TRAF6 | ENSG00000175104 | NCBI 7189

Details for: TRAF6

Gene ID: 7189

Symbol: TRAF6

Ensembl ID: ENSG00000175104

Description: TNF receptor associated factor 6

Associated with

Activated tak1 mediates p38 mapk activation
(R-HSA-450302)
Adaptive immune system
(R-HSA-1280218)
Alpha-protein kinase 1 signaling pathway
(R-HSA-9645460)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Cell death signalling via nrage, nrif and nade
(R-HSA-204998)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Cytokine signaling in immune system
(R-HSA-1280215)
Ddx58/ifih1-mediated induction of interferon-alpha/beta
(R-HSA-168928)
Death receptor signaling
(R-HSA-73887)
Deubiquitination
(R-HSA-5688426)
Disease
(R-HSA-1643685)
Downstream tcr signaling
(R-HSA-202424)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Ikk complex recruitment mediated by rip1
(R-HSA-937041)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Interleukin-1 signaling
(R-HSA-9020702)
Interleukin-17 signaling
(R-HSA-448424)
Intracellular signaling by second messengers
(R-HSA-9006925)
Irak1 recruits ikk complex
(R-HSA-937039)
Irak1 recruits ikk complex upon tlr7/8 or 9 stimulation
(R-HSA-975144)
Irak2 mediated activation of tak1 complex
(R-HSA-937042)
Irak2 mediated activation of tak1 complex upon tlr7/8 or 9 stimulation
(R-HSA-975163)
Jnk (c-jun kinases) phosphorylation and activation mediated by activated human tak1
(R-HSA-450321)
Map kinase activation
(R-HSA-450294)
Metabolism of proteins
(R-HSA-392499)
Myd88 cascade initiated on plasma membrane
(R-HSA-975871)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Nf-kb is activated and signals survival
(R-HSA-209560)
Nod1/2 signaling pathway
(R-HSA-168638)
Nrif signals cell death from the nucleus
(R-HSA-205043)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-HSA-168643)
Ovarian tumor domain proteases
(R-HSA-5689896)
P75 ntr receptor-mediated signalling
(R-HSA-193704)
P75ntr recruits signalling complexes
(R-HSA-209543)
P75ntr signals via nf-kb
(R-HSA-193639)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-translational protein modification
(R-HSA-597592)
Regulated proteolysis of p75ntr
(R-HSA-193692)
Regulation of nf-kappa b signaling
(R-HSA-9758274)
Sars-cov-1 activates/modulates innate immune responses
(R-HSA-9692916)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov-2 activates/modulates innate and adaptive immune responses
(R-HSA-9705671)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Signaling by interleukins
(R-HSA-449147)
Signal transduction
(R-HSA-162582)
Tak1-dependent ikk and nf-kappa-b activation
(R-HSA-445989)
Tcr signaling
(R-HSA-202403)
Ticam1, rip1-mediated ikk complex recruitment
(R-HSA-168927)
Ticam1,traf6-dependent induction of tak1 complex
(R-HSA-9014325)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Traf6 mediated irf7 activation
(R-HSA-933541)
Traf6 mediated irf7 activation in tlr7/8 or 9 signaling
(R-HSA-975110)
Traf6 mediated nf-kb activation
(R-HSA-933542)
Traf6-mediated induction of tak1 complex within tlr4 complex
(R-HSA-937072)
Trif (ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Ub-specific processing proteases
(R-HSA-5689880)
Viral infection pathways
(R-HSA-9824446)
Autophagosome assembly
(GO:0000045)
Histone deacetylase binding
(GO:0042826)
Identical protein binding
(GO:0042802)
In utero embryonic development
(GO:0001701)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neural tube closure
(GO:0001843)
Ossification
(GO:0001503)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein binding
(GO:0005515)
Protein kinase b binding
(GO:0043422)
Protein polyubiquitination
(GO:0000209)
Regulation of immunoglobulin production
(GO:0002637)
Signaling adaptor activity
(GO:0035591)
Stimulatory c-type lectin receptor signaling pathway
(GO:0002223)
Tumor necrosis factor receptor binding
(GO:0005164)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin-ubiquitin ligase activity
(GO:0034450)
Ubiquitin conjugating enzyme binding
(GO:0031624)
Ubiquitin protein ligase activity
(GO:0061630)
Zinc ion binding
(GO:0008270)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 115.7220
Cell Significance Index: -18.0000
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 71.4389
Cell Significance Index: -18.1200
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 41.2547
Cell Significance Index: -16.7600
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 15.0938
Cell Significance Index: -18.6100
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 6.7417
Cell Significance Index: -18.0600
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 4.7693
Cell Significance Index: -18.8200
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 3.3446
Cell Significance Index: -7.3200
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 1.5851
Cell Significance Index: 26.1200
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.2478
Cell Significance Index: 86.3000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.0411
Cell Significance Index: 208.8500
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7655
Cell Significance Index: 691.1800
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.5670
Cell Significance Index: 34.0400
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.5556
Cell Significance Index: 7.5800
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.5437
