TBP | ENSG00000112592 | NCBI 6908

Details for: TBP

Gene ID: 6908

Symbol: TBP

Ensembl ID: ENSG00000112592

Description: TATA-box binding protein

Associated with

B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Disease
(R-HSA-1643685)
Epigenetic regulation of gene expression
(R-HSA-212165)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Hiv infection
(R-HSA-162906)
Hiv life cycle
(R-HSA-162587)
Hiv transcription initiation
(R-HSA-167161)
Infectious disease
(R-HSA-5663205)
Late phase of hiv life cycle
(R-HSA-162599)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Norc negatively regulates rrna expression
(R-HSA-427413)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Regulation of tp53 activity
(R-HSA-5633007)
Regulation of tp53 activity through phosphorylation
(R-HSA-6804756)
Rna polymerase ii hiv promoter escape
(R-HSA-167162)
Rna polymerase iii abortive and retractive initiation
(R-HSA-749476)
Rna polymerase iii transcription
(R-HSA-74158)
Rna polymerase iii transcription initiation
(R-HSA-76046)
Rna polymerase iii transcription initiation from type 1 promoter
(R-HSA-76061)
Rna polymerase iii transcription initiation from type 2 promoter
(R-HSA-76066)
Rna polymerase iii transcription initiation from type 3 promoter
(R-HSA-76071)
Rna polymerase ii pre-transcription events
(R-HSA-674695)
Rna polymerase ii promoter escape
(R-HSA-73776)
Rna polymerase ii transcribes snrna genes
(R-HSA-6807505)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase ii transcription initiation
(R-HSA-75953)
Rna polymerase ii transcription initiation and promoter clearance
(R-HSA-76042)
Rna polymerase ii transcription pre-initiation and promoter opening
(R-HSA-73779)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i transcription
(R-HSA-73864)
Rna polymerase i transcription initiation
(R-HSA-73762)
Rna polymerase i transcription termination
(R-HSA-73863)
Signaling by nuclear receptors
(R-HSA-9006931)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transcription of the hiv genome
(R-HSA-167172)
Viral infection pathways
(R-HSA-9824446)
Aryl hydrocarbon receptor binding
(GO:0017162)
Chromatin
(GO:0000785)
Core promoter sequence-specific dna binding
(GO:0001046)
Cytoplasm
(GO:0005737)
Dna-binding transcription factor binding
(GO:0140297)
Dna-templated transcription initiation
(GO:0006352)
Enzyme binding
(GO:0019899)
Euchromatin
(GO:0000791)
Female germ cell nucleus
(GO:0001674)
Female pronucleus
(GO:0001939)
Male germ cell nucleus
(GO:0001673)
Male pronucleus
(GO:0001940)
Mrna transcription by rna polymerase ii
(GO:0042789)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of transcription initiation by rna polymerase ii
(GO:0060261)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Rna polymerase i core promoter sequence-specific dna binding
(GO:0001164)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii core promoter sequence-specific dna binding
(GO:0000979)
Rna polymerase ii general transcription initiation factor activity
(GO:0016251)
Rna polymerase ii general transcription initiation factor binding
(GO:0001091)
Rna polymerase iii general transcription initiation factor activity
(GO:0000995)
Rna polymerase ii preinitiation complex assembly
(GO:0051123)
Rna polymerase i preinitiation complex assembly
(GO:0001188)
Rna polymerase transcription factor sl1 complex
(GO:0005668)
Spermatogenesis
(GO:0007283)
Tfiib-class transcription factor binding
(GO:0001093)
Transcription by rna polymerase ii
(GO:0006366)
Transcription by rna polymerase iii
(GO:0006383)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription factor tfiia complex
(GO:0005672)
Transcription factor tfiid complex
(GO:0005669)
Transcription initiation at rna polymerase ii promoter
(GO:0006367)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 92.7062
Cell Significance Index: -14.4200
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 55.9053
Cell Significance Index: -14.1800
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 34.5840
Cell Significance Index: -14.0500
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 34.4826
Cell Significance Index: -16.2800
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 14.7160
Cell Significance Index: -14.0500
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 12.6769
Cell Significance Index: -15.6300
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 5.0768
Cell Significance Index: -13.6000
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 4.0674
Cell Significance Index: -16.0500
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 2.8512
Cell Significance Index: -6.2400
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.0856
Cell Significance Index: 107.3900
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.8355
Cell Significance Index: 754.4100
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.7957
Cell Significance Index: 47.7700
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.7211
Cell Significance Index: 78.4400
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.5645
Cell Significance Index: 112.0200
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5248
Cell Significance Index: 85.3600
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.4960
Cell Significance Index: 57.8000
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.4389
Cell Significance Index: 11.7200
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.4096
Cell Significance Index: 82.1700
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.3401
Cell Significance Index: 4.6400
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3146
Cell Significance Index: 9.0700
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.3132
Cell Significance Index: 36.9400
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2673
Cell Significance Index: 5.7900
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.2551
Cell Significance Index: 37.0800
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.2489
Cell Significance Index: 44.8700
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2389
Cell Significance Index: 10.8300
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.2306
Cell Significance Index: 12.9400
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2276
Cell Significance Index: 15.7400
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.2258
Cell Significance Index: 6.0500
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.2186
Cell Significance Index: 6.1100
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2134
Cell Significance Index: 76.5500
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.1925
Cell Significance Index: 12.1300
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.1604
Cell Significance Index: 4.0100
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.1584
Cell Significance Index: 12.1600
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1383
Cell Significance Index: 17.0100
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.1372
Cell Significance Index: 8.4300
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1367
Cell Significance Index: 74.6700
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1293
Cell Significance Index: 17.7500
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1192
Cell Significance Index: 82.4100
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.1158
Cell Significance Index: 3.4000
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1130
Cell Significance Index: 5.8700
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0987
Cell Significance Index: 43.6300
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.0873
Cell Significance Index: 5.6300
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.0871
Cell Significance Index: 2.2900
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0818
Cell Significance Index: 15.5700
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.0547
Cell Significance Index: 1.4900
