Details for: HIRA

Gene ID: 7290

Symbol: HIRA

Ensembl ID: ENSG00000100084

Description: histone cell cycle regulator

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 80.8125
    Cell Significance Index: -12.5700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 57.5217
    Cell Significance Index: -14.5900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 30.3195
    Cell Significance Index: -12.3200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 21.8696
    Cell Significance Index: -14.6800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.8935
    Cell Significance Index: -12.3100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.8982
    Cell Significance Index: -14.6700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.4314
    Cell Significance Index: -14.5500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.9001
    Cell Significance Index: -15.3900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.5450
    Cell Significance Index: -5.5700
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.2485
    Cell Significance Index: 23.8900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.3015
    Cell Significance Index: 19.2100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.0212
    Cell Significance Index: 22.3600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.9987
    Cell Significance Index: 25.6700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9938
    Cell Significance Index: 59.6700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8671
    Cell Significance Index: 782.8900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8280
    Cell Significance Index: 90.0600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7564
    Cell Significance Index: 10.3200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7298
    Cell Significance Index: 19.5600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6905
    Cell Significance Index: 137.0400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6479
    Cell Significance Index: 64.0900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6394
    Cell Significance Index: 103.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5649
    Cell Significance Index: 113.3200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5520
    Cell Significance Index: 15.9100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.5474
    Cell Significance Index: 11.7000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4863
    Cell Significance Index: 13.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4642
    Cell Significance Index: 54.1000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.4332
    Cell Significance Index: 10.3900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4297
    Cell Significance Index: 26.4100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4162
    Cell Significance Index: 28.7900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3000
    Cell Significance Index: 7.5000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2973
    Cell Significance Index: 6.4400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2952
    Cell Significance Index: 105.9000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2895
    Cell Significance Index: 13.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2884
    Cell Significance Index: 22.1400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.1769
    Cell Significance Index: 2.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1512
    Cell Significance Index: 27.2700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1496
    Cell Significance Index: 10.0600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1432
    Cell Significance Index: 2.9700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1274
    Cell Significance Index: 15.6600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1094
    Cell Significance Index: 148.7000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1061
    Cell Significance Index: 2.2600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0988
    Cell Significance Index: 53.9700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0872
    Cell Significance Index: 38.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0685
    Cell Significance Index: 3.0300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0666
    Cell Significance Index: 3.7400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0656
    Cell Significance Index: 9.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0608
    Cell Significance Index: 2.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0567
    Cell Significance Index: 10.7900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0444
    Cell Significance Index: 2.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0410
    Cell Significance Index: 63.1600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0395
    Cell Significance Index: 2.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0379
    Cell Significance Index: 71.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0340
    Cell Significance Index: 62.6500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0259
    Cell Significance Index: 0.9800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0150
    Cell Significance Index: 6.8000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0113
    Cell Significance Index: 0.7100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0088
    Cell Significance Index: 5.5700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0079
    Cell Significance Index: 0.1400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0054
    Cell Significance Index: 0.9200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0088
    Cell Significance Index: -6.5200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0102
    Cell Significance Index: -7.5000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0123
    Cell Significance Index: -9.2800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0198
    Cell Significance Index: -0.5300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0220
    Cell Significance Index: -12.4300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0256
    Cell Significance Index: -15.9800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0307
    Cell Significance Index: -2.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0331
    Cell Significance Index: -1.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0435
    Cell Significance Index: -4.9800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0454
    Cell Significance Index: -0.6500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0472
    Cell Significance Index: -6.0600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0481
    Cell Significance Index: -3.1000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0499
    Cell Significance Index: -7.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0513
    Cell Significance Index: -14.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0584
    Cell Significance Index: -5.9700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0630
    Cell Significance Index: -8.1400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0663
    Cell Significance Index: -7.8200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0720
    Cell Significance Index: -15.1700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0791
    Cell Significance Index: -1.1100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0804
    Cell Significance Index: -1.5700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0883
    Cell Significance Index: -2.5200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1131
    Cell Significance Index: -11.7800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1193
    Cell Significance Index: -2.9100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1228
    Cell Significance Index: -9.1600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1440
    Cell Significance Index: -3.9200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1444
    Cell Significance Index: -11.4400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1579
    Cell Significance Index: -8.2900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1614
    Cell Significance Index: -5.1700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1626
    Cell Significance Index: -3.4500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1662
    Cell Significance Index: -3.5900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1678
    Cell Significance Index: -1.7400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1761
    Cell Significance Index: -2.6000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1824
    Cell Significance Index: -5.2300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1864
    Cell Significance Index: -9.7100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1871
    Cell Significance Index: -5.9600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1920
    Cell Significance Index: -11.7700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1927
    Cell Significance Index: -2.3900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1963
    Cell Significance Index: -3.9400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1963
    Cell Significance Index: -1.3300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1990
    Cell Significance Index: -3.3300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2062
    Cell Significance Index: -6.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell Cycle Regulation:** HIRA is a key regulator of the cell cycle, influencing the assembly of nucleosomes and chromatin remodeling. 2. **DNA Damage Response:** HIRA has been implicated in the response to DNA damage, including telomere stress-induced senescence. 3. **Chromatin Remodeling:** HIRA interacts with various chromatin remodeling complexes, influencing gene expression and transcriptional regulation. 4. **Transcriptional Regulation:** HIRA acts as a transcriptional corepressor, modulating the activity of RNA polymerase II. 5. **Cellular Senescence:** HIRA has been linked to the regulation of cellular senescence, a state characterized by cell cycle arrest and the formation of senescence-associated heterochromatin foci (SAHFs). **Pathways and Functions:** 1. **Anatomical Structure Morphogenesis:** HIRA plays a crucial role in the development and morphogenesis of various tissues, including the lens, kidney, and brain. 2. **Cellular Responses to Stimuli:** HIRA is involved in the regulation of cellular responses to stimuli, including DNA damage, telomere stress, and oxidative stress. 3. **Chromatin Dynamics:** HIRA influences chromatin dynamics, including nucleosome assembly, chromatin remodeling, and histone binding. 4. **DNA Damage/Telomere Stress-Induced Senescence:** HIRA has been implicated in the regulation of DNA damage response and telomere stress-induced senescence. 5. **Regulation of Transcription:** HIRA acts as a transcriptional corepressor, modulating the activity of RNA polymerase II and influencing gene expression. **Clinical Significance:** 1. **Cancer:** Dysregulation of HIRA has been implicated in various types of cancer, including breast, lung, and colon cancer. 2. **Aging and Senescence:** HIRA has been linked to the regulation of cellular senescence, a state characterized by cell cycle arrest and tissue dysfunction. 3. **Neurological Disorders:** HIRA has been implicated in the regulation of gene expression and chromatin dynamics in the brain, making it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Developmental Disorders:** HIRA has been linked to the regulation of development and morphogenesis, making it a potential target for the treatment of developmental disorders, such as lens opacity and cataracts. In conclusion, the HIRA gene is a crucial regulator of cellular processes, including cell cycle regulation, DNA damage response, and transcriptional regulation. Its dysregulation has been implicated in various diseases, including cancer, aging, and neurological disorders. Further research is necessary to fully understand the functions and significance of HIRA and to explore its potential as a therapeutic target.

