Details for: TFR2

Gene ID: 7036

Symbol: TFR2

Ensembl ID: ENSG00000106327

Description: transferrin receptor 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 3.62
    Marker Score: 11852.5
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.23
    Marker Score: 11965.5
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.85
    Marker Score: 7976
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.85
    Marker Score: 11870.5
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.77
    Marker Score: 1203
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1166
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.5
    Marker Score: 1060.5
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169642
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 851
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.16
    Marker Score: 1210.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71825
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48049.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.98
    Marker Score: 485
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.97
    Marker Score: 1037
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.96
    Marker Score: 308
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5280
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 369.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.91
    Marker Score: 377
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.82
    Marker Score: 616
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.81
    Marker Score: 555
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 610.5
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.78
    Marker Score: 3285
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 706
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.72
    Marker Score: 476
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 458
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.7
    Marker Score: 2725
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.66
    Marker Score: 655.5
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.66
    Marker Score: 276
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.62
    Marker Score: 1181
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.57
    Marker Score: 178
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.55
    Marker Score: 330
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 170
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.53
    Marker Score: 32743
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.53
    Marker Score: 1068
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.51
    Marker Score: 193
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.5
    Marker Score: 133
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.49
    Marker Score: 219
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.47
    Marker Score: 238
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.46
    Marker Score: 460
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.45
    Marker Score: 922
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.44
    Marker Score: 141
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.44
    Marker Score: 4570
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.44
    Marker Score: 119.5
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.43
    Marker Score: 417
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.42
    Marker Score: 261
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.41
    Marker Score: 206
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.41
    Marker Score: 1592
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.39
    Marker Score: 106
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.38
    Marker Score: 5993
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.37
    Marker Score: 2867
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.37
    Marker Score: 442
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.36
    Marker Score: 13790
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.36
    Marker Score: 1474
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.36
    Marker Score: 150
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.35
    Marker Score: 331
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.34
    Marker Score: 1431
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.33
    Marker Score: 176
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.33
    Marker Score: 152
  • Cell Name: reticulocyte (CL0000558)
    Fold Change: 0.33
    Marker Score: 140
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.33
    Marker Score: 114
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.32
    Marker Score: 650
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.32
    Marker Score: 4746
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.31
    Marker Score: 6232
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.29
    Marker Score: 2457
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.28
    Marker Score: 105
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.28
    Marker Score: 154
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.27
    Marker Score: 2545
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.27
    Marker Score: 9000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.27
    Marker Score: 9796
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.26
    Marker Score: 82
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.25
    Marker Score: 121
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.23
    Marker Score: 1402
  • Cell Name: enucleate erythrocyte (CL0000595)
    Fold Change: 0.23
    Marker Score: 91
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.23
    Marker Score: 74
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.22
    Marker Score: 1020
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 62
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.21
    Marker Score: 62
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 71
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.21
    Marker Score: 109
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.2
    Marker Score: 577
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.2
    Marker Score: 1912
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.2
    Marker Score: 88
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.19
    Marker Score: 108
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.19
    Marker Score: 293
  • Cell Name: eosinophil (CL0000771)
    Fold Change: 0.18
    Marker Score: 60
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.18
    Marker Score: 277
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.18
    Marker Score: 69
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.17
    Marker Score: 3038
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.17
    Marker Score: 95

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Other Information

**Key Characteristics:** 1. **Structure:** TFR2 is a transmembrane receptor with two extracellular domains and two transmembrane domains, allowing it to bind to transferrin, a protein that transports iron in the bloodstream. 2. **Expression:** TFR2 is widely expressed in various cell types, including hepatocytes, erythroid progenitor cells, and intestinal epithelial cells. 3. **Function:** TFR2 mediates the endocytosis of transferrin, regulating iron uptake and homeostasis. It also participates in the transport of small molecules and plays a role in the regulation of post-synaptic membrane neurotransmitter receptor levels. **Pathways and Functions:** 1. **Iron Homeostasis:** TFR2 is essential for the regulation of iron uptake and homeostasis. It binds to transferrin, which carries iron from the bloodstream to cells, and facilitates its internalization. 2. **Endocytic Iron Import:** TFR2 is involved in the endocytosis of transferrin, allowing iron to be transported into cells. 3. **Co-receptor Binding:** TFR2 interacts with other co-receptors, such as CD63 and CD81, to form a complex that enhances transferrin binding. 4. **Regulation of Transcription:** TFR2 can regulate the transcription of genes involved in iron homeostasis and other cellular processes. 5. **Neurotransmitter Regulation:** TFR2 has been implicated in the regulation of post-synaptic membrane neurotransmitter receptor levels, suggesting its potential role in neurological disorders. **Clinical Significance:** 1. **Hemochromatosis:** Mutations in the TFR2 gene have been associated with hereditary hemochromatosis, a disorder characterized by excessive iron accumulation in the body. 2. **Anemia:** TFR2 plays a crucial role in iron homeostasis, and alterations in its function can lead to anemia. 3. **Neurological Disorders:** The involvement of TFR2 in neurotransmitter regulation suggests its potential role in neurological disorders, such as Parkinson's disease and Alzheimer's disease. 4. **Cancer:** TFR2 has been implicated in the regulation of iron homeostasis in cancer cells, suggesting its potential as a therapeutic target. In conclusion, the transferrin receptor 2 (TFR2) is a multifunctional protein that plays a critical role in iron homeostasis and beyond. Its dysregulation has been implicated in various diseases, highlighting its potential as a therapeutic target. Further research is needed to fully understand the mechanisms by which TFR2 regulates iron homeostasis and its role in different diseases.

