Details for: NSD2
Gene ID: 7468
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: NSD2
Ensembl ID: ENSG00000109685
Description: nuclear receptor binding SET domain protein 2
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 31.77rCSI 32.53%PRS 50.19
-
CSI 21.54rCSI 36.15%PRS 19.76
-
CSI 20.82rCSI 50.61%PRS 19.26
-
CSI 20.5rCSI 23.67%PRS 27.49
-
CSI 15.89rCSI 49.67%PRS 20.71
-
CSI 14.11rCSI 50.78%PRS 18.8
-
CSI 12.06rCSI 26.65%PRS 22.87
-
CSI 10.58rCSI 33.1%PRS 22.46
-
CSI 10.43rCSI 22.96%PRS 35.18
-
CSI 10.27rCSI 38.8%PRS 20.57
-
CSI 9.75rCSI 9.38%PRS 32.35
-
CSI 9.01rCSI 7.73%PRS 42.89
-
CSI 8.84rCSI 10.99%PRS 18.62
-
CSI 8.67rCSI 51.07%PRS 20.84
-
CSI 8.28rCSI 13.31%PRS 21.48
-
CSI 8.1rCSI 12.04%PRS 34.9
-
CSI 8.03rCSI 27.51%PRS 26.69
-
CSI 7.76rCSI 10.6%PRS 34.16
-
CSI 7.68rCSI 8.88%PRS 23.75
-
CSI 7.45rCSI 6.17%PRS 32.03
-
CSI 6.85rCSI 5.42%PRS 22.09
-
CSI 6.34rCSI 27.84%PRS 51.44
-
CSI 6.34rCSI 8.13%PRS 35.97
-
CSI 6.23rCSI 8.65%PRS 31.71
-
CSI 5.93rCSI 7.16%PRS 37.54
-
CSI 5.82rCSI 7.24%PRS 33.65
-
CSI 5.74rCSI 23.17%PRS 30.24
-
CSI 5.59rCSI 7.17%PRS 30.06
-
CSI 5.34rCSI 4.15%PRS 45.51
-
CSI 5.15rCSI 4.57%PRS 31.24
-
CSI 4.96rCSI 7.58%PRS 35.68
-
CSI 4.79rCSI 13.88%PRS 25.16
-
CSI 4.75rCSI 34.9%PRS 21.75
-
CSI 4.46rCSI 7.81%PRS 25.28
-
CSI 4.36rCSI 7.7%PRS 19.16
-
CSI 4.11rCSI 3.89%PRS 32.59
-
CSI 3.68rCSI 7.38%PRS 23.79
-
CSI 3.61rCSI 5.31%PRS 29.2
-
CSI 3.6rCSI 7.01%PRS 32.66
-
CSI 3.6rCSI 13.47%PRS 26.72
-
CSI 3.59rCSI 5.73%PRS 26.93
-
CSI 3.56rCSI 26.74%PRS 51.79
-
CSI 3.49rCSI 4.17%PRS 19.62
-
CSI 3.39rCSI 2.43%PRS 42.19
-
CSI 3.35rCSI 3.49%PRS 32.08
-
CSI 3.31rCSI 7.65%PRS 25.87
-
CSI 3.3rCSI 2.29%PRS 37.92
-
CSI 3.3rCSI 5.92%PRS 26.49
-
CSI 3.24rCSI 5.6%PRS 24.43
-
CSI 3.15rCSI 4.06%PRS 20.48
-
CSI 3.12rCSI 27.43%PRS 22.97
-
CSI 3.01rCSI 2.8%PRS 31.42
-
CSI 3rCSI 2.32%PRS 30.99
-
CSI 2.99rCSI 6.84%PRS 30.98
-
CSI 2.91rCSI 2.35%PRS 43.09
-
CSI 2.89rCSI 7.67%PRS 44.54
-
CSI 2.89rCSI 2.14%PRS 27.11
-
CSI 2.89rCSI 9.23%PRS 28.32
-
CSI 2.87rCSI 7.43%PRS 28.93
-
CSI 2.87rCSI 16.56%PRS 35.88
-
CSI 2.84rCSI 57.8%PRS 26.64
-
CSI 2.78rCSI 2.09%PRS 33.8
-
CSI 2.77rCSI 4.56%PRS 36.24
-
CSI 2.76rCSI 2.42%PRS 35.71
-
CSI 2.72rCSI 2.62%PRS 24.06
