Details for: TRPS1
Gene ID: 7227
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: TRPS1
Ensembl ID: ENSG00000104447
Description: transcriptional repressor GATA binding 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 59.21rCSI 81.01%PRS 28.9
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CSI 54.69rCSI 70.22%PRS 28.44
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CSI 40.54rCSI 86.37%PRS 16.73
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CSI 40.4rCSI 81.98%PRS 17.19
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CSI 38.12rCSI 85.47%PRS 19.32
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CSI 33.22rCSI 55.76%PRS 18.7
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CSI 29.46rCSI 36.65%PRS 17.59
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CSI 27.24rCSI 44.61%PRS 23.43
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CSI 24.11rCSI 75.39%PRS 21.29
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CSI 21.51rCSI 53.24%PRS 28.2
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CSI 19.42rCSI 60.68%PRS 19.59
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CSI 19.03rCSI 26.02%PRS 33.71
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CSI 18.75rCSI 48.2%PRS 35.47
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CSI 17.01rCSI 25.99%PRS 37.91
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CSI 15.77rCSI 38.52%PRS 28.47
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CSI 15.77rCSI 32.72%PRS 29.35
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CSI 15.74rCSI 51.24%PRS 34.02
-
CSI 15.63rCSI 28.4%PRS 25.95
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CSI 15.55rCSI 39.45%PRS 23.27
-
CSI 15.41rCSI 18.06%PRS 41.84
-
CSI 15.21rCSI 28.71%PRS 37.83
-
CSI 15.03rCSI 22.68%PRS 30.9
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CSI 15.02rCSI 27.28%PRS 44.27
-
CSI 14.45rCSI 16.69%PRS 26.08
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CSI 14.44rCSI 31.77%PRS 21.62
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CSI 14.31rCSI 34.77%PRS 18.22
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CSI 14.06rCSI 36.66%PRS 28.87
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CSI 13.89rCSI 31.66%PRS 30.03
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CSI 12.32rCSI 15.81%PRS 28.62
-
CSI 12.2rCSI 19.63%PRS 23.22
-
CSI 11.68rCSI 16.92%PRS 43.9
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CSI 11.15rCSI 24.54%PRS 33.63
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CSI 10.25rCSI 23.39%PRS 25.8
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CSI 9.99rCSI 7.5%PRS 32.13
-
CSI 9.78rCSI 6.59%PRS 37.4
-
CSI 9.69rCSI 7.66%PRS 20.93
-
CSI 9.64rCSI 7.79%PRS 41.78
-
CSI 9.49rCSI 53.11%PRS 45.46
-
CSI 9.24rCSI 6.42%PRS 36.16
-
CSI 9.15rCSI 12.96%PRS 27.88
-
CSI 8.67rCSI 13.94%PRS 20.36
-
CSI 8.61rCSI 14.9%PRS 23.18
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CSI 8.57rCSI 18.58%PRS 23.03
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CSI 8.56rCSI 40.04%PRS 50.84
