Details for: TLE3

Gene ID: 7090

Symbol: TLE3

Ensembl ID: ENSG00000140332

Description: TLE family member 3, transcriptional corepressor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 181.1692
    Cell Significance Index: -28.1800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 108.3017
    Cell Significance Index: -27.4700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 60.7497
    Cell Significance Index: -24.6800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 55.6004
    Cell Significance Index: -28.6000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 44.3353
    Cell Significance Index: -29.7500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 26.3212
    Cell Significance Index: -25.1300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.2142
    Cell Significance Index: -29.8600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.6538
    Cell Significance Index: -28.5400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.7090
    Cell Significance Index: -30.4200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.3390
    Cell Significance Index: -19.4700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.7571
    Cell Significance Index: -12.6000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.9038
    Cell Significance Index: 338.4100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.7506
    Cell Significance Index: 284.7100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.4996
    Cell Significance Index: 20.4600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1988
    Cell Significance Index: 32.6300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1588
    Cell Significance Index: 69.5700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1564
    Cell Significance Index: 125.7800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.8668
    Cell Significance Index: 16.0200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7229
    Cell Significance Index: 51.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7018
    Cell Significance Index: 18.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6982
    Cell Significance Index: 39.1800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6753
    Cell Significance Index: 14.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6309
    Cell Significance Index: 125.2100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6197
    Cell Significance Index: 17.8600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5565
    Cell Significance Index: 246.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5061
    Cell Significance Index: 22.9400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4965
    Cell Significance Index: 12.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4633
    Cell Significance Index: 92.9300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4544
    Cell Significance Index: 44.9500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4120
    Cell Significance Index: 52.8200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3063
    Cell Significance Index: 8.7800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3015
    Cell Significance Index: 14.1700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3009
    Cell Significance Index: 271.7100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2262
    Cell Significance Index: 123.5200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2050
    Cell Significance Index: 5.7300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1718
    Cell Significance Index: 8.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1653
    Cell Significance Index: 59.2800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1589
    Cell Significance Index: 30.2300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1563
    Cell Significance Index: 8.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1455
    Cell Significance Index: 17.8900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1209
    Cell Significance Index: 15.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1200
    Cell Significance Index: 21.6400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1187
    Cell Significance Index: 3.1800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0886
    Cell Significance Index: 6.6000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0804
    Cell Significance Index: 9.4800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0559
    Cell Significance Index: 1.1900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0469
    Cell Significance Index: 32.4200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0454
    Cell Significance Index: 0.9500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0444
    Cell Significance Index: 2.8700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0397
    Cell Significance Index: 25.1900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0289
    Cell Significance Index: 54.3400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0227
    Cell Significance Index: 0.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0112
    Cell Significance Index: 15.2400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0091
    Cell Significance Index: 0.2400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0056
    Cell Significance Index: 8.6200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0022
    Cell Significance Index: -4.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0219
    Cell Significance Index: -9.9500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0222
    Cell Significance Index: -16.2700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0278
    Cell Significance Index: -21.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0323
    Cell Significance Index: -23.9000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0344
    Cell Significance Index: -1.2100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0416
    Cell Significance Index: -1.0700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0452
    Cell Significance Index: -4.6200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0458
