Details for: TPBG

Gene ID: 7162

Symbol: TPBG

Ensembl ID: ENSG00000146242

Description: trophoblast glycoprotein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 97.2625
    Cell Significance Index: -24.6700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 50.0506
    Cell Significance Index: -23.6300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 35.2149
    Cell Significance Index: -23.6300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.3616
    Cell Significance Index: -25.1100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.8993
    Cell Significance Index: -23.8400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.3355
    Cell Significance Index: -25.0000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.1266
    Cell Significance Index: -11.2200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 3.2636
    Cell Significance Index: 20.0900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.2159
    Cell Significance Index: 87.5400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.9630
    Cell Significance Index: 62.0200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.0268
    Cell Significance Index: 58.1000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.8506
    Cell Significance Index: 352.1800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.8478
    Cell Significance Index: 29.6500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.7670
    Cell Significance Index: 122.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.6569
    Cell Significance Index: 86.0700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.5912
    Cell Significance Index: 21.7100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9880
    Cell Significance Index: 160.7000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9292
    Cell Significance Index: 101.0700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.9215
    Cell Significance Index: 9.6200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9045
    Cell Significance Index: 493.9800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.8284
    Cell Significance Index: 61.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7911
    Cell Significance Index: 97.2800
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.7751
    Cell Significance Index: 4.5500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.7038
    Cell Significance Index: 26.6500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.6502
    Cell Significance Index: 4.0400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6419
    Cell Significance Index: 17.9400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6371
    Cell Significance Index: 38.2500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6270
    Cell Significance Index: 277.2100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.6060
    Cell Significance Index: 14.0000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.5964
    Cell Significance Index: 26.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5751
    Cell Significance Index: 103.6800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5428
    Cell Significance Index: 38.3900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5341
    Cell Significance Index: 52.8300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.5300
    Cell Significance Index: 8.8700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.5220
    Cell Significance Index: 5.9300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4614
    Cell Significance Index: 12.3200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.4085
    Cell Significance Index: 6.3200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3302
    Cell Significance Index: 15.5200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2833
    Cell Significance Index: 12.8400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2177
    Cell Significance Index: 10.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2103
    Cell Significance Index: 42.1900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1962
    Cell Significance Index: 2.9400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1944
    Cell Significance Index: 25.1200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1935
    Cell Significance Index: 9.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1763
    Cell Significance Index: 24.2100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1680
    Cell Significance Index: 4.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1338
    Cell Significance Index: 22.8400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0328
    Cell Significance Index: 1.1400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0077
    Cell Significance Index: 0.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0069
    Cell Significance Index: -13.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0109
    Cell Significance Index: -20.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0117
    Cell Significance Index: -7.4400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0119
    Cell Significance Index: -1.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0134
    Cell Significance Index: -9.9600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0157
    Cell Significance Index: -24.1800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0163
    Cell Significance Index: -10.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0187
    Cell Significance Index: -14.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0227
    Cell Significance Index: -30.8700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0234
    Cell Significance Index: -17.1500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0328
    Cell Significance Index: -18.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0412
    Cell Significance Index: -11.8500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0532
    Cell Significance Index: -24.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0534
    Cell Significance Index: -19.1700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0559
    Cell Significance Index: -6.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0568
    Cell Significance Index: -11.9600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0667
    Cell Significance Index: -9.7000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0818
    Cell Significance Index: -4.5900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0887
    Cell Significance Index: -1.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0907
    Cell Significance Index: -9.2700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0947
    Cell Significance Index: -10.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0981
    Cell Significance Index: -19.4700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1268
    Cell Significance Index: -4.0600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1410
    Cell Significance Index: -16.1000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1619
    Cell Significance Index: -6.6300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1996
    Cell Significance Index: -4.9900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2014
    Cell Significance Index: -3.9300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2198
    Cell Significance Index: -4.5600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2395
    Cell Significance Index: -24.9400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2409
    Cell Significance Index: -5.2200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2471
    Cell Significance Index: -15.9400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2732
    Cell Significance Index: -21.6400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3240
    Cell Significance Index: -5.7300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3282
    Cell Significance Index: -20.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3588
    Cell Significance Index: -27.5400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.4198
    Cell Significance Index: -6.6600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4470
    Cell Significance Index: -16.4100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4476
    Cell Significance Index: -11.7700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.4593
    Cell Significance Index: -5.9200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4674
    Cell Significance Index: -29.4600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4901
    Cell Significance Index: -25.7300
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.5031
    Cell Significance Index: -5.1900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.5107
    Cell Significance Index: -7.2700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.5425
    Cell Significance Index: -8.9400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6295
    Cell Significance Index: -16.1800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6434
    Cell Significance Index: -22.5400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.6541
    Cell Significance Index: -28.4400
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.6595
    Cell Significance Index: -9.1500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6831
    Cell Significance Index: -20.1200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.7351
    Cell Significance Index: -18.3600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.7522
    Cell Significance Index: -18.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TPBG is a glycoprotein, suggesting its involvement in carbohydrate-mediated interactions and cell-cell recognition. Its expression is restricted to specific cell types, which may indicate its role in tissue-specific functions. The protein's ability to regulate various signaling pathways, including the canonical Wnt pathway, phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) pathway, and Erk1/2 cascade, underscores its potential as a key regulator of cellular behavior. **Pathways and Functions:** TPBG's involvement in multiple signaling pathways highlights its role as a multifaceted regulator of cellular processes. Some of the key pathways and functions associated with TPBG include: 1. **Cell Adhesion:** TPBG may facilitate cell-cell interactions, influencing processes such as tissue development and cancer progression. 2. **Cell Chemotaxis:** TPBG's ability to regulate chemotaxis suggests its involvement in directed cell migration, which is crucial for tissue development, wound healing, and cancer metastasis. 3. **Synaptic Transmission:** TPBG's expression in basal cells of the trachea and bronchial goblet cells implies its potential role in regulating neurotransmitter release and synaptic function. 4. **Negative Regulation of Canonical Wnt Signaling Pathway:** TPBG's ability to suppress the canonical Wnt pathway may contribute to its tumor suppressor function, as dysregulation of this pathway is a hallmark of various cancers. 5. **Positive Regulation of Chemotaxis and Erk1/2 Cascade:** TPBG's activation of chemotaxis and Erk1/2 signaling pathways may promote cell migration and proliferation, respectively, contributing to cancer progression. **Clinical Significance:** TPBG's dysregulation has been associated with various cancers, including prostate and bladder cancers. Its expression in malignant cells suggests its potential as a diagnostic biomarker or therapeutic target. Further studies are needed to elucidate the mechanisms underlying TPBG's role in cancer progression and to explore its potential as a therapeutic agent. In conclusion, TPBG is a multifaceted protein that regulates various cellular processes, including cell adhesion, chemotaxis, and signaling pathways. Its dysregulation has been implicated in cancer progression, particularly in prostate and bladder cancers. Further research is necessary to fully understand TPBG's role in human disease and to explore its potential as a therapeutic agent.

