Details for: SUV39H1

Gene ID: 6839

Symbol: SUV39H1

Ensembl ID: ENSG00000101945

Description: SUV39H1 histone lysine methyltransferase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 15.1724
    Cell Significance Index: -2.3600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 14.5874
    Cell Significance Index: -3.7000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.4957
    Cell Significance Index: -4.3100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.5006
    Cell Significance Index: -4.0200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.1556
    Cell Significance Index: -4.5600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6488
    Cell Significance Index: 64.1800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6314
    Cell Significance Index: 120.1600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3974
    Cell Significance Index: 43.2200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3795
    Cell Significance Index: 61.7200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3590
    Cell Significance Index: 21.5500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2977
    Cell Significance Index: 18.7600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2806
    Cell Significance Index: 253.3500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.2708
    Cell Significance Index: 3.8800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.2149
    Cell Significance Index: 5.4900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1948
    Cell Significance Index: 22.9700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1603
    Cell Significance Index: 11.0900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1316
    Cell Significance Index: 2.7300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1163
    Cell Significance Index: 3.1100
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.0979
    Cell Significance Index: 0.6500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0757
    Cell Significance Index: 15.0300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0670
    Cell Significance Index: 7.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0615
    Cell Significance Index: 1.9700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0463
    Cell Significance Index: 2.4300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0429
    Cell Significance Index: 1.2000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0425
    Cell Significance Index: 29.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0407
    Cell Significance Index: 8.1700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0396
    Cell Significance Index: 17.5300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0391
    Cell Significance Index: 2.5300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0351
    Cell Significance Index: 1.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0278
    Cell Significance Index: 1.2600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0250
    Cell Significance Index: 13.6500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0243
    Cell Significance Index: 0.3900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0231
    Cell Significance Index: 0.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0210
    Cell Significance Index: 7.5400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0160
    Cell Significance Index: 0.8300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0135
    Cell Significance Index: 2.4400
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.0120
    Cell Significance Index: 0.1200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0108
    Cell Significance Index: 1.4000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0100
    Cell Significance Index: 0.3500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0097
    Cell Significance Index: 1.2400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0080
    Cell Significance Index: 0.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0079
    Cell Significance Index: 1.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0045
    Cell Significance Index: 0.2100
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0036
    Cell Significance Index: 0.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0001
    Cell Significance Index: -0.2400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0004
    Cell Significance Index: -0.7400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0006
    Cell Significance Index: -0.9600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0024
    Cell Significance Index: -3.3300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0032
    Cell Significance Index: -0.1100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0033
    Cell Significance Index: -0.0700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0039
    Cell Significance Index: -2.9400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0043
    Cell Significance Index: -0.4900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0048
    Cell Significance Index: -3.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0051
    Cell Significance Index: -3.7800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0054
    Cell Significance Index: -3.4100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0055
    Cell Significance Index: -0.0600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0060
    Cell Significance Index: -0.1600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0069
    Cell Significance Index: -0.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0072
    Cell Significance Index: -4.0600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0086
    Cell Significance Index: -0.5300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0092
    Cell Significance Index: -5.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0096
    Cell Significance Index: -0.9800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0100
    Cell Significance Index: -4.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0120
    Cell Significance Index: -1.7400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0126
    Cell Significance Index: -2.1600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0153
    Cell Significance Index: -1.0800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0160
    Cell Significance Index: -4.6100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0176
    Cell Significance Index: -1.3100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0208
    Cell Significance Index: -0.3300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0213
    Cell Significance Index: -0.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0262
    Cell Significance Index: -1.4700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0265
    Cell Significance Index: -5.5800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0293
    Cell Significance Index: -0.4200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0296
    Cell Significance Index: -1.8200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0317
    Cell Significance Index: -0.5300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0416
    Cell Significance Index: -1.0700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0419
    Cell Significance Index: -4.3600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0428
    Cell Significance Index: -0.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0452
    Cell Significance Index: -3.4700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0456
    Cell Significance Index: -2.1500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0489
    Cell Significance Index: -3.2900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0506
    Cell Significance Index: -1.0600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0521
    Cell Significance Index: -1.5300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0574
    Cell Significance Index: -4.5500
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0603
    Cell Significance Index: -0.4000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0617
    Cell Significance Index: -0.9300
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0662
    Cell Significance Index: -0.6300
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0664
    Cell Significance Index: -0.9300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0738
    Cell Significance Index: -1.9400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0770
    Cell Significance Index: -4.0100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0805
    Cell Significance Index: -0.9600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0889
    Cell Significance Index: -0.9200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0902
    Cell Significance Index: -1.2300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0920
    Cell Significance Index: -4.0700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0930
    Cell Significance Index: -0.6300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1019
    Cell Significance Index: -1.4300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1033
    Cell Significance Index: -3.9100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1068
    Cell Significance Index: -1.8300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1076
    Cell Significance Index: -3.7700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1112
    Cell Significance Index: -3.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Histone Lysine Methyltransferase Activity**: SUV39H1 is a histone lysine methyltransferase, specifically targeting histone H3 lysine 9 (H3K9) for methylation. 2. **Chromatin Silencing**: The methylation of H3K9 by SUV39H1 leads to the silencing of gene expression, playing a crucial role in maintaining genome stability and preventing aberrant gene expression. 3. **Cellular Specificity**: SUV39H1 is expressed in various cell types, including extravillous trophoblast, respiratory basal cell, goblet cell, and cardiac muscle myoblast, highlighting its importance in different tissues and developmental processes. 4. **Epigenetic Regulation**: SUV39H1 is involved in the regulation of transcription by interacting with chromatin-modifying enzymes and transcriptional regulators, highlighting its role in epigenetic programming. **Pathways and Functions** 1. **Cell Cycle Regulation**: SUV39H1 is involved in the regulation of the cell cycle, particularly in the maintenance of genome stability and preventing aberrant gene expression. 2. **Chromatin Organization**: SUV39H1 plays a crucial role in the organization of chromatin structure, particularly in the formation of heterochromatin, which is essential for maintaining genome stability. 3. **Epigenetic Regulation of Gene Expression**: SUV39H1 is involved in the regulation of gene expression by interacting with chromatin-modifying enzymes and transcriptional regulators, leading to the silencing of gene expression. 4. **Response to Environmental Stress**: SUV39H1 is involved in the cellular response to glucose starvation and hypoxia, highlighting its role in maintaining cellular homeostasis under adverse conditions. **Clinical Significance** 1. **Cancer Development**: Aberrant SUV39H1 expression has been linked to cancer development, highlighting its potential as a therapeutic target for cancer treatment. 2. **Neurological Disorders**: SUV39H1 is involved in the regulation of gene expression in the brain, particularly in the development and function of neurons, highlighting its potential role in neurological disorders such as Alzheimer's disease and Parkinson's disease. 3. **Developmental Disorders**: SUV39H1 is involved in the regulation of gene expression during development, particularly in the formation of neural crest cells, highlighting its potential role in developmental disorders such as neural tube defects. 4. **Regulatory T Cell Function**: SUV39H1 is involved in the regulation of regulatory T cell function, highlighting its potential role in immune system regulation and autoimmune diseases. In conclusion, SUV39H1 is a critical gene involved in the regulation of gene expression and chromatin structure, playing a crucial role in various cellular processes, including cell cycle regulation, chromatin organization, and epigenetic regulation of gene expression. Its aberrant expression has been linked to various diseases, highlighting its potential as a therapeutic target for cancer treatment, neurological disorders, and developmental disorders.