    Cell Significance Index: -25.8400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0469
    Cell Significance Index: -13.4900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0523
    Cell Significance Index: -32.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0689
    Cell Significance Index: -9.4600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0824
    Cell Significance Index: -4.2900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0934
    Cell Significance Index: -15.9500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1033
    Cell Significance Index: -15.0200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1554
    Cell Significance Index: -2.6000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1605
    Cell Significance Index: -33.8000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1752
    Cell Significance Index: -20.0700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2110
    Cell Significance Index: -11.0800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2145
    Cell Significance Index: -6.8700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2229
    Cell Significance Index: -14.9900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2272
    Cell Significance Index: -17.4400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2708
    Cell Significance Index: -9.4100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2714
    Cell Significance Index: -28.2600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3121
    Cell Significance Index: -24.7200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3503
    Cell Significance Index: -6.1900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3511
    Cell Significance Index: -8.9700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3657
    Cell Significance Index: -22.4200
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.4069
    Cell Significance Index: -5.7200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4457
    Cell Significance Index: -9.7600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4522
    Cell Significance Index: -7.7500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4688
    Cell Significance Index: -29.5500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.4704
    Cell Significance Index: -2.9000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4738
    Cell Significance Index: -29.1200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5272
    Cell Significance Index: -10.2900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.5762
    Cell Significance Index: -3.5800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6137
    Cell Significance Index: -22.5300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6171
    Cell Significance Index: -18.1800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6364
    Cell Significance Index: -18.6900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.6412
    Cell Significance Index: -5.9100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.6767
    Cell Significance Index: -10.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6846
    Cell Significance Index: -30.2800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6926
    Cell Significance Index: -14.8100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.6931
    Cell Significance Index: -21.9200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6942
    Cell Significance Index: -24.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Corepressor Activity:** TLE3 is a transcriptional corepressor, meaning it regulates the expression of target genes by recruiting histone deacetylases and other proteins to silence gene transcription. 2. **Wnt Signaling Pathway Modulation:** TLE3 is a key modulator of the Wnt signaling pathway, which is involved in cell fate determination, proliferation, and survival. 3. **Interactions with Transcriptional Regulators:** TLE3 interacts with various transcriptional regulators, including beta-catenin, TCF/LEF transcription factors, and Notch receptors, to modulate the activity of these pathways. 4. **Widespread Expression:** TLE3 is expressed in a variety of cell types, including neural progenitor cells, immune cells, epithelial cells, and stem cells. **Pathways and Functions:** 1. **Wnt Signaling Pathway:** TLE3 modulates the activity of the Wnt signaling pathway by interacting with beta-catenin and TCF/LEF transcription factors. 2. **Notch Signaling Pathway:** TLE3 interacts with Notch receptors and Notch1 intracellular domain to regulate Notch signaling. 3. **Estrogen-Dependent Gene Expression:** TLE3 is involved in the regulation of estrogen-dependent gene expression. 4. **Deactivation of Beta-Catenin:** TLE3 recruits histone deacetylases to deactivate beta-catenin, a key component of the Wnt signaling pathway. 5. **Degradation of Beta-Catenin:** TLE3 interacts with the destruction complex to degrade beta-catenin, regulating the Wnt signaling pathway. **Clinical Significance:** 1. **Cancer:** TLE3 has been implicated in the development and progression of various cancers, including colon, breast, and lung cancers. 2. **Immune Disorders:** TLE3 is involved in the regulation of immune responses, and dysregulation of TLE3 has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Neurological Disorders:** TLE3 has been implicated in the regulation of neural development and function, and dysregulation of TLE3 has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Developmental Disorders:** TLE3 is involved in the regulation of embryonic development, and dysregulation of TLE3 has been implicated in developmental disorders, such as Down syndrome. In conclusion, TLE3 is a multifunctional transcriptional corepressor that plays a crucial role in regulating various biological processes, including Wnt signaling, Notch signaling, and immune responses. Its dysregulation has been implicated in various diseases, including cancer, immune disorders, neurological disorders, and developmental disorders. Further research is needed to fully understand the mechanisms of TLE3 and its role in human disease.

