Details for: NEK4
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 131.0873
Cell Significance Index: -20.3900 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 85.1589
Cell Significance Index: -21.6000 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 46.2761
Cell Significance Index: -18.8000 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 42.7403
Cell Significance Index: -21.9900 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 34.1717
Cell Significance Index: -22.9300 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 19.6702
Cell Significance Index: -18.7800 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 17.9893
Cell Significance Index: -22.1800 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 8.0837
Cell Significance Index: -21.6600 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 5.6873
Cell Significance Index: -22.4400 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 4.3462
Cell Significance Index: 827.1000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.2961
Cell Significance Index: 259.9900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.2834
Cell Significance Index: 254.7000 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.8114
Cell Significance Index: 51.1400 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7981
Cell Significance Index: 720.6200 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.7113
Cell Significance Index: 42.7000 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.6568
Cell Significance Index: 235.5800 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5830
Cell Significance Index: 94.8200 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.4412
Cell Significance Index: 24.7600 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.4334
Cell Significance Index: 19.1700 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.4221
Cell Significance Index: 291.9100 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.3969
Cell Significance Index: 46.2600 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.3959
Cell Significance Index: 14.9900 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.3630
Cell Significance Index: 22.3100 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.3566
Cell Significance Index: 64.2800 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.3286
Cell Significance Index: 8.2200 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3165
Cell Significance Index: 21.8900 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.2687
Cell Significance Index: 20.6200 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.2649
Cell Significance Index: 17.8100 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2202
Cell Significance Index: 120.2600 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.2168
Cell Significance Index: 5.2000 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1913
Cell Significance Index: 9.9400 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1843
Cell Significance Index: 5.3100 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.1686
Cell Significance Index: 2.0100 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1388
Cell Significance Index: 17.0700 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.1362
Cell Significance Index: 2.9500 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1308
Cell Significance Index: 6.1000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1160
Cell Significance Index: 5.2600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1152
Cell Significance Index: 15.8200 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.0815
Cell Significance Index: 1.7900 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0748
Cell Significance Index: 2.0900 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.0718
Cell Significance Index: 0.9800 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0643
Cell Significance Index: 6.3600 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0614
Cell Significance Index: 27.1400 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0455
Cell Significance Index: 0.7800 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0352
Cell Significance Index: 4.5100 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0317
Cell Significance Index: 3.7400 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.0262
Cell Significance Index: 0.3200 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0253
Cell Significance Index: 0.8900 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0251
Cell Significance Index: 47.2000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0228
Cell Significance Index: 14.4600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0146
Cell Significance Index: 22.4700 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0143
Cell Significance Index: 26.3300 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0085
Cell Significance Index: 3.8500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0043
Cell Significance Index: 5.8900 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0154
Cell Significance Index: -11.3200 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0207
Cell Significance Index: -3.5300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0212
Cell Significance Index: -3.0800 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0212
Cell Significance Index: -16.0200 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0221
Cell Significance Index: -16.3900 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0362
Cell Significance Index: -20.4000 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0374
Cell Significance Index: -2.7900 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0376
Cell Significance Index: -0.8000 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0405
Cell Significance Index: -25.3000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0654
Cell Significance Index: -18.8100 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0751
Cell Significance Index: -7.6700 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0786
Cell Significance Index: -2.1100 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0822
Cell Significance Index: -5.3100 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0850
Cell Significance Index: -10.9800 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0949
Cell Significance Index: -6.7100 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1075
Cell Significance Index: -5.6000 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.1121
Cell Significance Index: -3.2000 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1157
Cell Significance Index: -24.3700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1210
Cell Significance Index: -13.8600 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.1569
Cell Significance Index: -3.3300 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1575
Cell Significance Index: -7.4000 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1653
Cell Significance Index: -5.7500 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1689
Cell Significance Index: -4.5100 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1908
Cell Significance Index: -19.8700 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1973
Cell Significance Index: -10.3600 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2044
Cell Significance Index: -5.3800 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.2101
Cell Significance Index: -4.4900 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.2167
Cell Significance Index: -5.5700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2362
Cell Significance Index: -14.4800 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2384
Cell Significance Index: -18.8800 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.2752
Cell Significance Index: -7.4900 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.2847
Cell Significance Index: -5.6300 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2986
Cell Significance Index: -9.5100 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3125
Cell Significance Index: -10.2300 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3153
Cell Significance Index: -10.1000 - Cell Name: decidual cell (CL2000002)
Fold Change: -0.3226
Cell Significance Index: -5.1800 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.3302
Cell Significance Index: -6.6300 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.3696
Cell Significance Index: -5.5700 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.3788
Cell Significance Index: -5.4300 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.4221
Cell Significance Index: -7.1100 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.4222
Cell Significance Index: -8.2400 - Cell Name: peg cell (CL4033014)
Fold Change: -0.4242
Cell Significance Index: -9.8000 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.4343
Cell Significance Index: -6.4100 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.4344
Cell Significance Index: -9.3900 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.4428
Cell Significance Index: -7.4100 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.4453
Cell Significance Index: -15.6000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1474375140
Symbol: NEK4_HUMAN
Name: Serine/threonine-protein kinase Nek4
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8208544
Title: Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern.