Genular Protein ID: 1247812470

Symbol: TFR2_HUMAN

Name: Transferrin receptor protein 2

UniProtKB Accession Codes:

Q9UP52 A6NGM7 O75422 Q1HE13 Q9HA99 Q9NX67

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 21 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SAM 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TCDB 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10409623

Title: Molecular cloning of transferrin receptor 2: a new member of the transferrin receptor-like family.

PubMed ID: 10409623

DOI: 10.1074/jbc.274.30.20826

PubMed ID: 9799793

Title: Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes.

PubMed ID: 9799793

DOI: 10.1101/gr.8.10.1060

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10802645

Title: The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22.

PubMed ID: 10802645

DOI: 10.1038/75534

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 11313241

Title: New mutations inactivating transferrin 2 in hemochromatosis type 3.

PubMed ID: 11313241

DOI: 10.1182/blood.v97.9.2555

PubMed ID: 12130528

Title: Transferrin receptor 2 (TfR2) and HFE mutational analysis in non-C282Y iron overload: identification of a novel TfR2 mutation.

PubMed ID: 12130528

DOI: 10.1182/blood-2002-01-0133

PubMed ID: 12150153

Title: Mutation analysis of transferrin-receptor 2 in patients with atypical hemochromatosis.

PubMed ID: 12150153

DOI: 10.1182/blood-2002-04-1077

PubMed ID: 14633868

Title: Identification of new mutations of the HFE, hepcidin, and transferrin receptor 2 genes by denaturing HPLC analysis of individuals with biochemical indications of iron overload.

PubMed ID: 14633868

DOI: 10.1373/clinchem.2003.023440

Sequence Information:

  • Length: 801
  • Mass: 88755
  • Checksum: D3D3082BA835413A
  • Sequence:
    • MERLWGLFQR AQQLSPRSSQ TVYQRVEGPR KGHLEEEEED GEEGAETLAH FCPMELRGPE 
PLGSRPRQPN LIPWAAAGRR AAPYLVLTAL LIFTGAFLLG YVAFRGSCQA CGDSVLVVSE 
DVNYEPDLDF HQGRLYWSDL QAMFLQFLGE GRLEDTIRQT SLRERVAGSA GMAALTQDIR 
AALSRQKLDH VWTDTHYVGL QFPDPAHPNT LHWVDEAGKV GEQLPLEDPD VYCPYSAIGN 
VTGELVYAHY GRPEDLQDLR ARGVDPVGRL LLVRVGVISF AQKVTNAQDF GAQGVLIYPE 
PADFSQDPPK PSLSSQQAVY GHVHLGTGDP YTPGFPSFNQ TQFPPVASSG LPSIPAQPIS 
ADIASRLLRK LKGPVAPQEW QGSLLGSPYH LGPGPRLRLV VNNHRTSTPI NNIFGCIEGR 
SEPDHYVVIG AQRDAWGPGA AKSAVGTAIL LELVRTFSSM VSNGFRPRRS LLFISWDGGD 
FGSVGSTEWL EGYLSVLHLK AVVYVSLDNA VLGDDKFHAK TSPLLTSLIE SVLKQVDSPN 
HSGQTLYEQV VFTNPSWDAE VIRPLPMDSS AYSFTAFVGV PAVEFSFMED DQAYPFLHTK 
EDTYENLHKV LQGRLPAVAQ AVAQLAGQLL IRLSHDRLLP LDFGRYGDVV LRHIGNLNEF 
SGDLKARGLT LQWVYSARGD YIRAAEKLRQ EIYSSEERDE RLTRMYNVRI MRVEFYFLSQ 
YVSPADSPFR HIFMGRGDHT LGALLDHLRL LRSNSSGTPG ATSSTGFQES RFRRQLALLT 
WTLQGAANAL SGDVWNIDNN F

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.