Details for: ICAM5

Gene ID: 7087

Symbol: ICAM5

Ensembl ID: ENSG00000105376

Description: intercellular adhesion molecule 5

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 2.97
    Marker Score: 11499
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1170
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 856
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 488
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.11
    Marker Score: 2100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 797
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71829
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48053
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.93
    Marker Score: 1896.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.9
    Marker Score: 8563
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.85
    Marker Score: 390
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.8
    Marker Score: 1232
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.74
    Marker Score: 45784
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2909
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.69
    Marker Score: 1153
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.66
    Marker Score: 5684
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 455
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.56
    Marker Score: 359
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.55
    Marker Score: 5172
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.54
    Marker Score: 1550
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.51
    Marker Score: 184
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.5
    Marker Score: 162
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.49
    Marker Score: 7298
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.44
    Marker Score: 203
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.42
    Marker Score: 8416
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.41
    Marker Score: 244
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.38
    Marker Score: 370
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.38
    Marker Score: 1466
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.35
    Marker Score: 5523
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.34
    Marker Score: 153
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.33
    Marker Score: 247
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.32
    Marker Score: 323
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.31
    Marker Score: 98
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.3
    Marker Score: 141
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.28
    Marker Score: 1141
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.27
    Marker Score: 10022
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.25
    Marker Score: 1241.5
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.25
    Marker Score: 1911
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.24
    Marker Score: 9296
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.24
    Marker Score: 74
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.24
    Marker Score: 292
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.24
    Marker Score: 64
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.22
    Marker Score: 1135.5
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.21
    Marker Score: 1365
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.21
    Marker Score: 863
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.2
    Marker Score: 128
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.18
    Marker Score: 322
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.18
    Marker Score: 2884
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.18
    Marker Score: 337
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.17
    Marker Score: 112
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.16
    Marker Score: 51
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.16
    Marker Score: 46
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.15
    Marker Score: 105
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.15
    Marker Score: 86
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.15
    Marker Score: 65
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.14
    Marker Score: 52
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.14
    Marker Score: 37
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.14
    Marker Score: 199
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.13
    Marker Score: 47
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.13
    Marker Score: 211
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.13
    Marker Score: 102
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.12
    Marker Score: 147
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.12
    Marker Score: 67
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.12
    Marker Score: 489
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.12
    Marker Score: 143
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.12
    Marker Score: 196
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.11
    Marker Score: 132
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.11
    Marker Score: 236
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.11
    Marker Score: 112
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.11
    Marker Score: 97
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.1
    Marker Score: 289
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.1
    Marker Score: 59
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.1
    Marker Score: 2091
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.1
    Marker Score: 61
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.09
    Marker Score: 85
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.09
    Marker Score: 91
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.09
    Marker Score: 21
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.09
    Marker Score: 265
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.09
    Marker Score: 104
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.09
    Marker Score: 22
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.09
    Marker Score: 357
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.09
    Marker Score: 56
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.09
    Marker Score: 21

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Other Information

**Key Characteristics:** 1. **Cell-Surface Expression:** ICAM5 is primarily expressed on the surface of cells, where it mediates adhesion interactions between cells. 2. **Adhesive Function:** ICAM5 binds to integrins, laminins, and other adhesion molecules, facilitating cell-cell and cell-extracellular matrix interactions. 3. **Regulatory Role:** ICAM5 modulates immune responses, including phagocytosis, synapse assembly, and the regulation of immune cell interactions. 4. **Widespread Expression:** ICAM5 is expressed in various cell types, including neural progenitor cells, colon goblet cells, cardiac endothelial cells, and immune cells. **Pathways and Functions:** 1. **Adaptive Immune System:** ICAM5 participates in the regulation of immune cell interactions, including T cell activation, antibody-dependent cellular cytotoxicity, and the modulation of immune responses. 2. **Cell-Cell Adhesion:** ICAM5 mediates adhesion interactions between cells, facilitating the exchange of signaling molecules and the regulation of cell migration and proliferation. 3. **Cell-Extracellular Matrix Organization:** ICAM5 contributes to the organization of the extracellular matrix, influencing cell behavior, migration, and tissue remodeling. 4. **Regulation of Synapse Assembly:** ICAM5 plays a role in the assembly and regulation of synapses, including those involved in neural communication and immune responses. **Clinical Significance:** ICAM5's involvement in various diseases underscores its importance as a therapeutic target. For example: 1. **Autoimmune Diseases:** ICAM5's role in regulating immune responses makes it a potential target for the treatment of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer:** ICAM5's expression in cancer cells and its involvement in cell-cell adhesion and migration make it a potential target for cancer therapy. 3. **Neurological Disorders:** ICAM5's role in regulating synapse assembly and neural communication makes it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, ICAM5 is a critical regulator of cell-cell adhesion and immune function, with significant implications for our understanding of immune responses and tissue homeostasis. Further research is needed to fully elucidate the mechanisms by which ICAM5 regulates immune responses and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 3207908545

Symbol: ICAM5_HUMAN

Name: Intercellular adhesion molecule 5

UniProtKB Accession Codes:

Q9UMF0 Q9Y6F3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 4 PRINTS 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8995416

Title: cDNA cloning and chromosomal localization of the human telencephalin and its distinctive interaction with lymphocyte function-associated antigen-1.

