Details for: EIPR1

Gene ID: 7260

Symbol: EIPR1

Ensembl ID: ENSG00000032389

Description: EARP complex and GARP complex interacting protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 63.0133
    Cell Significance Index: -29.7500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 59.6192
    Cell Significance Index: -24.5600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 59.5928
    Cell Significance Index: -24.2100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 25.5880
    Cell Significance Index: -24.4300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.4887
    Cell Significance Index: -22.7400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.8730
    Cell Significance Index: -21.1100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.2774
    Cell Significance Index: -11.5500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7759
    Cell Significance Index: 356.2500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.5233
    Cell Significance Index: 302.3000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.3264
    Cell Significance Index: 58.6700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.2193
    Cell Significance Index: 46.1700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0692
    Cell Significance Index: 965.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0088
    Cell Significance Index: 361.8500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8767
    Cell Significance Index: 52.6300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7633
    Cell Significance Index: 124.1400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7182
    Cell Significance Index: 496.7000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.6289
    Cell Significance Index: 42.2900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.6152
    Cell Significance Index: 32.3000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6028
    Cell Significance Index: 38.8900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5342
    Cell Significance Index: 62.2500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4921
    Cell Significance Index: 12.3000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.4850
    Cell Significance Index: 13.8400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4767
    Cell Significance Index: 24.7700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.4512
    Cell Significance Index: 9.8800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4378
    Cell Significance Index: 26.9100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3904
    Cell Significance Index: 38.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3888
    Cell Significance Index: 21.8200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3818
    Cell Significance Index: 10.6700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3799
    Cell Significance Index: 26.2800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3600
    Cell Significance Index: 22.6900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3277
    Cell Significance Index: 38.6500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2765
    Cell Significance Index: 49.8500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2621
    Cell Significance Index: 143.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1887
    Cell Significance Index: 14.4800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1828
    Cell Significance Index: 3.9600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1586
    Cell Significance Index: 70.1400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1434
    Cell Significance Index: 3.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1368
    Cell Significance Index: 16.8200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1200
    Cell Significance Index: 22.8300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0718
    Cell Significance Index: 1.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0619
    Cell Significance Index: 95.3500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0602
    Cell Significance Index: 1.7400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0583
    Cell Significance Index: 107.5100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0528
    Cell Significance Index: 0.6300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0427
    Cell Significance Index: 80.4500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0334
    Cell Significance Index: 1.1600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0217
    Cell Significance Index: 1.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0153
    Cell Significance Index: 20.8700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0129
    Cell Significance Index: 8.2000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0097
    Cell Significance Index: 0.3400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0042
    Cell Significance Index: 0.5700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0034
    Cell Significance Index: -0.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0100
    Cell Significance Index: -4.5200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0105
    Cell Significance Index: -0.5300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0165
    Cell Significance Index: -12.4800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0213
    Cell Significance Index: -15.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0222
    Cell Significance Index: -2.8400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0251
    Cell Significance Index: -18.6100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0389
    Cell Significance Index: -21.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0399
    Cell Significance Index: -1.8100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0438
    Cell Significance Index: -5.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0451
    Cell Significance Index: -0.9600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0534
    Cell Significance Index: -2.7800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0542
    Cell Significance Index: -33.8500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0548
    Cell Significance Index: -1.6100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0606
    Cell Significance Index: -10.3500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0650
    Cell Significance Index: -6.6400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0812
    Cell Significance Index: -23.3700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0817
    Cell Significance Index: -5.7800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0834
    Cell Significance Index: -2.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0903
    Cell Significance Index: -13.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0979
    Cell Significance Index: -7.3000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1236
    Cell Significance Index: -1.7700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1397
    Cell Significance Index: -16.0000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1417
    Cell Significance Index: -4.5400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1442
    Cell Significance Index: -30.3800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2145
    Cell Significance Index: -4.4900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2309
    Cell Significance Index: -24.0400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2618
    Cell Significance Index: -6.7300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2697
    Cell Significance Index: -7.3400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2909
    Cell Significance Index: -9.2000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3004
    Cell Significance Index: -23.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3038
    Cell Significance Index: -14.2800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3210
    Cell Significance Index: -8.4400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3262
    Cell Significance Index: -5.4600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3721
    Cell Significance Index: -11.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3769
    Cell Significance Index: -23.1100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3870
    Cell Significance Index: -12.6700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3897
    Cell Significance Index: -4.8600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3977
    Cell Significance Index: -8.4400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.4004
    Cell Significance Index: -5.7000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4117
    Cell Significance Index: -8.1400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.5206
    Cell Significance Index: -6.5700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5215
    Cell Significance Index: -10.4700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.5273
    Cell Significance Index: -4.3000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5386
    Cell Significance Index: -15.8700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5600
    Cell Significance Index: -7.6400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5620
    Cell Significance Index: -19.6900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5716
    Cell Significance Index: -12.3500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5808
    Cell Significance Index: -21.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** EIPR1 is highly expressed in specific neuronal populations, including GABAergic cortical interneurons, L2/3-6 intratelencephalic projecting glutamatergic neurons, and near-projecting glutamatergic cortical neurons. 2. **Interactions:** EIPR1 interacts with the Earp complex and GARP complex, two protein complexes involved in endocytic recycling and retrograde transport. 3. **Pathways:** EIPR1 is involved in the regulation of positive endocytic recycling, retrograde transport, and the trans-golgi network. 4. **Protein Binding:** EIPR1 binds to proteins, influencing their trafficking and localization within the cell. **Pathways and Functions:** 1. **Endocytic Recycling:** EIPR1 regulates the endocytic recycling of proteins and lipids, ensuring their proper sorting and trafficking within the cell. 2. **Retrograde Transport:** EIPR1 modulates the retrograde transport of proteins and lipids from the endoplasmic reticulum to the Golgi apparatus, influencing cellular homeostasis. 3. **Insulin Secretion:** EIPR1 is involved in the regulation of insulin secretion, highlighting its potential role in glucose metabolism and diabetes. 4. **Neuronal Function:** EIPR1 influences neuronal function, including synaptic plasticity and neuronal excitability, through its regulation of endocytic recycling and retrograde transport. **Clinical Significance:** 1. **Neurological Disorders:** Dysregulation of EIPR1 may contribute to neurological disorders, such as epilepsy, Alzheimer's disease, and Parkinson's disease, which are characterized by impaired endocytic recycling and retrograde transport. 2. **Diabetes:** EIPR1's involvement in insulin secretion makes it a potential target for the development of novel therapies for diabetes. 3. **Synaptic Plasticity:** EIPR1's regulation of synaptic plasticity may influence learning and memory processes, highlighting its potential role in neurological and psychiatric disorders. In conclusion, EIPR1 is a critical regulator of endocytic recycling and retrograde transport in the brain, with implications for various cellular processes, including insulin secretion, neuronal function, and synaptic plasticity. Further research is necessary to fully elucidate the mechanisms by which EIPR1 influences cellular homeostasis and to explore its potential as a therapeutic target for neurological and metabolic disorders.

