Details for: TPSAB1

Gene ID: 7177

Symbol: TPSAB1

Ensembl ID: ENSG00000172236

Description: tryptase alpha/beta 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 34.7166
    Cell Significance Index: -5.4000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 19.2396
    Cell Significance Index: -4.8800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 10.3184
    Cell Significance Index: 362.5800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 4.8085
    Cell Significance Index: 120.2000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 4.6866
    Cell Significance Index: 287.3400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.4203
    Cell Significance Index: -5.4500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 4.2689
    Cell Significance Index: 123.0000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.2435
    Cell Significance Index: -6.0100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 2.0136
    Cell Significance Index: 41.7700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.7046
    Cell Significance Index: 77.2700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.4720
    Cell Significance Index: 31.8900
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.2590
    Cell Significance Index: 5.2400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1850
    Cell Significance Index: 225.5100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9350
    Cell Significance Index: 92.5000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7704
    Cell Significance Index: 695.6100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.6690
    Cell Significance Index: 10.3500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.5581
    Cell Significance Index: 8.4100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4261
    Cell Significance Index: 9.0800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4138
    Cell Significance Index: 67.3000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.4019
    Cell Significance Index: 84.6500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3868
    Cell Significance Index: 42.0700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2033
    Cell Significance Index: 14.0600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1108
    Cell Significance Index: 5.7600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0783
    Cell Significance Index: 4.7000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0641
    Cell Significance Index: 40.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0222
    Cell Significance Index: 16.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0150
    Cell Significance Index: 0.4800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0044
    Cell Significance Index: 0.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0009
    Cell Significance Index: -0.6600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0018
    Cell Significance Index: -0.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0028
    Cell Significance Index: -5.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0033
    Cell Significance Index: -1.8800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0054
    Cell Significance Index: -0.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0087
    Cell Significance Index: -5.5300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0102
    Cell Significance Index: -5.5500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0123
    Cell Significance Index: -5.6000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0157
    Cell Significance Index: -1.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0158
    Cell Significance Index: -2.8500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0176
    Cell Significance Index: -3.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0176
    Cell Significance Index: -5.0500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0201
    Cell Significance Index: -2.3000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0270
    Cell Significance Index: -5.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0272
    Cell Significance Index: -5.4000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0301
    Cell Significance Index: -4.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0331
    Cell Significance Index: -3.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0333
    Cell Significance Index: -0.9300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0349
    Cell Significance Index: -4.2900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0374
    Cell Significance Index: -5.4400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0431
    Cell Significance Index: -5.5700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0444
    Cell Significance Index: -3.3100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0482
    Cell Significance Index: -1.2400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0505
    Cell Significance Index: -5.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0526
    Cell Significance Index: -5.4800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0564
    Cell Significance Index: -1.9800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0599
    Cell Significance Index: -1.4500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0772
    Cell Significance Index: -5.9300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0922
    Cell Significance Index: -5.9500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0936
    Cell Significance Index: -5.9000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0969
    Cell Significance Index: -1.3600
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1034
    Cell Significance Index: -1.4300
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1055
    Cell Significance Index: -1.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1061
    Cell Significance Index: -4.9900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1270
    Cell Significance Index: -5.9200
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1314
    Cell Significance Index: -1.3000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1343
    Cell Significance Index: -4.9300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1350
    Cell Significance Index: -4.4200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1357
    Cell Significance Index: -3.6300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1398
    Cell Significance Index: -1.8400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1453
    Cell Significance Index: -1.5800
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.1459
    Cell Significance Index: -1.5400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1468
    Cell Significance Index: -4.6800
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: -0.1469
    Cell Significance Index: -1.2400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1577
    Cell Significance Index: -2.2600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1699
    Cell Significance Index: -4.3400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1799
    Cell Significance Index: -5.3000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1840
    Cell Significance Index: -4.5900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1853
    Cell Significance Index: -2.7100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1996
    Cell Significance Index: -5.3300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2014
    Cell Significance Index: -5.0300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2016
    Cell Significance Index: -5.7800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2072
    Cell Significance Index: -5.6400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2104
    Cell Significance Index: -2.9900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2163
    Cell Significance Index: -3.1400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2171
    Cell Significance Index: -5.5300
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.2206
    Cell Significance Index: -2.6300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2214
    Cell Significance Index: -5.5200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2258
    Cell Significance Index: -5.5100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2273
    Cell Significance Index: -3.8600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2282
    Cell Significance Index: -4.5500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2302
    Cell Significance Index: -1.5600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2318
    Cell Significance Index: -3.8800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.2363
    Cell Significance Index: -3.0900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2388
    Cell Significance Index: -4.7000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2407
    Cell Significance Index: -5.2000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2407
    Cell Significance Index: -5.5600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2434
    Cell Significance Index: -5.3300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2445
    Cell Significance Index: -4.7800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2485
    Cell Significance Index: -4.8500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2487
    Cell Significance Index: -5.1900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2554
    Cell Significance Index: -5.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TPSAB1 is a member of the trypase family, which is characterized by its serine protease activity. The enzyme is composed of two subunits, alpha and beta, which are structurally similar and share a similar catalytic domain. TPSAB1 is predominantly expressed in various cell types, including basophils, mast cells, enterocytes, and GABAergic interneurons. Its expression pattern suggests a role in immune response, tissue remodeling, and cellular communication. **Pathways and Functions:** TPSAB1 is involved in multiple signaling pathways, including: 1. **Activation of matrix metalloproteinases (MMPs):** TPSAB1 can activate MMPs, which are essential for the degradation of the extracellular matrix (ECM) and tissue remodeling. 2. **Degradation of the extracellular matrix:** By activating MMPs, TPSAB1 contributes to the breakdown of ECM components, such as collagen and elastin, which is critical for cellular migration, tissue repair, and immune response. 3. **Proteolysis:** TPSAB1's serine protease activity enables it to cleave various proteins, including growth factors, cytokines, and chemokines, which modulate immune responses and cellular signaling. 4. **Extracellular matrix organization:** TPSAB1's role in ECM remodeling and degradation suggests that it may also contribute to the organization and maintenance of the ECM structure. **Clinical Significance:** The dysregulation of TPSAB1 has been implicated in various diseases, including: 1. **Allergic disorders:** Overexpression of TPSAB1 in mast cells and basophils contributes to the pathogenesis of allergic reactions, such as asthma and atopic dermatitis. 2. **Cancer:** TPSAB1's involvement in ECM remodeling and degradation suggests its potential role in cancer progression, tumor metastasis, and angiogenesis. 3. **Neurological disorders:** TPSAB1's expression in GABAergic interneurons and forebrain radial glial cells implies its involvement in neurological diseases, such as epilepsy and neurodevelopmental disorders. 4. **Inflammatory diseases:** TPSAB1's participation in immune response and ECM remodeling suggests its potential role in inflammatory diseases, such as rheumatoid arthritis and atherosclerosis. In conclusion, TPSAB1 is a multifunctional enzyme that plays a critical role in immune response, extracellular matrix dynamics, and tissue remodeling. Further research is needed to fully elucidate its mechanisms of action and its clinical significance in various diseases.

