Details for: TRPM2

Gene ID: 7226

Symbol: TRPM2

Ensembl ID: ENSG00000142185

Description: transient receptor potential cation channel subfamily M member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 68.8546
    Cell Significance Index: -10.7100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 40.6870
    Cell Significance Index: -10.3200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 22.5789
    Cell Significance Index: -10.6600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.6905
    Cell Significance Index: -10.7200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.6919
    Cell Significance Index: -9.8900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.9935
    Cell Significance Index: 132.4100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.8070
    Cell Significance Index: 106.3000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.4920
    Cell Significance Index: 54.5700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.9967
    Cell Significance Index: -4.3700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.8610
    Cell Significance Index: 24.5700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6751
    Cell Significance Index: 14.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6621
    Cell Significance Index: 237.4800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.5102
    Cell Significance Index: 4.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4721
    Cell Significance Index: 89.8500
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.3373
    Cell Significance Index: 4.5000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3371
    Cell Significance Index: 33.3500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2910
    Cell Significance Index: 262.7400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.2622
    Cell Significance Index: 3.2700
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.2421
    Cell Significance Index: 3.1400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2265
    Cell Significance Index: 14.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2217
    Cell Significance Index: 14.9100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1953
    Cell Significance Index: 3.6100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1607
    Cell Significance Index: 26.1400
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.1381
    Cell Significance Index: 1.1400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1342
    Cell Significance Index: 26.9200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1177
    Cell Significance Index: 3.1600
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.1142
    Cell Significance Index: 1.2600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0917
    Cell Significance Index: 9.9800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0802
    Cell Significance Index: 1.1300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: 0.0689
    Cell Significance Index: 0.8700
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.0535
    Cell Significance Index: 0.4100
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.0439
    Cell Significance Index: 0.4800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0132
    Cell Significance Index: 0.3800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0084
    Cell Significance Index: 0.2100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.0046
    Cell Significance Index: 0.1000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.0030
    Cell Significance Index: 0.0600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0029
    Cell Significance Index: 0.5700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0017
    Cell Significance Index: 0.0600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0026
    Cell Significance Index: -0.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0030
    Cell Significance Index: -5.6900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0041
    Cell Significance Index: -0.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0046
    Cell Significance Index: -8.5300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0047
    Cell Significance Index: -7.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0059
    Cell Significance Index: -3.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0067
    Cell Significance Index: -9.1700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0076
    Cell Significance Index: -0.4700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0090
    Cell Significance Index: -0.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0101
    Cell Significance Index: -0.4600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0114
    Cell Significance Index: -7.2700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0139
    Cell Significance Index: -10.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0145
    Cell Significance Index: -10.7300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0160
    Cell Significance Index: -7.2700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0174
    Cell Significance Index: -9.8300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0178
    Cell Significance Index: -3.2000
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: -0.0211
    Cell Significance Index: -0.1700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0224
    Cell Significance Index: -0.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0268
    Cell Significance Index: -7.7100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0273
    Cell Significance Index: -2.7900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0293
    Cell Significance Index: -4.2600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0293
    Cell Significance Index: -12.9400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0377
    Cell Significance Index: -0.9400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0402
    Cell Significance Index: -1.2800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0428