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0423
Cell Significance Index: 1.9700
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0289
Cell Significance Index: 54.4300
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0263
Cell Significance Index: 3.3700
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0224
Cell Significance Index: 41.3200
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0182
Cell Significance Index: 28.0100
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0132
Cell Significance Index: 8.4000
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0117
Cell Significance Index: 0.2500
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.0096
Cell Significance Index: 0.2100
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0076
Cell Significance Index: 1.3000
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0043
Cell Significance Index: 5.8300
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0007
Cell Significance Index: -0.3000
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0007
Cell Significance Index: -0.0300
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0021
Cell Significance Index: -0.1000
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0065
Cell Significance Index: -0.4600
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0089
Cell Significance Index: -6.5500
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0098
Cell Significance Index: -0.3700
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0155
Cell Significance Index: -11.7300
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0171
Cell Significance Index: -0.6000
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0177
Cell Significance Index: -13.1000
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0228
Cell Significance Index: -2.9500
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0241
Cell Significance Index: -0.4700
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0245
Cell Significance Index: -0.4200
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0248
Cell Significance Index: -13.9700
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0276
Cell Significance Index: -17.2500
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0357
Cell Significance Index: -3.6500
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0448
Cell Significance Index: -12.9000
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0485
Cell Significance Index: -3.2600
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0674
Cell Significance Index: -5.0300
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0704
Cell Significance Index: -1.8100
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0781
Cell Significance Index: -4.0700
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0800
Cell Significance Index: -16.8600
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0853
Cell Significance Index: -1.7700
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0972
Cell Significance Index: -11.1400
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1027
Cell Significance Index: -3.5700
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.1054
Cell Significance Index: -1.3500
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1105
Cell Significance Index: -1.8500
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.1271
Cell Significance Index: -2.6600
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1313
Cell Significance Index: -13.6700
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1393
Cell Significance Index: -7.3200
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.1409
Cell Significance Index: -3.7700
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1530
Cell Significance Index: -4.9000
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1681
Cell Significance Index: -4.3000
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1823
Cell Significance Index: -14.4400
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.1885
Cell Significance Index: -4.5200
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.2360
Cell Significance Index: -3.3800
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.2395
Cell Significance Index: -2.9700
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.2445
Cell Significance Index: -3.6100
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2613
Cell Significance Index: -16.0200
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.2846
Cell Significance Index: -6.0400
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2889
Cell Significance Index: -9.2000
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.2906
Cell Significance Index: -8.3300
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.2911
Cell Significance Index: -9.5300
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.2959
Cell Significance Index: -2.7300
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.2986
Cell Significance Index: -3.5600
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.3022
Cell Significance Index: -4.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** TBP is a multi-functional protein with several key characteristics: 1. **DNA-binding ability:** TBP exhibits a high degree of specificity for the TATA box, a 6-base pair sequence found in the promoter region of many genes. 2. **Transcriptional regulation:** TBP is a crucial component of the PIC, which assembles on the promoter region of genes, facilitating the recruitment of RNA polymerase II and the initiation of transcription. 3. **Heterodimerization:** TBP can form heterodimers with other transcription factors, such as TFIID, to regulate gene expression. 4. **Phosphorylation and post-translational modifications:** TBP undergoes various post-translational modifications, including phosphorylation, which can affect its activity and interactions with other proteins. 5. **Cellular localization:** TBP is primarily localized in the nucleus, where it regulates gene expression. **Pathways and Functions:** TBP is involved in several key pathways and functions, including: 1. **Transcriptional regulation:** TBP plays a central role in the regulation of gene expression by facilitating the assembly of the PIC and the recruitment of RNA polymerase II. 2. **Chromatin remodeling:** TBP interacts with chromatin remodeling complexes to facilitate the remodeling of chromatin structure and the accessibility of transcription factors to the promoter region. 3. **Cell cycle regulation:** TBP is involved in the regulation of cell cycle progression, particularly in the G1-S transition. 4. **Apoptosis:** TBP can regulate apoptosis by interacting with pro-apoptotic proteins, such as TP53. 5. **Viral replication:** TBP is essential for the replication of certain viruses, such as HIV, where it plays a role in the regulation of viral gene expression. **Clinical Significance:** Dysregulation of TBP has been implicated in various diseases, including: 1. **Cancer:** Overexpression of TBP has been observed in several types of cancer, including breast, lung, and colon cancer. 2. **Neurological disorders:** TBP has been implicated in the regulation of genes involved in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Viral infections:** TBP is essential for the replication of certain viruses, such as HIV, and its dysregulation can lead to impaired immune function. 4. **Aging:** TBP has been implicated in the regulation of genes involved in aging, including those involved in DNA repair and cellular senescence. In conclusion, TBP is a critical transcription factor that plays a central role in the regulation of gene expression in eukaryotic cells. Its dysregulation has been implicated in various diseases, highlighting the importance of TBP in maintaining cellular homeostasis and preventing disease. Further research is needed to fully understand the mechanisms of TBP regulation and its role in disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

