Details for: USP4

Gene ID: 7375

Symbol: USP4

Ensembl ID: ENSG00000114316

Description: ubiquitin specific peptidase 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 211.3212
    Cell Significance Index: -32.8700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 128.2115
    Cell Significance Index: -32.5200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 83.1416
    Cell Significance Index: -34.2500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 75.6910
    Cell Significance Index: -30.7500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 67.4203
    Cell Significance Index: -34.6800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 32.3333
    Cell Significance Index: -30.8700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 27.9734
    Cell Significance Index: -34.4900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.8745
    Cell Significance Index: -31.8100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.6529
    Cell Significance Index: -32.7200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.9102
    Cell Significance Index: -35.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.1622
    Cell Significance Index: 411.4800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.5566
    Cell Significance Index: 107.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5352
    Cell Significance Index: 307.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9949
    Cell Significance Index: 76.3500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.8988
    Cell Significance Index: 39.7600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.8087
    Cell Significance Index: 30.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7869
    Cell Significance Index: 282.2500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.7299
    Cell Significance Index: 13.4900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7246
    Cell Significance Index: 143.7900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7215
    Cell Significance Index: 130.0600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7016
    Cell Significance Index: 76.3200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6305
    Cell Significance Index: 102.5400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6125
    Cell Significance Index: 71.3800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6066
    Cell Significance Index: 74.5900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5921
    Cell Significance Index: 409.5200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5657
    Cell Significance Index: 55.9600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.5138
    Cell Significance Index: 11.2500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4917
    Cell Significance Index: 13.7400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4776
    Cell Significance Index: 431.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4542
    Cell Significance Index: 25.4900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3479
    Cell Significance Index: 41.0300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3254
    Cell Significance Index: 16.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3068
    Cell Significance Index: 8.8400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2783
    Cell Significance Index: 18.7100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2658
    Cell Significance Index: 17.1500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2336
    Cell Significance Index: 14.3600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1957
    Cell Significance Index: 4.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1871
    Cell Significance Index: 25.6900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1843
    Cell Significance Index: 100.6500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1322
    Cell Significance Index: 2.5800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1301
    Cell Significance Index: 57.5200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0909
    Cell Significance Index: 4.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0855
    Cell Significance Index: 4.4400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0819
    Cell Significance Index: 3.8200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0590
    Cell Significance Index: 111.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0507
    Cell Significance Index: 8.6600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0440
    Cell Significance Index: 81.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0362
    Cell Significance Index: 16.4400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0351
    Cell Significance Index: 53.9900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0325
    Cell Significance Index: 20.6100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0193
    Cell Significance Index: 2.4700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0093
    Cell Significance Index: 0.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0088
    Cell Significance Index: 11.9100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0071
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0148
    Cell Significance Index: -9.2700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0186
    Cell Significance Index: -13.8100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0243
    Cell Significance Index: -17.8000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0249
    Cell Significance Index: -0.7300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0320
    Cell Significance Index: -24.2400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0323
    Cell Significance Index: -3.3000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0364
    Cell Significance Index: -20.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0399
    Cell Significance Index: -5.8000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0454
    Cell Significance Index: -0.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0651
    Cell Significance Index: -3.0600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0705
