Details for: NEK4

Gene ID: 6787

Symbol: NEK4

Ensembl ID: ENSG00000114904

Description: NIMA related kinase 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 131.0873
    Cell Significance Index: -20.3900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 85.1589
    Cell Significance Index: -21.6000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 46.2761
    Cell Significance Index: -18.8000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 42.7403
    Cell Significance Index: -21.9900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 34.1717
    Cell Significance Index: -22.9300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.6702
    Cell Significance Index: -18.7800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.9893
    Cell Significance Index: -22.1800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.0837
    Cell Significance Index: -21.6600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.6873
    Cell Significance Index: -22.4400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 4.3462
    Cell Significance Index: 827.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2961
    Cell Significance Index: 259.9900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2834
    Cell Significance Index: 254.7000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.8114
    Cell Significance Index: 51.1400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7981
    Cell Significance Index: 720.6200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7113
    Cell Significance Index: 42.7000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6568
    Cell Significance Index: 235.5800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5830
    Cell Significance Index: 94.8200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4412
    Cell Significance Index: 24.7600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4334
    Cell Significance Index: 19.1700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4221
    Cell Significance Index: 291.9100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3969
    Cell Significance Index: 46.2600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3959
    Cell Significance Index: 14.9900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3630
    Cell Significance Index: 22.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3566
    Cell Significance Index: 64.2800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3286
    Cell Significance Index: 8.2200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3165
    Cell Significance Index: 21.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2687
    Cell Significance Index: 20.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2649
    Cell Significance Index: 17.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2202
    Cell Significance Index: 120.2600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2168
    Cell Significance Index: 5.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1913
    Cell Significance Index: 9.9400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1843
    Cell Significance Index: 5.3100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1686
    Cell Significance Index: 2.0100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1388
    Cell Significance Index: 17.0700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1362
    Cell Significance Index: 2.9500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1308
    Cell Significance Index: 6.1000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1160
    Cell Significance Index: 5.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1152
    Cell Significance Index: 15.8200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0815
    Cell Significance Index: 1.7900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0748
    Cell Significance Index: 2.0900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0718
    Cell Significance Index: 0.9800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0643
    Cell Significance Index: 6.3600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0614
    Cell Significance Index: 27.1400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0455
    Cell Significance Index: 0.7800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0352
    Cell Significance Index: 4.5100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0317
    Cell Significance Index: 3.7400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0262
    Cell Significance Index: 0.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0253
    Cell Significance Index: 0.8900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0251
    Cell Significance Index: 47.2000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0228
    Cell Significance Index: 14.4600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0146
    Cell Significance Index: 22.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0143
    Cell Significance Index: 26.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0085
    Cell Significance Index: 3.8500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0043
    Cell Significance Index: 5.8900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0154
    Cell Significance Index: -11.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0207
    Cell Significance Index: -3.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0212
    Cell Significance Index: -3.0800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0212
    Cell Significance Index: -16.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0221
    Cell Significance Index: -16.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0362
    Cell Significance Index: -20.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0374
    Cell Significance Index: -2.7900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0376
    Cell Significance Index: -0.8000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0405
    Cell Significance Index: -25.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0654
    Cell Significance Index: -18.8100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0751
    Cell Significance Index: -7.6700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0786
    Cell Significance Index: -2.1100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0822
    Cell Significance Index: -5.3100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0850
    Cell Significance Index: -10.9800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0949
    Cell Significance Index: -6.7100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1075
    Cell Significance Index: -5.6000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1121
    Cell Significance Index: -3.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1157
    Cell Significance Index: -24.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1210
    Cell Significance Index: -13.8600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1569
    Cell Significance Index: -3.3300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1575
    Cell Significance Index: -7.4000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1653
    Cell Significance Index: -5.7500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1689
    Cell Significance Index: -4.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1908
    Cell Significance Index: -19.8700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1973
    Cell Significance Index: -10.3600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2044
    Cell Significance Index: -5.3800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2101
    Cell Significance Index: -4.4900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2167
    Cell Significance Index: -5.5700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2362
    Cell Significance Index: -14.4800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2384
    Cell Significance Index: -18.8800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2752
    Cell Significance Index: -7.4900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2847
    Cell Significance Index: -5.6300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2986
    Cell Significance Index: -9.5100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3125
    Cell Significance Index: -10.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3153
    Cell Significance Index: -10.1000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.3226
    Cell Significance Index: -5.1800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3302
    Cell Significance Index: -6.6300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3696
    Cell Significance Index: -5.5700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3788
    Cell Significance Index: -5.4300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.4221
    Cell Significance Index: -7.1100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4222
    Cell Significance Index: -8.2400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4242
    Cell Significance Index: -9.8000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4343
    Cell Significance Index: -6.4100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4344
    Cell Significance Index: -9.3900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4428
    Cell Significance Index: -7.4100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4453
    Cell Significance Index: -15.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Serine/threonine kinase activity:** NEK4 possesses serine/threonine kinase activity, enabling it to phosphorylate and regulate various downstream targets. 2. **Cell cycle regulation:** NEK4 is involved in the regulation of the mitotic cell cycle, ensuring proper cell division and preventing aberrant cell proliferation. 3. **DNA damage response:** NEK4 plays a role in the DNA damage response, helping to repair DNA lesions and maintain genomic stability. 4. **Protein phosphorylation:** NEK4's kinase activity allows it to phosphorylate and regulate a diverse range of proteins, including transcription factors, kinases, and structural proteins. 5. **Expression in specific cell types:** NEK4 is highly expressed in germ cells, neurons, and interneurons, suggesting its importance in neural development and function. **Pathways and Functions:** 1. **Cell division:** NEK4 regulates the mitotic cell cycle, ensuring proper cell division and preventing aberrant cell proliferation. 2. **DNA damage response:** NEK4 plays a role in the DNA damage response, helping to repair DNA lesions and maintain genomic stability. 3. **Protein phosphorylation:** NEK4's kinase activity allows it to phosphorylate and regulate a diverse range of proteins, including transcription factors, kinases, and structural proteins. 4. **Ciliary function:** NEK4 is involved in the regulation of ciliary function, including ciliary basal body, ciliary plasm, ciliary rootlet, and ciliary transition zone. 5. **Regulation of cellular senescence:** NEK4 may play a role in regulating cellular senescence, helping to maintain cellular homeostasis and prevent premature aging. **Clinical Significance:** 1. **Neurological disorders:** Alterations in NEK4 expression or function may contribute to neurological disorders, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. 2. **Cancer:** NEK4's role in DNA damage response and cell cycle regulation may make it a potential therapeutic target for cancer treatment. 3. **Neurodevelopmental disorders:** NEK4's expression in specific cell types, including neurons and interneurons, suggests its importance in neural development and function, making it a potential target for neurodevelopmental disorders, such as autism spectrum disorder. 4. **Aging and age-related diseases:** NEK4's role in regulating cellular senescence may make it a potential therapeutic target for age-related diseases, such as age-related macular degeneration and osteoarthritis. In conclusion, NEK4 is a multifaceted enzyme with diverse roles in cellular processes, including cell division, DNA damage response, protein phosphorylation, and regulation of cellular senescence. Its expression in specific cell types highlights its importance in neural development and function, making it a potential target for various diseases and disorders. Further research is necessary to fully understand the mechanisms of NEK4 and its role in human disease.