TATA-box-binding protein
Q32MN7_HUMAN

Genular Protein ID: 2732328920

Symbol: TBP_HUMAN

Name: TATA-box-binding protein

UniProtKB Accession Codes:

P20226 B4E3B3 F5H869 Q16845 Q6IBM6 Q9UC02

Database IDs:

Citations:

PubMed ID: 2374612

Title: Highly conserved core domain and unique N-terminus with presumptive regulatory motifs in a human TATA factor (TFIID).

PubMed ID: 2374612

DOI: 10.1038/346387a0

PubMed ID: 2363050

Title: Functional domains and upstream activation properties of cloned human TATA binding protein.

PubMed ID: 2363050

DOI: 10.1126/science.2363050

PubMed ID: 2194289

Title: Cloning of a transcriptionally active human TATA binding factor.

PubMed ID: 2194289

DOI: 10.1126/science.2194289

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 8504927

Title: Multiple functional domains of human transcription factor IIB: distinct interactions with two general transcription factors and RNA polymerase II.

PubMed ID: 8504927

DOI: 10.1101/gad.7.6.1021

PubMed ID: 8392607

Title: ICP4, the major transcriptional regulatory protein of herpes simplex virus type 1, forms a tripartite complex with TATA-binding protein and TFIIB.

PubMed ID: 8392607

DOI: 10.1128/jvi.67.8.4676-4687.1993

PubMed ID: 7982918

Title: The RNA polymerase I transcription factor, upstream binding factor, interacts directly with the TATA box-binding protein.

PubMed ID: 7982918

DOI: 10.1016/s0021-9258(18)43788-x

PubMed ID: 8121496

Title: Direct interaction of human TFIID with the HIV-1 transactivator tat.

