Details for: TLE3

Gene ID: 7090

Symbol: TLE3

Ensembl ID: ENSG00000140332

Description: TLE family member 3, transcriptional corepressor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.46
    Marker Score: 5393
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.43
    Marker Score: 5533
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.34
    Marker Score: 3168
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.3
    Marker Score: 1411
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.29
    Marker Score: 407
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.22
    Marker Score: 1298
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.21
    Marker Score: 67735
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.18
    Marker Score: 18447
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.17
    Marker Score: 1236
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.15
    Marker Score: 8837
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.12
    Marker Score: 362
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.08
    Marker Score: 365
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.06
    Marker Score: 331
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.05
    Marker Score: 629
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.04
    Marker Score: 1111
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.03
    Marker Score: 360
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71652
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47875
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.99
    Marker Score: 2014
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.99
    Marker Score: 14756.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30385
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.98
    Marker Score: 1182
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.94
    Marker Score: 5727
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2386
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.94
    Marker Score: 31940.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.91
    Marker Score: 469
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.91
    Marker Score: 527
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.9
    Marker Score: 426
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.9
    Marker Score: 680
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.9
    Marker Score: 2261
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.89
    Marker Score: 2679
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.89
    Marker Score: 839
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.88
    Marker Score: 602
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.88
    Marker Score: 1294
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.85
    Marker Score: 18126
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.85
    Marker Score: 510
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.84
    Marker Score: 302
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.84
    Marker Score: 1763
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.83
    Marker Score: 627
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.83
    Marker Score: 862
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.83
    Marker Score: 4712
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.82
    Marker Score: 410
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.82
    Marker Score: 477
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.8
    Marker Score: 1426
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.8
    Marker Score: 1567
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.8
    Marker Score: 193
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.79
    Marker Score: 677
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.79
    Marker Score: 1934.5
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.78
    Marker Score: 325
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 311
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.78
    Marker Score: 316
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.77
    Marker Score: 1000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.77
    Marker Score: 185
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1257
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.77
    Marker Score: 223
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.77
    Marker Score: 190
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.77
    Marker Score: 6624
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.77
    Marker Score: 189
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.76
    Marker Score: 169
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.75
    Marker Score: 347
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.75
    Marker Score: 1772
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.75
    Marker Score: 195
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 573.5
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.75
    Marker Score: 1703
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.75
    Marker Score: 185
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.75
    Marker Score: 739
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.74
    Marker Score: 1214
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.74
    Marker Score: 168
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.74
    Marker Score: 451
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.74
    Marker Score: 782
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.73
    Marker Score: 166
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.73
    Marker Score: 790.5
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 469
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.73
    Marker Score: 1815
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.73
    Marker Score: 2010
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.73
    Marker Score: 184
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.72
    Marker Score: 192
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.72
    Marker Score: 157
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.71
    Marker Score: 248
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.71
    Marker Score: 291
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.71
    Marker Score: 2946.5
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.71
    Marker Score: 207
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.71
    Marker Score: 365
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 0.7
    Marker Score: 200
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.7
    Marker Score: 264
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.7
    Marker Score: 787
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.7
    Marker Score: 540
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.7
    Marker Score: 173
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.7
    Marker Score: 247
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.69
    Marker Score: 440
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.68
    Marker Score: 159
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.68
    Marker Score: 236
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.68
    Marker Score: 170
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.68
    Marker Score: 966
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.68
    Marker Score: 150
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.68
    Marker Score: 428
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2858