Genular Protein ID: 3164446811

Symbol: TPBG_HUMAN

Name: Trophoblast glycoprotein

UniProtKB Accession Codes:

Q13641 A8K555

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 6 EvolutionaryTrace 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 3 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8132670

Title: Isolation of a cDNA encoding 5T4 oncofetal trophoblast glycoprotein: an antigen associated with metastasis contains leucine rich repeats.

PubMed ID: 8132670

DOI: 10.1016/s0021-9258(17)37110-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12481437

Title: Attenuated recombinant vaccinia virus expressing oncofetal antigen (tumor-associated antigen) 5T4 induces active therapy of established tumors.

PubMed ID: 12481437

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 22100263

Title: Waif1/5T4 inhibits Wnt/beta-catenin signaling and activates noncanonical Wnt pathways by modifying LRP6 subcellular localization.

PubMed ID: 22100263

DOI: 10.1016/j.devcel.2011.10.015

PubMed ID: 24582434

Title: Structural insights into the inhibition of Wnt signaling by cancer antigen 5T4/Wnt-activated inhibitory factor 1.

PubMed ID: 24582434

DOI: 10.1016/j.str.2014.01.009

Sequence Information:

  • Length: 420
  • Mass: 46032
  • Checksum: 3C403211F40F18BC
  • Sequence:
    • MPGGCSRGPA AGDGRLRLAR LALVLLGWVS SSSPTSSASS FSSSAPFLAS AVSAQPPLPD 
QCPALCECSE AARTVKCVNR NLTEVPTDLP AYVRNLFLTG NQLAVLPAGA FARRPPLAEL 
AALNLSGSRL DEVRAGAFEH LPSLRQLDLS HNPLADLSPF AFSGSNASVS APSPLVELIL 
NHIVPPEDER QNRSFEGMVV AALLAGRALQ GLRRLELASN HFLYLPRDVL AQLPSLRHLD 
LSNNSLVSLT YVSFRNLTHL ESLHLEDNAL KVLHNGTLAE LQGLPHIRVF LDNNPWVCDC 
HMADMVTWLK ETEVVQGKDR LTCAYPEKMR NRVLLELNSA DLDCDPILPP SLQTSYVFLG 
IVLALIGAIF LLVLYLNRKG IKKWMHNIRD ACRDHMEGYH YRYEINADPR LTNLSSNSDV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.