Details for: TRPC3
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 17.8212
Cell Significance Index: -7.2400 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 9.2517
Cell Significance Index: 202.5800 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 2.1358
Cell Significance Index: 134.6100 - Cell Name: neuronal brush cell (CL0000555)
Fold Change: 1.3481
Cell Significance Index: 14.6300 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 1.0192
Cell Significance Index: 12.1500 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.4587
Cell Significance Index: 9.8100 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: 0.2157
Cell Significance Index: 2.6900 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1963
Cell Significance Index: 70.4000 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1892
Cell Significance Index: 130.8500 - Cell Name: chandelier cell (CL4023083)
Fold Change: 0.1226
Cell Significance Index: 0.9900 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0981
Cell Significance Index: 19.6700 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0849
Cell Significance Index: 5.2200 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.0842
Cell Significance Index: 4.7300 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.0388
Cell Significance Index: 0.3200 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0222
Cell Significance Index: 10.0800 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0145
Cell Significance Index: 22.3500 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: 0.0135
Cell Significance Index: 0.1700 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.0108
Cell Significance Index: 0.2600 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0086
Cell Significance Index: 5.4900 - Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: 0.0067
Cell Significance Index: 0.0700 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.0014
Cell Significance Index: 0.0300 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0030
Cell Significance Index: -5.5800 - Cell Name: radial glial cell (CL0000681)
Fold Change: -0.0034
Cell Significance Index: -0.0200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0034
Cell Significance Index: -6.3400 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0058
Cell Significance Index: -7.8600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0117
Cell Significance Index: -8.6700 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0117
Cell Significance Index: -8.8300 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.0136
Cell Significance Index: -2.2200 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0145
Cell Significance Index: -7.9300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0150
Cell Significance Index: -8.4500 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0176
Cell Significance Index: -2.2600 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0204
Cell Significance Index: -5.8600 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.0250
Cell Significance Index: -0.3800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0300
Cell Significance Index: -1.3600 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0338
Cell Significance Index: -6.1000 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: -0.0347
Cell Significance Index: -0.4500 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0362
Cell Significance Index: -5.2600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0364
Cell Significance Index: -7.2200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0391
Cell Significance Index: -3.9900 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0418
Cell Significance Index: -8.8100 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0434
Cell Significance Index: -7.4100 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0496
Cell Significance Index: -6.8100 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0517
Cell Significance Index: -0.7400 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0526
Cell Significance Index: -1.4700 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0552
Cell Significance Index: -6.7900 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0582
Cell Significance Index: -1.4100 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0612
Cell Significance Index: -6.3700 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0660
Cell Significance Index: -1.3700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0747
Cell Significance Index: -8.5600 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0747
Cell Significance Index: -8.8100 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.0781
Cell Significance Index: -1.6300 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0834
Cell Significance Index: -2.0800 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.0866
Cell Significance Index: -2.1600 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0873
Cell Significance Index: -2.7800 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0895
Cell Significance Index: -1.9000 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0961
Cell Significance Index: -2.4700 - Cell Name: neuron (CL0000540)
Fold Change: -0.1002
Cell Significance Index: -0.9500 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.1024
Cell Significance Index: -6.1500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1026
Cell Significance Index: -7.8700 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1106
Cell Significance Index: -3.6200 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1151
Cell Significance Index: -3.6900 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1215
Cell Significance Index: -8.1700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1285
Cell Significance Index: -7.8800 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1300
Cell Significance Index: -2.1800 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1327
Cell Significance Index: -6.9700 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.1341
Cell Significance Index: -3.6500 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1348
Cell Significance Index: -7.0200 - Cell Name: neural cell (CL0002319)
Fold Change: -0.1389
Cell Significance Index: -1.6200 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.1529
Cell Significance Index: -3.2000 - Cell Name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex (CL4023043)
Fold Change: -0.1534
Cell Significance Index: -1.5500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1597
Cell Significance Index: -7.5100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1765
Cell Significance Index: -8.2300 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: -0.1840
Cell Significance Index: -2.2000 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: -0.1857
Cell Significance Index: -1.3500 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1865
Cell Significance Index: -8.2500 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.1928
Cell Significance Index: -5.5600 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1938
Cell Significance Index: -6.7900 - Cell Name: retinal cone cell (CL0000573)
Fold Change: -0.1955
Cell Significance Index: -2.4400 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.2032
Cell Significance Index: -7.0600 - Cell Name: helper T cell (CL0000912)
Fold Change: -0.2034
Cell Significance Index: -2.8900 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.2100
Cell Significance Index: -7.3800 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.2115
Cell Significance Index: -8.0100 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2171
Cell Significance Index: -7.9700 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.2235
Cell Significance Index: -3.8300 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: -0.2359
Cell Significance Index: -2.8700 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.2376
Cell Significance Index: -1.6100 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.2434
Cell Significance Index: -7.1700 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.2460
Cell Significance Index: -4.8100 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.2467
Cell Significance Index: -7.0400 - Cell Name: stromal cell of endometrium (CL0002255)
Fold Change: -0.2510
Cell Significance Index: -3.5700 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.2532
Cell Significance Index: -6.7900 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.2533
Cell Significance Index: -8.0100 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.2570
Cell Significance Index: -2.9200 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.2588
Cell Significance Index: -7.4200 - Cell Name: keratocyte (CL0002363)
Fold Change: -0.2673
Cell Significance Index: -4.2400 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.2784
Cell Significance Index: -8.1800 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.2797
Cell Significance Index: -3.5300 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.2799
Cell Significance Index: -5.6200 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.2873
Cell Significance Index: -3.1300 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.2918
Cell Significance Index: -5.7700
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3861996531
Symbol: TRPC3_HUMAN
Name: Short transient receptor potential channel 3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8646775
Title: trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry.
