Details for: TFCP2

Gene ID: 7024

Symbol: TFCP2

Ensembl ID: ENSG00000135457

Description: transcription factor CP2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.99
    Marker Score: 29798
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.96
    Marker Score: 38958
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.91
    Marker Score: 7787
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.9
    Marker Score: 70002
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.89
    Marker Score: 14509
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.88
    Marker Score: 3616
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.87
    Marker Score: 71096
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.87
    Marker Score: 2151.5
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.83
    Marker Score: 7085
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.83
    Marker Score: 1583
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.82
    Marker Score: 38740
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.81
    Marker Score: 111133
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.77
    Marker Score: 2210
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.76
    Marker Score: 16730.5
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.76
    Marker Score: 16546.5
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.74
    Marker Score: 14930.5
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.73
    Marker Score: 17843
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.71
    Marker Score: 7080
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.7
    Marker Score: 30242
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.66
    Marker Score: 3641
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.65
    Marker Score: 3956
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.6
    Marker Score: 1763
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.59
    Marker Score: 53534.5
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.58
    Marker Score: 35227
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.56
    Marker Score: 6487
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.54
    Marker Score: 644.5
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.53
    Marker Score: 1177
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.53
    Marker Score: 2565
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.52
    Marker Score: 7019.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.51
    Marker Score: 2333
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.5
    Marker Score: 1041.5
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.44
    Marker Score: 1279.5
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.42
    Marker Score: 705
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.41
    Marker Score: 743
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.39
    Marker Score: 814
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.37
    Marker Score: 767
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.37
    Marker Score: 1548
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.35
    Marker Score: 3857
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.33
    Marker Score: 423
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.33
    Marker Score: 5580
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.31
    Marker Score: 1416.5
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.28
    Marker Score: 6902
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.28
    Marker Score: 350
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.26
    Marker Score: 1202
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.25
    Marker Score: 6583
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.25
    Marker Score: 1030
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.25
    Marker Score: 747
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.22
    Marker Score: 441
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.21
    Marker Score: 442
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.21
    Marker Score: 631
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.18
    Marker Score: 887
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.14
    Marker Score: 616
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.09
    Marker Score: 315
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.08
    Marker Score: 1331
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.07
    Marker Score: 600
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.07
    Marker Score: 395
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.04
    Marker Score: 7864
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.03
    Marker Score: 1241
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.02
    Marker Score: 880
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.01
    Marker Score: 3401
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.01
    Marker Score: 296
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.01
    Marker Score: 1429.5
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.01
    Marker Score: 2318
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1
    Marker Score: 362
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71708
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47934
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.99
    Marker Score: 261
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.98
    Marker Score: 198
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30392
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.98
    Marker Score: 571
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.97
    Marker Score: 473
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.96
    Marker Score: 3131
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.95
    Marker Score: 1148
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2402
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.94
    Marker Score: 524
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.94
    Marker Score: 465
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 482
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 438
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.93
    Marker Score: 3293
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.92
    Marker Score: 234
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.91
    Marker Score: 1483
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2711
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.9
    Marker Score: 14523
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.9
    Marker Score: 1215
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.88
    Marker Score: 2080
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.88
    Marker Score: 329
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.86
    Marker Score: 566
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4898
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.86
    Marker Score: 916
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.84
    Marker Score: 671
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.84
    Marker Score: 13101
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.82
    Marker Score: 389
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.81
    Marker Score: 615
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.8
    Marker Score: 5155
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.79
    Marker Score: 305
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.79
    Marker Score: 1114
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 603.5
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.78
    Marker Score: 403