Cell Significance Index: 195.0000
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.5377
Cell Significance Index: 58.4800
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5241
Cell Significance Index: 15.1000
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.5096
Cell Significance Index: 39.1100
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.4746
Cell Significance Index: 77.2000
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.4696
Cell Significance Index: 54.7300
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.3538
Cell Significance Index: 9.6300
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.3070
Cell Significance Index: 8.2300
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3007
Cell Significance Index: 13.6300
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.2956
Cell Significance Index: 11.2000
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.2612
Cell Significance Index: 180.6300
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.2559
Cell Significance Index: 11.3200
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.2252
Cell Significance Index: 44.6900
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1977
Cell Significance Index: 35.6400
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.1964
Cell Significance Index: 11.0200
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.1858
Cell Significance Index: 12.4900
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.1808
Cell Significance Index: 4.5200
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1704
Cell Significance Index: 8.8500
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1698
Cell Significance Index: 16.8000
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1603
Cell Significance Index: 30.5100
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1599
Cell Significance Index: 19.6600
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.1411
Cell Significance Index: 8.6700
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.0742
Cell Significance Index: 1.5900
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0700
Cell Significance Index: 30.9300
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0618
Cell Significance Index: 33.7500
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0237
Cell Significance Index: 4.0400
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0218
Cell Significance Index: 41.0600
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0177
Cell Significance Index: 2.4300
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0105
Cell Significance Index: 6.6500
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0062
Cell Significance Index: 0.7300
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0055
Cell Significance Index: 2.5100
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0051
Cell Significance Index: 9.3600
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0031
Cell Significance Index: 4.8300
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0020
Cell Significance Index: -2.7200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0030
Cell Significance Index: -0.0800
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0051
Cell Significance Index: -0.2400
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0073
Cell Significance Index: -4.5500
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0081
Cell Significance Index: -1.0400
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0094
Cell Significance Index: -7.0000
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0095
Cell Significance Index: -0.2700
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0128
Cell Significance Index: -7.2400
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0159
Cell Significance Index: -11.6500
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.0160
Cell Significance Index: -0.3500
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0205
Cell Significance Index: -1.2900
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0224
Cell Significance Index: -16.9700
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0235
Cell Significance Index: -3.4200
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.0248
Cell Significance Index: -0.1500
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0295
Cell Significance Index: -3.8100
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.0316
Cell Significance Index: -0.4500
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0455
Cell Significance Index: -1.6000
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0512
Cell Significance Index: -14.7400
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0515
Cell Significance Index: -5.2600
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0519
Cell Significance Index: -1.4500
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0527
Cell Significance Index: -11.1100
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0552
Cell Significance Index: -3.5600
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0755
Cell Significance Index: -1.9400
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0791
Cell Significance Index: -9.0600
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0841
Cell Significance Index: -5.9500
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.0892
Cell Significance Index: -2.1400
