Details for: TRPC3

Gene ID: 7222

Symbol: TRPC3

Ensembl ID: ENSG00000138741

Description: transient receptor potential cation channel subfamily C member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 17.8212
    Cell Significance Index: -7.2400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 9.2517
    Cell Significance Index: 202.5800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.1358
    Cell Significance Index: 134.6100
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.3481
    Cell Significance Index: 14.6300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.0192
    Cell Significance Index: 12.1500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.4587
    Cell Significance Index: 9.8100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.2157
    Cell Significance Index: 2.6900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1963
    Cell Significance Index: 70.4000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1892
    Cell Significance Index: 130.8500
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: 0.1226
    Cell Significance Index: 0.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0981
    Cell Significance Index: 19.6700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0849
    Cell Significance Index: 5.2200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0842
    Cell Significance Index: 4.7300
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.0388
    Cell Significance Index: 0.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0222
    Cell Significance Index: 10.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0145
    Cell Significance Index: 22.3500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: 0.0135
    Cell Significance Index: 0.1700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0108
    Cell Significance Index: 0.2600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0086
    Cell Significance Index: 5.4900
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.0067
    Cell Significance Index: 0.0700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.0014
    Cell Significance Index: 0.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0030
    Cell Significance Index: -5.5800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0034
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0034
    Cell Significance Index: -6.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0058
    Cell Significance Index: -7.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0117
    Cell Significance Index: -8.6700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0117
    Cell Significance Index: -8.8300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0136
    Cell Significance Index: -2.2200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0145
    Cell Significance Index: -7.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0150
    Cell Significance Index: -8.4500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0176
    Cell Significance Index: -2.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0204
    Cell Significance Index: -5.8600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0250
    Cell Significance Index: -0.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0300
    Cell Significance Index: -1.3600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0338
    Cell Significance Index: -6.1000
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0347
    Cell Significance Index: -0.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0362
    Cell Significance Index: -5.2600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0364
    Cell Significance Index: -7.2200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0391
    Cell Significance Index: -3.9900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0418
    Cell Significance Index: -8.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0434
    Cell Significance Index: -7.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0496
    Cell Significance Index: -6.8100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0517
    Cell Significance Index: -0.7400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0526
    Cell Significance Index: -1.4700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0552
    Cell Significance Index: -6.7900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0582
    Cell Significance Index: -1.4100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0612
    Cell Significance Index: -6.3700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0660
    Cell Significance Index: -1.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0747
    Cell Significance Index: -8.5600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0747
    Cell Significance Index: -8.8100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0781
    Cell Significance Index: -1.6300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0834
    Cell Significance Index: -2.0800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0866
    Cell Significance Index: -2.1600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0873
    Cell Significance Index: -2.7800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0895
    Cell Significance Index: -1.9000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0961
    Cell Significance Index: -2.4700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1002
    Cell Significance Index: -0.9500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1024
    Cell Significance Index: -6.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1026
    Cell Significance Index: -7.8700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1106
    Cell Significance Index: -3.6200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1151
    Cell Significance Index: -3.6900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1215
    Cell Significance Index: -8.1700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1285
    Cell Significance Index: -7.8800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1300
    Cell Significance Index: -2.1800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1327
    Cell Significance Index: -6.9700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1341
    Cell Significance Index: -3.6500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1348
    Cell Significance Index: -7.0200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1389
    Cell Significance Index: -1.6200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1529
    Cell Significance Index: -3.2000
  • Cell Name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex (CL4023043)
    Fold Change: -0.1534
    Cell Significance Index: -1.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1597
    Cell Significance Index: -7.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1765
    Cell Significance Index: -8.2300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1840
    Cell Significance Index: -2.2000
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.1857
    Cell Significance Index: -1.3500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1865
    Cell Significance Index: -8.2500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1928
    Cell Significance Index: -5.5600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1938
    Cell Significance Index: -6.7900
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.1955
    Cell Significance Index: -2.4400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2032
    Cell Significance Index: -7.0600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2034
    Cell Significance Index: -2.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2100
    Cell Significance Index: -7.3800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2115
    Cell Significance Index: -8.0100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2171
    Cell Significance Index: -7.9700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2235
    Cell Significance Index: -3.8300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.2359
    Cell Significance Index: -2.8700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2376
    Cell Significance Index: -1.6100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2434
    Cell Significance Index: -7.1700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2460
    Cell Significance Index: -4.8100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2467
    Cell Significance Index: -7.0400
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.2510
    Cell Significance Index: -3.5700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2532
    Cell Significance Index: -6.7900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2533
    Cell Significance Index: -8.0100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2570
    Cell Significance Index: -2.9200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2588
    Cell Significance Index: -7.4200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2673
    Cell Significance Index: -4.2400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2784
    Cell Significance Index: -8.1800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2797
    Cell Significance Index: -3.5300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2799
    Cell Significance Index: -5.6200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2873
    Cell Significance Index: -3.1300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2918
    Cell Significance Index: -5.7700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The TRPC3 channel is a non-selective cation channel, meaning it allows the passage of multiple types of positively charged ions, including calcium, sodium, and magnesium, into the cell. This channel is activated by a variety of stimuli, including increases in intracellular calcium concentrations, ATP, and certain neurotransmitters. The TRPC3 channel is also sensitive to pH changes, allowing it to regulate calcium influx in response to changes in the extracellular environment. In terms of its structure, the TRPC3 channel is a tetrameric complex composed of four subunits, each consisting of six transmembrane segments. **Pathways and Functions** The TRPC3 channel is involved in various signaling pathways, including: 1. **Calcium signaling**: The TRPC3 channel plays a critical role in regulating calcium influx into cells, which is essential for various cellular processes, including muscle contraction, neurotransmitter release, and cell proliferation. 2. **Neural function**: The TRPC3 channel is expressed in neurons and is involved in the regulation of neural excitability and synaptic transmission. 3. **Developmental biology**: The TRPC3 channel is expressed in embryonic tissues and is involved in the regulation of cell migration, differentiation, and patterning. 4. **Cardiac function**: The TRPC3 channel is expressed in cardiac muscle cells and is involved in the regulation of cardiac hypertrophy and fibrosis in response to stress. 5. **Inflammatory responses**: The TRPC3 channel is involved in the regulation of inflammatory responses, including platelet activation and aggregation. **Clinical Significance** Dysregulation of the TRPC3 channel has been implicated in various diseases, including: 1. **Cardiovascular disease**: Altered expression and function of the TRPC3 channel have been linked to cardiac hypertrophy, fibrosis, and arrhythmias. 2. **Neurological disorders**: Dysregulation of the TRPC3 channel has been implicated in various neurological disorders, including epilepsy, migraine, and Alzheimer's disease. 3. **Cancer**: The TRPC3 channel is involved in the regulation of cell proliferation and survival, and its dysregulation has been linked to cancer progression. 4. **Inflammatory disorders**: The TRPC3 channel is involved in the regulation of inflammatory responses, and its dysregulation has been linked to various inflammatory disorders, including arthritis and asthma. In conclusion, the TRPC3 gene plays a critical role in regulating various physiological processes, including calcium signaling, neural function, and developmental biology. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the function and regulation of this gene.

