Details for: ICAM5

Gene ID: 7087

Symbol: ICAM5

Ensembl ID: ENSG00000105376

Description: intercellular adhesion molecule 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 32.4664
    Cell Significance Index: -5.0500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 20.1858
    Cell Significance Index: -5.1200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.1526
    Cell Significance Index: -5.1200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.6694
    Cell Significance Index: 47.6400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.0819
    Cell Significance Index: 72.7500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: 0.7269
    Cell Significance Index: 9.6900
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.6522
    Cell Significance Index: 8.7000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6487
    Cell Significance Index: 130.1300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.5328
    Cell Significance Index: 7.6300
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.4283
    Cell Significance Index: 3.6400
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.3794
    Cell Significance Index: 2.9100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3364
    Cell Significance Index: 12.7400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3294
    Cell Significance Index: 14.5700
  • Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
    Fold Change: 0.2501
    Cell Significance Index: 2.7000
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron (CL4030065)
    Fold Change: 0.2053
    Cell Significance Index: 2.1500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1733
    Cell Significance Index: 62.1700
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.1387
    Cell Significance Index: 1.5300
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.1378
    Cell Significance Index: 1.3100
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.1246
    Cell Significance Index: 1.2900
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.1051
    Cell Significance Index: 1.0000
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: 0.0931
    Cell Significance Index: 1.0200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.0657
    Cell Significance Index: 1.3000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0603
    Cell Significance Index: 41.7000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.0188
    Cell Significance Index: 0.6000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0155
    Cell Significance Index: 8.4900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0152
    Cell Significance Index: 0.7900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0095
    Cell Significance Index: 0.5000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0085
    Cell Significance Index: 0.5300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0057
    Cell Significance Index: 0.1200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.0032
    Cell Significance Index: 0.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0024
    Cell Significance Index: -4.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0025
    Cell Significance Index: -0.2600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0025
    Cell Significance Index: -4.6300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0026
    Cell Significance Index: -4.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0034
    Cell Significance Index: -4.6700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0039
    Cell Significance Index: -1.7100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0054
    Cell Significance Index: -0.9800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0056
    Cell Significance Index: -4.2700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0064
    Cell Significance Index: -0.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0065
    Cell Significance Index: -4.7300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0074
    Cell Significance Index: -4.7200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0079
    Cell Significance Index: -4.4400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0088
    Cell Significance Index: -1.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0092
    Cell Significance Index: -4.1700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0131
    Cell Significance Index: -0.4300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0147
    Cell Significance Index: -4.2300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0204
    Cell Significance Index: -2.5100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0229
    Cell Significance Index: -2.9400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0230
    Cell Significance Index: -1.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0251
    Cell Significance Index: -3.4500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0267
    Cell Significance Index: -0.7500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0271
    Cell Significance Index: -4.6300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0288
    Cell Significance Index: -0.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0288
    Cell Significance Index: -5.7200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0300
    Cell Significance Index: -4.3600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0308
    Cell Significance Index: -3.9800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0311
    Cell Significance Index: -1.4500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0340
    Cell Significance Index: -0.3700
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0381
    Cell Significance Index: -0.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0416
    Cell Significance Index: -4.7700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0418
    Cell Significance Index: -0.8400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0437