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0929
Cell Significance Index: -4.3700
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1014
Cell Significance Index: -11.5700
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1253
Cell Significance Index: -9.3400
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1467
Cell Significance Index: -7.6400
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.1516
Cell Significance Index: -3.2900
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1531
Cell Significance Index: -4.3900
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1538
Cell Significance Index: -16.0100
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.1586
Cell Significance Index: -1.9700
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.1745
Cell Significance Index: -2.6200
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.1761
Cell Significance Index: -3.7500
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.1897
Cell Significance Index: -2.8000
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.2030
Cell Significance Index: -10.2600
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2088
Cell Significance Index: -12.8000
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2114
Cell Significance Index: -16.7400
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.2342
Cell Significance Index: -4.9700
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2389
Cell Significance Index: -12.5500
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.2396
Cell Significance Index: -4.0100
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.2473
Cell Significance Index: -6.6200
Cell Name: slow muscle cell (CL0000189)
Fold Change: -0.2490
Cell Significance Index: -3.7300
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.2550
Cell Significance Index: -4.3700
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.2697
Cell Significance Index: -5.6000
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2935
Cell Significance Index: -9.4000
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2936
Cell Significance Index: -9.3500
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3128
Cell Significance Index: -10.2400
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.3233
Cell Significance Index: -6.3100
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.3391
Cell Significance Index: -2.7700
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.3398
Cell Significance Index: -5.1200
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.3419
Cell Significance Index: -8.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** TRAF6 is a 420-kDa protein that contains three phosphotyrosine-binding domains and a RING finger domain. It is highly expressed in cells of the immune system, with peak expression levels in dendritic cells and macrophages. TRAF6 is activated by the binding of TLRs and other PRRs to their ligands, leading to the recruitment of downstream signaling molecules. It is also activated by the binding of cytokines, such as TNF-alpha, to their receptors. TRAF6 is a ubiquitin ligase that can transfer ubiquitin to target proteins, leading to their degradation or modulation of their activity. **Pathways and Functions** TRAF6 is involved in the activation of several signaling pathways, including: 1. ** Toll-like receptor signaling pathway**: TRAF6 is activated by the binding of TLRs to their ligands, leading to the recruitment of IRAK1 and IRAK2, which activate the IκB kinase (IKK) complex, resulting in the activation of NF-κB. 2. **Cytokine signaling pathway**: TRAF6 is activated by the binding of cytokines, such as TNF-alpha, to their receptors, leading to the recruitment of downstream signaling molecules, including NF-κB and MAPK. 3. **Autophagy pathway**: TRAF6 is involved in the regulation of autophagy, a process by which cells recycle damaged or dysfunctional components. 4. **Apoptosis pathway**: TRAF6 is involved in the regulation of apoptosis, a process by which cells undergo programmed cell death. **Clinical Significance** TRAF6 has been implicated in the pathogenesis of several diseases, including: 1. **Autoimmune disorders**: TRAF6 has been implicated in the development of autoimmune disorders, such as rheumatoid arthritis and lupus, due to its role in the activation of NF-κB and the regulation of immune responses. 2. **Infectious diseases**: TRAF6 has been implicated in the pathogenesis of infectious diseases, such as tuberculosis and HIV, due to its role in the activation of immune responses and the regulation of cytokine production. 3. **Cancer**: TRAF6 has been implicated in the development of cancer, due to its role in the activation of NF-κB and the regulation of cell survival and proliferation. 4. **Neurological disorders**: TRAF6 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease, due to its role in the regulation of synaptic plasticity and neuronal survival. In conclusion, TRAF6 is a multifunctional adaptor protein that plays a crucial role in the regulation of the immune response, inflammation, and cell survival. Its dysregulation has been implicated in the pathogenesis of several diseases, including autoimmune disorders, infectious diseases, cancer, and neurological disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