Genular Protein ID: 3861996531

Symbol: TRPC3_HUMAN

Name: Short transient receptor potential channel 3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8646775

Title: trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry.

PubMed ID: 8646775

DOI: 10.1016/s0092-8674(00)81233-7

PubMed ID: 9215637

Title: Coassembly of TRP and TRPL produces a distinct store-operated conductance.

PubMed ID: 9215637

DOI: 10.1016/s0092-8674(00)80302-5

PubMed ID: 15728370

Title: Molecular cloning of TRPC3a, an N-terminally extended, store-operated variant of the human C3 transient receptor potential channel.

PubMed ID: 15728370

DOI: 10.1073/pnas.0409908102

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7568191

Title: TRPC1, a human homolog of a Drosophila store-operated channel.

PubMed ID: 7568191

DOI: 10.1073/pnas.92.21.9652

PubMed ID: 9535843

Title: The membrane topology of human transient receptor potential 3 as inferred from glycosylation-scanning mutagenesis and epitope immunocytochemistry.

PubMed ID: 9535843

DOI: 10.1074/jbc.273.15.8675

PubMed ID: 9417057

Title: Receptor-activated Ca2+ influx via human Trp3 stably expressed in human embryonic kidney (HEK)293 cells. Evidence for a non-capacitative Ca2+ entry.

PubMed ID: 9417057

DOI: 10.1074/jbc.273.1.133

PubMed ID: 9853757

Title: Functional interaction between InsP3 receptors and store-operated Htrp3 channels.

PubMed ID: 9853757

DOI: 10.1038/24890

PubMed ID: 9930701

Title: Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol.

