Details for: MAP3K7

Gene ID: 6885

Symbol: MAP3K7

Ensembl ID: ENSG00000135341

Description: mitogen-activated protein kinase kinase kinase 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 240.3802
    Cell Significance Index: -37.3900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 146.5838
    Cell Significance Index: -37.1800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 94.9878
    Cell Significance Index: -39.1300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 85.3274
    Cell Significance Index: -40.2900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 83.9862
    Cell Significance Index: -34.1200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 35.7478
    Cell Significance Index: -34.1300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 32.2234
    Cell Significance Index: -39.7300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.8230
    Cell Significance Index: -37.0300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.8885
    Cell Significance Index: -36.5200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.2102
    Cell Significance Index: -40.2900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.5642
    Cell Significance Index: -16.5600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.3728
    Cell Significance Index: 133.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0013
    Cell Significance Index: 401.4600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.0972
    Cell Significance Index: 127.8700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.0888
    Cell Significance Index: 41.2300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.0565
    Cell Significance Index: 46.7300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0367
    Cell Significance Index: 371.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0148
    Cell Significance Index: 201.3900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.9673
    Cell Significance Index: 65.0500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.9475
    Cell Significance Index: 25.3000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.7886
    Cell Significance Index: 22.5100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7602
    Cell Significance Index: 82.6900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7556
    Cell Significance Index: 122.8900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.7100
    Cell Significance Index: 18.2500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6664
    Cell Significance Index: 460.8900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6604
    Cell Significance Index: 9.0100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6396
    Cell Significance Index: 49.0900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6079
    Cell Significance Index: 16.9900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.5978
    Cell Significance Index: 7.4200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5915
    Cell Significance Index: 35.5100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5222
    Cell Significance Index: 32.1000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4064
    Cell Significance Index: 10.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3589
    Cell Significance Index: 64.6900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3276
    Cell Significance Index: 22.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3249
    Cell Significance Index: 9.3600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2629
    Cell Significance Index: 143.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2497
    Cell Significance Index: 5.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2389
    Cell Significance Index: 32.8100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2247
    Cell Significance Index: 27.6300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2087
    Cell Significance Index: 39.7100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1884
    Cell Significance Index: 83.3000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1680
    Cell Significance Index: 19.8100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1039
    Cell Significance Index: 93.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0700
    Cell Significance Index: 1.9000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0679
    Cell Significance Index: 127.8600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0653
    Cell Significance Index: 6.4600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0635
    Cell Significance Index: 10.8400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0630
    Cell Significance Index: 40.0000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0446
    Cell Significance Index: 1.0700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0420
    Cell Significance Index: 0.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0406
    Cell Significance Index: 18.4200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0354
    Cell Significance Index: 1.6500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0272
    Cell Significance Index: 41.8600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0271
    Cell Significance Index: 49.9800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0250
    Cell Significance Index: 0.8700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0220
    Cell Significance Index: 29.9000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0152
    Cell Significance Index: 0.2600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0086
    Cell Significance Index: 0.3900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0099
    Cell Significance Index: -1.2700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0165
    Cell Significance Index: -10.3100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0183
    Cell Significance Index: -13.5800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0318
    Cell Significance Index: -0.6200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0330
    Cell Significance Index: -24.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0353
    Cell Significance Index: -19.9300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0360
    Cell Significance Index: -5.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0411
    Cell Significance Index: -31.0800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0452
    Cell Significance Index: -2.8500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0681
    Cell Significance Index: -3.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0819
    Cell Significance Index: -10.5800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0847
    Cell Significance Index: -8.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0998
    Cell Significance Index: -4.6900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1108
    Cell Significance Index: -7.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1119
    Cell Significance Index: -23.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1150
    Cell Significance Index: -33.0800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1182
    Cell Significance Index: -1.7000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1272
    Cell Significance Index: -3.3500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1332
    Cell Significance Index: -2.2300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1460
    Cell Significance Index: -1.7400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1557
    Cell Significance Index: -8.1100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1568
    Cell Significance Index: -8.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1885
    Cell Significance Index: -21.6000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1935
    Cell Significance Index: -14.4200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1953
    Cell Significance Index: -13.8100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2612
    Cell Significance Index: -7.0000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2665
    Cell Significance Index: -30.4200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3110
    Cell Significance Index: -32.3800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3630
    Cell Significance Index: -2.9600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3647
    Cell Significance Index: -11.6800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3701
    Cell Significance Index: -9.4600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4170
    Cell Significance Index: -8.8800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4444
    Cell Significance Index: -35.2000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4582
    Cell Significance Index: -9.8000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4772
    Cell Significance Index: -9.9000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5379
    Cell Significance Index: -32.9800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5882
    Cell Significance Index: -18.7400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5916
    Cell Significance Index: -19.3700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6129
    Cell Significance Index: -18.0000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.6464
    Cell Significance Index: -8.0600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6709
    Cell Significance Index: -13.2700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6773
    Cell Significance Index: -10.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MAP3K7 is a serine/threonine kinase that belongs to the MAP3K family, which is characterized by the presence of a catalytic domain and an N-terminal regulatory domain. The protein is highly conserved across species, with high sequence identity among mammals. MAP3K7 is activated by various stimuli, including cytokines, chemokines, and pathogens, leading to the phosphorylation and activation of downstream kinases. The protein is also involved in the regulation of transcriptional processes, including the activation of NF-κB and the repression of gene expression. **Pathways and Functions** MAP3K7 is involved in multiple signaling pathways that regulate immune responses, including: 1. **Toll-like receptor (TLR) signaling**: MAP3K7 is activated by TLRs, leading to the phosphorylation and activation of downstream kinases, including TRAF6 and IRAK2. 2. **NF-κB signaling**: MAP3K7 is involved in the activation of NF-κB, a transcription factor that regulates the expression of immune genes. 3. **p38 MAPK signaling**: MAP3K7 is activated by p38 MAPK, leading to the activation of downstream kinases, including JNK and PERK. 4. **JNK signaling**: MAP3K7 is involved in the activation of JNK, a transcription factor that regulates stress responses and immune cell activation. 5. **Adaptive immune system**: MAP3K7 is involved in the regulation of T cell cytokine production and the activation of immune cells. **Clinical Significance** MAP3K7 has been implicated in various diseases, including: 1. **Infectious diseases**: MAP3K7 is involved in the regulation of immune responses to pathogens, such as viruses and bacteria. 2. **Autoimmune diseases**: MAP3K7 is involved in the regulation of immune cell activation and cytokine production, which is critical in the development of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Cancer**: MAP3K7 is involved in the regulation of cell growth and survival, which is critical in the development of cancer. 4. **Neurological disorders**: MAP3K7 is involved in the regulation of neurotransmission and synaptic plasticity, which is critical in the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, MAP3K7 is a critical component of the immune system, playing a pivotal role in the activation of various signaling pathways that regulate immune responses. Further studies are needed to fully understand the mechanisms by which MAP3K7 regulates immune responses and to explore its potential as a therapeutic target in various diseases.