Genular Protein ID: 1442030542

Symbol: TLE3_HUMAN

Name: Transducin-like enhancer protein 3

UniProtKB Accession Codes:

Q04726 B4DPT0 E9PD64 F8W964 Q6PI57 Q8IVV6 Q8WVR2 Q9HCM5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 8 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 7 Pumba 1 RNAct 1 Reactome 5 RefSeq 7 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1303260

Title: Human homologs of a Drosophila enhancer of split gene product define a novel family of nuclear proteins.

PubMed ID: 1303260

DOI: 10.1038/ng1092-119

PubMed ID: 10997877

Title: Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10997877

DOI: 10.1093/dnares/7.4.271

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10748198

Title: Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta.

PubMed ID: 10748198

DOI: 10.1074/jbc.m910211199

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18254933

Title: The Groucho/TLE/Grg family of transcriptional co-repressors.

PubMed ID: 18254933

DOI: 10.1186/gb-2008-9-1-205

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22304967

Title: XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling.

PubMed ID: 22304967

DOI: 10.1016/j.molcel.2011.12.032

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26235987

Title: Mutations in TBX18 cause dominant urinary tract malformations via transcriptional dysregulation of ureter development.

PubMed ID: 26235987

DOI: 10.1016/j.ajhg.2015.07.001

PubMed ID: 28689657

Title: Wnt-dependent inactivation of the Groucho/TLE co-repressor by the HECT E3 ubiquitin ligase Hyd/UBR5.

PubMed ID: 28689657

DOI: 10.1016/j.molcel.2017.06.009

Sequence Information:

  • Length: 772
  • Mass: 83417
  • Checksum: A2A469D73BF04A43
  • Sequence:
    • MYPQGRHPAP HQPGQPGFKF TVAESCDRIK DEFQFLQAQY HSLKVEYDKL ANEKTEMQRH 
YVMYYEMSYG LNIEMHKQTE IAKRLNTILA QIMPFLSQEH QQQVAQAVER AKQVTMTELN 
AIIGQQQLQA QHLSHATHGP PVQLPPHPSG LQPPGIPPVT GSSSGLLALG ALGSQAHLTV 
KDEKNHHELD HRERESSANN SVSPSESLRA SEKHRGSADY SMEAKKRKAE EKDSLSRYDS 
DGDKSDDLVV DVSNEDPATP RVSPAHSPPE NGLDKARSLK KDAPTSPASV ASSSSTPSSK 
TKDLGHNDKS STPGLKSNTP TPRNDAPTPG TSTTPGLRSM PGKPPGMDPI GIMASALRTP 
ISITSSYAAP FAMMSHHEMN GSLTSPGAYA GLHNIPPQMS AAAAAAAAAY GRSPMVSFGA 
VGFDPHPPMR ATGLPSSLAS IPGGKPAYSF HVSADGQMQP VPFPHDALAG PGIPRHARQI 
NTLSHGEVVC AVTISNPTRH VYTGGKGCVK IWDISQPGSK SPISQLDCLN RDNYIRSCKL 
LPDGRTLIVG GEASTLTIWD LASPTPRIKA ELTSSAPACY ALAISPDAKV CFSCCSDGNI 
AVWDLHNQTL VRQFQGHTDG ASCIDISHDG TKLWTGGLDN TVRSWDLREG RQLQQHDFTS 
QIFSLGYCPT GEWLAVGMES SNVEVLHHTK PDKYQLHLHE SCVLSLKFAY CGKWFVSTGK 
DNLLNAWRTP YGASIFQSKE SSSVLSCDIS ADDKYIVTGS GDKKATVYEV IY

Genular Protein ID: 1690520725

Symbol: H0YL70_HUMAN

Name: N/A

UniProtKB Accession Codes:

H0YL70

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 HGNC 1 IntAct 1 InterPro 6 MINT 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 PhylomeDB 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 2 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 782
  • Mass: 84478
  • Checksum: 7534C596967A0A4F
  • Sequence:
    • MYPQGRHPAP HQPGQPGFKF TVAESCDRIK DEFQFLQAQY HSLKVEYDKL ANEKTEMQRH 
YVMYYEMSYG LNIEMHKQTE IAKRLNTILA QIMPFLSQEH QQQVAQAVER AKQVTMTELN 
AIIGVRGLPN LPLTQQQLQA QHLSHATHGP PVQLPPHPSG LQPPGIPPVT GSSSGLLALG 
ALGSQAHLTV KDEKNHHELD HRERESSANN SVSPSESLRA SEKHRGSADY SMEAKKRKAE 
EKDSLSRYDS DGDKSDDLVV DVSNEDPATP RVSPAHSPPE NGLDKARSLK KDAPTSPASV 
ASSSSTPSSK TKDLGHNDKS STPGLKSNTP TPRNDAPTPG TSTTPGLRSM PGKPPGMDPI 
GIMASALRTP ISITSSYAAP FAMMSHHEMN GSLTSPGAYA GLHNIPPQMS AAAAAAAAAY 
GRSPMVSFGA VGFDPHPPMR ATGLPSSLAS IPGGKPAYSF HVSADGQMQP VPFPHDALAG 
PGIPRHARQI NTLSHGEVVC AVTISNPTRH VYTGGKGCVK IWDISQPGSK SPISQLDCLN 
RDNYIRSCKL LPDGRTLIVG GEASTLTIWD LASPTPRIKA ELTSSAPACY ALAISPDAKV 
CFSCCSDGNI AVWDLHNQTL VRQFQGHTDG ASCIDISHDG TKLWTGGLDN TVRSWDLREG 
RQLQQHDFTS QIFSLGYCPT GEWLAVGMES SNVEVLHHTK PDKYQLHLHE SCVLSLKFAY 
CGKWFVSTGK DNLLNAWRTP YGASIFQSKE SSSVLSCDIS ADDKYIVTGS GDKKATVYEV 
IY

