Details for: STX1A

Gene ID: 6804

Symbol: STX1A

Ensembl ID: ENSG00000106089

Description: syntaxin 1A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 83.2555
    Cell Significance Index: -12.9500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 24.3319
    Cell Significance Index: -9.8900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.5032
    Cell Significance Index: -12.9500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.7856
    Cell Significance Index: -12.8200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.2995
    Cell Significance Index: -13.0200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.3050
    Cell Significance Index: 37.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2974
    Cell Significance Index: 260.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9321
    Cell Significance Index: 48.4200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.7629
    Cell Significance Index: 10.9300
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.7609
    Cell Significance Index: 10.1500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6333
    Cell Significance Index: 62.6500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6162
    Cell Significance Index: 556.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4806
    Cell Significance Index: 56.0100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4047
    Cell Significance Index: 11.6600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3433
    Cell Significance Index: 55.8400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3283
    Cell Significance Index: 35.7100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3101
    Cell Significance Index: 59.0200
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.3031
    Cell Significance Index: 2.3300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2946
    Cell Significance Index: 8.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2774
    Cell Significance Index: 99.5000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2272
    Cell Significance Index: 3.1000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2159
    Cell Significance Index: 13.2700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2144
    Cell Significance Index: 12.8700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1730
    Cell Significance Index: 6.0800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1576
    Cell Significance Index: 10.9000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1468
    Cell Significance Index: 3.1800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1411
    Cell Significance Index: 3.0900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1387
    Cell Significance Index: 7.2800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1135
    Cell Significance Index: 7.6300
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.1079
    Cell Significance Index: 1.1900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0924
    Cell Significance Index: 63.9200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0899
    Cell Significance Index: 17.8500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0781
    Cell Significance Index: 3.5400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0689
    Cell Significance Index: 1.1800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0615
    Cell Significance Index: 4.5800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0402
    Cell Significance Index: 7.2500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0372
    Cell Significance Index: 20.3000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0075
    Cell Significance Index: 5.5500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0047
    Cell Significance Index: 0.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0006
    Cell Significance Index: 0.0700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0000
    Cell Significance Index: -0.0200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0006
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0023
    Cell Significance Index: -1.4100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0045
    Cell Significance Index: -8.4900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0081
    Cell Significance Index: -15.0000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0094
    Cell Significance Index: -1.9900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0103
    Cell Significance Index: -15.8600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0105
    Cell Significance Index: -5.9300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0131
    Cell Significance Index: -17.8800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0146
    Cell Significance Index: -9.2800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0151
    Cell Significance Index: -11.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0156
    Cell Significance Index: -11.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0213
    Cell Significance Index: -3.6400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0264
    Cell Significance Index: -11.9900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0293
    Cell Significance Index: -0.8200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0303
    Cell Significance Index: -3.9200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0320
    Cell Significance Index: -1.4900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0338
    Cell Significance Index: -4.6400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0373
    Cell Significance Index: -4.2600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0379
    Cell Significance Index: -0.9100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0447
    Cell Significance Index: -6.5000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0454
    Cell Significance Index: -13.0600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0479
    Cell Significance Index: -6.1400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0688
    Cell Significance Index: -4.4400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0726
    Cell Significance Index: -3.4100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0809
    Cell Significance Index: -5.7200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0848
    Cell Significance Index: -1.4200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0851
    Cell Significance Index: -2.7100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0901
    Cell Significance Index: -2.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0932
    Cell Significance Index: -9.5300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0976
    Cell Significance Index: -11.5100
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0998
    Cell Significance Index: -0.9500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1017
    Cell Significance Index: -3.3300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1032
    Cell Significance Index: -6.3300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1133
    Cell Significance Index: -1.6100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1198
    Cell Significance Index: -9.2000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1291
    Cell Significance Index: -13.4400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1442
    Cell Significance Index: -11.4200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1452
    Cell Significance Index: -8.1500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1512
    Cell Significance Index: -3.2200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1608
    Cell Significance Index: -2.5800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1679
    Cell Significance Index: -3.3700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1691
    Cell Significance Index: -3.5900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1692
    Cell Significance Index: -5.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1840
    Cell Significance Index: -8.1400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1846
    Cell Significance Index: -3.6500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1851
    Cell Significance Index: -9.6400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1960
    Cell Significance Index: -4.8900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2056
    Cell Significance Index: -2.2400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2122
    Cell Significance Index: -8.0400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2224
    Cell Significance Index: -7.7900
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2292
    Cell Significance Index: -3.1800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2315
    Cell Significance Index: -5.9500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2434
    Cell Significance Index: -5.0800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2578
    Cell Significance Index: -5.5100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2690
    Cell Significance Index: -5.6300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2709
    Cell Significance Index: -7.9800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2741
    Cell Significance Index: -8.0500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2860
    Cell Significance Index: -7.5200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2879
    Cell Significance Index: -6.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Structural Homology**: STX1A is a member of the syntaxin family, which consists of six members (STX1A-6). These proteins share a high degree of sequence homology and structural similarity, with STX1A being the most widely expressed and studied. 2. **SNARE Complex Formation**: STX1A forms a complex with SNAP-25 and synaptobrevin 2, which is essential for the fusion of synaptic vesicles with the presynaptic active zone membrane. 3. **Regulation of Neurotransmitter Release**: STX1A is involved in the regulation of neurotransmitter release, including glutamate, GABA, and dopamine. 4. **Disease Implications**: Dysregulation of STX1A has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. **Pathways and Functions** 1. **Acetylcholine Neurotransmitter Release Cycle**: STX1A is involved in the regulation of acetylcholine release, which is essential for muscle contraction and cognitive function. 2. **Calcium-ion Regulated Exocytosis**: STX1A plays a crucial role in calcium-ion regulated exocytosis, which is essential for neurotransmitter release and synaptic transmission. 3. **Cytokine Signaling in Immune System**: STX1A is involved in cytokine signaling, which is essential for the regulation of immune responses. 4. **Extracellular Region**: STX1A is located in the extracellular region of the presynaptic active zone membrane, where it interacts with synaptic vesicles and other proteins. **Clinical Significance** 1. **Neurological Disorders**: Dysregulation of STX1A has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. 2. **Cognitive Impairment**: STX1A dysfunction has been linked to cognitive impairment and memory loss. 3. **Mood Disorders**: STX1A has been implicated in the regulation of mood and emotional responses, and dysfunction has been linked to mood disorders, including depression and bipolar disorder. 4. **Therapeutic Targets**: STX1A has been identified as a potential therapeutic target for the treatment of neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, STX1A is a crucial protein in the regulation of neurotransmitter release and synaptic transmission. Its dysfunction has been implicated in various neurological disorders, and it has been identified as a potential therapeutic target for the treatment of these disorders. Further research is needed to fully understand the mechanisms of STX1A and its role in human health and disease.