Genular Protein ID: 1912169065

Symbol: M3K7_HUMAN

Name: Mitogen-activated protein kinase kinase kinase 7

UniProtKB Accession Codes:

O43318 B2RE27 E1P523 O43317 O43319 Q5TDN2 Q5TDN3 Q5TDT7 Q9NTR3 Q9NZ70

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CORUM 1 CPTAC 7 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 2 EMBL 13 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 62 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 23 PDBsum 23 PIR 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 18 RefSeq 4 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9480845

Title: TGF-beta-activated kinase 1 stimulates NF-kappa B activation by an NF-kappa B-inducing kinase-independent mechanism.

PubMed ID: 9480845

DOI: 10.1006/bbrc.1998.8124

PubMed ID: 11118615

Title: Alternative splicing and gene structure of the transforming growth factor beta-activated kinase 1.

PubMed ID: 11118615

DOI: 10.1016/s0167-4781(00)00258-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8663074

Title: A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3.

PubMed ID: 8663074

DOI: 10.1074/jbc.271.23.13675

PubMed ID: 8638164

Title: TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction.

PubMed ID: 8638164

DOI: 10.1126/science.272.5265.1179

PubMed ID: 9079627

Title: TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase.

PubMed ID: 9079627

DOI: 10.1074/jbc.272.13.8141

PubMed ID: 10094049

Title: The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway.