    Cell Significance Index: -0.8600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0432
    Cell Significance Index: -1.0400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0461
    Cell Significance Index: -0.6600
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0475
    Cell Significance Index: -0.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0520
    Cell Significance Index: -6.3900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0532
    Cell Significance Index: -11.2100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0573
    Cell Significance Index: -7.4000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0576
    Cell Significance Index: -3.4600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0587
    Cell Significance Index: -10.0200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0610
    Cell Significance Index: -3.7400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0623
    Cell Significance Index: -4.6400
  • Cell Name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex (CL4023043)
    Fold Change: -0.0643
    Cell Significance Index: -0.6500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0668
    Cell Significance Index: -9.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0679
    Cell Significance Index: -3.1900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0764
    Cell Significance Index: -2.5000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0767
    Cell Significance Index: -9.0400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0922
    Cell Significance Index: -7.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0929
    Cell Significance Index: -10.6400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0967
    Cell Significance Index: -2.0100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1025
    Cell Significance Index: -10.6800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1147
    Cell Significance Index: -6.0200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1157
    Cell Significance Index: -2.4700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1169
    Cell Significance Index: -2.4400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1178
    Cell Significance Index: -1.5700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1209
    Cell Significance Index: -1.5000
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1285
    Cell Significance Index: -1.5900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1302
    Cell Significance Index: -4.5600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1331
    Cell Significance Index: -1.4500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1365
    Cell Significance Index: -7.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1368
    Cell Significance Index: -6.3800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1385
    Cell Significance Index: -2.9600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1403
    Cell Significance Index: -17.9900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1520
    Cell Significance Index: -2.2900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1526
    Cell Significance Index: -9.6200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1634
    Cell Significance Index: -4.8000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1657
    Cell Significance Index: -4.6300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1707
    Cell Significance Index: -8.8900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1723
    Cell Significance Index: -9.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Non-selective cation channel:** The TRPM2 channel is a non-selective cation channel that allows the influx of multiple cations, including calcium, sodium, and potassium ions. 2. **Calcium-mediated signaling:** The TRPM2 channel is activated by calcium ions, which triggers a signaling cascade that regulates various cellular processes. 3. **Hydrogen peroxide and purine-binding sensitivity:** The TRPM2 channel is also activated by hydrogen peroxide and purine-containing compounds, making it a critical component of cellular response to oxidative stress and inflammatory signals. 4. **Cellular expression:** The TRPM2 gene is expressed in a variety of cell types, including retinal bipolar neurons, microglial cells, and neurons in the cortex and thalamus. **Pathways and Functions:** 1. **Calcium-mediated signaling:** The TRPM2 channel regulates calcium homeostasis by allowing the influx of calcium ions into the cell, which triggers a signaling cascade that regulates various cellular processes. 2. **Immune response:** The TRPM2 channel is involved in the regulation of immune response, particularly in the response to oxidative stress and inflammatory signals. 3. **Neurotransmitter release:** The TRPM2 channel is involved in the regulation of neurotransmitter release, particularly in the context of calcium homeostasis. 4. **Cytoskeleton organization:** The TRPM2 channel regulates actin cytoskeleton organization, which is essential for cellular processes such as cell migration and division. **Clinical Significance:** 1. **Neurological disorders:** The TRPM2 gene has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 2. **Neuropathic pain:** The TRPM2 channel is involved in the regulation of pain perception, and alterations in its function have been linked to neuropathic pain. 3. **Neuroinflammation:** The TRPM2 channel is involved in the regulation of neuroinflammation, and its dysfunction has been linked to neurodegenerative diseases. 4. **Cancer:** The TRPM2 channel is involved in the regulation of cancer cell growth and survival, and its dysfunction has been linked to cancer progression. In conclusion, the TRPM2 gene plays a critical role in calcium signaling and immune response, and its dysfunction has been linked to various neurological and psychiatric disorders. Further research is needed to fully understand the functions of the TRPM2 gene and its implications for human health and disease.