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Other Information

**Key Characteristics:** 1. **Transcriptional Corepressor Activity:** TLE3 is a transcriptional corepressor, meaning it regulates the expression of target genes by recruiting histone deacetylases and other proteins to silence gene transcription. 2. **Wnt Signaling Pathway Modulation:** TLE3 is a key modulator of the Wnt signaling pathway, which is involved in cell fate determination, proliferation, and survival. 3. **Interactions with Transcriptional Regulators:** TLE3 interacts with various transcriptional regulators, including beta-catenin, TCF/LEF transcription factors, and Notch receptors, to modulate the activity of these pathways. 4. **Widespread Expression:** TLE3 is expressed in a variety of cell types, including neural progenitor cells, immune cells, epithelial cells, and stem cells. **Pathways and Functions:** 1. **Wnt Signaling Pathway:** TLE3 modulates the activity of the Wnt signaling pathway by interacting with beta-catenin and TCF/LEF transcription factors. 2. **Notch Signaling Pathway:** TLE3 interacts with Notch receptors and Notch1 intracellular domain to regulate Notch signaling. 3. **Estrogen-Dependent Gene Expression:** TLE3 is involved in the regulation of estrogen-dependent gene expression. 4. **Deactivation of Beta-Catenin:** TLE3 recruits histone deacetylases to deactivate beta-catenin, a key component of the Wnt signaling pathway. 5. **Degradation of Beta-Catenin:** TLE3 interacts with the destruction complex to degrade beta-catenin, regulating the Wnt signaling pathway. **Clinical Significance:** 1. **Cancer:** TLE3 has been implicated in the development and progression of various cancers, including colon, breast, and lung cancers. 2. **Immune Disorders:** TLE3 is involved in the regulation of immune responses, and dysregulation of TLE3 has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Neurological Disorders:** TLE3 has been implicated in the regulation of neural development and function, and dysregulation of TLE3 has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Developmental Disorders:** TLE3 is involved in the regulation of embryonic development, and dysregulation of TLE3 has been implicated in developmental disorders, such as Down syndrome. In conclusion, TLE3 is a multifunctional transcriptional corepressor that plays a crucial role in regulating various biological processes, including Wnt signaling, Notch signaling, and immune responses. Its dysregulation has been implicated in various diseases, including cancer, immune disorders, neurological disorders, and developmental disorders. Further research is needed to fully understand the mechanisms of TLE3 and its role in human disease.

Genular Protein ID: 1442030542

Symbol: TLE3_HUMAN

Name: Transducin-like enhancer protein 3

UniProtKB Accession Codes:

Q04726 B4DPT0 E9PD64 F8W964 Q6PI57 Q8IVV6 Q8WVR2 Q9HCM5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 8 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 7 Pumba 1 RNAct 1 Reactome 5 RefSeq 7 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1303260

Title: Human homologs of a Drosophila enhancer of split gene product define a novel family of nuclear proteins.

PubMed ID: 1303260

DOI: 10.1038/ng1092-119

PubMed ID: 10997877

Title: Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10997877

DOI: 10.1093/dnares/7.4.271

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10748198

Title: Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta.

PubMed ID: 10748198

DOI: 10.1074/jbc.m910211199

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18254933

Title: The Groucho/TLE/Grg family of transcriptional co-repressors.

PubMed ID: 18254933

DOI: 10.1186/gb-2008-9-1-205

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22304967

Title: XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling.

PubMed ID: 22304967

DOI: 10.1016/j.molcel.2011.12.032

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26235987

Title: Mutations in TBX18 cause dominant urinary tract malformations via transcriptional dysregulation of ureter development.

PubMed ID: 26235987

DOI: 10.1016/j.ajhg.2015.07.001

Sequence Information:

