Details for: TPSAB1

Gene ID: 7177

Symbol: TPSAB1

Ensembl ID: ENSG00000172236

Description: tryptase alpha/beta 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: basophil (CL0000767)
    Fold Change: 3.85
    Marker Score: 1829
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1989
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1165
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4807
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 791
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71817
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48042
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.98
    Marker Score: 571
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.93
    Marker Score: 632
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5310
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.9
    Marker Score: 374.5
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.81
    Marker Score: 374.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 682
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 459
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.67
    Marker Score: 300
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.66
    Marker Score: 213
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.51
    Marker Score: 339
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.48
    Marker Score: 349
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 275
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.46
    Marker Score: 116
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.43
    Marker Score: 178
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.42
    Marker Score: 541
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.36
    Marker Score: 151
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.35
    Marker Score: 505
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.34
    Marker Score: 146
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.34
    Marker Score: 89
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.29
    Marker Score: 142
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.27
    Marker Score: 299
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.27
    Marker Score: 166
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.27
    Marker Score: 299
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.26
    Marker Score: 153
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 89
  • Cell Name: eosinophil (CL0000771)
    Fold Change: 0.25
    Marker Score: 83
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.23
    Marker Score: 207
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.23
    Marker Score: 221
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.23
    Marker Score: 64
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.22
    Marker Score: 117
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.22
    Marker Score: 146
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.22
    Marker Score: 218
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.21
    Marker Score: 200
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.2
    Marker Score: 69
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.2
    Marker Score: 325.5
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.2
    Marker Score: 114
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.2
    Marker Score: 68
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.19
    Marker Score: 45
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.18
    Marker Score: 530
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.18
    Marker Score: 132
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.18
    Marker Score: 158.5
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.17
    Marker Score: 300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.17
    Marker Score: 72
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.17
    Marker Score: 75
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.16
    Marker Score: 60
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.16
    Marker Score: 153
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.15
    Marker Score: 172
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.15
    Marker Score: 151
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.15
    Marker Score: 135
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.15
    Marker Score: 32
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.14
    Marker Score: 31
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.14
    Marker Score: 94
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.14
    Marker Score: 353
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.14
    Marker Score: 373
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.13
    Marker Score: 64
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.13
    Marker Score: 328
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.13
    Marker Score: 76
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.13
    Marker Score: 100
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.13
    Marker Score: 172
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.13
    Marker Score: 129
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.13
    Marker Score: 94
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.13
    Marker Score: 32
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: 0.13
    Marker Score: 39
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.13
    Marker Score: 32
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.13
    Marker Score: 128
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.12
    Marker Score: 76
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.12
    Marker Score: 31
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.12
    Marker Score: 31
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.12
    Marker Score: 41
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.12
    Marker Score: 30
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.11
    Marker Score: 37
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.11
    Marker Score: 29
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.11
    Marker Score: 185
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.11
    Marker Score: 118
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.11
    Marker Score: 74
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.11
    Marker Score: 728

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Other Information

**Key Characteristics:** TPSAB1 is a member of the trypase family, which is characterized by its serine protease activity. The enzyme is composed of two subunits, alpha and beta, which are structurally similar and share a similar catalytic domain. TPSAB1 is predominantly expressed in various cell types, including basophils, mast cells, enterocytes, and GABAergic interneurons. Its expression pattern suggests a role in immune response, tissue remodeling, and cellular communication. **Pathways and Functions:** TPSAB1 is involved in multiple signaling pathways, including: 1. **Activation of matrix metalloproteinases (MMPs):** TPSAB1 can activate MMPs, which are essential for the degradation of the extracellular matrix (ECM) and tissue remodeling. 2. **Degradation of the extracellular matrix:** By activating MMPs, TPSAB1 contributes to the breakdown of ECM components, such as collagen and elastin, which is critical for cellular migration, tissue repair, and immune response. 3. **Proteolysis:** TPSAB1's serine protease activity enables it to cleave various proteins, including growth factors, cytokines, and chemokines, which modulate immune responses and cellular signaling. 4. **Extracellular matrix organization:** TPSAB1's role in ECM remodeling and degradation suggests that it may also contribute to the organization and maintenance of the ECM structure. **Clinical Significance:** The dysregulation of TPSAB1 has been implicated in various diseases, including: 1. **Allergic disorders:** Overexpression of TPSAB1 in mast cells and basophils contributes to the pathogenesis of allergic reactions, such as asthma and atopic dermatitis. 2. **Cancer:** TPSAB1's involvement in ECM remodeling and degradation suggests its potential role in cancer progression, tumor metastasis, and angiogenesis. 3. **Neurological disorders:** TPSAB1's expression in GABAergic interneurons and forebrain radial glial cells implies its involvement in neurological diseases, such as epilepsy and neurodevelopmental disorders. 4. **Inflammatory diseases:** TPSAB1's participation in immune response and ECM remodeling suggests its potential role in inflammatory diseases, such as rheumatoid arthritis and atherosclerosis. In conclusion, TPSAB1 is a multifunctional enzyme that plays a critical role in immune response, extracellular matrix dynamics, and tissue remodeling. Further research is needed to fully elucidate its mechanisms of action and its clinical significance in various diseases.