Genular Protein ID: 3582814922

Symbol: B3KUA2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KUA2

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 699
  • Mass: 74878
  • Checksum: A648F432B0F46948
  • Sequence:
    • MSYGLNIEMH KQTEIAKRLN TILAQIMPFL SQEHQQQVAQ AVERAKQVTM TELNAIIGVR 
GLPNLPLTQQ QLQAQHLSHA THGPPVQLPP QPSGLQPPGI PPVTGSSSGL LALGALGSQD 
HLTVKDEKNH HELDHRERES SANNSVSPSE SLRASEKHRG SADYSMEAKK RKAEEKDSLS 
RYDSDGDKSD DLVVDVSNED PATPRVSPAH SPPENGLDKA RSLKKDAPTS PASVASSSST 
PSSKTKDLGH NDKSSTPGLK SNTPTPRNDA PTPGTSTTPG LRSMPASALR TPISITSSYA 
APFAMMSHHE MNGSLTSPGA YAGLHNIPPQ MSAAAAAAAA AYGRSPMVGF DPHPPMRATG 
LPSSLASIPG GKPAYSFHVS ADGQMQPVPF PHDALAGPGI PRHARQINTL SHGEVVCAVT 
ISNPTRHVYT GGKGCVKIWD ISQPGSKSPI SQLGCLNRDN YIRSCKLLPD GRTLIVGGEA 
STLTIWDLAS PTPRIKAELT SSAPACYALA ISPDAKVCFS CCSDGNIAVW DLHNQTLVRQ 
FQGHTDGASC IDISHDGTKL WTGGLDNTVR SWDLREGRQL QQHDFTSQIF SLGYCPTGEW 
LAVGMESSNV EVLHHTKPDK YQLHLHESCV LSLKFAYCGK WFVSTGKDNL LNAWRTPYGA 
SIFQSKESSS VLSCDISADD KYIVTGSGDK KATVYEVIY

Genular Protein ID: 2081614852

Symbol: Q6PRX3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6PRX3

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 RefSeq 1 SAM 2 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 764
  • Mass: 82661
  • Checksum: D8D48782C7EB80C2
  • Sequence:
    • MYPQGRHPAP HQPGQPGFKF TVAESCDRIK DEFQFLQAQY HSLKVEYDKL ANEKTEMQRH 
YVMYYEMSYG LNIEMHKQTE IAKRLNTILA QIMPFLSQEH QQQVAQAVER AKQVTMTELN 
AIIGQQQLQA QHLSHATHGP PVQLPPHPSG LQPPGIPPVT GSSSGLLALG ALGSQAHLTV 
KDEKNHHELD HRERESSANN SVSPSESLRA SEKHRGSADY SMEAKKRKAE EKDSLSRYDS 
DGDKSDDLVV DVSNEDPATP RVSPAHSPPE NGLVKARSLK KDAPTSPASV ASSSSAPSSK 
TKDLGHNDKS STPGLKSNTP TPRNDAPTPG TSTTPGLRSM PGKPPGMDPI ASALRTPISI 
TSSYAAPFAM MSHHEMNGSL TSPGAYAGLH NIPPQMSAAA AAAAAAYGRS PMVGFDPHPP 
MRATGLPSSL ASIPGGKPAY SFHVSADGQM QPVPFPHDAL AGPGIPRHAR QINTLSHGEV 
VCAVTISNPT RHVYTGGKGC VKIWDISQPG SKSPISQLDC LNRDNYIRSC KLLPDGRTLI 
VGGEASTLTI WDLASPTPRI KAELTSSAPA CYALAISPDA KVCFSCRSDG NIAVWDLHNQ 
TLVRQFQGHT DGASCIDISH DGTKLWTGGL DNTVRSWDLR EGRQLQQHDF TSQIFSLGYC 
PTGEWLAVGM ESSNVEVLHH TKPDKYQLHL HESCVLSLKF AYCGKWFVST GKDNLLNAWR 
TPYGASIFQS KESSSVLSCD ISADDKYIVT GSGDKKATVY EVIY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.