PubMed ID: 8995416

DOI: 10.1074/jbc.272.2.1156

PubMed ID: 9828136

Title: Mapping of the ICAM-5 (telencephalin) gene, a neuronal member of the ICAM family, to a location between ICAM-1 and ICAM-3 on human chromosome 19p13.2.

PubMed ID: 9828136

DOI: 10.1006/geno.1998.5565

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 18691975

Title: An unusual allosteric mobility of the C-terminal helix of a high-affinity alphaL integrin I domain variant bound to ICAM-5.

PubMed ID: 18691975

DOI: 10.1016/j.molcel.2008.06.022

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 924
  • Mass: 97116
  • Checksum: 97D0A9467BD16D30
  • Sequence:
    • MPGPSPGLRR ALLGLWAALG LGLFGLSAVS QEPFWADLQP RVAFVERGGS LWLNCSTNCP 
RPERGGLETS LRRNGTQRGL RWLARQLVDI REPETQPVCF FRCARRTLQA RGLIRTFQRP 
DRVELMPLPP WQPVGENFTL SCRVPGAGPR ASLTLTLLRG AQELIRRSFA GEPPRARGAV 
LTATVLARRE DHGANFSCRA ELDLRPHGLG LFENSSAPRE LRTFSLSPDA PRLAAPRLLE 
VGSERPVSCT LDGLFPASEA RVYLALGDQN LSPDVTLEGD AFVATATATA SAEQEGARQL 
VCNVTLGGEN RETRENVTIY SFPAPLLTLS EPSVSEGQMV TVTCAAGAQA LVTLEGVPAA 
VPGQPAQLQL NATENDDRRS FFCDATLDVD GETLIKNRSA ELRVLYAPRL DDSDCPRSWT 
WPEGPEQTLR CEARGNPEPS VHCARSDGGA VLALGLLGPV TRALSGTYRC KAANDQGEAV 
KDVTLTVEYA PALDSVGCPE RITWLEGTEA SLSCVAHGVP PPDVICVRSG ELGAVIEGLL 
RVAREHAGTY RCEATNPRGS AAKNVAVTVE YGPRFEEPSC PSNWTWVEGS GRLFSCEVDG 
KPQPSVKCVG SGGATEGVLL PLAPPDPSPR APRIPRVLAP GIYVCNATNR HGSVAKTVVV 
SAESPPEMDE STCPSHQTWL EGAEASALAC AARGRPSPGV RCSREGIPWP EQQRVSREDA 
GTYHCVATNA HGTDSRTVTV GVEYRPVVAE LAASPPGGVR PGGNFTLTCR AEAWPPAQIS 
WRAPPGALNI GLSSNNSTLS VAGAMGSHGG EYECAATNAH GRHARRITVR VAGPWLWVAV 
GGAAGGAALL AAGAGLAFYV QSTACKKGEY NVQEAESSGE AVCLNGAGGG AGGAAGAEGG 
PEAAGGAAES PAEGEVFAIQ LTSA

Genular Protein ID: 1209509476

Symbol: Q8N6I2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8N6I2

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 9 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 2 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 2 SMART 2 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 812
  • Mass: 84617
  • Checksum: 28746AC9193B1FB3
  • Sequence:
    • LFPLAERPDR VELMPLPPWQ PVGENFTLSC RVPGAGPRAS LTLTLLRGAQ ELIRRSFAGE 
PPRARGAVLT ATVLARREDH GANFSCRAEL DLRPHGLGLF ENSSAPRELR TFSLSPDAPR 
LAAPRLLEVG SERPVSCTLD GLFPASEARV YLALGDQNLS PDVTLEGDAF VATATATASA 
EQEGARQLIC NVTLGGENRE TRENVTIYSF PAPLLTLSEP SVSEGQMVTV TCAAGTQALV 
TLEGVPAAVP GQPAQLQLNA TENDDRRSFF CDATLDVDGE TLIKNRSAEL RVLYAPRLDD 
SDCPRSWTWP EGPEQTLRCE ARGNPEPSVH CARSDGGAVL ALGLLGPVTR ALSGTYRCKA 
ANDQGEAVKD VTLTVEYAPA LDSVGCPERI TWLEGTEASL SCVAHGVPPP DVICVRSGEL 
GAVIEGLLRV AREHAGTYRC EATNPRGSAA KNVAVTVEYG PRFEEPSCPS NWTWVEGSGR 
LFSCEVDGKP QPSVKCVGSG GATEGVLLPL APPDPSPRAP RIPRVLAPGI YVCNATNRHG 
SVAKTVVVSA ESPPEMDEST CPSHQTWLEG AEASALACAA RGRPSPGVRC SREGIPWPEQ 
QRVSREDAGT YHCVATNAHG TDSRTVTVGV EYRPVVAELA ASPPGGVRPG GNFTLTCRAE 
AWPPAQISWR APPGALNIGL SSNNSTLSVA GAMGSHGGEY ECAATNAHGR HARRITVRVA 
GPWLWVAVGG AAGGAALLAA GAGLAFYVQS TACKKGEYNV QEAESSGEAV CLNGAGGGAG 
GAAGAEGGPE AAGGAAESPA EGEVFAIQLT SA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.