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CSI 8.54rCSI 16%PRS 22.44
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CSI 8.41rCSI 11.68%PRS 30.18
-
CSI 8.17rCSI 11.98%PRS 38.83
-
CSI 8.1rCSI 12.37%PRS 30.3
-
CSI 8.03rCSI 20.75%PRS 27.67
-
CSI 7.91rCSI 15.88%PRS 22.54
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CSI 7.82rCSI 26.5%PRS 27.92
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CSI 7.52rCSI 7.39%PRS 44.04
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CSI 7.46rCSI 11.9%PRS 25.61
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CSI 7.37rCSI 11.32%PRS 36.33
-
CSI 7.32rCSI 35.09%PRS 27.3
-
CSI 6.95rCSI 8.97%PRS 19.37
-
CSI 6.94rCSI 12.17%PRS 23.96
-
CSI 6.74rCSI 5.81%PRS 40.85
-
CSI 6.6rCSI 33.2%PRS 47.25
-
CSI 6.54rCSI 24.5%PRS 25.4
-
CSI 6.51rCSI 17.4%PRS 25.26
-
CSI 6.1rCSI 7.82%PRS 34.4
-
CSI 5.95rCSI 8.49%PRS 32.71
-
CSI 5.88rCSI 14.04%PRS 41.67
-
CSI 5.81rCSI 16.01%PRS 28.05
-
CSI 5.74rCSI 23.38%PRS 30.1
-
CSI 5.55rCSI 14.79%PRS 25.63
-
CSI 5.53rCSI 22.76%PRS 55.8
-
CSI 5.46rCSI 6.59%PRS 35.79
-
CSI 5.37rCSI 38.37%PRS 41.82
-
CSI 5.36rCSI 5.16%PRS 30.87
-
CSI 5.29rCSI 9.33%PRS 29.22
-
CSI 5.28rCSI 28.05%PRS 36.78
-
CSI 5.26rCSI 45.34%PRS 19.2
-
CSI 5.25rCSI 38.6%PRS 20.34
-
CSI 5.22rCSI 3.86%PRS 25.82
-
CSI 5.22rCSI 12.04%PRS 24.63
-
CSI 5.2rCSI 26.61%PRS 32.57
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CSI 5.15rCSI 13.56%PRS 52.69
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CSI 5.07rCSI 13.18%PRS 36.06
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CSI 5.06rCSI 6.3%PRS 40.1
-
CSI 4.93rCSI 4.34%PRS 22.14
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CSI 4.89rCSI 3.97%PRS 30.98
-
CSI 4.88rCSI 5.34%PRS 33.24
-
CSI 4.65rCSI 13.8%PRS 39.98
-
CSI 4.58rCSI 4.2%PRS 35.62
-
CSI 4.46rCSI 5.33%PRS 18.52
-
CSI 4.33rCSI 13.86%PRS 26.67
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CSI 4.3rCSI 5.74%PRS 32.02
-
CSI 4.15rCSI 6.1%PRS 27.85
-
CSI 4.14rCSI 17.59%PRS 31.24
-
CSI 3.99rCSI 14.02%PRS 46.67
-
CSI 3.95rCSI 11.23%PRS 31.86
-
CSI 3.94rCSI 11.42%PRS 23.91
-
CSI 3.92rCSI 15.79%PRS 46.34
-
CSI 3.91rCSI 3.63%PRS 29.98
-
CSI 3.82rCSI 4.81%PRS 42.78
-
CSI 3.77rCSI 12.51%PRS 32.74
-
CSI 3.77rCSI 10.79%PRS 47.87
-
CSI 3.72rCSI 6.57%PRS 18.13
-
CSI 0.3rCSI 1.7%PRS 41.5%
-
CSI 0.3rCSI 3.4%PRS 47.8%
-
CSI 0.4rCSI 7.1%PRS 26.6%
-
CSI 0.4rCSI 1.9%PRS 28.1%
-
CSI 0.5rCSI 0.5%PRS 31.7%
-
CSI 0.5rCSI 1.9%PRS 46.2%
-
CSI 0.5rCSI 6.9%PRS 24.7%
-
CSI 0.6rCSI 3.7%PRS 24.4%
-
CSI 0.6rCSI 12.8%PRS 25.2%
-
CSI 0.7rCSI 5.5%PRS 30.1%
-
CSI 0.7rCSI 3.1%PRS 53.6%
-
CSI 0.8rCSI 1.6%PRS 54.7%
-
CSI 0.8rCSI 2.3%PRS 46.0%
-
CSI 0.9rCSI 1.0%PRS 28.9%
-
CSI 0.9rCSI 6.2%PRS 30.1%
-
CSI 0.9rCSI 2.3%PRS 28.7%
-
CSI 1.0rCSI 2.1%PRS 27.7%
-
CSI 1.0rCSI 5.1%PRS 42.2%
-
CSI 1.0rCSI 2.4%PRS 35.8%
-
CSI 1.0rCSI 10.6%PRS 34.4%
-
CSI 1.0rCSI 6.4%PRS 40.3%
-
CSI 1.0rCSI 2.4%PRS 22.0%
-
CSI 1.1rCSI 6.9%PRS 54.7%
-
CSI 1.1rCSI 3.6%PRS 39.2%
-
CSI 1.1rCSI 8.4%PRS 29.6%
-
CSI 1.1rCSI 1.1%PRS 22.7%
-
CSI 1.2rCSI 1.9%PRS 30.5%
-
CSI 1.3rCSI 5.6%PRS 59.0%
-