    Cell Significance Index: -1.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0773
    Cell Significance Index: -9.9900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0955
    Cell Significance Index: -10.9500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1053
    Cell Significance Index: -2.2500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1062
    Cell Significance Index: -30.5500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1068
    Cell Significance Index: -22.5000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1222
    Cell Significance Index: -1.1300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1545
    Cell Significance Index: -4.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1684
    Cell Significance Index: -12.5500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1924
    Cell Significance Index: -2.8400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2254
    Cell Significance Index: -25.7300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2259
    Cell Significance Index: -15.9800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2377
    Cell Significance Index: -5.7000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2529
    Cell Significance Index: -13.2800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2630
    Cell Significance Index: -6.7600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2650
    Cell Significance Index: -16.7100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2727
    Cell Significance Index: -28.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2844
    Cell Significance Index: -9.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3050
    Cell Significance Index: -8.0200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3165
    Cell Significance Index: -11.1200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3302
    Cell Significance Index: -6.8500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3847
    Cell Significance Index: -30.4700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3932
    Cell Significance Index: -11.2200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3940
    Cell Significance Index: -13.6900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4058
    Cell Significance Index: -24.8800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4150
    Cell Significance Index: -6.9500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4632
    Cell Significance Index: -9.8300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4632
    Cell Significance Index: -6.3200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4691
    Cell Significance Index: -9.9900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4957
    Cell Significance Index: -7.1300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5659
    Cell Significance Index: -15.1400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6005
    Cell Significance Index: -15.3400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6228
    Cell Significance Index: -20.3900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6344
    Cell Significance Index: -20.2100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6886
    Cell Significance Index: -19.7400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7398
    Cell Significance Index: -25.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Ubiquitin-specific protease activity**: USP4 is a member of the ubiquitin-specific protease (USP) family, which is responsible for removing ubiquitin from proteins, thereby regulating their degradation, localization, or activity. 2. **Dual specificity**: USP4 has a dual specificity for ubiquitin and polyubiquitin, allowing it to recognize and remove various types of ubiquitin chains. 3. **Regulation of protein stability**: USP4 plays a crucial role in regulating protein stability by deubiquitinating proteins that are marked for degradation, thereby preventing their proteolysis. 4. **Involvement in various cellular pathways**: USP4 is involved in multiple cellular pathways, including adenosine receptor binding, death receptor signaling, and TNF signaling, highlighting its central role in maintaining cellular homeostasis. **Pathways and Functions:** 1. **Deubiquitination**: USP4 is involved in the deubiquitination of proteins that are marked for degradation, thereby regulating their proteolysis and localization. 2. **Regulation of protein stability**: USP4 plays a crucial role in regulating protein stability by removing ubiquitin from proteins that are marked for degradation. 3. **Regulation of cell surface proteins**: USP4 is involved in the regulation of cell surface proteins, including the deubiquitination of proteins involved in cell adhesion and signaling. 4. **Regulation of immune responses**: USP4 has been implicated in the regulation of immune responses, including the deubiquitination of proteins involved in inflammation and immune cell function. **Clinical Significance:** 1. **Neurological disorders**: USP4 has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), highlighting its potential role in neurodegeneration. 2. **Cancer progression**: USP4 has been implicated in cancer progression, including the deubiquitination of proteins involved in cell proliferation and survival. 3. **Immune-related disorders**: USP4 has been implicated in immune-related disorders, including rheumatoid arthritis and multiple sclerosis, highlighting its potential role in regulating immune responses. 4. **Therapeutic potential**: USP4 has been identified as a potential therapeutic target for various diseases, including neurological disorders and cancer, underscoring its importance in maintaining cellular homeostasis. In conclusion, USP4 plays a multifaceted role in maintaining cellular homeostasis, regulating protein stability, and modulating various cellular pathways. Its involvement in neurological disorders, cancer progression, and immune-related disorders highlights its clinical significance and potential therapeutic potential. Further research is needed to fully elucidate the role of USP4 in various diseases and to explore its therapeutic applications.