PubMed ID: 8208544
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 21685204
Title: The ciliopathy-associated protein homologs RPGRIP1 and RPGRIP1L are linked to cilium integrity through interaction with Nek4 serine/threonine kinase.
PubMed ID: 21685204
DOI: 10.1093/hmg/ddr280
PubMed ID: 22851694
Title: Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblasts.
PubMed ID: 22851694
DOI: 10.1128/mcb.00436-12
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24129315
Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
PubMed ID: 24129315
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 841
- Mass: 94597
- Checksum: 43E8F11BA4007263
- Sequence:
MPLAAYCYLR VVGKGSYGEV TLVKHRRDGK QYVIKKLNLR NASSRERRAA EQEAQLLSQL KHPNIVTYKE SWEGGDGLLY IVMGFCEGGD LYRKLKEQKG QLLPENQVVE WFVQIAMALQ YLHEKHILHR DLKTQNVFLT RTNIIKVGDL GIARVLENHC DMASTLIGTP YYMSPELFSN KPYNYKSDVW ALGCCVYEMA TLKHAFNAKD MNSLVYRIIE GKLPPMPRDY SPELAELIRT MLSKRPEERP SVRSILRQPY IKRQISFFLE ATKIKTSKNN IKNGDSQSKP FATVVSGEAE SNHEVIHPQP LSSEGSQTYI MGEGKCLSQE KPRASGLLKS PASLKAHTCK QDLSNTTELA TISSVNIDIL PAKGRDSVSD GFVQENQPRY LDASNELGGI CSISQVEEEM LQDNTKSSAQ PENLIPMWSS DIVTGEKNEP VKPLQPLIKE QKPKDQSLAL SPKLECSGTI LAHSNLRLLG SSDSPASASR VAGITGVCHH AQDQVAGECI IEKQGRIHPD LQPHNSGSEP SLSRQRRQKR REQTEHRGEK RQVRRDLFAF QESPPRFLPS HPIVGKVDVT STQKEAENQR RVVTGSVSSS RSSEMSSSKD RPLSARERRR LKQSQEEMSS SGPSVRKASL SVAGPGKPQE EDQPLPARRL SSDCSVTQER KQIHCLSEDE LSSSTSSTDK SDGDYGEGKG QTNEINALVQ LMTQTLKLDS KESCEDVPVA NPVSEFKLHR KYRDTLILHG KVAEEAEEIH FKELPSAIMP GSEKIRRLVE VLRTDVIRGL GVQLLEQVYD LLEEEDEFDR EVRLREHMGE KYTTYSVKAR QLKFFEENMN F
Genular Protein ID: 2633703945
Symbol: Q05DF6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 451
- Mass: 50822
- Checksum: 13AD5B1B743FC1E8
- Sequence:
MPLAAYCYLR VVGKGSYGEV TLVKHRRDGK QYVIKKLNLR NASSRERRAA EQEAQLLSQL KHPNIVTYKE SWEGGDGLLY IVMGFCEGGD LYRKLKEQKG QLLPENQVVE WFVQIAMALQ YLHEKHILHR DLKTQNVFLT RTNIIKVGDL GIARVLENHC DMASTLIGTP YYMSPELFSN KPYNYKSDVW ALGCCVYEMA TLKHAFNAKD MNSLVYRIIE GKLPPMPRDY SPELAELIRT MLSKRPEERP SVRSILRQPY IKRQISFFLE ATKIKTSKNN IKNGDSQSKP FATVVSGEAE SNHEVIHPQP LSSEGSQTYI MGEGKCLSQE KPRASGLLKS PASLKAHTCK QDLSNTTELA TISSVNIDIL PAKGRDSVSD GFVQENQPRY LDASNELGGI CSISQVEEEM LQDNTKSSAQ PENLIPMWSS DIVTGEKNEP VKPLQPLKKK K
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.