQH ISTLESIYQR DPLKLVATFR QILQGEKKAV MEQFRHLPMP 
FHWKQEELKF KTGLRRLQHR VGEIHLLREA LQKGAEAGQV SLHSLIETPA NGTGPSEALA 
MLLQETTGEL EAAKALVLKR IQIWKRQQQL AGNGAPFEES LAPLQERCES LVDIYSQLQQ 
EVGAAGGELE PKTRASLTGR LDEVLRTLVT SCFLVEKQPP QVLKTQTKFQ AGVRFLLGLR 
FLGAPAKPPL VRADMVTEKQ ARELSVPQGP GAGAESTGEI INNTVPLENS IPGNCCSALF 
KNLLLKKIKR CERKGTESVT EEKCAVLFSA SFTLGPGKLP IQLQALSLPL VVIVHGNQDN 
NAKATILWDN AFSEMDRVPF VVAERVPWEK MCETLNLKFM AEVGTNRGLL PEHFLFLAQK 
IFNDNSLSME AFQHRSVSWS QFNKEILLGR GFTFWQWFDG VLDLTKRCLR SYWSDRLIIG 
FISKQYVTSL LLNEPDGTFL LRFSDSEIGG ITIAHVIRGQ DGSPQIENIQ PFSAKDLSIR 
SLGDRIRDLA QLKNLYPKKP KDEAFRSHYK PEQMGKDGRG YVPATIKMTV ERDQPLPTPE 
LQMPTMVPSY DLGMAPDSSM SMQLGPDMVP QVYPPHSHSI PPYQGLSPEE SVNVLSAFQE 
PHLQMPPSLG QMSLPFDQPH PQGLLPCQPQ EHAVSSPDPL LCSDVTMVED SCLSQPVTAF 
PQGTWIGEDI FPPLLPPTEQ DLTKLLLEGQ GESGGGSLGA QPLLQPSHYG QSGISMSHMD 
LRANPSW

Genular Protein ID: 3998412497

Symbol: A8K4S9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K4S9

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 9 Gene3D 4 InterPro 13 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 6 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SUPFAM 4

Sequence Information:

  • Length: 847
  • Mass: 94134
  • Checksum: A35075F29729CBC6
  • Sequence:
    • MSLWGLVSKM PPEKVQRLYV DFPQHLRHLL GDWLESQPWE FLVGSDAFCC NLASALLSDT 
VQHLQASVGE QGEGSTILQH ISTLESIYQR DPLKLVATFR QILQGEKKAV MEQFRHLPMP 
FHWKQEELKF KTGLRRLQHR VGEIHLLREA LQKGAEAGQV SLHSLIETPA NGTGPSEALA 
MLLQETTGEL EAAKALVLKR IQIWKRQQQL AGNGAPFEES LAPLQERCES LVDIYSQLQQ 
EVGAAGGELE PKTRASLTGR LDEVLRTLVT SCFLVEKQPP QVLKTQTKFQ AGVRFLLGLR 
FLGAPAKPPL VRADMVTEKQ ARELSVPQGP GAGAESTGEI INNTVPLENS IPGNCCSALF 
KNLLLKKIKR CERKGTESVT EEKCAVLFSA SFTLGPGKLP IQLQALSLPL VVIVHGNQDN 
NAKATILWDN AFSEMDRVPF VVAERVPWEK MCETLNLKFM AEVGTNRGLL PEHFLFLAQK 
IFNDNSLSME AFQHRSVSWS QFNKEILLGR GFTFWQWFDG VLDLTKRCLR SYWSDRLIIG 
FISKQYVTSL LLNEPDGTFL LRFSDSEIGG ITIAHVIRGQ DGSPQIENIQ PFSAKDLSIR 
SLGNRIRDLA QLKNLYPKKP KDEAFRSHYK PEQMGKDGRG YVPATIKMTV ERDQPLPTPE 
LQMPTMVPSY DLGMAPDSSM SMQLGPDMVP QVYPPHSHSI PPYQGLSPEE SVNVLSAFQE 
PHLQMPPSLG QMSLPFDQPH PQGLLPCQPQ EHAVSSPDPL LCSDVTMVED SCLSQPVTAF 
PQGTWIGEDI FPPLLPPTEQ DLTKLLLEGQ GESGGGSLGA QPLLQPSHYG QSGISMSHMD 
LRANPSW

Genular Protein ID: 3368359579

Symbol: B4DQB3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DQB3

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 9 Gene3D 4 InterPro 11 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 5 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SUPFAM 3

Sequence Information:

  • Length: 737
  • Mass: 81628
  • Checksum: BDCB514CA20336BB
  • Sequence:
    • MEQFRHLPMP SHWKQEELKF KTGLRRLQHR VGEIHLLREA LQKGAEAGQV SLHSLIETPA 
NGTGPSEALA MLLQETTGEL EAAKALVLKR IQIWKRQQQL AGNGAPFEES LAPLQERCES 
LVDIYSQLQQ EVGAAGGELE PKTRASLTGR LDEVLRTLVT SCFLVEKQPP QVLKTQTKFQ 
AGVRFLLGLR FLGAPAKPPL VRADMVTEKQ ARELSVPQGP GAGAESTGEI INNTVPLENS 
IPGNCCSALF KNLLLKKIKR CERKGTESVT EEKCAVLFSA SFTLGPGKLP IQLQALSLPL 
VVIVHGNQDN NAKATILWDN AFSEMDRVPF VVAERVPWEK MCETLNLKFM AEVGTNRGLL 
PEHFLFLAQK IFNDNSLSME ASQHRSVSWS QFNKEILLGR GFTFWQWFDG VLDLTKRCLR 
SYWSDRLIIG FISKQYVTSL LLNEPDGTFL LRFSDSEIGG ITIAHVIRGQ DGSPQIENIQ 
PFSAKDLSIR SLGDRIRDLA QLKNLYPKKP KDEAFRSHYK PEQMGKDGRG YVPATIKMTV 
ERDQPLPTPE LQMPTMVPSY DLGMAPDSSM SMQLGPDMVP QVYPPHSHSI PPYQGLSPEE 
SVNVLSAFQE PHLQMPPSLG QMSLPFDQPH PQGLLPCQPQ EHAVSSPDPL LCSDVTMVED 
SCLSQPVTAF PQGTWIGEDI FPPLLPPTEQ DLTKLLLEGQ GESGGGSLGA QPLLQPSHYG 
QSGISMSHMD LRANPSW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.