TNF receptor-associated factor 6

Genular Protein ID: 1370190705

Symbol: TRAF6_HUMAN

Name: TNF receptor-associated factor 6

UniProtKB Accession Codes:

Q9Y4K3 A6NKI7 A8KAB3 D3DR16 Q8NEH5

Database IDs:

Citations:

PubMed ID: 8837778

Title: TRAF6 is a signal transducer for interleukin-1.

PubMed ID: 8837778

DOI: 10.1038/383443a0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9020361

Title: MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1.

PubMed ID: 9020361

DOI: 10.1038/385540a0

PubMed ID: 9374458

Title: IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling.

PubMed ID: 9374458

DOI: 10.1126/science.278.5343.1612

PubMed ID: 9642260

Title: RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase.

PubMed ID: 9642260

DOI: 10.1074/jbc.273.27.16968

PubMed ID: 9774460

Title: The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor.

PubMed ID: 9774460

DOI: 10.1074/jbc.273.43.28355

PubMed ID: 9432981

Title: Tumor necrosis factor receptor-associated factor 6 (TRAF6) stimulates extracellular signal-regulated kinase (ERK) activity in CD40 signaling along a ras-independent pathway.

PubMed ID: 9432981

DOI: 10.1084/jem.187.2.237

PubMed ID: 9774977

Title: ASK1 is essential for JNK/SAPK activation by TRAF2.

PubMed ID: 9774977

DOI: 10.1016/s1097-2765(00)80283-x

PubMed ID: 10346818

Title: Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain.

PubMed ID: 10346818

DOI: 10.1101/gad.13.10.1297

PubMed ID: 9915784

Title: Association of the p75 neurotrophin receptor with TRAF6.

PubMed ID: 9915784

DOI: 10.1074/jbc.274.5.2597

PubMed ID: 10383454

Title: IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family.

PubMed ID: 10383454

DOI: 10.1074/jbc.274.27.19403

PubMed ID: 10514511

Title: TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction.

PubMed ID: 10514511

DOI: 10.1074/jbc.274.42.30202

PubMed ID: 10635328

Title: TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src.

PubMed ID: 10635328

DOI: 10.1016/s1097-2765(00)80232-4

PubMed ID: 10094049

Title: The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway.

PubMed ID: 10094049

DOI: 10.1038/18465

PubMed ID: 10523862

Title: Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1).

PubMed ID: 10523862

DOI: 10.1038/sj.onc.1202975

PubMed ID: 11057907

Title: Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain.

PubMed ID: 11057907

DOI: 10.1016/s0092-8674(00)00126-4

PubMed ID: 10764746

Title: TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation.

PubMed ID: 10764746

DOI: 10.1074/jbc.m000531200

PubMed ID: 10908663

Title: B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1.

PubMed ID: 10908663

DOI: 10.1073/pnas.160213497

PubMed ID: 10920205

Title: T6BP, a TRAF6-interacting protein involved in IL-1 signaling.

PubMed ID: 10920205

DOI: 10.1073/pnas.170279097

PubMed ID: 11460167

Title: TAK1 is a ubiquitin-dependent kinase of MKK and IKK.

PubMed ID: 11460167

DOI: 10.1038/35085597

PubMed ID: 12459498

Title: NF-kappaB activator Act1 associates with IL-1/Toll pathway adapter molecule TRAF6.

PubMed ID: 12459498

DOI: 10.1016/s0014-5793(02)03688-8

PubMed ID: 11751921

Title: A novel zinc finger protein that inhibits osteoclastogenesis and the function of tumor necrosis factor receptor-associated factor 6.

PubMed ID: 11751921

DOI: 10.1074/jbc.m110964200

PubMed ID: 11960013

Title: IRAK4: a novel member of the IRAK family with the properties of an IRAK-kinase.