CSI 1.3rCSI 4.4%PRS 66.7%
-
CSI 1.3rCSI 1.5%PRS 22.5%
-
CSI 1.3rCSI 1.6%PRS 38.2%
-
CSI 1.3rCSI 2.3%PRS 51.3%
-
CSI 1.4rCSI 5.6%PRS 41.1%
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CSI 1.4rCSI 2.0%PRS 31.9%
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CSI 1.4rCSI 2.5%PRS 38.9%
-
CSI 1.5rCSI 10.4%PRS 29.2%
-
CSI 1.5rCSI 2.1%PRS 23.7%
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CSI 1.6rCSI 4.4%PRS 34.4%
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CSI 1.6rCSI 3.5%PRS 21.7%
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CSI 1.6rCSI 5.2%PRS 30.7%
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CSI 1.7rCSI 13.6%PRS 27.7%
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CSI 1.7rCSI 14.9%PRS 36.8%
-
CSI 1.7rCSI 5.0%PRS 44.1%
-
CSI 1.9rCSI 6.4%PRS 22.2%
-
CSI 1.9rCSI 1.5%PRS 40.3%
-
CSI 1.9rCSI 5.0%PRS 30.2%
-
CSI 1.9rCSI 7.4%PRS 27.2%
-
CSI 1.9rCSI 2.6%PRS 41.4%
-
CSI 1.9rCSI 3.1%PRS 38.3%
-
CSI 2.0rCSI 7.7%PRS 47.6%
-
CSI 2.0rCSI 4.2%PRS 52.4%
-
CSI 2.0rCSI 11.0%PRS 38.4%
-
CSI 2.1rCSI 2.9%PRS 39.9%
-
CSI 2.1rCSI 4.7%PRS 35.0%
-
CSI 2.2rCSI 1.7%PRS 29.4%
-
CSI 2.2rCSI 2.0%PRS 49.6%
-
CSI 2.2rCSI 8.6%PRS 11.8%
-
CSI 2.4rCSI 10.6%PRS 21.0%
-
CSI 2.4rCSI 4.3%PRS 28.2%
-
CSI 2.4rCSI 3.8%PRS 25.3%
-
CSI 2.4rCSI 2.2%PRS 43.6%
-
CSI 2.4rCSI 4.0%PRS 34.7%
-
CSI 2.5rCSI 7.2%PRS 28.8%
-
CSI 2.5rCSI 3.2%PRS 34.4%
-
CSI 2.5rCSI 1.7%PRS 34.5%
-
CSI 2.5rCSI 11.7%PRS 30.7%
-
CSI 2.6rCSI 59.9%PRS 51.8%
-
CSI 2.6rCSI 5.9%PRS 51.7%
-
CSI 2.6rCSI 5.4%PRS 28.1%
-
CSI 2.6rCSI 7.7%PRS 65.1%
-
CSI 2.7rCSI 2.0%PRS 28.4%
-
CSI 2.7rCSI 6.1%PRS 29.5%
-
CSI 2.8rCSI 66.8%PRS 18.7%
-
CSI 2.8rCSI 9.5%PRS 25.5%
-
CSI 2.8rCSI 66.9%PRS 17.9%
-
CSI 2.8rCSI 13.4%PRS 34.1%
-
CSI 2.8rCSI 5.0%PRS 37.7%
-
CSI 2.9rCSI 4.6%PRS 32.8%
-
CSI 2.9rCSI 4.9%PRS 55.3%
-
CSI 2.9rCSI 17.1%PRS 19.7%
-
CSI 3.0rCSI 8.6%PRS 33.0%
-
CSI 3.0rCSI 13.2%PRS 26.4%
-
CSI 3.0rCSI 2.1%PRS 57.1%
-
CSI 3.1rCSI 10.0%PRS 21.8%
-
CSI 3.1rCSI 7.4%PRS 33.0%
-
CSI 3.2rCSI 8.3%PRS 35.5%
-
CSI 3.2rCSI 3.3%PRS 35.0%
-
CSI 3.2rCSI 11.6%PRS 17.8%
-
CSI 3.3rCSI 8.3%PRS 36.6%
-
CSI 3.4rCSI 15.0%PRS 28.9%
-
CSI 3.4rCSI 19.0%PRS 19.6%
-
CSI 3.4rCSI 8.1%PRS 45.3%
-
CSI 3.4rCSI 2.7%PRS 43.4%
-
CSI 3.5rCSI 3.2%PRS 31.1%
-
CSI 3.5rCSI 13.2%PRS 19.5%
-
CSI 3.5rCSI 14.3%PRS 28.6%
-
CSI 3.7rCSI 7.3%PRS 30.6%
-
CSI 3.7rCSI 6.6%PRS 18.1%
-
CSI 3.8rCSI 10.8%PRS 47.9%
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CSI 3.8rCSI 12.5%PRS 32.7%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1304941636
Symbol: TRPS1_HUMAN
Name: Zinc finger transcription factor Trps1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10615131
Title: Mutations in a new gene, encoding a zinc-finger protein, cause tricho-rhino-phalangeal syndrome type I.
PubMed ID: 10615131
DOI: 10.1038/71717
PubMed ID: 10974077
Title: Characterization of a zinc-finger protein and its association with apoptosis in prostate cancer cells.
PubMed ID: 10974077
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16421571
Title: DNA sequence and analysis of human chromosome 8.