PubMed ID: 8121496

DOI: 10.1038/367295a0

PubMed ID: 8146144

Title: The zinc finger region of the adenovirus E1A transactivating domain complexes with the TATA box binding protein.

PubMed ID: 8146144

DOI: 10.1073/pnas.91.7.2488

PubMed ID: 7801123

Title: Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits.

PubMed ID: 7801123

DOI: 10.1126/science.7801123

PubMed ID: 7608968

Title: Evidence for functional interaction between the HIV-1 Tat transactivator and the TATA box binding protein in vivo.

PubMed ID: 7608968

DOI: 10.1006/jmbi.1995.0368

PubMed ID: 9748258

Title: Characterization of functional domains of an embryonic stem cell coactivator UTF1 which are conserved and essential for potentiation of ATF-2 activity.

PubMed ID: 9748258

DOI: 10.1074/jbc.273.40.25840

PubMed ID: 9836642

Title: Requirement of RSF and FACT for transcription of chromatin templates in vitro.

PubMed ID: 9836642

DOI: 10.1126/science.282.5395.1900

PubMed ID: 10197586

Title: The partial homeodomain of the transcription factor Pax-5 (BSAP) is an interaction motif for the retinoblastoma and TATA-binding proteins.

PubMed ID: 10197586

PubMed ID: 11005381

Title: Potential targets for HSF1 within the preinitiation complex.

PubMed ID: 11005381

DOI: 10.1379/1466-1268(2000)005<0229:ptfhwt>2.0.co;2

PubMed ID: 15970593

Title: TBP-TAF complex SL1 directs RNA polymerase I pre-initiation complex formation and stabilizes upstream binding factor at the rDNA promoter.

PubMed ID: 15970593

DOI: 10.1074/jbc.m501595200

PubMed ID: 17570761

Title: Genomics, evolution, and expression of TBPL2, a member of the TBP family.

PubMed ID: 17570761

DOI: 10.1089/dna.2006.0527

PubMed ID: 10196196

Title: SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1.

PubMed ID: 10196196

DOI: 10.1074/jbc.274.16.11115

PubMed ID: 10567404

Title: A nuclear factor ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo.

PubMed ID: 10567404

DOI: 10.1074/jbc.274.48.34283

PubMed ID: 10391676

Title: Exon 4-encoded acidic domain in the epithelium-restricted Ets factor, ESX, confers potent transactivating capacity and binds to TATA-binding protein (TBP).

PubMed ID: 10391676

DOI: 10.1038/sj.onc.1202674

PubMed ID: 11564744

Title: BRFU, a TFIIB-like factor, is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters through its interaction with TATA-binding protein.

PubMed ID: 11564744

DOI: 10.1074/jbc.m108515200

PubMed ID: 11438666

Title: The TFIID components human TAFII140 and Drosophila BIP2 (TAFII155) are novel metazoan homologues of yeast TAFII47 containing a histone fold and a PHD finger.

PubMed ID: 11438666

DOI: 10.1128/mcb.21.15.5109-5121.2001

PubMed ID: 12217962

Title: Functional substitution for TAF(II)250 by a retroposed homolog that is expressed in human spermatogenesis.

PubMed ID: 12217962

DOI: 10.1093/hmg/11.19.2341

PubMed ID: 12621023

Title: The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition.

PubMed ID: 12621023

DOI: 10.1074/jbc.m204247200

PubMed ID: 15719058

Title: HIV-1 Tat stimulates transcription complex assembly through recruitment of TBP in the absence of TAFs.

PubMed ID: 15719058

DOI: 10.1371/journal.pbio.0030044

PubMed ID: 19106100

Title: MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity.

PubMed ID: 19106100

DOI: 10.1074/jbc.m807098200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 30619292

Title: Herpes Simplex Virus Type 2 Infection-Induced Expression of CXCR3 Ligands Promotes CD4+ T Cell Migration and Is Regulated by the Viral Immediate-Early Protein ICP4.

PubMed ID: 30619292

DOI: 10.3389/fimmu.2018.02932

PubMed ID: 8643494

Title: Crystal structure of a human TATA box-binding protein/TATA element complex.