Genular Protein ID: 453913026

Symbol: EIPR1_HUMAN

Name: Tumor-suppressing STF cDNA 1 protein

UniProtKB Accession Codes:

Q53HC9 D6W4Y1 O43179 Q53S19 Q53SG2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9403053

Title: A 2.5-Mb transcript map of a tumor-suppressing subchromosomal transferable fragment from 11p15.5, and isolation and sequence analysis of three novel genes.

PubMed ID: 9403053

DOI: 10.1006/geno.1997.4981

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 27440922

Title: TSSC1 is novel component of the endosomal retrieval machinery.

PubMed ID: 27440922

DOI: 10.1091/mbc.e16-04-0209

Sequence Information:

  • Length: 387
  • Mass: 43603
  • Checksum: 7B1CCD35B7C38780
  • Sequence:
    • MEDDAPVIYG LEFQARALTP QTAETDAIRF LVGTQSLKYD NQIHIIDFDD ENNIINKNVL 
LHQAGEIWHI SASPADRGVL TTCYNRTSDS KVLTCAAVWR MPKELESGSH ESPDDSSSTA 
QTLELLCHLD NTAHGNMACV VWEPMGDGKK IISLADNHIL LWDLQESSSQ AVLASSASLE 
GKGQLKFTSG RWSPHHNCTQ VATANDTTLR GWDTRSMSQI YCIENAHGQL VRDLDFNPNK 
QYYLASCGDD CKVKFWDTRN VTEPVKTLEE HSHWVWNVRY NHSHDQLVLT GSSDSRVILS 
NMVSISSEPF GHLVDDDDIS DQEDHRSEEK SKEPLQDNVI ATYEEHEDSV YAVDWSSADP 
WLFASLSYDG RLVINRVPRA LKYHILL

Genular Protein ID: 873465091

Symbol: A8MUM1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8MUM1

Database IDs:

ARBA 9 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 1 PhylomeDB 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 414
  • Mass: 46320
  • Checksum: FFBEE242BA422CEC
  • Sequence:
    • MEDDAPVIYG LEFQARALTP QTAETDAIRF LVGTQSLKYD NQIHIIDFDD ENNIINKNVL 
LHQAGEIWHI SASPADRGVL TTCYNRTFCC VLSLDSFGAL GKSAAQLFIA LATSSDSKVL 
TCAAVWRMPK ELESGSHESP DDSSSTAQTL ELLCHLDNTA HGNMACVVWE PMGDGKKIIS 
LADNHILLWD LQESSSQAVL ASSASLEGKG QLKFTSGRWS PHHNCTQVAT ANDTTLRGWD 
TRSMSQIYCI ENAHGQLVRD LDFNPNKQYY LASCGDDCKV KFWDTRNVTE PVKTLEEHSH 
WVWNVRYNHS HDQLVLTGSS DSRVILSNMV SISSEPFGHL VDDDDISDQE DHRSEEKSKE 
PLQDNVIATY EEHEDSVYAV DWSSADPWLF ASLSYDGRLV INRVPRALKY HILL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.