Details for: TRPC1

Gene ID: 7220

Symbol: TRPC1

Ensembl ID: ENSG00000144935

Description: transient receptor potential cation channel subfamily C member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 312.3529
    Cell Significance Index: -48.5900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 193.4606
    Cell Significance Index: -49.0700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 98.1525
    Cell Significance Index: -46.3400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 94.0907
    Cell Significance Index: -38.2300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 40.1050
    Cell Significance Index: -38.2900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 39.4824
    Cell Significance Index: -48.6800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.4454
    Cell Significance Index: -49.1100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.4007
    Cell Significance Index: -27.1400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.5953
    Cell Significance Index: 520.6200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.3036
    Cell Significance Index: 44.9600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.2484
    Cell Significance Index: 806.4500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.9603
    Cell Significance Index: 110.0000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.8340
    Cell Significance Index: 140.7400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.4723
    Cell Significance Index: 35.3100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.3632
    Cell Significance Index: 29.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2873
    Cell Significance Index: 255.4700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.2185
    Cell Significance Index: 74.8900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.0755
    Cell Significance Index: 743.8500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.0484
    Cell Significance Index: 39.7000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.0028
    Cell Significance Index: 67.4300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.9873
    Cell Significance Index: 43.6700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.9472
    Cell Significance Index: 27.0300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5867
    Cell Significance Index: 36.9800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5606
    Cell Significance Index: 106.6900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3818
    Cell Significance Index: 718.9000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.3816
    Cell Significance Index: 5.4800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.3780
    Cell Significance Index: 240.0900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3414
    Cell Significance Index: 5.8500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2559
    Cell Significance Index: 116.1600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1698
    Cell Significance Index: 153.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1534
    Cell Significance Index: 236.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1276
    Cell Significance Index: 235.3400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1218
    Cell Significance Index: 3.2600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0408
    Cell Significance Index: 55.4100
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.0355
    Cell Significance Index: 0.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0315
    Cell Significance Index: 5.6700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0030
    Cell Significance Index: -0.4300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0034
    Cell Significance Index: -0.5400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0188
    Cell Significance Index: -1.8600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0234
    Cell Significance Index: -0.2900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0235
    Cell Significance Index: -10.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0256
    Cell Significance Index: -0.9000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0475
    Cell Significance Index: -25.9400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0480
    Cell Significance Index: -1.2000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0488
    Cell Significance Index: -36.1200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0532
    Cell Significance Index: -0.7900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0544
    Cell Significance Index: -7.4700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0559
    Cell Significance Index: -41.0200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0684
    Cell Significance Index: -1.9700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0703
    Cell Significance Index: -53.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0753
    Cell Significance Index: -42.4900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0835
    Cell Significance Index: -52.1600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0990
    Cell Significance Index: -10.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1391
    Cell Significance Index: -40.0300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1413
    Cell Significance Index: -18.1200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1427
    Cell Significance Index: -1.7800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2229
    Cell Significance Index: -10.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2249
    Cell Significance Index: -27.6500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2358
    Cell Significance Index: -24.5500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2392
    Cell Significance Index: -50.3900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2458
    Cell Significance Index: -15.0700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2655
    Cell Significance Index: -15.9400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2740