PubMed ID: 8643494

DOI: 10.1073/pnas.93.10.4862

PubMed ID: 8757291

Title: How proteins recognize the TATA box.

PubMed ID: 8757291

DOI: 10.1006/jmbi.1996.0456

PubMed ID: 10619841

Title: Structural basis of preinitiation complex assembly on human pol II promoters.

PubMed ID: 10619841

DOI: 10.1093/emboj/19.1.25

PubMed ID: 11461703

Title: Crystal structure of negative cofactor 2 recognizing the TBP-DNA transcription complex.

PubMed ID: 11461703

DOI: 10.1016/s0092-8674(01)00417-2

PubMed ID: 10484774

Title: A neurological disease caused by an expanded CAG trinucleotide repeat in the TATA-binding protein gene: a new polyglutamine disease?

PubMed ID: 10484774

DOI: 10.1093/hmg/8.11.2047

PubMed ID: 11313753

Title: Different types of repeat expansion in the TATA-binding protein gene are associated with a new form of inherited ataxia.

PubMed ID: 11313753

DOI: 10.1038/sj.ejhg.5200617

PubMed ID: 11448935

Title: SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA-binding protein.

PubMed ID: 11448935

DOI: 10.1093/hmg/10.14.1441

PubMed ID: 11939898

Title: Trinucleotide repeats in 202 families with ataxia: a small expanded (CAG)n allele at the SCA17 locus.

PubMed ID: 11939898

DOI: 10.1001/archneur.59.4.623

PubMed ID: 26638071

Title: Redox signaling by the RNA polymerase III TFIIB-related factor Brf2.

PubMed ID: 26638071

DOI: 10.1016/j.cell.2015.11.005

PubMed ID: 27193682

Title: Near-atomic resolution visualization of human transcription promoter opening.

PubMed ID: 27193682

DOI: 10.1038/nature17970

PubMed ID: 27007846

Title: Structure of promoter-bound TFIID and model of human pre-initiation complex assembly.

PubMed ID: 27007846

DOI: 10.1038/nature17394

PubMed ID: 33795473

Title: Structural insights into preinitiation complex assembly on core promoters.

PubMed ID: 33795473

DOI: 10.1126/science.aba8490

Sequence Information:

Length: 339
Mass: 37698
Checksum: A61A578D972B970B
Sequence:

MDQNNSLPPY AQGLASPQGA MTPGIPIFSP MMPYGTGLTP QPIQNTNSLS ILEEQQRQQQ 
QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQAVAAA AVQQSTSQQA TQGTSGQAPQ 
LFHSQTLTTA PLPGTTPLYP SPMTPMTPIT PATPASESSG IVPQLQNIVS TVNLGCKLDL 
KTIALRARNA EYNPKRFAAV IMRIREPRTT ALIFSSGKMV CTGAKSEEQS RLAARKYARV 
VQKLGFPAKF LDFKIQNMVG SCDVKFPIRL EGLVLTHQQF SSYEPELFPG LIYRMIKPRI 
VLLIFVSGKV VLTGAKVRAE IYEAFENIYP ILKGFRKTT

Genular Protein ID: 2292327580

Symbol: Q32MN7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q32MN7

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 338
Mass: 37570
Checksum: E86EDE3259A236C9
Sequence:

MDQNNSLPPY AQGLASPQGA MTPGIPIFSP MMPYGTGLTP QPIQNTNSLS ILEEQQRQQQ 
QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQAVAAAA VQQSTSQQAT QGTSGQAPQL 
FHSQTLTTAP LPGTTPLYPS PMTPMTPITP ATPASESSGI VPQLQNIVST VNLGCKLDLK 
TIALRARNAE YNPKRFAAVI MRIREPRTTA LIFSSGKMVC TGAKSEEQSR LAARKYARVV 
QKLGFPAKFL DFKIQNMVGS CDVKFPIRLE GLVLTHQQFS SYEPELFPGL IYRMIKPRIV 
LLIFVSGKVV LTGAKVRAEI YEAFENIYPI LKGFRKTT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TBP

Associated with

Cells (max top 100)

Other Information

Highly conserved core domain and unique N-terminus with presumptive regulatory motifs in a human TATA factor (TFIID). PubMed ID: 2374612

Functional domains and upstream activation properties of cloned human TATA binding protein. PubMed ID: 2363050