Genular Protein ID: 942812366

Symbol: UBP4_HUMAN

Name: Ubiquitin carboxyl-terminal hydrolase 4

UniProtKB Accession Codes:

Q13107 A8K6Y0 C9IY91 O43452 O43453 Q08AK8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 7 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 4 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7784062

Title: Elevated expression of Unph, a proto-oncogene at 3p21.3, in human lung tumors.

PubMed ID: 7784062

PubMed ID: 9464533

Title: The human UNP locus at 3p21.31 encodes two tissue-selective, cytoplasmic isoforms with deubiquitinating activity that have reduced expression in small cell lung carcinoma cell lines.

PubMed ID: 9464533

DOI: 10.1038/sj.onc.1201537

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11571652

Title: The de-ubiquitinating enzyme Unp interacts with the retinoblastoma protein.

PubMed ID: 11571652

DOI: 10.1038/sj.onc.1204824

PubMed ID: 16316627

Title: Oncogenic protein UnpEL/Usp4 deubiquitinates Ro52 by its isopeptidase activity.

PubMed ID: 16316627

DOI: 10.1016/j.bbrc.2005.11.076

PubMed ID: 16472766

Title: UnpEL/Usp4 is ubiquitinated by Ro52 and deubiquitinated by itself.

PubMed ID: 16472766

DOI: 10.1016/j.bbrc.2006.01.144

PubMed ID: 16339847

Title: The ubiquitin-specific protease Usp4 regulates the cell surface level of the A2A receptor.

PubMed ID: 16339847

DOI: 10.1124/mol.105.015818

PubMed ID: 20595234

Title: The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome.

PubMed ID: 20595234

DOI: 10.1101/gad.1925010

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21415856

Title: Ubiquitin-specific protease 4 is inhibited by its ubiquitin-like domain.

PubMed ID: 21415856

DOI: 10.1038/embor.2011.33

PubMed ID: 24398133

Title: Retraction: 'Ubiquitin-specific protease 4 is inhibited by its ubiquitin-like domain' by MP Luna-Vargas, AC Faesen, WJ van Dijk, M Rape, A Fish, TK Sixma.

PubMed ID: 24398133

DOI: 10.1002/embr.201470010

PubMed ID: 22347420

Title: Ubiquitin-specific protease 4 inhibits mono-ubiquitination of the master growth factor signaling kinase PDK1.

PubMed ID: 22347420

DOI: 10.1371/journal.pone.0031003

PubMed ID: 28604766

Title: The deubiquitinating enzymes USP4 and USP17 target hyaluronan synthase 2 and differentially affect its function.

PubMed ID: 28604766

DOI: 10.1038/oncsis.2017.45

PubMed ID: 30514904

Title: Ubiquitination of Rheb governs growth factor-induced mTORC1 activation.

PubMed ID: 30514904

DOI: 10.1038/s41422-018-0120-9

PubMed ID: 25404403

Title: The DUSP-Ubl domain of USP4 enhances its catalytic efficiency by promoting ubiquitin exchange.

PubMed ID: 25404403

DOI: 10.1038/ncomms6399

Sequence Information:

  • Length: 963
  • Mass: 108565
  • Checksum: 63055C9ADFE36713
  • Sequence:
    • MAEGGGCRER PDAETQKSEL GPLMRTTLQR GAQWYLIDSR WFKQWKKYVG FDSWDMYNVG 
EHNLFPGPID NSGLFSDPES QTLKEHLIDE LDYVLVPTEA WNKLLNWYGC VEGQQPIVRK 
VVEHGLFVKH CKVEVYLLEL KLCENSDPTN VLSCHFSKAD TIATIEKEMR KLFNIPAERE 
TRLWNKYMSN TYEQLSKLDN TVQDAGLYQG QVLVIEPQNE DGTWPRQTLQ SKSSTAPSRN 
FTTSPKSSAS PYSSVSASLI ANGDSTSTCG MHSSGVSRGG SGFSASYNCQ EPPSSHIQPG 
LCGLGNLGNT CFMNSALQCL SNTAPLTDYF LKDEYEAEIN RDNPLGMKGE IAEAYAELIK 
QMWSGRDAHV APRMFKTQVG RFAPQFSGYQ QQDSQELLAF LLDGLHEDLN RVKKKPYLEL 
KDANGRPDAV VAKEAWENHR LRNDSVIVDT FHGLFKSTLV CPECAKVSVT FDPFCYLTLP 
LPLKKDRVME VFLVPADPHC RPTQYRVTVP LMGAVSDLCE ALSRLSGIAA ENMVVADVYN 
HRFHKIFQMD EGLNHIMPRD DIFVYEVCST SVDGSECVTL PVYFRERKSR PSSTSSASAL 
YGQPLLLSVP KHKLTLESLY QAVCDRISRY VKQPLPDEFG SSPLEPGACN GSRNSCEGED 
EEEMEHQEEG KEQLSETEGS GEDEPGNDPS ETTQKKIKGQ PCPKRLFTFS LVNSYGTADI 
NSLAADGKLL KLNSRSTLAM DWDSETRRLY YDEQESEAYE KHVSMLQPQK KKKTTVALRD 
CIELFTTMET LGEHDPWYCP NCKKHQQATK KFDLWSLPKI LVVHLKRFSY NRYWRDKLDT 
VVEFPIRGLN MSEFVCNLSA RPYVYDLIAV SNHYGAMGVG HYTAYAKNKL NGKWYYFDDS 
NVSLASEDQI VTKAAYVLFY QRRDDEFYKT PSLSSSGSSD GGTRPSSSQQ GFGDDEACSM 
DTN