Genular Protein ID: 1441711663

Symbol: TRPM2_HUMAN

Name: Transient receptor potential cation channel subfamily M member 2

UniProtKB Accession Codes:

O94759 D3DSL6 Q5KTC2 Q6J3P5 Q96KN6 Q96Q93

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 10 EMDB 9 Ensembl 3 ExpressionAtlas 1 GO 36 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 2 RefSeq 4 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9806837

Title: Molecular cloning of a novel putative Ca2+ channel protein (TRPC7) highly expressed in brain.

PubMed ID: 9806837

DOI: 10.1006/geno.1998.5551

PubMed ID: 11960981

Title: Activation of the cation channel long transient receptor potential channel 2 (LTRPC2) by hydrogen peroxide. A splice variant reveals a mode of activation independent of ADP-ribose.

PubMed ID: 11960981

DOI: 10.1074/jbc.m112096200

PubMed ID: 12594222

Title: A novel TRPM2 isoform inhibits calcium influx and susceptibility to cell death.

PubMed ID: 12594222

DOI: 10.1074/jbc.m300298200

PubMed ID: 15708008

Title: Characterization of human and mouse TRPM2 genes: identification of a novel N-terminal truncated protein specifically expressed in human striatum.

PubMed ID: 15708008

DOI: 10.1016/j.bbrc.2005.01.086

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 11385575

Title: ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology.

PubMed ID: 11385575

DOI: 10.1038/35079100

PubMed ID: 11509734

Title: Immunocyte Ca2+ influx system mediated by LTRPC2.

PubMed ID: 11509734

DOI: 10.1126/science.1062473

PubMed ID: 11804595

Title: LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death.

PubMed ID: 11804595

DOI: 10.1016/s1097-2765(01)00438-5

PubMed ID: 15561722

Title: Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels.

PubMed ID: 15561722

DOI: 10.1074/jbc.m411446200

PubMed ID: 16601673

Title: TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion.

PubMed ID: 16601673

DOI: 10.1038/sj.emboj.7601083

PubMed ID: 19171771

Title: Four Ca2+ ions activate TRPM2 channels by binding in deep crevices near the pore but intracellularly of the gate.

PubMed ID: 19171771

DOI: 10.1085/jgp.200810109

PubMed ID: 19454650

Title: TRPM2 functions as a lysosomal Ca2+-release channel in beta cells.

PubMed ID: 19454650

DOI: 10.1126/scisignal.2000278

PubMed ID: 20650899

Title: Identification of direct and indirect effectors of the transient receptor potential melastatin 2 (TRPM2) cation channel.

PubMed ID: 20650899

DOI: 10.1074/jbc.m109.066464

PubMed ID: 20660597

Title: State-dependent inhibition of TRPM2 channel by acidic pH.

PubMed ID: 20660597

DOI: 10.1074/jbc.m110.139774

PubMed ID: 22493272

Title: Redox signal-mediated sensitization of transient receptor potential melastatin 2 (TRPM2) to temperature affects macrophage functions.

PubMed ID: 22493272

DOI: 10.1073/pnas.1114193109

PubMed ID: 25562606

Title: TRPM2-mediated intracellular Zn2+ release triggers pancreatic beta-cell death.

PubMed ID: 25562606

DOI: 10.1042/bj20140747

PubMed ID: 25918360

Title: Ruling out pyridine dinucleotides as true TRPM2 channel activators reveals novel direct agonist ADP-ribose-2'-phosphate.

PubMed ID: 25918360

DOI: 10.1085/jgp.201511377

PubMed ID: 25620041

Title: Functional characterisation of a TRPM2 orthologue from the sea anemone Nematostella vectensis in human cells.

PubMed ID: 25620041

DOI: 10.1038/srep08032

PubMed ID: 27383051

Title: The proposed channel-enzyme transient receptor potential melastatin 2 does not possess ADP ribose hydrolase activity.

PubMed ID: 27383051

DOI: 10.7554/elife.17600

PubMed ID: 27068538

Title: Reciprocal regulation of actin cytoskeleton remodelling and cell migration by Ca2+ and Zn2+: role of TRPM2 channels.

PubMed ID: 27068538

DOI: 10.1242/jcs.179796

PubMed ID: 28775320

Title: Modulation of activation and inactivation by Ca2+ and 2-APB in the pore of an archetypal TRPM channel from Nematostella vectensis.

PubMed ID: 28775320

DOI: 10.1038/s41598-017-07652-4

PubMed ID: 29745897

Title: Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation.

PubMed ID: 29745897

DOI: 10.7554/elife.36409

PubMed ID: 30467180

Title: Structures and gating mechanism of human TRPM2.

PubMed ID: 30467180

DOI: 10.1126/science.aav4809

Sequence Information:

  • Length: 1503
  • Mass: 171198
  • Checksum: 02338437501ABFAB
  • Sequence:
    • MEPSALRKAG SEQEEGFEGL PRRVTDLGMV SNLRRSNSSL FKSWRLQCPF GNNDKQESLS 
SWIPENIKKK ECVYFVESSK LSDAGKVVCQ CGYTHEQHLE EATKPHTFQG TQWDPKKHVQ 
EMPTDAFGDI VFTGLSQKVK KYVRVSQDTP SSVIYHLMTQ HWGLDVPNLL ISVTGGAKNF 
NMKPRLKSIF RRGLVKVAQT TGAWIITGGS HTGVMKQVGE AVRDFSLSSS YKEGELITIG 
VATWGTVHRR EGLIHPTGSF PAEYILDEDG QGNLTCLDSN HSHFILVDDG THGQYGVEIP 
LRTRLEKFIS EQTKERGGVA IKIPIVCVVL EGGPGTLHTI DNATTNGTPC VVVEGSGRVA 
DVIAQVANLP VSDITISLIQ QKLSVFFQEM FETFTESRIV EWTKKIQDIV RRRQLLTVFR 
EGKDGQQDVD VAILQALLKA SRSQDHFGHE NWDHQLKLAV AWNRVDIARS EIFMDEWQWK 
PSDLHPTMTA ALISNKPEFV KLFLENGVQL KEFVTWDTLL YLYENLDPSC LFHSKLQKVL 
VEDPERPACA PAAPRLQMHH VAQVLRELLG DFTQPLYPRP RHNDRLRLLL PVPHVKLNVQ 
GVSLRSLYKR SSGHVTFTMD PIRDLLIWAI VQNRRELAGI IWAQSQDCIA AALACSKILK 
ELSKEEEDTD SSEEMLALAE EYEHRAIGVF TECYRKDEER AQKLLTRVSE AWGKTTCLQL 
ALEAKDMKFV SHGGIQAFLT KVWWGQLSVD NGLWRVTLCM LAFPLLLTGL ISFREKRLQD 
VGTPAARARA FFTAPVVVFH LNILSYFAFL CLFAYVLMVD FQPVPSWCEC AIYLWLFSLV 
CEEMRQLFYD PDECGLMKKA ALYFSDFWNK LDVGAILLFV AGLTCRLIPA TLYPGRVILS 
LDFILFCLRL MHIFTISKTL GPKIIIVKRM MKDVFFFLFL LAVWVVSFGV AKQAILIHNE 
RRVDWLFRGA VYHSYLTIFG QIPGYIDGVN FNPEHCSPNG TDPYKPKCPE SDATQQRPAF 
PEWLTVLLLC LYLLFTNILL LNLLIAMFNY TFQQVQEHTD QIWKFQRHDL IEEYHGRPAA 
PPPFILLSHL QLFIKRVVLK TPAKRHKQLK NKLEKNEEAA LLSWEIYLKE NYLQNRQFQQ 
KQRPEQKIED ISNKVDAMVD LLDLDPLKRS GSMEQRLASL EEQVAQTAQA LHWIVRTLRA 
SGFSSEADVP TLASQKAAEE PDAEPGGRKK TEEPGDSYHV NARHLLYPNC PVTRFPVPNE 
KVPWETEFLI YDPPFYTAER KDAAAMDPMG DTLEPLSTIQ YNVVDGLRDR RSFHGPYTVQ 
AGLPLNPMGR TGLRGRGSLS CFGPNHTLYP MVTRWRRNED GAICRKSIKK MLEVLVVKLP 
LSEHWALPGG SREPGEMLPR KLKRILRQEH WPSFENLLKC GMEVYKGYMD DPRNTDNAWI 
ETVAVSVHFQ DQNDVELNRL NSNLHACDSG ASIRWQVVDR RIPLYANHKT LLQKAAAEFG 
AHY

Genular Protein ID: 2072543672

Symbol: B4DVI8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DVI8

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 GO 1 Gene3D 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 RefSeq 3 SMR 1 SUPFAM 1

Citations:

PubMed ID: 18957938

Title: Identification of novel sense and antisense transcription at the TRPM2 locus in cancer.

PubMed ID: 18957938

DOI: 10.1038/cr.2008.296

Sequence Information:

  • Length: 184
  • Mass: 21083
  • Checksum: E13BE61986C6AA10
  • Sequence:
    • MDPMGENPMG RTGLRGRGSL SCFGPNHTLY PMVTRWRRNE DGAICRKSIK KMLEVLVVKL 
PLSEHWALPG GSREPGEMLP RKLKRILRQE HWPSFENLLK CGMEVYKGYM DDPRNTDNAW 
IETVAVSVHF QDQNDVELNR LNSNLHACDS GASIRWQVVD RRIPLYANHK TLLQKAAAEF 
GAHY