PubMed ID: 10094049

DOI: 10.1038/18465

PubMed ID: 10838074

Title: Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1.

PubMed ID: 10838074

DOI: 10.1016/s0014-5793(00)01588-x

PubMed ID: 10702308

Title: TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop.

PubMed ID: 10702308

DOI: 10.1074/jbc.275.10.7359

PubMed ID: 11104763

Title: Regulation of the TAK1 signaling pathway by protein phosphatase 2C.

PubMed ID: 11104763

DOI: 10.1074/jbc.m007773200

PubMed ID: 11460167

Title: TAK1 is a ubiquitin-dependent kinase of MKK and IKK.

PubMed ID: 11460167

DOI: 10.1038/35085597

PubMed ID: 12242293

Title: Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol.

PubMed ID: 12242293

DOI: 10.1128/mcb.22.20.7158-7167.2002

PubMed ID: 12804775

Title: Pellino2 activates the mitogen activated protein kinase pathway.

PubMed ID: 12804775

DOI: 10.1016/s0014-5793(03)00533-7

PubMed ID: 12874243

Title: Pellino3, a novel member of the Pellino protein family, promotes activation of c-Jun and Elk-1 and may act as a scaffolding protein.

PubMed ID: 12874243

DOI: 10.4049/jimmunol.171.3.1500

PubMed ID: 12589052

Title: Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3.

PubMed ID: 12589052

DOI: 10.1091/mbc.02-03-0037

PubMed ID: 14670075

Title: TAB3, a new binding partner of the protein kinase TAK1.

PubMed ID: 14670075

DOI: 10.1042/bj20031794

PubMed ID: 15894542

Title: Disabled-2 (Dab2) mediates transforming growth factor beta (TGFbeta)-stimulated fibronectin synthesis through TGFbeta-activated kinase 1 and activation of the JNK pathway.

PubMed ID: 15894542

DOI: 10.1074/jbc.m501150200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16845370

Title: The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway.

PubMed ID: 16845370

DOI: 10.1038/sj.embor.7400754

PubMed ID: 16893890

Title: Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways.

PubMed ID: 16893890

DOI: 10.1074/jbc.m603627200

PubMed ID: 17079228

Title: Protein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway.

PubMed ID: 17079228

DOI: 10.1074/jbc.m608155200

PubMed ID: 17449468

Title: RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation.

PubMed ID: 17449468

DOI: 10.1074/jbc.m701913200

PubMed ID: 17548520

Title: Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses.

PubMed ID: 17548520

DOI: 10.1084/jem.20062694

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18758450

Title: The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner.

PubMed ID: 18758450

DOI: 10.1038/ncb1780

PubMed ID: 18286207

Title: Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein.

PubMed ID: 18286207

DOI: 10.1371/journal.pone.0001660

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19521662

Title: WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4-induced NF-kappaB activation pathway.

PubMed ID: 19521662

DOI: 10.1007/s00018-009-0059-6

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19675569

Title: Direct activation of protein kinases by unanchored polyubiquitin chains.

PubMed ID: 19675569

DOI: 10.1038/nature08247

PubMed ID: 17496917

Title: Ubiquitin-mediated activation of TAK1 and IKK.

PubMed ID: 17496917

DOI: 10.1038/sj.onc.1210413

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20060931

Title: The TAK1-TRAF6 signalling pathway.

PubMed ID: 20060931

DOI: 10.1016/j.biocel.2009.12.023

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22084099

Title: Tripartite motif 8 (TRIM8) modulates TNFalpha- and IL-1beta-triggered NF-kappaB activation by targeting TAK1 for K63-linked polyubiquitination.

PubMed ID: 22084099

DOI: 10.1073/pnas.1110946108

PubMed ID: 21512573

Title: TRIM5 is an innate immune sensor for the retrovirus capsid lattice.

PubMed ID: 21512573

DOI: 10.1038/nature09976

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22520462

Title: Yersinia pseudotuberculosis effector YopJ subverts the Nod2/RICK/TAK1 pathway and activates caspase-1 to induce intestinal barrier dysfunction.

PubMed ID: 22520462

DOI: 10.1016/j.chom.2012.02.009

PubMed ID: 22406003

Title: Lys48-linked TAK1 polyubiquitination at lysine-72 downregulates TNFalpha-induced NF-kappaB activation via mediating TAK1 degradation.

