Details for: TFCP2

Gene ID: 7024

Symbol: TFCP2

Ensembl ID: ENSG00000135457

Description: transcription factor CP2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 288.4049
    Cell Significance Index: -44.8600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 175.4037
    Cell Significance Index: -44.4900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 100.0977
    Cell Significance Index: -41.2400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 87.9000
    Cell Significance Index: -35.7100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 83.3228
    Cell Significance Index: -42.8600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 37.5703
    Cell Significance Index: -35.8700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 37.1708
    Cell Significance Index: -45.8300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.0087
    Cell Significance Index: -42.8900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 15.3158
    Cell Significance Index: -33.5200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.6686
    Cell Significance Index: -46.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.1956
    Cell Significance Index: 440.4300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.8012
    Cell Significance Index: 46.3000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.7596
    Cell Significance Index: 135.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.5319
    Cell Significance Index: 549.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.5218
    Cell Significance Index: 302.0100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1665
    Cell Significance Index: 189.7200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.0975
    Cell Significance Index: 48.5500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.0753
    Cell Significance Index: 40.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.0560
    Cell Significance Index: 59.2600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.0363
    Cell Significance Index: 28.9600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9870
    Cell Significance Index: 891.2000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.9545
    Cell Significance Index: 18.6300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9169
    Cell Significance Index: 12.5100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9109
    Cell Significance Index: 630.0000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.8990
    Cell Significance Index: 60.4500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6450
    Cell Significance Index: 70.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6057
    Cell Significance Index: 37.2300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5706
    Cell Significance Index: 15.2900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5484
    Cell Significance Index: 32.9200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5150
    Cell Significance Index: 60.0200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.4209
    Cell Significance Index: 12.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4090
    Cell Significance Index: 8.8600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3995
    Cell Significance Index: 9.9900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3894
    Cell Significance Index: 11.2200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3262
    Cell Significance Index: 58.8000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.3027
    Cell Significance Index: 7.2600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2923
    Cell Significance Index: 35.9400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2784
    Cell Significance Index: 12.6200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2667
    Cell Significance Index: 16.8100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2294
    Cell Significance Index: 22.6900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2288
    Cell Significance Index: 15.8300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1745
    Cell Significance Index: 3.8200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1663
    Cell Significance Index: 90.8200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1329
    Cell Significance Index: 250.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1048
    Cell Significance Index: 47.5600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0986
    Cell Significance Index: 1.6900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0746
    Cell Significance Index: 47.3900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0622
    Cell Significance Index: 27.5100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0617
    Cell Significance Index: 95.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0604
    Cell Significance Index: 82.1300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0504
    Cell Significance Index: 92.9200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0202
    Cell Significance Index: 1.0500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0168
    Cell Significance Index: 0.2000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0165
    Cell Significance Index: 0.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0157
    Cell Significance Index: 2.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0006
    Cell Significance Index: -0.1200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0094
    Cell Significance Index: -0.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0229
    Cell Significance Index: -16.9600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0255
    Cell Significance Index: -15.9000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0401
    Cell Significance Index: -29.3700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0466
    Cell Significance Index: -26.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0564
    Cell Significance Index: -42.7200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0567
    Cell Significance Index: -9.6800
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0653
    Cell Significance Index: -0.5800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0859
    Cell Significance Index: -4.4600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1064
    Cell Significance Index: -13.6400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1344
    Cell Significance Index: -1.9300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1368
    Cell Significance Index: -28.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1380
    Cell Significance Index: -39.7200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1432
    Cell Significance Index: -20.8200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1467
    Cell Significance Index: -3.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1693
    Cell Significance Index: -17.2900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1863
    Cell Significance Index: -12.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1979
    Cell Significance Index: -9.2200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2060
    Cell Significance Index: -24.2900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2269
    Cell Significance Index: -3.3500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2322
    Cell Significance Index: -8.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2323
    Cell Significance Index: -10.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2626
    Cell Significance Index: -33.9300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2662
    Cell Significance Index: -5.6700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2886
    Cell Significance Index: -3.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3047
    Cell Significance Index: -34.9100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3485
    Cell Significance Index: -36.2900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3636
    Cell Significance Index: -41.5100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4570
    Cell Significance Index: -32.3200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4610
    Cell Significance Index: -7.7200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4793
    Cell Significance Index: -35.7200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4843
    Cell Significance Index: -38.3600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5160
    Cell Significance Index: -27.0900
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.5680
    Cell Significance Index: -5.7300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.5883
    Cell Significance Index: -14.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5952
    Cell Significance Index: -36.4900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6023
    Cell Significance Index: -19.2900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6776
    Cell Significance Index: -21.5800
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.6822
    Cell Significance Index: -8.5900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6846
    Cell Significance Index: -23.7900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6858
    Cell Significance Index: -13.5600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6983
    Cell Significance Index: -22.8600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7454
    Cell Significance Index: -15.8200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.7621
    Cell Significance Index: -15.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TFCP2 is a transcription factor that belongs to the CTCF family, characterized by its ability to bind to specific DNA sequences and regulate gene expression. It is primarily expressed in neurons, GABAergic cortical interneurons, and other cell types involved in the development and maintenance of the nervous system. TFCP2 has been shown to interact with various proteins, including RNA polymerase II, and is involved in the regulation of transcription by RNA polymerase II. **Pathways and Functions:** TFCP2 is involved in several key pathways, including: 1. **Chromatin and Cis-regulatory Region Sequence-Specific DNA Binding:** TFCP2 binds to specific DNA sequences, such as the CTCF motif, and regulates chromatin structure and gene expression. 2. **Positive Regulation of Transcription by RNA Polymerase II:** TFCP2 interacts with RNA polymerase II and enhances its transcriptional activity, leading to the regulation of gene expression. 3. **DNA Binding and Sequence-Specific Double-Stranded DNA Binding:** TFCP2 binds to double-stranded DNA and regulates gene expression by interacting with other transcription factors and chromatin-modifying enzymes. 4. **Regulation of Transcription by RNA Polymerase II:** TFCP2 regulates transcription by RNA polymerase II, which is essential for the expression of genes involved in neuronal development and function. **Clinical Significance:** TFCP2 has been implicated in various diseases, including: 1. **Neurological Disorders:** TFCP2 has been linked to neurological disorders, such as epilepsy, schizophrenia, and autism spectrum disorder, where aberrant gene expression and chromatin structure contribute to disease pathogenesis. 2. **Cancer:** TFCP2 has been shown to play a role in cancer development and progression, particularly in glioblastoma and other brain tumors. 3. **Kidney Disease:** TFCP2 has been implicated in kidney disease, where aberrant gene expression and chromatin structure contribute to disease pathogenesis. In conclusion, TFCP2 is a critical transcription factor that regulates gene expression and plays a significant role in various cellular processes. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its mechanisms of action and its clinical significance. Further research is needed to elucidate the role of TFCP2 in disease pathogenesis and to develop therapeutic strategies to target its dysregulated activity. **References:** * [Insert references to relevant studies and publications] Note: This article is a hypothetical example and should not be cited as an actual publication.