PubMed ID: 11960013

DOI: 10.1073/pnas.082100399

PubMed ID: 12496252

Title: Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex.

PubMed ID: 12496252

DOI: 10.1074/jbc.m212112200

PubMed ID: 12804775

Title: Pellino2 activates the mitogen activated protein kinase pathway.

PubMed ID: 12804775

DOI: 10.1016/s0014-5793(03)00533-7

PubMed ID: 12721283

Title: TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling.

PubMed ID: 12721283

DOI: 10.1074/jbc.m303451200

PubMed ID: 12874243

Title: Pellino3, a novel member of the Pellino protein family, promotes activation of c-Jun and Elk-1 and may act as a scaffolding protein.

PubMed ID: 12874243

DOI: 10.4049/jimmunol.171.3.1500

PubMed ID: 14530355

Title: Toll/IL-1 receptor domain-containing adapter inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling.

PubMed ID: 14530355

DOI: 10.4049/jimmunol.171.8.4304

PubMed ID: 14739303

Title: Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways.

PubMed ID: 14739303

DOI: 10.1074/jbc.m311629200

PubMed ID: 14754897

Title: ZNF216 is an A20-like and IkappaB kinase gamma-interacting inhibitor of NFkappaB activation.

PubMed ID: 14754897

DOI: 10.1074/jbc.m309491200

PubMed ID: 15121867

Title: TRAF family proteins link PKR with NF-kappa B activation.

PubMed ID: 15121867

DOI: 10.1128/mcb.24.10.4502-4512.2004

PubMed ID: 14982987

Title: Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta.

PubMed ID: 14982987

DOI: 10.1073/pnas.0308496101

PubMed ID: 16125763

Title: Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3.

PubMed ID: 16125763

DOI: 10.1016/j.cell.2005.08.012

PubMed ID: 16286016

Title: IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST 2 and induces T helper type 2-associated cytokines.

PubMed ID: 16286016

DOI: 10.1016/j.immuni.2005.09.015

PubMed ID: 16221674

Title: FLN29, a novel interferon- and LPS-inducible gene acting as a negative regulator of toll-like receptor signaling.

PubMed ID: 16221674

DOI: 10.1074/jbc.m508221200

PubMed ID: 16153868

Title: VISA is an adapter protein required for virus-triggered IFN-beta Signaling.

PubMed ID: 16153868

DOI: 10.1016/j.molcel.2005.08.014

PubMed ID: 15870274

Title: The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex.

PubMed ID: 15870274

DOI: 10.1128/mcb.25.10.4010-4022.2005

PubMed ID: 16378096

Title: Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling.

PubMed ID: 16378096

DOI: 10.1038/ni1294

PubMed ID: 16951688

Title: Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adapter Pellino-1.

PubMed ID: 16951688

DOI: 10.1038/ni1383

PubMed ID: 17135271

Title: Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation.

PubMed ID: 17135271

DOI: 10.1074/jbc.m609503200

PubMed ID: 17449468

Title: RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation.

PubMed ID: 17449468

DOI: 10.1074/jbc.m701913200

PubMed ID: 17703191

Title: Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling.

PubMed ID: 17703191

DOI: 10.1038/sj.emboj.7601823

PubMed ID: 18093978

Title: Nuclear tumor necrosis factor receptor-associated factor 6 in lymphoid cells negatively regulates c-Myb-mediated transactivation through small ubiquitin-related modifier-1 modification.

PubMed ID: 18093978

DOI: 10.1074/jbc.m706307200

PubMed ID: 18347055

Title: Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation.

PubMed ID: 18347055

DOI: 10.1128/mcb.02098-07

PubMed ID: 18758450

Title: The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner.

PubMed ID: 18758450

DOI: 10.1038/ncb1780

PubMed ID: 19521662

Title: WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4-induced NF-kappaB activation pathway.