-
CSI 2.72rCSI 2.46%PRS 28.8
-
CSI 2.7rCSI 7.96%PRS 36.11
-
CSI 2.64rCSI 2.19%PRS 30.03
-
CSI 2.62rCSI 62.62%PRS 19.07
-
CSI 2.6rCSI 52.92%PRS 27.89
-
CSI 2.57rCSI 4.09%PRS 26.62
-
CSI 2.56rCSI 61.74%PRS 19.86
-
CSI 2.53rCSI 3.45%PRS 27.14
-
CSI 2.5rCSI 2.68%PRS 29.39
-
CSI 2.49rCSI 5.91%PRS 37.28
-
CSI 2.48rCSI 4.25%PRS 40.41
-
CSI 2.46rCSI 6.99%PRS 33.22
-
CSI 2.46rCSI 7.29%PRS 41.66
-
CSI 2.44rCSI 34.69%PRS 26.18
-
CSI 2.42rCSI 2.53%PRS 29.42
-
CSI 2.41rCSI 2.11%PRS 40.28
-
CSI 2.4rCSI 4.97%PRS 30.75
-
CSI 2.39rCSI 5.45%PRS 27.06
-
CSI 2.36rCSI 3.87%PRS 24.68
-
CSI 2.36rCSI 4.42%PRS 23.73
-
CSI 2.35rCSI 2.14%PRS 45.43
-
CSI 2.32rCSI 3.7%PRS 34.39
-
CSI 2.3rCSI 2.71%PRS 35.11
-
CSI 2.23rCSI 2.86%PRS 29.7
-
CSI 2.21rCSI 5.01%PRS 38.25
-
CSI 2.18rCSI 5.41%PRS 29.72
-
CSI 2.17rCSI 5.3%PRS 29.65
-
CSI 2.17rCSI 13.53%PRS 25.73
-
CSI 2.17rCSI 5.65%PRS 30.47
-
CSI 2.15rCSI 7.2%PRS 23.41
-
CSI 2.13rCSI 3.43%PRS 24.46
-
CSI 2.04rCSI 3.65%PRS 29.7
-
CSI 2rCSI 10.81%PRS 46.86
-
CSI 2rCSI 8.15%PRS 31.38
-
CSI 2rCSI 8.78%PRS 29.66
-
CSI 0.2rCSI 2.0%PRS 60.7%
-
CSI 0.3rCSI 3.1%PRS 35.6%
-
CSI 0.3rCSI 0.6%PRS 39.7%
-
CSI 0.3rCSI 5.1%PRS 32.9%
-
CSI 0.4rCSI 1.8%PRS 54.6%
-
CSI 0.5rCSI 2.3%PRS 30.3%
-
CSI 0.5rCSI 3.6%PRS 31.4%
-
CSI 0.6rCSI 4.8%PRS 20.7%
-
CSI 0.6rCSI 5.8%PRS 77.4%
-
CSI 0.7rCSI 6.0%PRS 37.6%
-
CSI 0.7rCSI 2.0%PRS 45.9%
-
CSI 0.7rCSI 4.9%PRS 32.0%
-
CSI 0.8rCSI 2.8%PRS 49.4%
-
CSI 0.8rCSI 4.6%PRS 31.6%
-
CSI 0.8rCSI 1.2%PRS 47.4%
-
CSI 0.8rCSI 3.2%PRS 28.3%
-
CSI 0.9rCSI 4.9%PRS 20.8%
-
CSI 0.9rCSI 3.5%PRS 49.6%
-
CSI 0.9rCSI 4.3%PRS 31.8%
-
CSI 1.0rCSI 4.6%PRS 22.2%
-
CSI 1.1rCSI 9.5%PRS 31.2%
-
CSI 1.1rCSI 5.9%PRS 47.5%
-
CSI 1.1rCSI 3.7%PRS 32.1%
-
CSI 1.2rCSI 3.1%PRS 39.9%
-
CSI 1.2rCSI 3.3%PRS 47.0%
-
CSI 1.2rCSI 1.7%PRS 34.2%
-
CSI 1.2rCSI 3.9%PRS 23.1%
-
CSI 1.2rCSI 6.0%PRS 32.9%
-
CSI 1.2rCSI 2.9%PRS 23.3%
-
CSI 1.2rCSI 1.8%PRS 45.8%
-
CSI 1.3rCSI 3.0%PRS 43.6%
-
CSI 1.3rCSI 2.7%PRS 29.3%
-
CSI 1.3rCSI 1.8%PRS 42.8%
-
CSI 1.3rCSI 3.6%PRS 26.6%
-
CSI 1.4rCSI 1.9%PRS 30.2%
-
CSI 1.4rCSI 1.7%PRS 28.0%
-
CSI 1.4rCSI 2.1%PRS 29.2%
-
CSI 1.4rCSI 3.7%PRS 31.7%
-
CSI 1.4rCSI 3.7%PRS 37.5%
-
CSI 1.5rCSI 3.2%PRS 40.7%
-