Genular Protein ID: 2923392815

Symbol: Q14DR2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q14DR2

Database IDs:

ARBA 11 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 2 IntAct 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 2 RefSeq 2 SAM 2 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1553
  • Mass: 176564
  • Checksum: FCEFDCF73FAD12DF
  • Sequence:
    • MEPSALRKAG SEQEEGFEGL PRRVTDLGMV SNLRRSNSSL FKSWRLQCPF GNNDKQESLS 
SWIPENIKKK ECVYFVESSK LSDAGKVVCQ CGYTHEQHLE EATKPHTFQG TQWDPKKHVQ 
EMPTDAFGDI VFTGLSQKVK KYVRVSQDTP SSVIYHLMTQ HWGLDVPNLL ISVTGGAKNF 
NMKPRLKSIF RRGLVKVAQT TGAWIITGGS HTGVMKQVGE AVRDFSLSSS YKEGELITIG 
VATWGTVHRR EGLIHPTGSF PAEYILDEDG QGNLTCLDSN HSHFILVDDG THGQYGVEIP 
LRTRLEKFIS EQTKERGGVA IKIPIVCVVL EGGPGTLHTI DNATTNGTPC VVVEGSGRVA 
DVIAQVANLP VSDITISLIQ QKLSVFFQEM FETFTESRIV EWTKKIQDIV RRRQLLTVFR 
EGKDGQQDVD VAILQALLKA SRSQDHFGHE NWDHQLKLAV AWNRVDIARS EIFMDEWQWK 
PSDLHPTMTA ALISNKPEFV KLFLENGVQL KEFVTWDTLL YLYENLDPSC LFHSKLQKVL 
VEDPERPACA PAAPRLQMHH VAQVLRELLG DFTQPLYPRP RHNDRLRLLL PVPHVKLNVQ 
GVSLRSLYKR SSGHVTFTMD PIRDLLIWAI VQNRRELAGI IWAQSQDCIA AALACSKILK 
ELSKEEEDTD SSEEMLALAE EYEHRAIGVF TECYRKDEER AQKLLTRVSE AWGKTTCLQL 
ALEAKDMKFV SHGGIQAFLT KVWWGQLSVD NGLWRVTLCM LAFPLLLTGL ISFREKRLQD 
VGTPAARARA FFTAPVVVFH LNILSYFAFL CLFAYVLMVD FQPVPSWCEC AIYLWLFSLV 
CEEMRQLFYD PDECGLMKKA ALYFSDFWNK LDVGAILLFV AGLTCRLIPA TLYPGRVILS 
LDFILFCLRL MHIFTISKTL GPKIIIVKRM MKDVFFFLFL LAVWVVSFGV AKQAILIHNE 
RRVDWLFRGA VYHSYLTIFG QIPGYIDGVN FNPEHCSPNG TDPYKPKCPE SDATQQRPAF 
PEWLTVLLLC LYLLFTNILL LNLLIAMFNY TFQQVQEHTD QIWKFQRHDL IEEYHGRPAA 
PPPFILLSHL QLFIKRVVLK TPAKRHKQLK NKLEKNEEAA LLSWEIYLKE NYLQNRQFQQ 
KQRPEQKIED ISNKAGLELW GSRTSSVCKS RQFLHLTVVE SRGSEKAPVT TLACLQGCLG 
KHGRVDAMVD LLDLDPLKRS GSMEQRLASL EEQVAQTARA LHWIVRTLRA SGFSSEADVP 
TLASQKAAEE PDAEPGGRKK TEEPGDSYHV NARHLLYPNC PVTRFPVPNE KVPWETEFLI 
YDPPFYTAER KDAAAMDPMG DTLEPLSTIQ YNVVDGLRDR RSFHGPYTVQ AGLPLNPMGR 
TGLRGRGSLS CFGPNHTLYP MVTRWRRNED GAICRKSIKK MLEVLVVKLP LSEHWALPGG 
SREPGEMLPR KLKRILRQEH WPSFENLLKC GMEVYKGYMD DPRNTDNAWI ETVAVSVHFQ 
DQNDVELNRL NSNLHACDSG ASIRWQVVDR RIPLYANHKT LLQKAAAEFG AHY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.