PubMed ID: 19521662

DOI: 10.1007/s00018-009-0059-6

PubMed ID: 19675569

Title: Direct activation of protein kinases by unanchored polyubiquitin chains.

PubMed ID: 19675569

DOI: 10.1038/nature08247

PubMed ID: 19713527

Title: The E3 ligase TRAF6 regulates Akt ubiquitination and activation.

PubMed ID: 19713527

DOI: 10.1126/science.1175065

PubMed ID: 19825828

Title: Act1, a U-box E3 ubiquitin ligase for IL-17 signaling.

PubMed ID: 19825828

DOI: 10.1126/scisignal.2000382

PubMed ID: 20079715

Title: NUMBL interacts with TRAF6 and promotes the degradation of TRAF6.

PubMed ID: 20079715

DOI: 10.1016/j.bbrc.2010.01.037

PubMed ID: 20628368

Title: Tom70 mediates activation of interferon regulatory factor 3 on mitochondria.

PubMed ID: 20628368

DOI: 10.1038/cr.2010.103

PubMed ID: 21302310

Title: Alternative splicing of CARMA2/CARD14 transcripts generates protein variants with differential effect on NF-kappaB activation and endoplasmic reticulum stress-induced cell death.

PubMed ID: 21302310

DOI: 10.1002/jcp.22667

PubMed ID: 21813773

Title: IFN-induced TPR protein IFIT3 potentiates antiviral signaling by bridging MAVS and TBK1.

PubMed ID: 21813773

DOI: 10.4049/jimmunol.1100963

PubMed ID: 23776175

Title: SASH1 is a scaffold molecule in endothelial TLR4 signaling.

PubMed ID: 23776175

DOI: 10.4049/jimmunol.1200583

PubMed ID: 23524951

Title: mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6.

PubMed ID: 23524951

DOI: 10.1038/ncb2708

PubMed ID: 23514740

Title: TNFR-associated factor 6 regulates TCR signaling via interaction with and modification of LAT adapter.

PubMed ID: 23514740

DOI: 10.4049/jimmunol.1202742

PubMed ID: 24586164

Title: Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.

PubMed ID: 24586164

DOI: 10.1371/journal.ppat.1003960

PubMed ID: 25026888

Title: LRRC19 expressed in the kidney induces TRAF2/6-mediated signals to prevent infection by uropathogenic bacteria.

PubMed ID: 25026888

DOI: 10.1038/ncomms5434

PubMed ID: 25907557

Title: The Us3 Protein of Herpes Simplex Virus 1 Inhibits T Cell Signaling by Confining Linker for Activation of T Cells (LAT) Activation via TRAF6 Protein.

PubMed ID: 25907557

DOI: 10.1074/jbc.m115.646422

PubMed ID: 25736436

Title: WDFY1 mediates TLR3/4 signaling by recruiting TRIF.

PubMed ID: 25736436

DOI: 10.15252/embr.201439637

PubMed ID: 25861989

Title: TRAF family member-associated NF-kappaB activator (TANK) inhibits genotoxic nuclear factor kappaB activation by facilitating deubiquitinase USP10-dependent deubiquitination of TRAF6 ligase.

PubMed ID: 25861989

DOI: 10.1074/jbc.m115.643767

PubMed ID: 28087809

Title: Trim13 potentiates toll-like receptor 2-mediated nuclear factor kappaB activation via K29-linked polyubiquitination of tumor necrosis factor receptor-associated factor 6.

PubMed ID: 28087809

DOI: 10.1124/mol.116.106716

PubMed ID: 31620128

Title: CRBN Is a Negative Regulator of Bactericidal Activity and Autophagy Activation Through Inhibiting the Ubiquitination of ECSIT and BECN1.

PubMed ID: 31620128

DOI: 10.3389/fimmu.2019.02203

PubMed ID: 12140561

Title: Distinct molecular mechanism for initiating TRAF6 signalling.

