Details for: TSPYL1

Gene ID: 7259

Symbol: TSPYL1

Ensembl ID: ENSG00000189241

Description: TSPY like 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 291.3622
    Cell Significance Index: -45.3200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 173.0382
    Cell Significance Index: -43.8900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 102.7064
    Cell Significance Index: -48.4900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 90.7880
    Cell Significance Index: -46.7000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 72.3374
    Cell Significance Index: -48.5400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 39.4094
    Cell Significance Index: -48.5900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.2349
    Cell Significance Index: -46.1700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.8915
    Cell Significance Index: -48.8100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.8001
    Cell Significance Index: -50.5100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 4.8210
    Cell Significance Index: 77.3500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 3.2289
    Cell Significance Index: 525.1600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.4191
    Cell Significance Index: 65.8500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.7591
    Cell Significance Index: 92.3600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.7239
    Cell Significance Index: 23.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5666
    Cell Significance Index: 314.2500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.3714
    Cell Significance Index: 102.2100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.2953
    Cell Significance Index: 37.1300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.2542
    Cell Significance Index: 154.2200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.2074
    Cell Significance Index: 34.4600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0798
    Cell Significance Index: 387.3100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.0509
    Cell Significance Index: 70.6700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.9694
    Cell Significance Index: 25.4900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9534
    Cell Significance Index: 171.8800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9322
    Cell Significance Index: 412.1300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8948
    Cell Significance Index: 41.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8046
    Cell Significance Index: 110.4900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7968
    Cell Significance Index: 435.1500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7917
    Cell Significance Index: 101.4900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7031
    Cell Significance Index: 48.6200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.7015
    Cell Significance Index: 6.4600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6784
    Cell Significance Index: 87.6400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.6512
    Cell Significance Index: 5.4700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.6292
    Cell Significance Index: 392.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6226
    Cell Significance Index: 32.3400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6147
    Cell Significance Index: 28.8900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5991
    Cell Significance Index: 37.7600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5881
    Cell Significance Index: 41.5900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4432
    Cell Significance Index: 15.4000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4260
    Cell Significance Index: 11.4200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4191
    Cell Significance Index: 9.0800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.3688
    Cell Significance Index: 8.5200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3382
    Cell Significance Index: 57.7500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2764
    Cell Significance Index: 3.1400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2352
    Cell Significance Index: 15.1800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.2161
    Cell Significance Index: 1.3300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1470
    Cell Significance Index: 14.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0959
    Cell Significance Index: 19.0400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0898
    Cell Significance Index: 17.0800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0514
    Cell Significance Index: 0.8800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0428
    Cell Significance Index: 1.9400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0367
    Cell Significance Index: 26.9200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0320
    Cell Significance Index: 0.5400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0289
    Cell Significance Index: 3.4100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0233
    Cell Significance Index: 1.4300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0017
    Cell Significance Index: 1.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0010
    Cell Significance Index: -1.8000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0199
    Cell Significance Index: -14.7400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0304
    Cell Significance Index: -19.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0316
    Cell Significance Index: -58.3000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0357
    Cell Significance Index: -54.9900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0415
    Cell Significance Index: -23.3900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0440
    Cell Significance Index: -59.8100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0531
    Cell Significance Index: -2.3500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0556
    Cell Significance Index: -5.6800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0738
    Cell Significance Index: -1.9700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0887
    Cell Significance Index: -40.2800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1124
    Cell Significance Index: -23.6700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1152
    Cell Significance Index: -3.2200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1320
    Cell Significance Index: -37.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1375
    Cell Significance Index: -15.7500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1378
    Cell Significance Index: -5.2200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2089
    Cell Significance Index: -2.4900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2627
    Cell Significance Index: -1.7800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2666
    Cell Significance Index: -38.7600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2743
    Cell Significance Index: -31.9700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3014
    Cell Significance Index: -23.8700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3077
    Cell Significance Index: -35.1200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.3464
    Cell Significance Index: -9.9800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4159
    Cell Significance Index: -10.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4231
    Cell Significance Index: -13.5500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.4658
    Cell Significance Index: -3.5900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4768
    Cell Significance Index: -49.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5460
    Cell Significance Index: -41.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6018
    Cell Significance Index: -33.7700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.6079
    Cell Significance Index: -14.5800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.6683
    Cell Significance Index: -5.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6908
    Cell Significance Index: -42.3500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.7705
    Cell Significance Index: -16.4100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.8867
    Cell Significance Index: -15.6700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.9305
    Cell Significance Index: -23.2600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.9579
    Cell Significance Index: -24.4700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.0119
    Cell Significance Index: -20.3200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.0120
    Cell Significance Index: -32.2300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.0206
    Cell Significance Index: -20.1800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.0234
    Cell Significance Index: -37.5700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.0342
    Cell Significance Index: -33.8600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.0380
    Cell Significance Index: -22.0300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0557
    Cell Significance Index: -31.1000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -1.0601
    Cell Significance Index: -14.8700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.1012
    Cell Significance Index: -38.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TSPYL1 is a non-coding gene, meaning it does not encode a protein. Despite its non-coding nature, TSPYL1 exhibits a unique expression pattern, with high levels detected in various cell types, including kidney collecting duct principal cells, fibroblasts from mammary glands, and neurons. Notably, TSPYL1 is testis-specific, suggesting a potential role in reproductive biology. The gene's expression is also tissue-specific, with significant levels observed in the kidney, bladder, and mammary gland. **Pathways and Functions:** TSPYL1 is involved in several cellular processes, including chromatin regulation, histone binding, and nucleosome assembly. Its expression is tightly linked to the regulation of gene expression, particularly in the context of chromatin remodeling. TSPYL1 interacts with various proteins, including histones, chromatin-binding proteins, and transcription factors, to modulate gene expression. These interactions suggest a role for TSPYL1 in the regulation of cellular differentiation, proliferation, and survival. Furthermore, TSPYL1 has been implicated in the regulation of neuronal function, particularly in the context of GABAergic neurons. Its expression in GABAergic cortical interneurons and amacrine cells suggests a potential role in the development and maintenance of neural circuits. **Clinical Significance:** The clinical significance of TSPYL1 is an area of active research. Given its expression in various tissues, TSPYL1 may play a role in the development and progression of various diseases, including cancer, neurodegenerative disorders, and reproductive disorders. Notably, TSPYL1 has been associated with several types of cancer, including breast, ovarian, and prostate cancer. Its expression is often upregulated in cancerous tissues, suggesting a potential role in tumorigenesis. Furthermore, TSPYL1 has been implicated in the regulation of neuronal function, particularly in the context of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. Its expression is often altered in these diseases, suggesting a potential role in disease progression. In conclusion, TSPYL1 is a unique gene with far-reaching implications for our understanding of cellular regulation and disease. Further research is needed to fully elucidate the role of TSPYL1 in human health and disease, but its potential significance is undeniable. **Recommendations:** 1. Further investigation into the molecular mechanisms underlying TSPYL1 expression and function is necessary to fully understand its role in cellular regulation. 2. The clinical significance of TSPYL1 should be further explored, particularly in the context of cancer and neurodegenerative disorders. 3. The development of novel therapeutic strategies targeting TSPYL1 may offer new avenues for the treatment of various diseases. By continuing to unravel the mysteries of TSPYL1, we may uncover new insights into the complex interplay between genes, proteins, and cellular processes, ultimately leading to the development of innovative therapies for human disease.