    Cell Significance Index: -5.1500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0446
    Cell Significance Index: -1.9400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0461
    Cell Significance Index: -1.1500
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0485
    Cell Significance Index: -0.4800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0560
    Cell Significance Index: -1.4400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0571
    Cell Significance Index: -4.3800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0619
    Cell Significance Index: -2.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0634
    Cell Significance Index: -2.9800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0637
    Cell Significance Index: -4.7500
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0649
    Cell Significance Index: -0.9000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0662
    Cell Significance Index: -3.0000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0663
    Cell Significance Index: -1.5900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0800
    Cell Significance Index: -5.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0811
    Cell Significance Index: -4.5500
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.0846
    Cell Significance Index: -0.8700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0899
    Cell Significance Index: -2.5900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0907
    Cell Significance Index: -1.0300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1096
    Cell Significance Index: -3.8500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1128
    Cell Significance Index: -4.1400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1179
    Cell Significance Index: -1.8700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1203
    Cell Significance Index: -1.1400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1290
    Cell Significance Index: -3.5100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1294
    Cell Significance Index: -2.7000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1305
    Cell Significance Index: -1.8700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1336
    Cell Significance Index: -2.6300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1419
    Cell Significance Index: -4.9300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1429
    Cell Significance Index: -4.5200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1456
    Cell Significance Index: -4.2900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1469
    Cell Significance Index: -3.9300
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.1477
    Cell Significance Index: -1.9200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1522
    Cell Significance Index: -1.9200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1586
    Cell Significance Index: -3.2900
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.1595
    Cell Significance Index: -2.2300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1601
    Cell Significance Index: -4.5900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1607
    Cell Significance Index: -3.2100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1614
    Cell Significance Index: -5.1700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1617
    Cell Significance Index: -3.2900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1655
    Cell Significance Index: -3.5900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1677
    Cell Significance Index: -2.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell-Surface Expression:** ICAM5 is primarily expressed on the surface of cells, where it mediates adhesion interactions between cells. 2. **Adhesive Function:** ICAM5 binds to integrins, laminins, and other adhesion molecules, facilitating cell-cell and cell-extracellular matrix interactions. 3. **Regulatory Role:** ICAM5 modulates immune responses, including phagocytosis, synapse assembly, and the regulation of immune cell interactions. 4. **Widespread Expression:** ICAM5 is expressed in various cell types, including neural progenitor cells, colon goblet cells, cardiac endothelial cells, and immune cells. **Pathways and Functions:** 1. **Adaptive Immune System:** ICAM5 participates in the regulation of immune cell interactions, including T cell activation, antibody-dependent cellular cytotoxicity, and the modulation of immune responses. 2. **Cell-Cell Adhesion:** ICAM5 mediates adhesion interactions between cells, facilitating the exchange of signaling molecules and the regulation of cell migration and proliferation. 3. **Cell-Extracellular Matrix Organization:** ICAM5 contributes to the organization of the extracellular matrix, influencing cell behavior, migration, and tissue remodeling. 4. **Regulation of Synapse Assembly:** ICAM5 plays a role in the assembly and regulation of synapses, including those involved in neural communication and immune responses. **Clinical Significance:** ICAM5's involvement in various diseases underscores its importance as a therapeutic target. For example: 1. **Autoimmune Diseases:** ICAM5's role in regulating immune responses makes it a potential target for the treatment of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer:** ICAM5's expression in cancer cells and its involvement in cell-cell adhesion and migration make it a potential target for cancer therapy. 3. **Neurological Disorders:** ICAM5's role in regulating synapse assembly and neural communication makes it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, ICAM5 is a critical regulator of cell-cell adhesion and immune function, with significant implications for our understanding of immune responses and tissue homeostasis. Further research is needed to fully elucidate the mechanisms by which ICAM5 regulates immune responses and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 3207908545