PubMed ID: 8646775
PubMed ID: 9215637
Title: Coassembly of TRP and TRPL produces a distinct store-operated conductance.
PubMed ID: 9215637
PubMed ID: 15728370
Title: Molecular cloning of TRPC3a, an N-terminally extended, store-operated variant of the human C3 transient receptor potential channel.
PubMed ID: 15728370
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7568191
Title: TRPC1, a human homolog of a Drosophila store-operated channel.
PubMed ID: 7568191
PubMed ID: 9535843
Title: The membrane topology of human transient receptor potential 3 as inferred from glycosylation-scanning mutagenesis and epitope immunocytochemistry.
PubMed ID: 9535843
PubMed ID: 9417057
Title: Receptor-activated Ca2+ influx via human Trp3 stably expressed in human embryonic kidney (HEK)293 cells. Evidence for a non-capacitative Ca2+ entry.
PubMed ID: 9417057
PubMed ID: 9853757
Title: Functional interaction between InsP3 receptors and store-operated Htrp3 channels.
PubMed ID: 9853757
DOI: 10.1038/24890
PubMed ID: 9930701
Title: Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol.
PubMed ID: 9930701
DOI: 10.1038/16711
PubMed ID: 10611319
Title: Modulation of Ca(2+) entry by polypeptides of the inositol 1,4, 5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): evidence for roles of TRP and IP3R in store depletion-activated Ca(2+) entry.
PubMed ID: 10611319
PubMed ID: 15757897
Title: MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC.
PubMed ID: 15757897
PubMed ID: 17850865
Title: RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC.
PubMed ID: 17850865
PubMed ID: 20095964
Title: S165F mutation of junctophilin 2 affects Ca2+ signalling in skeletal muscle.
PubMed ID: 20095964
DOI: 10.1042/bj20091225
PubMed ID: 17258231
Title: The TRPC3 channel has a large internal chamber surrounded by signal sensing antennas.
PubMed ID: 17258231
PubMed ID: 29700422
Title: Structure of the receptor-activated human TRPC6 and TRPC3 ion channels.
PubMed ID: 29700422
PubMed ID: 30139744
Title: Structure-function analyses of the ion channel TRPC3 reveal that its cytoplasmic domain allosterically modulates channel gating.
PubMed ID: 30139744
PubMed ID: 29726814
Title: Structure of the human lipid-gated cation channel TRPC3.
PubMed ID: 29726814
DOI: 10.7554/elife.36852
PubMed ID: 35051376
Title: Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites.
PubMed ID: 35051376
PubMed ID: 25477146
Title: Do mutations in the murine ataxia gene TRPC3 cause cerebellar ataxia in humans?
PubMed ID: 25477146
DOI: 10.1002/mds.26096
Sequence Information:
- Length: 921
- Mass: 105538
- Checksum: 8D7E0D144EF4BE51
- Sequence:
MSTKVRKCKE QARVTFPAPE EEEDEGEDEG AEPQRRRRGW RGVNGGLEPR SAPSQREPHG YCPPPFSHGP DLSMEGSPSL RRMTVMREKG RRQAVRGPAF MFNDRGTSLT AEEERFLDAA EYGNIPVVRK MLEESKTLNV NCVDYMGQNA LQLAVGNEHL EVTELLLKKE NLARIGDALL LAISKGYVRI VEAILNHPGF AASKRLTLSP CEQELQDDDF YAYDEDGTRF SPDITPIILA AHCQKYEVVH MLLMKGARIE RPHDYFCKCG DCMEKQRHDS FSHSRSRINA YKGLASPAYL SLSSEDPVLT ALELSNELAK LANIEKEFKN DYRKLSMQCK DFVVGVLDLC RDSEEVEAIL NGDLESAEPL EVHRHKASLS RVKLAIKYEV KKFVAHPNCQ QQLLTIWYEN LSGLREQTIA IKCLVVLVVA LGLPFLAIGY WIAPCSRLGK ILRSPFMKFV AHAASFIIFL GLLVFNASDR FEGITTLPNI TVTDYPKQIF RVKTTQFTWT EMLIMVWVLG MMWSECKELW LEGPREYILQ LWNVLDFGML SIFIAAFTAR FLAFLQATKA QQYVDSYVQE SDLSEVTLPP EIQYFTYARD KWLPSDPQII SEGLYAIAVV LSFSRIAYIL PANESFGPLQ ISLGRTVKDI FKFMVLFIMV FFAFMIGMFI LYSYYLGAKV NAAFTTVEES FKTLFWSIFG LSEVTSVVLK YDHKFIENIG YVLYGIYNVT MVVVLLNMLI AMINSSYQEI EDDSDVEWKF ARSKLWLSYF DDGKTLPPPF SLVPSPKSFV YFIMRIVNFP KCRRRRLQKD IEMGMGNSKS RLNLFTQSNS RVFESHSFNS ILNQPTRYQQ IMKRLIKRYV LKAQVDKEND EVNEGELKEI KQDISSLRYE LLEDKSQATE ELAILIHKLS EKLNPSMLRC E
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.