  • Length: 772
  • Mass: 83417
  • Checksum: A2A469D73BF04A43
  • Sequence:
    • MYPQGRHPAP HQPGQPGFKF TVAESCDRIK DEFQFLQAQY HSLKVEYDKL ANEKTEMQRH 
YVMYYEMSYG LNIEMHKQTE IAKRLNTILA QIMPFLSQEH QQQVAQAVER AKQVTMTELN 
AIIGQQQLQA QHLSHATHGP PVQLPPHPSG LQPPGIPPVT GSSSGLLALG ALGSQAHLTV 
KDEKNHHELD HRERESSANN SVSPSESLRA SEKHRGSADY SMEAKKRKAE EKDSLSRYDS 
DGDKSDDLVV DVSNEDPATP RVSPAHSPPE NGLDKARSLK KDAPTSPASV ASSSSTPSSK 
TKDLGHNDKS STPGLKSNTP TPRNDAPTPG TSTTPGLRSM PGKPPGMDPI GIMASALRTP 
ISITSSYAAP FAMMSHHEMN GSLTSPGAYA GLHNIPPQMS AAAAAAAAAY GRSPMVSFGA 
VGFDPHPPMR ATGLPSSLAS IPGGKPAYSF HVSADGQMQP VPFPHDALAG PGIPRHARQI 
NTLSHGEVVC AVTISNPTRH VYTGGKGCVK IWDISQPGSK SPISQLDCLN RDNYIRSCKL 
LPDGRTLIVG GEASTLTIWD LASPTPRIKA ELTSSAPACY ALAISPDAKV CFSCCSDGNI 
AVWDLHNQTL VRQFQGHTDG ASCIDISHDG TKLWTGGLDN TVRSWDLREG RQLQQHDFTS 
QIFSLGYCPT GEWLAVGMES SNVEVLHHTK PDKYQLHLHE SCVLSLKFAY CGKWFVSTGK 
DNLLNAWRTP YGASIFQSKE SSSVLSCDIS ADDKYIVTGS GDKKATVYEV IY

Genular Protein ID: 1690520725

Symbol: H0YL70_HUMAN

Name: N/A

UniProtKB Accession Codes:

H0YL70

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 EPD 2 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 IntAct 1 InterPro 6 MINT 1 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 Pfam 3 PhylomeDB 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 2 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 782
  • Mass: 84478
  • Checksum: 7534C596967A0A4F
  • Sequence:
    • MYPQGRHPAP HQPGQPGFKF TVAESCDRIK DEFQFLQAQY HSLKVEYDKL ANEKTEMQRH 
YVMYYEMSYG LNIEMHKQTE IAKRLNTILA QIMPFLSQEH QQQVAQAVER AKQVTMTELN 
AIIGVRGLPN LPLTQQQLQA QHLSHATHGP PVQLPPHPSG LQPPGIPPVT GSSSGLLALG 
ALGSQAHLTV KDEKNHHELD HRERESSANN SVSPSESLRA SEKHRGSADY SMEAKKRKAE 
EKDSLSRYDS DGDKSDDLVV DVSNEDPATP RVSPAHSPPE NGLDKARSLK KDAPTSPASV 
ASSSSTPSSK TKDLGHNDKS STPGLKSNTP TPRNDAPTPG TSTTPGLRSM PGKPPGMDPI 
GIMASALRTP ISITSSYAAP FAMMSHHEMN GSLTSPGAYA GLHNIPPQMS AAAAAAAAAY 
GRSPMVSFGA VGFDPHPPMR ATGLPSSLAS IPGGKPAYSF HVSADGQMQP VPFPHDALAG 
PGIPRHARQI NTLSHGEVVC AVTISNPTRH VYTGGKGCVK IWDISQPGSK SPISQLDCLN 
RDNYIRSCKL LPDGRTLIVG GEASTLTIWD LASPTPRIKA ELTSSAPACY ALAISPDAKV 
CFSCCSDGNI AVWDLHNQTL VRQFQGHTDG ASCIDISHDG TKLWTGGLDN TVRSWDLREG 
RQLQQHDFTS QIFSLGYCPT GEWLAVGMES SNVEVLHHTK PDKYQLHLHE SCVLSLKFAY 
CGKWFVSTGK DNLLNAWRTP YGASIFQSKE SSSVLSCDIS ADDKYIVTGS GDKKATVYEV 
IY