CSI 1.5rCSI 3.0%PRS 18.3%
-
CSI 1.6rCSI 1.8%PRS 54.8%
-
CSI 1.6rCSI 7.7%PRS 41.4%
-
CSI 1.6rCSI 2.3%PRS 40.9%
-
CSI 1.6rCSI 13.1%PRS 28.9%
-
CSI 1.7rCSI 2.6%PRS 42.4%
-
CSI 1.7rCSI 2.5%PRS 46.8%
-
CSI 1.7rCSI 3.7%PRS 45.2%
-
CSI 1.7rCSI 2.4%PRS 29.3%
-
CSI 1.7rCSI 1.7%PRS 27.0%
-
CSI 1.7rCSI 3.4%PRS 32.0%
-
CSI 1.7rCSI 3.2%PRS 27.3%
-
CSI 1.8rCSI 4.5%PRS 24.5%
-
CSI 1.8rCSI 5.0%PRS 29.5%
-
CSI 1.9rCSI 4.4%PRS 34.5%
-
CSI 1.9rCSI 4.2%PRS 20.3%
-
CSI 1.9rCSI 2.4%PRS 39.8%
-
CSI 1.9rCSI 2.9%PRS 31.9%
-
CSI 1.9rCSI 2.9%PRS 35.6%
-
CSI 2.0rCSI 3.0%PRS 29.8%
-
CSI 2.0rCSI 5.2%PRS 26.8%
-
CSI 2.0rCSI 4.3%PRS 24.4%
-
CSI 2.0rCSI 3.5%PRS 30.6%
-
CSI 2.0rCSI 2.9%PRS 25.0%
-
CSI 2.0rCSI 8.8%PRS 29.7%
-
CSI 2.0rCSI 8.2%PRS 31.4%
-
CSI 2.0rCSI 10.8%PRS 46.9%
-
CSI 2.0rCSI 3.7%PRS 29.7%
-
CSI 2.1rCSI 3.4%PRS 24.5%
-
CSI 2.2rCSI 7.2%PRS 23.4%
-
CSI 2.2rCSI 5.7%PRS 30.5%
-
CSI 2.2rCSI 13.5%PRS 25.7%
-
CSI 2.2rCSI 5.3%PRS 29.7%
-
CSI 2.2rCSI 5.4%PRS 29.7%
-
CSI 2.2rCSI 5.0%PRS 38.3%
-
CSI 2.2rCSI 2.9%PRS 29.7%
-
CSI 2.3rCSI 2.7%PRS 35.1%
-
CSI 2.3rCSI 3.7%PRS 34.4%
-
CSI 2.4rCSI 2.1%PRS 45.4%
-
CSI 2.4rCSI 4.4%PRS 23.7%
-
CSI 2.4rCSI 3.9%PRS 24.7%
-
CSI 2.4rCSI 5.5%PRS 27.1%
-
CSI 2.4rCSI 5.0%PRS 30.8%
-
CSI 2.4rCSI 2.1%PRS 40.3%
-
CSI 2.4rCSI 2.5%PRS 29.4%
-
CSI 2.4rCSI 34.7%PRS 26.2%
-
CSI 2.5rCSI 7.3%PRS 41.7%
-
CSI 2.5rCSI 7.0%PRS 33.2%
-
CSI 2.5rCSI 4.3%PRS 40.4%
-
CSI 2.5rCSI 5.9%PRS 37.3%
-
CSI 2.5rCSI 2.7%PRS 29.4%
-
CSI 2.5rCSI 3.5%PRS 27.1%
-
CSI 2.6rCSI 61.7%PRS 19.9%
-
CSI 2.6rCSI 4.1%PRS 26.6%
-
CSI 2.6rCSI 52.9%PRS 27.9%
-
CSI 2.6rCSI 62.6%PRS 19.1%
-
CSI 2.6rCSI 2.2%PRS 30.0%
-
CSI 2.7rCSI 8.0%PRS 36.1%
-
CSI 2.7rCSI 2.5%PRS 28.8%
-
CSI 2.7rCSI 2.6%PRS 24.1%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 547293036
Symbol: NSD2_HUMAN
Name: Histone-lysine N-methyltransferase NSD2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9787135
Title: The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts.
PubMed ID: 9787135
PubMed ID: 9618163
Title: WHSC1, a 90 kb SET domain-containing gene, expressed in early development and homologous to a Drosophila dysmorphy gene maps in the Wolf-Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple myeloma.