Genular Protein ID: 4145121639

Symbol: Q08AK7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q08AK7

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 5 Gene3D 2 IntAct 1 InterPro 8 KEGG 1 MEROPS 1 MINT 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 6 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 963
  • Mass: 108523
  • Checksum: DE745C9ADFE36716
  • Sequence:
    • MAEGGGCRER PDAETQKSEL GPLMRTTLQR GAQWYLIDSR WFKQWKKYVG FDSWDMYNVG 
EHNLFPGPID NSGLFSDPES QTLKEHLIDE LDYVLVPTEA WNKLLNWYGC VEGQQPIVRK 
VVEHGLFVKH CKVEVYLLEL KLCENSDPTN VLSCHFSKAD TIATIEKEMR KLFNIPAERE 
TRLWNKYMSN TYEQLSKLDN TVQDAGLYQG QVLVIEPQNE DGTWPRQTLQ SKSSTAPSRN 
FTTSPKSSAS PYSSVSASLI ANGDSTSTCG MHSSGVSRGG SGFSASYNCQ EPPSSHIQPG 
LCGLGNLGNT CFMNSALQCL SNTAPLTDYF LKDEYEAEIN RDNPLGMKGE IAEAYAELIK 
QMWSGRDAHV APRMFKTQVG RFAPQFSGYQ QQDSQELLAF LLDGLHEDLN RVKKKPYLEL 
KDANGRPDAV VAKEAWENHR LRNDSVIVDT FHGLFKSTLG CPECAKVSVT FDPFCYLTLP 
LPLKKDRVME VFLVPADPHC RPTQYRVTVP LMGAVSDLCE ALSRLSGIAA ENMVVADVYN 
HRFHKIFQMD EGLNHIMPRD DIFVYEVCST SVDGSECVTL PVYFRERKSR PSSTSSASAL 
YGQPLLLSVP KHKLTLESLY QAVCDRISRY VKQPLPDEFG SSPLEPGACN GSRNSCEGED 
EEEMEHQEEG KEQLSETEGS GEDEPGNDPS ETTQKKIKGQ PCPKRLFTFS LVNSYGTADI 
NSLAADGKLL KLNSRSTLAM DWDSETRRLY YDEQESEAYE KHVSMLQPQK KKKTTVALRD 
CIELFTTMET LGEHDPWYCP NCKKHQQATK KFDLWSLPKI LVVHLKRFSY NRYWRDKLDT 
VVEFPIRGLN MSEFVCNLSA RPYVYDLIAV SNHYGAMGVG HYTAYAKNKL NGKWYYFDDS 
NVSLASEDQI VTKAAYVLFY QRRDDEFYKT PSLSSSGSSD GGTRPSSSQQ GFGDDEACSM 
DTN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.