PubMed ID: 9930701

DOI: 10.1038/16711

PubMed ID: 10611319

Title: Modulation of Ca(2+) entry by polypeptides of the inositol 1,4, 5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): evidence for roles of TRP and IP3R in store depletion-activated Ca(2+) entry.

PubMed ID: 10611319

DOI: 10.1073/pnas.96.26.14955

PubMed ID: 15757897

Title: MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC.

PubMed ID: 15757897

DOI: 10.1074/jbc.m500391200

PubMed ID: 17850865

Title: RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC.

PubMed ID: 17850865

DOI: 10.1016/j.ceca.2007.07.009

PubMed ID: 20095964

Title: S165F mutation of junctophilin 2 affects Ca2+ signalling in skeletal muscle.

PubMed ID: 20095964

DOI: 10.1042/bj20091225

PubMed ID: 17258231

Title: The TRPC3 channel has a large internal chamber surrounded by signal sensing antennas.

PubMed ID: 17258231

DOI: 10.1016/j.jmb.2006.12.043

PubMed ID: 29700422

Title: Structure of the receptor-activated human TRPC6 and TRPC3 ion channels.

PubMed ID: 29700422

DOI: 10.1038/s41422-018-0038-2

PubMed ID: 30139744

Title: Structure-function analyses of the ion channel TRPC3 reveal that its cytoplasmic domain allosterically modulates channel gating.

PubMed ID: 30139744

DOI: 10.1074/jbc.ra118.005066

PubMed ID: 29726814

Title: Structure of the human lipid-gated cation channel TRPC3.

PubMed ID: 29726814

DOI: 10.7554/elife.36852

PubMed ID: 35051376

Title: Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites.

PubMed ID: 35051376

DOI: 10.1016/j.neuron.2021.12.023

PubMed ID: 25477146

Title: Do mutations in the murine ataxia gene TRPC3 cause cerebellar ataxia in humans?

PubMed ID: 25477146

DOI: 10.1002/mds.26096

Sequence Information:

  • Length: 921
  • Mass: 105538
  • Checksum: 8D7E0D144EF4BE51
  • Sequence:
  • MSTKVRKCKE QARVTFPAPE EEEDEGEDEG AEPQRRRRGW RGVNGGLEPR SAPSQREPHG 
    YCPPPFSHGP DLSMEGSPSL RRMTVMREKG RRQAVRGPAF MFNDRGTSLT AEEERFLDAA 
    EYGNIPVVRK MLEESKTLNV NCVDYMGQNA LQLAVGNEHL EVTELLLKKE NLARIGDALL 
    LAISKGYVRI VEAILNHPGF AASKRLTLSP CEQELQDDDF YAYDEDGTRF SPDITPIILA 
    AHCQKYEVVH MLLMKGARIE RPHDYFCKCG DCMEKQRHDS FSHSRSRINA YKGLASPAYL 
    SLSSEDPVLT ALELSNELAK LANIEKEFKN DYRKLSMQCK DFVVGVLDLC RDSEEVEAIL 
    NGDLESAEPL EVHRHKASLS RVKLAIKYEV KKFVAHPNCQ QQLLTIWYEN LSGLREQTIA 
    IKCLVVLVVA LGLPFLAIGY WIAPCSRLGK ILRSPFMKFV AHAASFIIFL GLLVFNASDR 
    FEGITTLPNI TVTDYPKQIF RVKTTQFTWT EMLIMVWVLG MMWSECKELW LEGPREYILQ 
    LWNVLDFGML SIFIAAFTAR FLAFLQATKA QQYVDSYVQE SDLSEVTLPP EIQYFTYARD 
    KWLPSDPQII SEGLYAIAVV LSFSRIAYIL PANESFGPLQ ISLGRTVKDI FKFMVLFIMV 
    FFAFMIGMFI LYSYYLGAKV NAAFTTVEES FKTLFWSIFG LSEVTSVVLK YDHKFIENIG 
    YVLYGIYNVT MVVVLLNMLI AMINSSYQEI EDDSDVEWKF ARSKLWLSYF DDGKTLPPPF 
    SLVPSPKSFV YFIMRIVNFP KCRRRRLQKD IEMGMGNSKS RLNLFTQSNS RVFESHSFNS 
    ILNQPTRYQQ IMKRLIKRYV LKAQVDKEND EVNEGELKEI KQDISSLRYE LLEDKSQATE 
    ELAILIHKLS EKLNPSMLRC E

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.