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Other Information

**Key Characteristics:** TFCP2 is a transcription factor that belongs to the CTCF family, characterized by its ability to bind to specific DNA sequences and regulate gene expression. It is primarily expressed in neurons, GABAergic cortical interneurons, and other cell types involved in the development and maintenance of the nervous system. TFCP2 has been shown to interact with various proteins, including RNA polymerase II, and is involved in the regulation of transcription by RNA polymerase II. **Pathways and Functions:** TFCP2 is involved in several key pathways, including: 1. **Chromatin and Cis-regulatory Region Sequence-Specific DNA Binding:** TFCP2 binds to specific DNA sequences, such as the CTCF motif, and regulates chromatin structure and gene expression. 2. **Positive Regulation of Transcription by RNA Polymerase II:** TFCP2 interacts with RNA polymerase II and enhances its transcriptional activity, leading to the regulation of gene expression. 3. **DNA Binding and Sequence-Specific Double-Stranded DNA Binding:** TFCP2 binds to double-stranded DNA and regulates gene expression by interacting with other transcription factors and chromatin-modifying enzymes. 4. **Regulation of Transcription by RNA Polymerase II:** TFCP2 regulates transcription by RNA polymerase II, which is essential for the expression of genes involved in neuronal development and function. **Clinical Significance:** TFCP2 has been implicated in various diseases, including: 1. **Neurological Disorders:** TFCP2 has been linked to neurological disorders, such as epilepsy, schizophrenia, and autism spectrum disorder, where aberrant gene expression and chromatin structure contribute to disease pathogenesis. 2. **Cancer:** TFCP2 has been shown to play a role in cancer development and progression, particularly in glioblastoma and other brain tumors. 3. **Kidney Disease:** TFCP2 has been implicated in kidney disease, where aberrant gene expression and chromatin structure contribute to disease pathogenesis. In conclusion, TFCP2 is a critical transcription factor that regulates gene expression and plays a significant role in various cellular processes. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its mechanisms of action and its clinical significance. Further research is needed to elucidate the role of TFCP2 in disease pathogenesis and to develop therapeutic strategies to target its dysregulated activity. **References:** * [Insert references to relevant studies and publications] Note: This article is a hypothetical example and should not be cited as an actual publication.

Genular Protein ID: 904077891

Symbol: TFCP2_HUMAN

Name: Alpha-globin transcription factor CP2

UniProtKB Accession Codes:

Q12800 A8K5E9 Q12801 Q9UD75 Q9UD77

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 3 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 RefSeq 3 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1732747

Title: Molecular cloning of the alpha-globin transcription factor CP2.

PubMed ID: 1732747

DOI: 10.1128/mcb.12.2.828-835.1992

PubMed ID: 8114710

Title: Characterization of a family of related cellular transcription factors which can modulate human immunodeficiency virus type 1 transcription in vitro.

PubMed ID: 8114710

DOI: 10.1128/mcb.14.3.1776-1785.1994

PubMed ID: 8035790

Title: One exon of the human LSF gene includes conserved regions involved in novel DNA-binding and dimerization motifs.

PubMed ID: 8035790

DOI: 10.1128/mcb.14.8.5076-5087.1994

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8157699

Title: Characterization of the genomic structure, chromosomal location, promoter, and development expression of the alpha-globin transcription factor CP2.

PubMed ID: 8157699

DOI: 10.1016/s0021-9258(19)78176-9

PubMed ID: 7828600

Title: Hemoglobin switching in man and chicken is mediated by a heteromeric complex between the ubiquitous transcription factor CP2 and a developmentally specific protein.

PubMed ID: 7828600

DOI: 10.1002/j.1460-2075.1995.tb06979.x

PubMed ID: 10455131

Title: Purification and characterization of the serum amyloid A3 enhancer factor.

PubMed ID: 10455131

DOI: 10.1074/jbc.274.35.24649

PubMed ID: 11003662

Title: Induction of human fetal globin gene expression by a novel erythroid factor, NF-E4.

PubMed ID: 11003662

DOI: 10.1128/mcb.20.20.7662-7672.2000

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 502
  • Mass: 57256
  • Checksum: B93825C2687F89FF
  • Sequence:
    • MAWALKLPLA DEVIESGLVQ DFDASLSGIG QELGAGAYSM SDVLALPIFK QEESSLPPDN 
ENKILPFQYV LCAATSPAVK LHDETLTYLN QGQSYEIRML DNRKLGELPE INGKLVKSIF 
RVVFHDRRLQ YTEHQQLEGW RWNRPGDRIL DIDIPMSVGI IDPRANPTQL NTVEFLWDPA 
KRTSVFIQVH CISTEFTMRK HGGEKGVPFR VQIDTFKENE NGEYTEHLHS ASCQIKVFKP 
KGADRKQKTD REKMEKRTPH EKEKYQPSYE TTILTECSPW PEITYVNNSP SPGFNSSHSS 
FSLGEGNGSP NHQPEPPPPV TDNLLPTTTP QEAQQWLHRN RFSTFTRLFT NFSGADLLKL 
TRDDVIQICG PADGIRLFNA LKGRMVRPRL TIYVCQESLQ LREQQQQQQQ QQQKHEDGDS 
NGTFFVYHAI YLEELTAVEL TEKIAQLFSI SPCQISQIYK QGPTGIHVLI SDEMIQNFQE 
EACFILDTMK AETNDSYHII LK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.