Genular Protein ID: 3748748428

Symbol: TSYL1_HUMAN

Name: Testis-specific Y-encoded-like protein 1

UniProtKB Accession Codes:

Q9H0U9 O75885 Q5TFE6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9730615

Title: Murine and human TSPYL genes: novel members of the TSPY-SET-NAP1L1 family.

PubMed ID: 9730615

DOI: 10.1159/000015042

PubMed ID: 12429849

Title: Functional proteomic analysis of human nucleolus.

PubMed ID: 12429849

DOI: 10.1091/mbc.e02-05-0271

PubMed ID: 15273283

Title: Mapping of sudden infant death with dysgenesis of the testes syndrome (SIDDT) by a SNP genome scan and identification of TSPYL loss of function.

PubMed ID: 15273283

DOI: 10.1073/pnas.0401194101

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 29779948

Title: The eukaryotic proteome is shaped by E3 ubiquitin ligases targeting C-terminal degrons.

PubMed ID: 29779948

DOI: 10.1016/j.cell.2018.04.028

Sequence Information:

  • Length: 437
  • Mass: 49192
  • Checksum: D651A6FAA7CF811F
  • Sequence:
    • MSGLDGVKRT TPLQTHSIII SDQVPSDQDA HQYLRLRDQS EATQVMAEPG EGGSETVALP 
PPPPSEEGGV PQDAAGRGGT PQIRVVGGRG HVAIKAGQEE GQPPAEGLAA ASVVMAADRS 
LKKGVQGGEK ALEICGAQRS ASELTAGAEA EAEEVKTGKC ATVSAAVAER ESAEVVKEGL 
AEKEVMEEQM EVEEQPPEGE EIEVAEEDRL EEEAREEEGP WPLHEALRMD PLEAIQLELD 
TVNAQADRAF QQLEHKFGRM RRHYLERRNY IIQNIPGFWM TAFRNHPQLS AMIRGQDAEM 
LRYITNLEVK ELRHPRTGCK FKFFFRRNPY FRNKLIVKEY EVRSSGRVVS LSTPIIWRRG 
HEPQSFIRRN QDLICSFFTW FSDHSLPESD KIAEIIKEDL WPNPLQYYLL REGVRRARRR 
PLREPVEIPR PFGFQSG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.