Genular Protein ID: 1577028649

Symbol: STX1A_HUMAN

Name: Syntaxin-1A

UniProtKB Accession Codes:

Q16623 O15447 O15448 Q12936 Q75MD9 Q7Z5K3 Q9BPZ6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 21 Ensembl 2 ExpressionAtlas 1 GO 35 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 14 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7622072

Title: Cloning and sequence analysis of a cDNA encoding human syntaxin 1A, a polypeptide essential for exocytosis.

PubMed ID: 7622072

DOI: 10.1016/0378-1119(95)00152-v

PubMed ID: 9311751

Title: Hemizygous deletion of the syntaxin 1A gene in individuals with Williams syndrome.

PubMed ID: 9311751

DOI: 10.1086/514850

PubMed ID: 11977160

Title: Refinement of the genomic structure of STX1A and mutation analysis in nondeletion Williams syndrome patients.

PubMed ID: 11977160

DOI: 10.1002/ajmg.10321

PubMed ID: 9003414

Title: Novel isoform of syntaxin 1 is expressed in mammalian cells.

PubMed ID: 9003414

DOI: 10.1042/bj3210151

PubMed ID: 9177791

Title: Mapping of the human HPC-1/syntaxin 1A gene (STX1A) to chromosome 7 band q11.2.

PubMed ID: 9177791

DOI: 10.1006/geno.1997.4650

PubMed ID: 12586365

Title: Expression of syntaxin 1C, an alternative splice variant of HPC-1/syntaxin 1A, is enhanced by phorbol-ester stimulation in astroglioma: participation of the PKC signaling pathway.

PubMed ID: 12586365

DOI: 10.1016/s0014-5793(03)00015-2

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10644452

Title: Expression analysis of the human HPC-1/syntaxin 1A, a gene deleted in Williams syndrome.

PubMed ID: 10644452

DOI: 10.1006/geno.1999.5987

PubMed ID: 12130530

Title: Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion.

PubMed ID: 12130530

DOI: 10.1182/blood.v100.3.1081

PubMed ID: 12730201

Title: Ca2+-dependent phosphorylation of syntaxin-1A by the death-associated protein (DAP) kinase regulates its interaction with Munc18.

PubMed ID: 12730201

DOI: 10.1074/jbc.m300492200

PubMed ID: 15459722

Title: Syntabulin is a microtubule-associated protein implicated in syntaxin transport in neurons.

PubMed ID: 15459722

DOI: 10.1038/ncb1169

PubMed ID: 15822905

Title: Phosphoproteomic analysis of synaptosomes from human cerebral cortex.

PubMed ID: 15822905

DOI: 10.1021/pr0498436

PubMed ID: 23091057

Title: Munc18-1 controls SNARE protein complex assembly during human sperm acrosomal exocytosis.

PubMed ID: 23091057

DOI: 10.1074/jbc.m112.409649

PubMed ID: 26635000

Title: SUMOylation of Syntaxin1A regulates presynaptic endocytosis.

PubMed ID: 26635000

DOI: 10.1038/srep17669

Sequence Information:

  • Length: 288
  • Mass: 33023
  • Checksum: 8AC787EFCE65ACA1
  • Sequence:
    • MKDRTQELRT AKDSDDDDDV AVTVDRDRFM DEFFEQVEEI RGFIDKIAEN VEEVKRKHSA 
ILASPNPDEK TKEELEELMS DIKKTANKVR SKLKSIEQSI EQEEGLNRSS ADLRIRKTQH 
STLSRKFVEV MSEYNATQSD YRERCKGRIQ RQLEITGRTT TSEELEDMLE SGNPAIFASG 
IIMDSSISKQ ALSEIETRHS EIIKLENSIR ELHDMFMDMA MLVESQGEMI DRIEYNVEHA 
VDYVERAVSD TKKAVKYQSK ARRKKIMIII CCVILGIVIA STVGGIFA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.