Genular Protein ID: 904077891

Symbol: TFCP2_HUMAN

Name: Alpha-globin transcription factor CP2

UniProtKB Accession Codes:

Q12800 A8K5E9 Q12801 Q9UD75 Q9UD77

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1732747

Title: Molecular cloning of the alpha-globin transcription factor CP2.

PubMed ID: 1732747

DOI: 10.1128/mcb.12.2.828-835.1992

PubMed ID: 8114710

Title: Characterization of a family of related cellular transcription factors which can modulate human immunodeficiency virus type 1 transcription in vitro.

PubMed ID: 8114710

DOI: 10.1128/mcb.14.3.1776-1785.1994

PubMed ID: 8035790

Title: One exon of the human LSF gene includes conserved regions involved in novel DNA-binding and dimerization motifs.

PubMed ID: 8035790

DOI: 10.1128/mcb.14.8.5076-5087.1994

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8157699

Title: Characterization of the genomic structure, chromosomal location, promoter, and development expression of the alpha-globin transcription factor CP2.

PubMed ID: 8157699

DOI: 10.1016/s0021-9258(19)78176-9

PubMed ID: 7828600

Title: Hemoglobin switching in man and chicken is mediated by a heteromeric complex between the ubiquitous transcription factor CP2 and a developmentally specific protein.

PubMed ID: 7828600

DOI: 10.1002/j.1460-2075.1995.tb06979.x

PubMed ID: 10455131

Title: Purification and characterization of the serum amyloid A3 enhancer factor.

PubMed ID: 10455131

DOI: 10.1074/jbc.274.35.24649

PubMed ID: 11003662

Title: Induction of human fetal globin gene expression by a novel erythroid factor, NF-E4.

PubMed ID: 11003662

DOI: 10.1128/mcb.20.20.7662-7672.2000

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 502
  • Mass: 57256
  • Checksum: B93825C2687F89FF
  • Sequence:
    • MAWALKLPLA DEVIESGLVQ DFDASLSGIG QELGAGAYSM SDVLALPIFK QEESSLPPDN 
ENKILPFQYV LCAATSPAVK LHDETLTYLN QGQSYEIRML DNRKLGELPE INGKLVKSIF 
RVVFHDRRLQ YTEHQQLEGW RWNRPGDRIL DIDIPMSVGI IDPRANPTQL NTVEFLWDPA 
KRTSVFIQVH CISTEFTMRK HGGEKGVPFR VQIDTFKENE NGEYTEHLHS ASCQIKVFKP 
KGADRKQKTD REKMEKRTPH EKEKYQPSYE TTILTECSPW PEITYVNNSP SPGFNSSHSS 
FSLGEGNGSP NHQPEPPPPV TDNLLPTTTP QEAQQWLHRN RFSTFTRLFT NFSGADLLKL 
TRDDVIQICG PADGIRLFNA LKGRMVRPRL TIYVCQESLQ LREQQQQQQQ QQQKHEDGDS 
NGTFFVYHAI YLEELTAVEL TEKIAQLFSI SPCQISQIYK QGPTGIHVLI SDEMIQNFQE 
EACFILDTMK AETNDSYHII LK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.