Genular Protein ID: 4271886303

Symbol: HIRA_HUMAN

Name: Protein HIRA

UniProtKB Accession Codes:

P54198 Q05BU9 Q8IXN2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 8 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7633437

Title: A human homolog of the S. cerevisiae HIR1 and HIR2 transcriptional repressors cloned from the DiGeorge syndrome critical region.

PubMed ID: 7633437

DOI: 10.1093/hmg/4.5.791

PubMed ID: 8681138

Title: Structural organization of the WD repeat protein-encoding gene HIRA in the DiGeorge syndrome critical region of human chromosome 22.

PubMed ID: 8681138

DOI: 10.1101/gr.6.1.43

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8111380

Title: Isolation of a putative transcriptional regulator from the region of 22q11 deleted in DiGeorge syndrome, Shprintzen syndrome and familial congenital heart disease.

PubMed ID: 8111380

DOI: 10.1093/hmg/2.12.2099

PubMed ID: 9063745

Title: The murine homologue of HIRA, a DiGeorge syndrome candidate gene, is expressed in embryonic structures affected in human CATCH22 patients.

PubMed ID: 9063745

DOI: 10.1093/hmg/6.2.247

PubMed ID: 9710638

Title: Core histones and HIRIP3, a novel histone-binding protein, directly interact with WD repeat protein HIRA.