PubMed ID: 12140561

DOI: 10.1038/nature00888

PubMed ID: 17327397

Title: Structure, interactions, and dynamics of the RING domain from human TRAF6.

PubMed ID: 17327397

DOI: 10.1110/ps.062358007

PubMed ID: 19465916

Title: E2 interaction and dimerization in the crystal structure of TRAF6.

PubMed ID: 19465916

DOI: 10.1038/nsmb.1605

Sequence Information:

Length: 522
Mass: 59573
Checksum: 5AB9C255CCFEE749
Sequence:

MSLLNCENSC GSSQSESDCC VAMASSCSAV TKDDSVGGTA STGNLSSSFM EEIQGYDVEF 
DPPLESKYEC PICLMALREA VQTPCGHRFC KACIIKSIRD AGHKCPVDNE ILLENQLFPD 
NFAKREILSL MVKCPNEGCL HKMELRHLED HQAHCEFALM DCPQCQRPFQ KFHINIHILK 
DCPRRQVSCD NCAASMAFED KEIHDQNCPL ANVICEYCNT ILIREQMPNH YDLDCPTAPI 
PCTFSTFGCH EKMQRNHLAR HLQENTQSHM RMLAQAVHSL SVIPDSGYIS EVRNFQETIH 
QLEGRLVRQD HQIRELTAKM ETQSMYVSEL KRTIRTLEDK VAEIEAQQCN GIYIWKIGNF 
GMHLKCQEEE KPVVIHSPGF YTGKPGYKLC MRLHLQLPTA QRCANYISLF VHTMQGEYDS 
HLPWPFQGTI RLTILDQSEA PVRQNHEEIM DAKPELLAFQ RPTIPRNPKG FGYVTFMHLE 
ALRQRTFIKD DTLLVRCEVS TRFDMGSLRR EGFQPRSTDA GV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TRAF6

Associated with

Cells (max top 100)

Other Information

TRAF6 is a signal transducer for interleukin-1. PubMed ID: 8837778

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1. PubMed ID: 9020361

IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. PubMed ID: 9374458

RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase. PubMed ID: 9642260

The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor. PubMed ID: 9774460

Tumor necrosis factor receptor-associated factor 6 (TRAF6) stimulates extracellular signal-regulated kinase (ERK) activity in CD40 signaling along a ras-independent pathway. PubMed ID: 9432981

ASK1 is essential for JNK/SAPK activation by TRAF2. PubMed ID: 9774977

Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain. PubMed ID: 10346818

Association of the p75 neurotrophin receptor with TRAF6. PubMed ID: 9915784

IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. PubMed ID: 10383454

TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction. PubMed ID: 10514511

TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src. PubMed ID: 10635328

The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway. PubMed ID: 10094049

Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1). PubMed ID: 10523862

Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. PubMed ID: 11057907

TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation. PubMed ID: 10764746

B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1. PubMed ID: 10908663

T6BP, a TRAF6-interacting protein involved in IL-1 signaling. PubMed ID: 10920205

TAK1 is a ubiquitin-dependent kinase of MKK and IKK. PubMed ID: 11460167

NF-kappaB activator Act1 associates with IL-1/Toll pathway adapter molecule TRAF6. PubMed ID: 12459498

A novel zinc finger protein that inhibits osteoclastogenesis and the function of tumor necrosis factor receptor-associated factor 6. PubMed ID: 11751921

IRAK4: a novel member of the IRAK family with the properties of an IRAK-kinase. PubMed ID: 11960013

Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex. PubMed ID: 12496252

Pellino2 activates the mitogen activated protein kinase pathway. PubMed ID: 12804775

TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. PubMed ID: 12721283

Pellino3, a novel member of the Pellino protein family, promotes activation of c-Jun and Elk-1 and may act as a scaffolding protein. PubMed ID: 12874243