Genular Protein ID: 3582814922

Symbol: B3KUA2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KUA2

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 699
  • Mass: 74878
  • Checksum: A648F432B0F46948
  • Sequence:
    • MSYGLNIEMH KQTEIAKRLN TILAQIMPFL SQEHQQQVAQ AVERAKQVTM TELNAIIGVR 
GLPNLPLTQQ QLQAQHLSHA THGPPVQLPP QPSGLQPPGI PPVTGSSSGL LALGALGSQD 
HLTVKDEKNH HELDHRERES SANNSVSPSE SLRASEKHRG SADYSMEAKK RKAEEKDSLS 
RYDSDGDKSD DLVVDVSNED PATPRVSPAH SPPENGLDKA RSLKKDAPTS PASVASSSST 
PSSKTKDLGH NDKSSTPGLK SNTPTPRNDA PTPGTSTTPG LRSMPASALR TPISITSSYA 
APFAMMSHHE MNGSLTSPGA YAGLHNIPPQ MSAAAAAAAA AYGRSPMVGF DPHPPMRATG 
LPSSLASIPG GKPAYSFHVS ADGQMQPVPF PHDALAGPGI PRHARQINTL SHGEVVCAVT 
ISNPTRHVYT GGKGCVKIWD ISQPGSKSPI SQLGCLNRDN YIRSCKLLPD GRTLIVGGEA 
STLTIWDLAS PTPRIKAELT SSAPACYALA ISPDAKVCFS CCSDGNIAVW DLHNQTLVRQ 
FQGHTDGASC IDISHDGTKL WTGGLDNTVR SWDLREGRQL QQHDFTSQIF SLGYCPTGEW 
LAVGMESSNV EVLHHTKPDK YQLHLHESCV LSLKFAYCGK WFVSTGKDNL LNAWRTPYGA 
SIFQSKESSS VLSCDISADD KYIVTGSGDK KATVYEVIY

Genular Protein ID: 2081614852

Symbol: Q6PRX3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6PRX3

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 GenomeRNAi 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 RefSeq 1 SAM 2 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 764
  • Mass: 82661
  • Checksum: D8D48782C7EB80C2
  • Sequence:
    • MYPQGRHPAP HQPGQPGFKF TVAESCDRIK DEFQFLQAQY HSLKVEYDKL ANEKTEMQRH 
YVMYYEMSYG LNIEMHKQTE IAKRLNTILA QIMPFLSQEH QQQVAQAVER AKQVTMTELN 
AIIGQQQLQA QHLSHATHGP PVQLPPHPSG LQPPGIPPVT GSSSGLLALG ALGSQAHLTV 
KDEKNHHELD HRERESSANN SVSPSESLRA SEKHRGSADY SMEAKKRKAE EKDSLSRYDS 
DGDKSDDLVV DVSNEDPATP RVSPAHSPPE NGLVKARSLK KDAPTSPASV ASSSSAPSSK 
TKDLGHNDKS STPGLKSNTP TPRNDAPTPG TSTTPGLRSM PGKPPGMDPI ASALRTPISI 
TSSYAAPFAM MSHHEMNGSL TSPGAYAGLH NIPPQMSAAA AAAAAAYGRS PMVGFDPHPP 
MRATGLPSSL ASIPGGKPAY SFHVSADGQM QPVPFPHDAL AGPGIPRHAR QINTLSHGEV 
VCAVTISNPT RHVYTGGKGC VKIWDISQPG SKSPISQLDC LNRDNYIRSC KLLPDGRTLI 
VGGEASTLTI WDLASPTPRI KAELTSSAPA CYALAISPDA KVCFSCRSDG NIAVWDLHNQ 
TLVRQFQGHT DGASCIDISH DGTKLWTGGL DNTVRSWDLR EGRQLQQHDF TSQIFSLGYC 
PTGEWLAVGM ESSNVEVLHH TKPDKYQLHL HESCVLSLKF AYCGKWFVST GKDNLLNAWR 
TPYGASIFQS KESSSVLSCD ISADDKYIVT GSGDKKATVY EVIY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.