PubMed ID: 9710638

DOI: 10.1128/mcb.18.9.5546

PubMed ID: 11238922

Title: HIRA, the human homologue of yeast Hir1p and Hir2p, is a novel cyclin-cdk2 substrate whose expression blocks S-phase progression.

PubMed ID: 11238922

DOI: 10.1128/mcb.21.5.1854-1865.2001

PubMed ID: 12370293

Title: Coupling of DNA synthesis and histone synthesis in S phase independent of cyclin/cdk2 activity.

PubMed ID: 12370293

DOI: 10.1128/mcb.22.21.7459-7472.2002

PubMed ID: 14680630

Title: Structure and function of the conserved core of histone deposition protein Asf1.

PubMed ID: 14680630

DOI: 10.1016/j.cub.2003.11.027

PubMed ID: 14718166

Title: Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis.

PubMed ID: 14718166

DOI: 10.1016/s0092-8674(03)01064-x

PubMed ID: 15621527

Title: Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA.

PubMed ID: 15621527

DOI: 10.1016/j.devcel.2004.10.019

PubMed ID: 15561718

Title: Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates.

PubMed ID: 15561718

DOI: 10.1074/jbc.m411718200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19029251

Title: Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells.

PubMed ID: 19029251

DOI: 10.1128/mcb.01047-08

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28334823

Title: H3.Y discriminates between HIRA and DAXX chaperone complexes and reveals unexpected insights into human DAXX-H3.3-H4 binding and deposition requirements.

PubMed ID: 28334823

DOI: 10.1093/nar/gkx131

PubMed ID: 16980972

Title: Structure of a human ASF1a-HIRA complex and insights into specificity of histone chaperone complex assembly.

PubMed ID: 16980972

DOI: 10.1038/nsmb1147

Sequence Information:

  • Length: 1017
  • Mass: 111835
  • Checksum: 475784B2FF9D16D6
  • Sequence:
    • MKLLKPTWVN HNGKPIFSVD IHPDGTKFAT GGQGQDSGKV VIWNMSPVLQ EDDEKDENIP 
KMLCQMDNHL ACVNCVRWSN SGMYLASGGD DKLIMVWKRA TYIGPSTVFG SSGKLANVEQ 
WRCVSILRNH SGDVMDVAWS PHDAWLASCS VDNTVVIWNA VKFPEILATL RGHSGLVKGL 
TWDPVGKYIA SQADDRSLKV WRTLDWQLET SITKPFDECG GTTHVLRLSW SPDGHYLVSA 
HAMNNSGPTA QIIEREGWKT NMDFVGHRKA VTVVKFNPKI FKKKQKNGSS AKPSCPYCCC 
AVGSKDRSLS VWLTCLKRPL VVIHELFDKS IMDISWTLNG LGILVCSMDG SVAFLDFSQD 
ELGDPLSEEE KSRIHQSTYG KSLAIMTEAQ LSTAVIENPE MLKYQRRQQQ QQLDQKSAAT 
REMGSATSVA GVVNGESLED IRKNLLKKQV ETRTADGRRR ITPLCIAQLD TGDFSTAFFN 
SIPLSGSLAG TMLSSHSSPQ LLPLDSSTPN SFGASKPCTE PVVAASARPA GDSVNKDSMN 
ATSTPAALSP SVLTTPSKIE PMKAFDSRFT ERSKATPGAP ALTSMTPTAV ERLKEQNLVK 
ELRPRDLLES SSDSDEKVPL AKASSLSKRK LELEVETVEK KKKGRPRKDS RLMPVSLSVQ 
SPAALTAEKE AMCLSAPALA LKLPIPSPQR AFTLQVSSDP SMYIEVENEV TVVGGVKLSR 
LKCNREGKEW ETVLTSRILT AAGSCDVVCV ACEKRMLSVF STCGRRLLSP ILLPSPISTL 
HCTGSYVMAL TAAATLSVWD VHRQVVVVKE ESLHSILAGS DMTVSQILLT QHGIPVMNLS 
DGKAYCFNPS LSTWNLVSDK QDSLAQCADF RSSLPSQDAM LCSGPLAIIQ GRTSNSGRQA 
ARLFSVPHVV QQETTLAYLE NQVAAALTLQ SSHEYRHWLL VYARYLVNEG FEYRLREICK 
DLLGPVHYST GSQWESTVVG LRKRELLKEL LPVIGQNLRF QRLFTECQEQ LDILRDK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.