Genular Protein ID: 99302528

Symbol: TRYB1_HUMAN

Name: Tryptase alpha/beta-1

UniProtKB Accession Codes:

Q15661 D2E6R9 D2E6S1 P15157 Q15663 Q6B052 Q9H2Y4 Q9H2Y5 Q9UQI1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 2 EMBL 12 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 2 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 23 PDBsum 17 PIR 3 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2677049

Title: Cloning and characterization of complementary DNA for human tryptase.

PubMed ID: 2677049

DOI: 10.1172/jci114284

PubMed ID: 2187193

Title: Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family.

PubMed ID: 2187193

DOI: 10.1073/pnas.87.10.3811

PubMed ID: 9920877

Title: Characterization of genes encoding known and novel human mast cell tryptases on chromosome 16p13.3.

PubMed ID: 9920877

DOI: 10.1074/jbc.274.6.3355

PubMed ID: 18854315

Title: Alternate mRNA splicing in multiple human tryptase genes is predicted to regulate tetramer formation.

PubMed ID: 18854315

DOI: 10.1074/jbc.m807553200

PubMed ID: 19748655

Title: Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations.

PubMed ID: 19748655

DOI: 10.1016/j.jaci.2009.07.026

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3543004

Title: Human pituitary tryptase: molecular forms, NH2-terminal sequence, immunocytochemical localization, and specificity with prohormone and fluorogenic substrates.

PubMed ID: 3543004

DOI: 10.1016/s0021-9258(19)75795-0

PubMed ID: 14670919

Title: Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers.

PubMed ID: 14670919

DOI: 10.1182/blood-2003-08-2981

PubMed ID: 18039527

Title: Active monomers of human beta-tryptase have expanded substrate specificities.

PubMed ID: 18039527

DOI: 10.1016/j.intimp.2007.07.007

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27749843

Title: Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number.

PubMed ID: 27749843

DOI: 10.1038/ng.3696

PubMed ID: 12162961

Title: The crystal structure of human alpha1-tryptase reveals a blocked substrate-binding region.

PubMed ID: 12162961

DOI: 10.1016/s0022-2836(02)00625-3

PubMed ID: 10898108

Title: Characterization of two highly polymorphic human tryptase loci and comparison with a newly discovered monkey tryptase ortholog.

PubMed ID: 10898108

DOI: 10.1097/00008571-200007000-00002

Sequence Information:

  • Length: 275
  • Mass: 30515
  • Checksum: ADC48FDC51F37112
  • Sequence:
    • MLNLLLLALP VLASRAYAAP APGQALQRVG IVGGQEAPRS KWPWQVSLRV HGPYWMHFCG 
GSLIHPQWVL TAAHCVGPDV KDLAALRVQL REQHLYYQDQ LLPVSRIIVH PQFYTAQIGA 
DIALLELEEP VNVSSHVHTV TLPPASETFP PGMPCWVTGW GDVDNDERLP PPFPLKQVKV 
PIMENHICDA KYHLGAYTGD DVRIVRDDML CAGNTRRDSC QGDSGGPLVC KVNGTWLQAG 
VVSWGEGCAQ PNRPGIYTRV TYYLDWIHHY VPKKP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.