Genular Protein ID: 99302528

Symbol: TRYB1_HUMAN

Name: Tryptase alpha/beta-1

UniProtKB Accession Codes:

Q15661 D2E6R9 D2E6S1 P15157 Q15663 Q6B052 Q9H2Y4 Q9H2Y5 Q9UQI1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 2 EMBL 12 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 2 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 17 PIR 3 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2677049

Title: Cloning and characterization of complementary DNA for human tryptase.

PubMed ID: 2677049

DOI: 10.1172/jci114284

PubMed ID: 2187193

Title: Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family.

PubMed ID: 2187193

DOI: 10.1073/pnas.87.10.3811

PubMed ID: 9920877

Title: Characterization of genes encoding known and novel human mast cell tryptases on chromosome 16p13.3.

PubMed ID: 9920877

DOI: 10.1074/jbc.274.6.3355

PubMed ID: 18854315

Title: Alternate mRNA splicing in multiple human tryptase genes is predicted to regulate tetramer formation.

PubMed ID: 18854315

DOI: 10.1074/jbc.m807553200

PubMed ID: 19748655

Title: Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations.

PubMed ID: 19748655

DOI: 10.1016/j.jaci.2009.07.026

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3543004

Title: Human pituitary tryptase: molecular forms, NH2-terminal sequence, immunocytochemical localization, and specificity with prohormone and fluorogenic substrates.

PubMed ID: 3543004

DOI: 10.1016/s0021-9258(19)75795-0

PubMed ID: 14670919

Title: Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers.

PubMed ID: 14670919

DOI: 10.1182/blood-2003-08-2981

PubMed ID: 18039527

Title: Active monomers of human beta-tryptase have expanded substrate specificities.

PubMed ID: 18039527

DOI: 10.1016/j.intimp.2007.07.007

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27749843

Title: Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number.

PubMed ID: 27749843

DOI: 10.1038/ng.3696

PubMed ID: 12162961

Title: The crystal structure of human alpha1-tryptase reveals a blocked substrate-binding region.

PubMed ID: 12162961

DOI: 10.1016/s0022-2836(02)00625-3

PubMed ID: 10898108

Title: Characterization of two highly polymorphic human tryptase loci and comparison with a newly discovered monkey tryptase ortholog.

PubMed ID: 10898108

DOI: 10.1097/00008571-200007000-00002

Sequence Information:

  • Length: 275
  • Mass: 30515
  • Checksum: ADC48FDC51F37112
  • Sequence:
    • MLNLLLLALP VLASRAYAAP APGQALQRVG IVGGQEAPRS KWPWQVSLRV HGPYWMHFCG 
GSLIHPQWVL TAAHCVGPDV KDLAALRVQL REQHLYYQDQ LLPVSRIIVH PQFYTAQIGA 
DIALLELEEP VNVSSHVHTV TLPPASETFP PGMPCWVTGW GDVDNDERLP PPFPLKQVKV 
PIMENHICDA KYHLGAYTGD DVRIVRDDML CAGNTRRDSC QGDSGGPLVC KVNGTWLQAG 
VVSWGEGCAQ PNRPGIYTRV TYYLDWIHHY VPKKP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.