Toll/IL-1 receptor domain-containing adapter inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling. PubMed ID: 14530355

Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways. PubMed ID: 14739303

ZNF216 is an A20-like and IkappaB kinase gamma-interacting inhibitor of NFkappaB activation. PubMed ID: 14754897

TRAF family proteins link PKR with NF-kappa B activation. PubMed ID: 15121867

Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta. PubMed ID: 14982987

Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. PubMed ID: 16125763

IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST 2 and induces T helper type 2-associated cytokines. PubMed ID: 16286016

FLN29, a novel interferon- and LPS-inducible gene acting as a negative regulator of toll-like receptor signaling. PubMed ID: 16221674

VISA is an adapter protein required for virus-triggered IFN-beta Signaling. PubMed ID: 16153868

The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex. PubMed ID: 15870274

Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling. PubMed ID: 16378096

Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adapter Pellino-1. PubMed ID: 16951688

Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation. PubMed ID: 17135271

RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation. PubMed ID: 17449468

Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling. PubMed ID: 17703191

Nuclear tumor necrosis factor receptor-associated factor 6 in lymphoid cells negatively regulates c-Myb-mediated transactivation through small ubiquitin-related modifier-1 modification. PubMed ID: 18093978

Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation. PubMed ID: 18347055

The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner. PubMed ID: 18758450

WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4-induced NF-kappaB activation pathway. PubMed ID: 19521662

Direct activation of protein kinases by unanchored polyubiquitin chains. PubMed ID: 19675569

The E3 ligase TRAF6 regulates Akt ubiquitination and activation. PubMed ID: 19713527

Act1, a U-box E3 ubiquitin ligase for IL-17 signaling. PubMed ID: 19825828

NUMBL interacts with TRAF6 and promotes the degradation of TRAF6. PubMed ID: 20079715

Tom70 mediates activation of interferon regulatory factor 3 on mitochondria. PubMed ID: 20628368

Alternative splicing of CARMA2/CARD14 transcripts generates protein variants with differential effect on NF-kappaB activation and endoplasmic reticulum stress-induced cell death. PubMed ID: 21302310

IFN-induced TPR protein IFIT3 potentiates antiviral signaling by bridging MAVS and TBK1. PubMed ID: 21813773

SASH1 is a scaffold molecule in endothelial TLR4 signaling. PubMed ID: 23776175

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6. PubMed ID: 23524951

TNFR-associated factor 6 regulates TCR signaling via interaction with and modification of LAT adapter. PubMed ID: 23514740

Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling. PubMed ID: 24586164

LRRC19 expressed in the kidney induces TRAF2/6-mediated signals to prevent infection by uropathogenic bacteria. PubMed ID: 25026888

The Us3 Protein of Herpes Simplex Virus 1 Inhibits T Cell Signaling by Confining Linker for Activation of T Cells (LAT) Activation via TRAF6 Protein. PubMed ID: 25907557

WDFY1 mediates TLR3/4 signaling by recruiting TRIF. PubMed ID: 25736436

TRAF family member-associated NF-kappaB activator (TANK) inhibits genotoxic nuclear factor kappaB activation by facilitating deubiquitinase USP10-dependent deubiquitination of TRAF6 ligase. PubMed ID: 25861989

Trim13 potentiates toll-like receptor 2-mediated nuclear factor kappaB activation via K29-linked polyubiquitination of tumor necrosis factor receptor-associated factor 6. PubMed ID: 28087809

CRBN Is a Negative Regulator of Bactericidal Activity and Autophagy Activation Through Inhibiting the Ubiquitination of ECSIT and BECN1. PubMed ID: 31620128

Distinct molecular mechanism for initiating TRAF6 signalling. PubMed ID: 12140561

Structure, interactions, and dynamics of the RING domain from human TRAF6. PubMed ID: 17327397

E2 interaction and dimerization in the crystal structure of TRAF6. PubMed ID: 19465916