Genular Protein ID: 1474375140

Symbol: NEK4_HUMAN

Name: Serine/threonine-protein kinase Nek4

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8208544

Title: Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern.

PubMed ID: 8208544

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21685204

Title: The ciliopathy-associated protein homologs RPGRIP1 and RPGRIP1L are linked to cilium integrity through interaction with Nek4 serine/threonine kinase.

PubMed ID: 21685204

DOI: 10.1093/hmg/ddr280

PubMed ID: 22851694

Title: Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblasts.

PubMed ID: 22851694

DOI: 10.1128/mcb.00436-12

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 841
  • Mass: 94597
  • Checksum: 43E8F11BA4007263
  • Sequence:
  • MPLAAYCYLR VVGKGSYGEV TLVKHRRDGK QYVIKKLNLR NASSRERRAA EQEAQLLSQL 
    KHPNIVTYKE SWEGGDGLLY IVMGFCEGGD LYRKLKEQKG QLLPENQVVE WFVQIAMALQ 
    YLHEKHILHR DLKTQNVFLT RTNIIKVGDL GIARVLENHC DMASTLIGTP YYMSPELFSN 
    KPYNYKSDVW ALGCCVYEMA TLKHAFNAKD MNSLVYRIIE GKLPPMPRDY SPELAELIRT 
    MLSKRPEERP SVRSILRQPY IKRQISFFLE ATKIKTSKNN IKNGDSQSKP FATVVSGEAE 
    SNHEVIHPQP LSSEGSQTYI MGEGKCLSQE KPRASGLLKS PASLKAHTCK QDLSNTTELA 
    TISSVNIDIL PAKGRDSVSD GFVQENQPRY LDASNELGGI CSISQVEEEM LQDNTKSSAQ 
    PENLIPMWSS DIVTGEKNEP VKPLQPLIKE QKPKDQSLAL SPKLECSGTI LAHSNLRLLG 
    SSDSPASASR VAGITGVCHH AQDQVAGECI IEKQGRIHPD LQPHNSGSEP SLSRQRRQKR 
    REQTEHRGEK RQVRRDLFAF QESPPRFLPS HPIVGKVDVT STQKEAENQR RVVTGSVSSS 
    RSSEMSSSKD RPLSARERRR LKQSQEEMSS SGPSVRKASL SVAGPGKPQE EDQPLPARRL 
    SSDCSVTQER KQIHCLSEDE LSSSTSSTDK SDGDYGEGKG QTNEINALVQ LMTQTLKLDS 
    KESCEDVPVA NPVSEFKLHR KYRDTLILHG KVAEEAEEIH FKELPSAIMP GSEKIRRLVE 
    VLRTDVIRGL GVQLLEQVYD LLEEEDEFDR EVRLREHMGE KYTTYSVKAR QLKFFEENMN 
    F

Genular Protein ID: 2633703945

Symbol: Q05DF6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 451
  • Mass: 50822
  • Checksum: 13AD5B1B743FC1E8
  • Sequence:
  • MPLAAYCYLR VVGKGSYGEV TLVKHRRDGK QYVIKKLNLR NASSRERRAA EQEAQLLSQL 
    KHPNIVTYKE SWEGGDGLLY IVMGFCEGGD LYRKLKEQKG QLLPENQVVE WFVQIAMALQ 
    YLHEKHILHR DLKTQNVFLT RTNIIKVGDL GIARVLENHC DMASTLIGTP YYMSPELFSN 
    KPYNYKSDVW ALGCCVYEMA TLKHAFNAKD MNSLVYRIIE GKLPPMPRDY SPELAELIRT 
    MLSKRPEERP SVRSILRQPY IKRQISFFLE ATKIKTSKNN IKNGDSQSKP FATVVSGEAE 
    SNHEVIHPQP LSSEGSQTYI MGEGKCLSQE KPRASGLLKS PASLKAHTCK QDLSNTTELA 
    TISSVNIDIL PAKGRDSVSD GFVQENQPRY LDASNELGGI CSISQVEEEM LQDNTKSSAQ 
    PENLIPMWSS DIVTGEKNEP VKPLQPLKKK K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.