Details for: VWFP1

Gene ID: 7451

Symbol: VWFP1

Ensembl ID: ENSG00000241717

Description: von Willebrand factor pseudogene 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.2335
    Cell Significance Index: 3.0200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.0631
    Cell Significance Index: 0.6700
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.0479
    Cell Significance Index: 0.6200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0434
    Cell Significance Index: 0.9500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0212
    Cell Significance Index: 0.3100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0165
    Cell Significance Index: 0.2200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0118
    Cell Significance Index: 0.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0005
    Cell Significance Index: -0.9200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0010
    Cell Significance Index: -0.6100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0015
    Cell Significance Index: -0.6700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0016
    Cell Significance Index: -0.3100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0110
    Cell Significance Index: -0.3500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0119
    Cell Significance Index: -0.1300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0127
    Cell Significance Index: -0.3400
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0204
    Cell Significance Index: -0.2800
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.0217
    Cell Significance Index: -0.2300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0234
    Cell Significance Index: -1.0900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0264
    Cell Significance Index: -0.2500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0266
    Cell Significance Index: -0.6800
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0277
    Cell Significance Index: -0.3400
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0439
    Cell Significance Index: -0.5400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0440
    Cell Significance Index: -0.6000
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0469
    Cell Significance Index: -0.5700
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: -0.0473
    Cell Significance Index: -0.4000
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0475
    Cell Significance Index: -0.5400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0483
    Cell Significance Index: -0.6100
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0492
    Cell Significance Index: -0.5900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0510
    Cell Significance Index: -0.6100
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0516
    Cell Significance Index: -0.6100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0525
    Cell Significance Index: -0.6900
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0542
    Cell Significance Index: -0.6300
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.0546
    Cell Significance Index: -0.6200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0569
    Cell Significance Index: -0.6100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0577
    Cell Significance Index: -0.6600
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0581
    Cell Significance Index: -0.6500
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0583
    Cell Significance Index: -0.7000
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0594
    Cell Significance Index: -0.5400
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.0601
    Cell Significance Index: -0.6300
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.0604
    Cell Significance Index: -0.6700
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: -0.0604
    Cell Significance Index: -0.7300
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0615
    Cell Significance Index: -0.7000
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0620
    Cell Significance Index: -0.7300
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0634
    Cell Significance Index: -0.6200
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0654
    Cell Significance Index: -0.7100
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0665
    Cell Significance Index: -0.5500
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0673
    Cell Significance Index: -0.7300
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.0675
    Cell Significance Index: -0.7500
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0677
    Cell Significance Index: -0.7500
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0683
    Cell Significance Index: -0.7500
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0686
    Cell Significance Index: -0.7000
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0695
    Cell Significance Index: -0.8700
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0723
    Cell Significance Index: -1.1000
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0735
    Cell Significance Index: -0.6900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0755
    Cell Significance Index: -1.0800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0780
    Cell Significance Index: -0.9300
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0789
    Cell Significance Index: -0.8100
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0797
    Cell Significance Index: -1.0000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0801
    Cell Significance Index: -1.0900
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0806
    Cell Significance Index: -0.7500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0825
    Cell Significance Index: -1.0000
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0829
    Cell Significance Index: -0.7300
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0840
    Cell Significance Index: -0.9200
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0845
    Cell Significance Index: -0.5500
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0858
    Cell Significance Index: -0.7500
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0899
    Cell Significance Index: -1.0700
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0908
    Cell Significance Index: -0.5700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0918
    Cell Significance Index: -0.8700
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0939
    Cell Significance Index: -1.0100
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0953
    Cell Significance Index: -0.8800
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0965
    Cell Significance Index: -1.0000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0969
    Cell Significance Index: -0.5800
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.1003
    Cell Significance Index: -0.9400
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1199
    Cell Significance Index: -0.9900
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1300
    Cell Significance Index: -1.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** VWFP1 is a pseudogene, meaning it has undergone significant mutations and is no longer capable of producing a functional protein. Despite this, it remains stably expressed in multiple cell types, including: * Schwann cells, which play a crucial role in myelination and nerve regeneration * Endothelial cells, which line blood vessels and regulate blood flow and clotting * Ependymal cells, which form the lining of the central nervous system's ventricles * A2 amacrine cells, a subtype of retinal ganglion cells involved in visual processing * Oligodendrocyte precursor cells, which differentiate into myelinating cells in the central nervous system * Astrocytes, a type of glial cell involved in brain function and repair * Capillary endothelial cells, which regulate blood flow in capillaries * Central nervous system macrophages, which play a role in immune responses within the brain **Pathways and Functions:** The cellular expression patterns of VWFP1 suggest that it may be involved in various biological processes, including: * Cell adhesion and migration: VWFP1 may play a role in the adhesion and migration of cells, particularly in the context of vascular development and repair. * Angiogenesis: The expression of VWFP1 in endothelial cells and capillary endothelial cells hints at its potential involvement in angiogenesis, the process of new blood vessel formation. * Neuroinflammation: The presence of VWFP1 in central nervous system macrophages and astrocytes may indicate its role in regulating immune responses within the brain. * Myelination: VWFP1's expression in Schwann cells and oligodendrocyte precursor cells suggests that it may be involved in the process of myelination, the formation of myelin sheaths around axons. **Clinical Significance:** While VWFP1 is a pseudogene, its expression in various cell types raises questions about its potential functional significance. Further research is needed to determine whether VWFP1 plays a role in human disease. Potential areas of investigation include: * Vascular disorders: VWFP1's expression in endothelial cells and capillary endothelial cells may be relevant to vascular diseases, such as atherosclerosis and thrombosis. * Neurological disorders: The presence of VWFP1 in central nervous system macrophages and astrocytes may be linked to neuroinflammatory conditions, such as multiple sclerosis. * Cancer: VWFP1's expression in various cell types may be relevant to cancer biology, particularly in the context of angiogenesis and tumor growth. In conclusion, VWFP1 is a pseudogene with intriguing cellular expression patterns and potential functional significance. Further research is needed to uncover the role of VWFP1 in human health and disease, and to determine its potential as a therapeutic target or biomarker.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.