Details for: TPBG

Gene ID: 7162

Symbol: TPBG

Ensembl ID: ENSG00000146242

Description: trophoblast glycoprotein

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.79
    Marker Score: 60972
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.4
    Marker Score: 584
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.38
    Marker Score: 47682
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3
    Marker Score: 1919
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.28
    Marker Score: 9497
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.27
    Marker Score: 625
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.25
    Marker Score: 312
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.24
    Marker Score: 312
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.22
    Marker Score: 2978
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.19
    Marker Score: 15973
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.18
    Marker Score: 4539
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.16
    Marker Score: 915
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.16
    Marker Score: 1217
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.11
    Marker Score: 1521
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.1
    Marker Score: 1943.5
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.08
    Marker Score: 1662
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.04
    Marker Score: 2081
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.04
    Marker Score: 655.5
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251765.5
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.03
    Marker Score: 298
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.03
    Marker Score: 480
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.02
    Marker Score: 3770
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.01
    Marker Score: 641
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71784
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48008
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.98
    Marker Score: 312
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.98
    Marker Score: 221
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.97
    Marker Score: 649
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 498
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.96
    Marker Score: 3792
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 453
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.95
    Marker Score: 10702
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2408
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.94
    Marker Score: 217
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.94
    Marker Score: 1712
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.94
    Marker Score: 535
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.93
    Marker Score: 263
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.92
    Marker Score: 986
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.92
    Marker Score: 234
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2727
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.9
    Marker Score: 11901
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.88
    Marker Score: 1440
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4977
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5271
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.85
    Marker Score: 1218.5
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.84
    Marker Score: 2210
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.83
    Marker Score: 8547
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.83
    Marker Score: 280
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.82
    Marker Score: 991
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.82
    Marker Score: 235
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.8
    Marker Score: 682
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 314
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 585.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1242
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.76
    Marker Score: 519
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.76
    Marker Score: 419
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.75
    Marker Score: 1718
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.75
    Marker Score: 206
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 389
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.74
    Marker Score: 908
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 665
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.72
    Marker Score: 198
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.72
    Marker Score: 232
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.71
    Marker Score: 830
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.7
    Marker Score: 625
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.7
    Marker Score: 168
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.68
    Marker Score: 711
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2866.5
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.68
    Marker Score: 273
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.67
    Marker Score: 259
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.66
    Marker Score: 369
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.66
    Marker Score: 635
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.66
    Marker Score: 824
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.64
    Marker Score: 275
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.63
    Marker Score: 695
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.63
    Marker Score: 366
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.63
    Marker Score: 710
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.62
    Marker Score: 625
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.61
    Marker Score: 719
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.6
    Marker Score: 1423
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.6
    Marker Score: 290
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.59
    Marker Score: 2559
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.59
    Marker Score: 1596
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.57
    Marker Score: 2787
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.57
    Marker Score: 1902
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.56
    Marker Score: 600
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.56
    Marker Score: 135
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.54
    Marker Score: 698
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.54
    Marker Score: 232
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.54
    Marker Score: 4643
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.53
    Marker Score: 222
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.53
    Marker Score: 323.5
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.52
    Marker Score: 181
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.52
    Marker Score: 1178
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.52
    Marker Score: 968

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Other Information

**Key Characteristics:** TPBG is a glycoprotein, suggesting its involvement in carbohydrate-mediated interactions and cell-cell recognition. Its expression is restricted to specific cell types, which may indicate its role in tissue-specific functions. The protein's ability to regulate various signaling pathways, including the canonical Wnt pathway, phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) pathway, and Erk1/2 cascade, underscores its potential as a key regulator of cellular behavior. **Pathways and Functions:** TPBG's involvement in multiple signaling pathways highlights its role as a multifaceted regulator of cellular processes. Some of the key pathways and functions associated with TPBG include: 1. **Cell Adhesion:** TPBG may facilitate cell-cell interactions, influencing processes such as tissue development and cancer progression. 2. **Cell Chemotaxis:** TPBG's ability to regulate chemotaxis suggests its involvement in directed cell migration, which is crucial for tissue development, wound healing, and cancer metastasis. 3. **Synaptic Transmission:** TPBG's expression in basal cells of the trachea and bronchial goblet cells implies its potential role in regulating neurotransmitter release and synaptic function. 4. **Negative Regulation of Canonical Wnt Signaling Pathway:** TPBG's ability to suppress the canonical Wnt pathway may contribute to its tumor suppressor function, as dysregulation of this pathway is a hallmark of various cancers. 5. **Positive Regulation of Chemotaxis and Erk1/2 Cascade:** TPBG's activation of chemotaxis and Erk1/2 signaling pathways may promote cell migration and proliferation, respectively, contributing to cancer progression. **Clinical Significance:** TPBG's dysregulation has been associated with various cancers, including prostate and bladder cancers. Its expression in malignant cells suggests its potential as a diagnostic biomarker or therapeutic target. Further studies are needed to elucidate the mechanisms underlying TPBG's role in cancer progression and to explore its potential as a therapeutic agent. In conclusion, TPBG is a multifaceted protein that regulates various cellular processes, including cell adhesion, chemotaxis, and signaling pathways. Its dysregulation has been implicated in cancer progression, particularly in prostate and bladder cancers. Further research is necessary to fully understand TPBG's role in human disease and to explore its potential as a therapeutic agent.

Genular Protein ID: 3164446811

Symbol: TPBG_HUMAN

Name: Trophoblast glycoprotein

UniProtKB Accession Codes:

Q13641 A8K555

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 6 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 3 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8132670

Title: Isolation of a cDNA encoding 5T4 oncofetal trophoblast glycoprotein: an antigen associated with metastasis contains leucine rich repeats.

PubMed ID: 8132670

DOI: 10.1016/s0021-9258(17)37110-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12481437

Title: Attenuated recombinant vaccinia virus expressing oncofetal antigen (tumor-associated antigen) 5T4 induces active therapy of established tumors.

PubMed ID: 12481437

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 22100263

Title: Waif1/5T4 inhibits Wnt/beta-catenin signaling and activates noncanonical Wnt pathways by modifying LRP6 subcellular localization.

PubMed ID: 22100263

DOI: 10.1016/j.devcel.2011.10.015

PubMed ID: 24582434

Title: Structural insights into the inhibition of Wnt signaling by cancer antigen 5T4/Wnt-activated inhibitory factor 1.

PubMed ID: 24582434

DOI: 10.1016/j.str.2014.01.009

Sequence Information:

  • Length: 420
  • Mass: 46032
  • Checksum: 3C403211F40F18BC
  • Sequence:
    • MPGGCSRGPA AGDGRLRLAR LALVLLGWVS SSSPTSSASS FSSSAPFLAS AVSAQPPLPD 
QCPALCECSE AARTVKCVNR NLTEVPTDLP AYVRNLFLTG NQLAVLPAGA FARRPPLAEL 
AALNLSGSRL DEVRAGAFEH LPSLRQLDLS HNPLADLSPF AFSGSNASVS APSPLVELIL 
NHIVPPEDER QNRSFEGMVV AALLAGRALQ GLRRLELASN HFLYLPRDVL AQLPSLRHLD 
LSNNSLVSLT YVSFRNLTHL ESLHLEDNAL KVLHNGTLAE LQGLPHIRVF LDNNPWVCDC 
HMADMVTWLK ETEVVQGKDR LTCAYPEKMR NRVLLELNSA DLDCDPILPP SLQTSYVFLG 
IVLALIGAIF LLVLYLNRKG IKKWMHNIRD ACRDHMEGYH YRYEINADPR LTNLSSNSDV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.