Genular Protein ID: 1155768560

Symbol: SUV91_HUMAN

Name: Histone-lysine N-methyltransferase SUV39H1

UniProtKB Accession Codes:

O43463 B2R6E8 B4DST0 Q53G60 Q6FHK6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CPTC 1 CTD 1 ChEBI 25 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DNASU 1 DisGeNET 1 EC 1 EMBL 9 Ensembl 2 EvolutionaryTrace 1 GO 35 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIRSF 1 PRO 1 PROSITE 6 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 3 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10202156

Title: Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31.

PubMed ID: 10202156

DOI: 10.1093/emboj/18.7.1923

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10671371

Title: Mitotic phosphorylation of SUV39H1, a novel component of active centromeres, coincides with transient accumulation at mammalian centromeres.

PubMed ID: 10671371

DOI: 10.1242/jcs.113.5.817

PubMed ID: 10949293

Title: Regulation of chromatin structure by site-specific histone H3 methyltransferases.

PubMed ID: 10949293

DOI: 10.1038/35020506

PubMed ID: 10848615

Title: Set domain-dependent regulation of transcriptional silencing and growth control by SUV39H1, a mammalian ortholog of Drosophila Su(var)3-9.

PubMed ID: 10848615

DOI: 10.1128/mcb.20.13.4900-4909.2000

PubMed ID: 11242053

Title: Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.

PubMed ID: 11242053

DOI: 10.1038/35065132

PubMed ID: 11484059

Title: Rb targets histone H3 methylation and HP1 to promoters.

PubMed ID: 11484059

DOI: 10.1038/35087620

PubMed ID: 12711603

Title: Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression.

PubMed ID: 12711603

DOI: 10.1074/jbc.m302283200

PubMed ID: 12101246

Title: Selective interactions between vertebrate polycomb homologs and the SUV39H1 histone lysine methyltransferase suggest that histone H3-K9 methylation contributes to chromosomal targeting of Polycomb group proteins.

PubMed ID: 12101246

DOI: 10.1128/mcb.22.15.5539-5553.2002

PubMed ID: 12917624

Title: SUV39H1 interacts with AML1 and abrogates AML1 transactivity. AML1 is methylated in vivo.