Cloning of a transcriptionally active human TATA binding factor. PubMed ID: 2194289

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

Multiple functional domains of human transcription factor IIB: distinct interactions with two general transcription factors and RNA polymerase II. PubMed ID: 8504927

ICP4, the major transcriptional regulatory protein of herpes simplex virus type 1, forms a tripartite complex with TATA-binding protein and TFIIB. PubMed ID: 8392607

The RNA polymerase I transcription factor, upstream binding factor, interacts directly with the TATA box-binding protein. PubMed ID: 7982918

Direct interaction of human TFIID with the HIV-1 transactivator tat. PubMed ID: 8121496

The zinc finger region of the adenovirus E1A transactivating domain complexes with the TATA box binding protein. PubMed ID: 8146144

Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits. PubMed ID: 7801123

Evidence for functional interaction between the HIV-1 Tat transactivator and the TATA box binding protein in vivo. PubMed ID: 7608968

Characterization of functional domains of an embryonic stem cell coactivator UTF1 which are conserved and essential for potentiation of ATF-2 activity. PubMed ID: 9748258

Requirement of RSF and FACT for transcription of chromatin templates in vitro. PubMed ID: 9836642

The partial homeodomain of the transcription factor Pax-5 (BSAP) is an interaction motif for the retinoblastoma and TATA-binding proteins. PubMed ID: 10197586

Potential targets for HSF1 within the preinitiation complex. PubMed ID: 11005381

TBP-TAF complex SL1 directs RNA polymerase I pre-initiation complex formation and stabilizes upstream binding factor at the rDNA promoter. PubMed ID: 15970593

Genomics, evolution, and expression of TBPL2, a member of the TBP family. PubMed ID: 17570761

SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1. PubMed ID: 10196196

A nuclear factor ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo. PubMed ID: 10567404

Exon 4-encoded acidic domain in the epithelium-restricted Ets factor, ESX, confers potent transactivating capacity and binds to TATA-binding protein (TBP). PubMed ID: 10391676

BRFU, a TFIIB-like factor, is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters through its interaction with TATA-binding protein. PubMed ID: 11564744

The TFIID components human TAFII140 and Drosophila BIP2 (TAFII155) are novel metazoan homologues of yeast TAFII47 containing a histone fold and a PHD finger. PubMed ID: 11438666

Functional substitution for TAF(II)250 by a retroposed homolog that is expressed in human spermatogenesis. PubMed ID: 12217962

The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition. PubMed ID: 12621023

HIV-1 Tat stimulates transcription complex assembly through recruitment of TBP in the absence of TAFs. PubMed ID: 15719058

MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity. PubMed ID: 19106100

Initial characterization of the human central proteome. PubMed ID: 21269460

Herpes Simplex Virus Type 2 Infection-Induced Expression of CXCR3 Ligands Promotes CD4+ T Cell Migration and Is Regulated by the Viral Immediate-Early Protein ICP4. PubMed ID: 30619292

Crystal structure of a human TATA box-binding protein/TATA element complex. PubMed ID: 8643494

How proteins recognize the TATA box. PubMed ID: 8757291

Structural basis of preinitiation complex assembly on human pol II promoters. PubMed ID: 10619841

Crystal structure of negative cofactor 2 recognizing the TBP-DNA transcription complex. PubMed ID: 11461703

A neurological disease caused by an expanded CAG trinucleotide repeat in the TATA-binding protein gene: a new polyglutamine disease? PubMed ID: 10484774

Different types of repeat expansion in the TATA-binding protein gene are associated with a new form of inherited ataxia. PubMed ID: 11313753

SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA-binding protein. PubMed ID: 11448935

Trinucleotide repeats in 202 families with ataxia: a small expanded (CAG)n allele at the SCA17 locus. PubMed ID: 11939898

Redox signaling by the RNA polymerase III TFIIB-related factor Brf2. PubMed ID: 26638071

Near-atomic resolution visualization of human transcription promoter opening. PubMed ID: 27193682

Structure of promoter-bound TFIID and model of human pre-initiation complex assembly. PubMed ID: 27007846

Structural insights into preinitiation complex assembly on core promoters. PubMed ID: 33795473

The sequence of the human genome. PubMed ID: 11181995

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334