PubMed ID: 22406003

DOI: 10.1016/j.cellsig.2012.02.017

PubMed ID: 22802624

Title: Serine/threonine acetylation of TGFbeta-activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling.

PubMed ID: 22802624

DOI: 10.1073/pnas.1008203109

PubMed ID: 23776175

Title: SASH1 is a scaffold molecule in endothelial TLR4 signaling.

PubMed ID: 23776175

DOI: 10.4049/jimmunol.1200583

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26334375

Title: IFIT5 positively regulates NF-kappaB signaling through synergizing the recruitment of IkappaB kinase (IKK) to TGF-beta-activated kinase 1 (TAK1).

PubMed ID: 26334375

DOI: 10.1016/j.cellsig.2015.08.018

PubMed ID: 27426733

Title: Mutations in MAP3K7 that alter the activity of the TAK1 signaling complex cause frontometaphyseal dysplasia.

PubMed ID: 27426733

DOI: 10.1016/j.ajhg.2016.05.024

PubMed ID: 27426734

Title: Heterozygous mutations in MAP3K7, encoding TGF-beta-activated kinase 1, cause cardiospondylocarpofacial syndrome.

PubMed ID: 27426734

DOI: 10.1016/j.ajhg.2016.06.005

PubMed ID: 28827540

Title: The Us2 Gene Product of herpes dimplex virus 2 modulates NF-kappaB activation by targeting TAK1.

PubMed ID: 28827540

DOI: 10.1038/s41598-017-08856-4

PubMed ID: 28424289

Title: Disruption of MDA5-Mediated Innate Immune Responses by the 3C Proteins of Coxsackievirus A16, Coxsackievirus A6, and Enterovirus D68.

PubMed ID: 28424289

DOI: 10.1128/jvi.00546-17

PubMed ID: 29291351

Title: The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis.

PubMed ID: 29291351

DOI: 10.1038/nm.4461

PubMed ID: 37832545

Title: TAK1 is an essential kinase for STING trafficking.

PubMed ID: 37832545

DOI: 10.1016/j.molcel.2023.09.009

PubMed ID: 16289117

Title: Structural basis for the interaction of TAK1 kinase with its activating protein TAB1.

PubMed ID: 16289117

DOI: 10.1016/j.jmb.2005.09.098

PubMed ID: 28397838

Title: Mapping autosomal recessive intellectual disability: combined microarray and exome sequencing identifies 26 novel candidate genes in 192 consanguineous families.

PubMed ID: 28397838

DOI: 10.1038/mp.2017.60

Sequence Information:

  • Length: 606
  • Mass: 67196
  • Checksum: 3D8F8147CD174013
  • Sequence:
    • MSTASAASSS SSSSAGEMIE APSQVLNFEE IDYKEIEVEE VVGRGAFGVV CKAKWRAKDV 
AIKQIESESE RKAFIVELRQ LSRVNHPNIV KLYGACLNPV CLVMEYAEGG SLYNVLHGAE 
PLPYYTAAHA MSWCLQCSQG VAYLHSMQPK ALIHRDLKPP NLLLVAGGTV LKICDFGTAC 
DIQTHMTNNK GSAAWMAPEV FEGSNYSEKC DVFSWGIILW EVITRRKPFD EIGGPAFRIM 
WAVHNGTRPP LIKNLPKPIE SLMTRCWSKD PSQRPSMEEI VKIMTHLMRY FPGADEPLQY 
PCQYSDEGQS NSATSTGSFM DIASTNTSNK SDTNMEQVPA TNDTIKRLES KLLKNQAKQQ 
SESGRLSLGA SRGSSVESLP PTSEGKRMSA DMSEIEARIA ATTAYSKPKR GHRKTASFGN 
ILDVPEIVIS GNGQPRRRSI QDLTVTGTEP GQVSSRSSSP SVRMITTSGP TSEKPTRSHP 
WTPDDSTDTN GSDNSIPMAY LTLDHQLQPL APCPNSKESM AVFEQHCKMA QEYMKVQTEI 
ALLLQRKQEL VAELDQDEKD QQNTSRLVQE HKKLLDENKS LSTYYQQCKK QLEVIRSQQQ 
KRQGTS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.