    Cell Significance Index: -5.5000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2829
    Cell Significance Index: -48.3000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3223
    Cell Significance Index: -22.2900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3364
    Cell Significance Index: -7.1400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3535
    Cell Significance Index: -45.6700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3605
    Cell Significance Index: -7.8100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3652
    Cell Significance Index: -42.5600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3818
    Cell Significance Index: -7.9200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3890
    Cell Significance Index: -4.9100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3906
    Cell Significance Index: -39.9000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3998
    Cell Significance Index: -12.8100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4081
    Cell Significance Index: -48.1300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4144
    Cell Significance Index: -5.9600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4198
    Cell Significance Index: -8.3000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4309
    Cell Significance Index: -49.3700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4716
    Cell Significance Index: -15.4400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4860
    Cell Significance Index: -15.4800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5458
    Cell Significance Index: -43.2300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5638
    Cell Significance Index: -29.3700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5970
    Cell Significance Index: -42.2200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.6167
    Cell Significance Index: -45.9600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6232
    Cell Significance Index: -32.7200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6566
    Cell Significance Index: -18.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.7269
    Cell Significance Index: -37.7600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.7358
    Cell Significance Index: -47.4700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.7366
    Cell Significance Index: -15.7500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.7676
    Cell Significance Index: -9.1500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.8242
    Cell Significance Index: -38.7400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.8424
    Cell Significance Index: -18.2000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8920
    Cell Significance Index: -31.2500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.8960
    Cell Significance Index: -23.5600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.9012
    Cell Significance Index: -22.4800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.9210
    Cell Significance Index: -15.9300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.9566
    Cell Significance Index: -11.1600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.9583
    Cell Significance Index: -44.6800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.9692
    Cell Significance Index: -12.4300
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.9869
    Cell Significance Index: -13.8000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.0422
    Cell Significance Index: -26.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Ion Channel Function:** TRPC1 is a non-selective cation channel that allows the influx of multiple cations, including calcium, magnesium, and sodium, into cells. 2. **Cellular Localization:** TRPC1 is expressed in various tissues, including the nervous system, immune cells, and cardiac muscle cells. 3. **Regulation:** TRPC1 is regulated by a complex interplay of signaling pathways, including the activation of second messengers, calcium ion transport, and protein binding. 4. **Expression:** TRPC1 is highly expressed in cells involved in immune response, development, and disease, including pigmented epithelial cells, cardiac myocytes, and inhibitory interneurons. **Pathways and Functions:** 1. **Adaptive Immune System:** TRPC1 plays a critical role in the activation of B cells and the generation of second messengers, which are essential for the adaptive immune response. 2. **Developmental Biology:** TRPC1 is involved in the regulation of cardiac conduction, muscle contraction, and axon guidance, highlighting its importance in developmental processes. 3. **Ion Homeostasis:** TRPC1 helps maintain calcium ion homeostasis, which is essential for various cellular processes, including muscle contraction, neurotransmission, and cell growth. 4. **Signaling Pathways:** TRPC1 is involved in the regulation of various signaling pathways, including the activation of protein kinase C, phospholipase C, and calcineurin. **Clinical Significance:** 1. **Cardiac Disease:** TRPC1 has been implicated in the development of cardiac arrhythmias, hypertension, and heart failure, highlighting its importance in cardiac function. 2. **Immune System Disorders:** TRPC1 has been associated with autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, suggesting its role in immune system regulation. 3. **Neurological Disorders:** TRPC1 has been linked to neurological disorders, including epilepsy, Parkinson's disease, and Alzheimer's disease, underscoring its importance in neuronal function and development. 4. **Cancer:** TRPC1 has been implicated in cancer progression, with its expression and activity contributing to tumor growth, invasion, and metastasis. In conclusion, TRPC1 is a multifunctional gene that plays a critical role in various cellular processes, including immune response, development, and disease. Its dysregulation has been implicated in various human diseases, highlighting the need for further research into the mechanisms underlying TRPC1's functions and the development of therapeutic strategies targeting this gene.