PubMed ID: 12917624

DOI: 10.1038/sj.onc.1206600

PubMed ID: 12789259

Title: pRb2/p130-E2F4/5-HDAC1-SUV39H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 multimolecular complexes mediate the transcription of estrogen receptor-alpha in breast cancer.

PubMed ID: 12789259

DOI: 10.1038/sj.onc.1206578

PubMed ID: 14765126

Title: A Suv39h-dependent mechanism for silencing S-phase genes in differentiating but not in cycling cells.

PubMed ID: 14765126

DOI: 10.1038/sj.emboj.7600074

PubMed ID: 15107829

Title: Suv39h histone methyltransferases interact with Smads and cooperate in BMP-induced repression.

PubMed ID: 15107829

DOI: 10.1038/sj.onc.1207660

PubMed ID: 16103223

Title: A glue for heterochromatin maintenance: stable SUV39H1 binding to heterochromatin is reinforced by the SET domain.

PubMed ID: 16103223

DOI: 10.1083/jcb.200502154

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16688220

Title: Gfi1b alters histone methylation at target gene promoters and sites of gamma-satellite containing heterochromatin.

PubMed ID: 16688220

DOI: 10.1038/sj.emboj.7601124

PubMed ID: 16818776

Title: The histone methyltransferase Suv39h1 increases class switch recombination specifically to IgA.

PubMed ID: 16818776

DOI: 10.4049/jimmunol.177.2.1179

PubMed ID: 16519522

Title: Catalytic properties and kinetic mechanism of human recombinant Lys-9 histone H3 methyltransferase SUV39H1: participation of the chromodomain in enzymatic catalysis.

PubMed ID: 16519522

DOI: 10.1021/bi051997r

PubMed ID: 16858404

Title: Histone methyltransferase Suv39h1 represses MyoD-stimulated myogenic differentiation.

PubMed ID: 16858404

DOI: 10.1038/sj.emboj.7601229

PubMed ID: 16449642

Title: Recruitment of the histone methyltransferase SUV39H1 and its role in the oncogenic properties of the leukemia-associated PML-retinoic acid receptor fusion protein.

PubMed ID: 16449642

DOI: 10.1128/mcb.26.4.1288-1296.2006

PubMed ID: 16652147

Title: RUNX1 associates with histone deacetylases and SUV39H1 to repress transcription.

PubMed ID: 16652147

DOI: 10.1038/sj.onc.1209591

PubMed ID: 16409643

Title: SUV39H1 interacts with HTLV-1 Tax and abrogates Tax transactivation of HTLV-1 LTR.

PubMed ID: 16409643

DOI: 10.1186/1742-4690-3-5

PubMed ID: 18004385

Title: SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation.

PubMed ID: 18004385

DOI: 10.1038/nature06268

PubMed ID: 18485871

Title: Epigenetic control of rDNA loci in response to intracellular energy status.

PubMed ID: 18485871

DOI: 10.1016/j.cell.2008.03.030

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19218236

Title: Inhibition of SUV39H1 methyltransferase activity by DBC1.

PubMed ID: 19218236

DOI: 10.1074/jbc.m900956200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23695662

Title: Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model.

PubMed ID: 23695662

DOI: 10.1038/ncomms2885

PubMed ID: 29170282

Title: Histone methyltransferase SUV39H1 participates in host defense by methylating mycobacterial histone-like protein HupB.

PubMed ID: 29170282

DOI: 10.15252/embj.201796918

PubMed ID: 30111536

Title: DCAF13 promotes pluripotency by negatively regulating SUV39H1 stability during early embryonic development.

PubMed ID: 30111536

DOI: 10.15252/embj.201898981

Sequence Information:

  • Length: 412
  • Mass: 47907
  • Checksum: AF6F959AD20C6C76
  • Sequence:
    • MAENLKGCSV CCKSSWNQLQ DLCRLAKLSC PALGISKRNL YDFEVEYLCD YKKIREQEYY 
LVKWRGYPDS ESTWEPRQNL KCVRILKQFH KDLERELLRR HHRSKTPRHL DPSLANYLVQ 
KAKQRRALRR WEQELNAKRS HLGRITVENE VDLDGPPRAF VYINEYRVGE GITLNQVAVG 
CECQDCLWAP TGGCCPGASL HKFAYNDQGQ VRLRAGLPIY ECNSRCRCGY DCPNRVVQKG 
IRYDLCIFRT DDGRGWGVRT LEKIRKNSFV MEYVGEIITS EEAERRGQIY DRQGATYLFD 
LDYVEDVYTV DAAYYGNISH FVNHSCDPNL QVYNVFIDNL DERLPRIAFF ATRTIRAGEE 
LTFDYNMQVD PVDMESTRMD SNFGLAGLPG SPKKRVRIEC KCGTESCRKY LF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.