Symbol: ICAM5_HUMAN

Name: Intercellular adhesion molecule 5

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8995416

Title: cDNA cloning and chromosomal localization of the human telencephalin and its distinctive interaction with lymphocyte function-associated antigen-1.

PubMed ID: 8995416

DOI: 10.1074/jbc.272.2.1156

PubMed ID: 9828136

Title: Mapping of the ICAM-5 (telencephalin) gene, a neuronal member of the ICAM family, to a location between ICAM-1 and ICAM-3 on human chromosome 19p13.2.

PubMed ID: 9828136

DOI: 10.1006/geno.1998.5565

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 18691975

Title: An unusual allosteric mobility of the C-terminal helix of a high-affinity alphaL integrin I domain variant bound to ICAM-5.

PubMed ID: 18691975

DOI: 10.1016/j.molcel.2008.06.022

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 924
  • Mass: 97116
  • Checksum: 97D0A9467BD16D30
  • Sequence:
  • MPGPSPGLRR ALLGLWAALG LGLFGLSAVS QEPFWADLQP RVAFVERGGS LWLNCSTNCP 
    RPERGGLETS LRRNGTQRGL RWLARQLVDI REPETQPVCF FRCARRTLQA RGLIRTFQRP 
    DRVELMPLPP WQPVGENFTL SCRVPGAGPR ASLTLTLLRG AQELIRRSFA GEPPRARGAV 
    LTATVLARRE DHGANFSCRA ELDLRPHGLG LFENSSAPRE LRTFSLSPDA PRLAAPRLLE 
    VGSERPVSCT LDGLFPASEA RVYLALGDQN LSPDVTLEGD AFVATATATA SAEQEGARQL 
    VCNVTLGGEN RETRENVTIY SFPAPLLTLS EPSVSEGQMV TVTCAAGAQA LVTLEGVPAA 
    VPGQPAQLQL NATENDDRRS FFCDATLDVD GETLIKNRSA ELRVLYAPRL DDSDCPRSWT 
    WPEGPEQTLR CEARGNPEPS VHCARSDGGA VLALGLLGPV TRALSGTYRC KAANDQGEAV 
    KDVTLTVEYA PALDSVGCPE RITWLEGTEA SLSCVAHGVP PPDVICVRSG ELGAVIEGLL 
    RVAREHAGTY RCEATNPRGS AAKNVAVTVE YGPRFEEPSC PSNWTWVEGS GRLFSCEVDG 
    KPQPSVKCVG SGGATEGVLL PLAPPDPSPR APRIPRVLAP GIYVCNATNR HGSVAKTVVV 
    SAESPPEMDE STCPSHQTWL EGAEASALAC AARGRPSPGV RCSREGIPWP EQQRVSREDA 
    GTYHCVATNA HGTDSRTVTV GVEYRPVVAE LAASPPGGVR PGGNFTLTCR AEAWPPAQIS 
    WRAPPGALNI GLSSNNSTLS VAGAMGSHGG EYECAATNAH GRHARRITVR VAGPWLWVAV 
    GGAAGGAALL AAGAGLAFYV QSTACKKGEY NVQEAESSGE AVCLNGAGGG AGGAAGAEGG 
    PEAAGGAAES PAEGEVFAIQ LTSA

Genular Protein ID: 1209509476

Symbol: Q8N6I2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 812
  • Mass: 84617
  • Checksum: 28746AC9193B1FB3
  • Sequence:
  • LFPLAERPDR VELMPLPPWQ PVGENFTLSC RVPGAGPRAS LTLTLLRGAQ ELIRRSFAGE 
    PPRARGAVLT ATVLARREDH GANFSCRAEL DLRPHGLGLF ENSSAPRELR TFSLSPDAPR 
    LAAPRLLEVG SERPVSCTLD GLFPASEARV YLALGDQNLS PDVTLEGDAF VATATATASA 
    EQEGARQLIC NVTLGGENRE TRENVTIYSF PAPLLTLSEP SVSEGQMVTV TCAAGTQALV 
    TLEGVPAAVP GQPAQLQLNA TENDDRRSFF CDATLDVDGE TLIKNRSAEL RVLYAPRLDD 
    SDCPRSWTWP EGPEQTLRCE ARGNPEPSVH CARSDGGAVL ALGLLGPVTR ALSGTYRCKA 
    ANDQGEAVKD VTLTVEYAPA LDSVGCPERI TWLEGTEASL SCVAHGVPPP DVICVRSGEL 
    GAVIEGLLRV AREHAGTYRC EATNPRGSAA KNVAVTVEYG PRFEEPSCPS NWTWVEGSGR 
    LFSCEVDGKP QPSVKCVGSG GATEGVLLPL APPDPSPRAP RIPRVLAPGI YVCNATNRHG 
    SVAKTVVVSA ESPPEMDEST CPSHQTWLEG AEASALACAA RGRPSPGVRC SREGIPWPEQ 
    QRVSREDAGT YHCVATNAHG TDSRTVTVGV EYRPVVAELA ASPPGGVRPG GNFTLTCRAE 
    AWPPAQISWR APPGALNIGL SSNNSTLSVA GAMGSHGGEY ECAATNAHGR HARRITVRVA 
    GPWLWVAVGG AAGGAALLAA GAGLAFYVQS TACKKGEYNV QEAESSGEAV CLNGAGGGAG 
    GAAGAEGGPE AAGGAAESPA EGEVFAIQLT SA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.