Genular Protein ID: 1521013310

Symbol: TRPC1_HUMAN

Name: Short transient receptor potential channel 1

UniProtKB Accession Codes:

P48995 Q14CE4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChEMBL 3 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 4 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7589464

Title: Molecular cloning of a widely expressed human homologue for the Drosophila trp gene.

PubMed ID: 7589464

DOI: 10.1016/0014-5793(95)01038-g

PubMed ID: 7568191

Title: TRPC1, a human homolog of a Drosophila store-operated channel.

PubMed ID: 7568191

DOI: 10.1073/pnas.92.21.9652

PubMed ID: 8663995

Title: Cloning and functional expression of a human Ca2+-permeable cation channel activated by calcium store depletion.

PubMed ID: 8663995

DOI: 10.1016/s0896-6273(00)80145-2

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9215637

Title: Coassembly of TRP and TRPL produces a distinct store-operated conductance.

PubMed ID: 9215637

DOI: 10.1016/s0092-8674(00)80302-5

PubMed ID: 10766822

Title: Assembly of Trp1 in a signaling complex associated with caveolin-scaffolding lipid raft domains.

PubMed ID: 10766822

DOI: 10.1074/jbc.275.16.11934

PubMed ID: 11139478

Title: TrpC1 is a membrane-spanning subunit of store-operated Ca(2+) channels in native vascular smooth muscle cells.

PubMed ID: 11139478

DOI: 10.1161/01.res.88.1.84

PubMed ID: 12032305

Title: Subunit composition of mammalian transient receptor potential channels in living cells.

PubMed ID: 12032305

DOI: 10.1073/pnas.102596199

PubMed ID: 15016832

Title: Protein kinase Calpha phosphorylates the TRPC1 channel and regulates store-operated Ca2+ entry in endothelial cells.

PubMed ID: 15016832

DOI: 10.1074/jbc.m313975200

PubMed ID: 15757897

Title: MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC.

PubMed ID: 15757897

DOI: 10.1074/jbc.m500391200

PubMed ID: 17850865

Title: RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC.

PubMed ID: 17850865

DOI: 10.1016/j.ceca.2007.07.009

PubMed ID: 19945390

Title: Peptidyl-prolyl isomerase FKBP52 controls chemotropic guidance of neuronal growth cones via regulation of TRPC1 channel opening.

PubMed ID: 19945390

DOI: 10.1016/j.neuron.2009.09.025

Sequence Information:

  • Length: 793
  • Mass: 91212
  • Checksum: F4CC57ADDFA320AE
  • Sequence:
    • MMAALYPSTD LSGASSSSLP SSPSSSSPNE VMALKDVREV KEENTLNEKL FLLACDKGDY 
YMVKKILEEN SSGDLNINCV DVLGRNAVTI TIENENLDIL QLLLDYGCQS ADALLVAIDS 
EVVGAVDILL NHRPKRSSRP TIVKLMERIQ NPEYSTTMDV APVILAAHRN NYEILTMLLK 
QDVSLPKPHA VGCECTLCSA KNKKDSLRHS RFRLDIYRCL ASPALIMLTE EDPILRAFEL 
SADLKELSLV EVEFRNDYEE LARQCKMFAK DLLAQARNSR ELEVILNHTS SDEPLDKRGL 
LEERMNLSRL KLAIKYNQKE FVSQSNCQQF LNTVWFGQMS GYRRKPTCKK IMTVLTVGIF 
WPVLSLCYLI APKSQFGRII HTPFMKFIIH GASYFTFLLL LNLYSLVYNE DKKNTMGPAL 
ERIDYLLILW IIGMIWSDIK RLWYEGLEDF LEESRNQLSF VMNSLYLATF ALKVVAHNKF 
HDFADRKDWD AFHPTLVAEG LFAFANVLSY LRLFFMYTTS SILGPLQISM GQMLQDFGKF 
LGMFLLVLFS FTIGLTQLYD KGYTSKEQKD CVGIFCEQQS NDTFHSFIGT CFALFWYIFS 
LAHVAIFVTR FSYGEELQSF VGAVIVGTYN VVVVIVLTKL LVAMLHKSFQ LIANHEDKEW 
KFARAKLWLS YFDDKCTLPP PFNIIPSPKT ICYMISSLSK WICSHTSKGK VKRQNSLKEW 
RNLKQKRDEN YQKVMCCLVH RYLTSMRQKM QSTDQATVEN LNELRQDLSK FRNEIRDLLG 
FRTSKYAMFY PRN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.