PubMed ID: 16421571
DOI: 10.1038/nature04406
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12885770
Title: The RING finger protein RNF4, a co-regulator of transcription, interacts with the TRPS1 transcription factor.
PubMed ID: 12885770
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 17391059
Title: SUMOylation modulates transcriptional repression by TRPS1.
PubMed ID: 17391059
DOI: 10.1515/bc.2007.051
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19389374
Title: Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3.
PubMed ID: 19389374
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25218447
Title: Uncovering global SUMOylation signaling networks in a site-specific manner.
PubMed ID: 25218447
DOI: 10.1038/nsmb.2890
PubMed ID: 25114211
Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.
PubMed ID: 25114211
PubMed ID: 25772364
Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.
PubMed ID: 25772364
PubMed ID: 25755297
Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.
PubMed ID: 25755297
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 11112658
Title: Genotypic and phenotypic spectrum in tricho-rhino-phalangeal syndrome types I and III.
PubMed ID: 11112658
DOI: 10.1086/316926
PubMed ID: 11807863
Title: Missense mutation of TRPS1 in a family of tricho-rhino-phalangeal syndrome type III.
PubMed ID: 11807863
DOI: 10.1002/ajmg.10081
PubMed ID: 14560312
Title: Novel missense mutations in the TRPS1 transcription factor define the nuclear localization signal.
PubMed ID: 14560312
Sequence Information:
- Length: 1281
- Mass: 141521
- Checksum: 2157B04F5BEB71CC
- Sequence:
MVRKKNPPLR NVASEGEGQI LEPIGTESKV SGKNKEFSAD QMSENTDQSD AAELNHKEEH SLHVQDPSSS SKKDLKSAVL SEKAGFNYES PSKGGNFPSF PHDEVTDRNM LAFSSPAAGG VCEPLKSPQR AEADDPQDMA CTPSGDSLET KEDQKMSPKA TEETGQAQSG QANCQGLSPV SVASKNPQVP SDGGVRLNKS KTDLLVNDNP DPAPLSPELQ DFKCNICGYG YYGNDPTDLI KHFRKYHLGL HNRTRQDAEL DSKILALHNM VQFSHSKDFQ KVNRSVFSGV LQDINSSRPV LLNGTYDVQV TSGGTFIGIG RKTPDCQGNT KYFRCKFCNF TYMGNSSTEL EQHFLQTHPN KIKASLPSSE VAKPSEKNSN KSIPALQSSD SGDLGKWQDK ITVKAGDDTP VGYSVPIKPL DSSRQNGTEA TSYYWCKFCS FSCESSSSLK LLEHYGKQHG AVQSGGLNPE LNDKLSRGSV INQNDLAKSS EGETMTKTDK SSSGAKKKDF SSKGAEDNMV TSYNCQFCDF RYSKSHGPDV IVVGPLLRHY QQLHNIHKCT IKHCPFCPRG LCSPEKHLGE ITYPFACRKS NCSHCALLLL HLSPGAAGSS RVKHQCHQCS FTTPDVDVLL FHYESVHESQ ASDVKQEANH LQGSDGQQSV KESKEHSCTK CDFITQVEEE ISRHYRRAHS CYKCRQCSFT AADTQSLLEH FNTVHCQEQD ITTANGEEDG HAISTIKEEP KIDFRVYNLL TPDSKMGEPV SESVVKREKL EEKDGLKEKV WTESSSDDLR NVTWRGADIL RGSPSYTQAS LGLLTPVSGT QEQTKTLRDS PNVEAAHLAR PIYGLAVETK GFLQGAPAGG EKSGALPQQY PASGENKSKD ESQSLLRRRR GSGVFCANCL TTKTSLWRKN ANGGYVCNAC GLYQKLHSTP RPLNIIKQNN GEQIIRRRTR KRLNPEALQA EQLNKQQRGS NEEQVNGSPL ERRSEDHLTE SHQREIPLPS LSKYEAQGSL TKSHSAQQPV LVSQTLDIHK RMQPLHIQIK SPQESTGDPG NSSSVSEGKG SSERGSPIEK YMRPAKHPNY SPPGSPIEKY QYPLFGLPFV HNDFQSEADW LRFWSKYKLS VPGNPHYLSH VPGLPNPCQN YVPYPTFNLP PHFSAVGSDN DIPLDLAIKH SRPGPTANGA SKEKTKAPPN VKNEGPLNVV KTEKVDRSTQ DELSTKCVHC GIVFLDEVMY ALHMSCHGDS GPFQCSICQH LCTDKYDFTT HIQRGLHRNN AQVEKNGKPK E