PubMed ID: 9618163
DOI: 10.1093/hmg/7.7.1071
PubMed ID: 11152655
Title: A unique mRNA initiated within a middle intron of WHSC1/MMSET encodes a DNA binding protein that suppresses human IL-5 transcription.
PubMed ID: 11152655
PubMed ID: 15677557
Title: Overexpression of transcripts originating from the MMSET locus characterizes all t(4;14)(p16;q32)-positive multiple myeloma patients.
PubMed ID: 15677557
PubMed ID: 10470851
Title: Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 10470851
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10945609
Title: Detection of t(4;14)(p16.3;q32) chromosomal translocation in multiple myeloma by reverse transcription-polymerase chain reaction analysis of IGH-MMSET fusion transcripts.
PubMed ID: 10945609
PubMed ID: 11337357
Title: Translocation T(4;14)(p16.3;q32) is a recurrent genetic lesion in primary amyloidosis.
PubMed ID: 11337357
PubMed ID: 12433679
Title: A subset of multiple myeloma harboring the t(4;14)(p16;q32) translocation lacks FGFR3 expression but maintains an IGH/MMSET fusion transcript.
PubMed ID: 12433679
PubMed ID: 15257719
Title: Identification of a novel IGH-MMSET fusion transcript in a human myeloma cell line with the t(4;14)(p16.3;q32) chromosomal translocation.
PubMed ID: 15257719
PubMed ID: 16115125
Title: Identification of ID-1 as a potential target gene of MMSET in multiple myeloma.
PubMed ID: 16115125
PubMed ID: 16197452
Title: Transcription repression activity is associated with the type I isoform of the MMSET gene involved in t(4;14) in multiple myeloma.
PubMed ID: 16197452
PubMed ID: 15734578
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18172012
Title: Multiple-myeloma-related WHSC1/MMSET isoform RE-IIBP is a histone methyltransferase with transcriptional repression activity.
PubMed ID: 18172012
DOI: 10.1128/mcb.02130-07
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19808676
Title: The target of the NSD family of histone lysine methyltransferases depends on the nature of the substrate.
PubMed ID: 19808676
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 22099308
Title: NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming.
PubMed ID: 22099308
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24129315
Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
PubMed ID: 24129315
PubMed ID: 29760529
Title: De novo nonsense mutation in WHSC1 (NSD2) in patient with intellectual disability and dysmorphic features.
PubMed ID: 29760529
PubMed ID: 29728617
Title: Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function.
PubMed ID: 29728617
PubMed ID: 27571355
Title: Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives.
PubMed ID: 27571355
PubMed ID: 29892088
Title: De novo truncating variants in WHSC1 recapitulate the Wolf-Hirschhorn (4p16.3 microdeletion) syndrome phenotype.
PubMed ID: 29892088
PubMed ID: 33941880
Title: Loss-of-function and missense variants in NSD2 cause decreased methylation activity and are associated with a distinct developmental phenotype.
PubMed ID: 33941880
Sequence Information:
- Length: 1365
- Mass: 152258
- Checksum: 7B3128E1FA893AAA
- Sequence:
MEFSIKQSPL SVQSVVKCIK MKQAPEILGS ANGKTPSCEV NRECSVFLSK AQLSSSLQEG VMQKFNGHDA LPFIPADKLK DLTSRVFNGE PGAHDAKLRF ESQEMKGIGT PPNTTPIKNG SPEIKLKITK TYMNGKPLFE SSICGDSAAD VSQSEENGQK PENKARRNRK RSIKYDSLLE QGLVEAALVS KISSPSDKKI PAKKESCPNT GRDKDHLLKY NVGDLVWSKV SGYPWWPCMV SADPLLHSYT KLKGQKKSAR QYHVQFFGDA PERAWIFEKS LVAFEGEGQF EKLCQESAKQ APTKAEKIKL LKPISGKLRA QWEMGIVQAE EAASMSVEER KAKFTFLYVG DQLHLNPQVA KEAGIAAESL GEMAESSGVS EEAAENPKSV REECIPMKRR RRAKLCSSAE TLESHPDIGK STPQKTAEAD PRRGVGSPPG RKKTTVSMPR SRKGDAASQF LVFCQKHRDE VVAEHPDASG EEIEELLRSQ WSLLSEKQRA RYNTKFALVA PVQAEEDSGN VNGKKRNHTK RIQDPTEDAE AEDTPRKRLR TDKHSLRKRD TITDKTARTS SYKAMEAASS LKSQAATKNL SDACKPLKKR NRASTAASSA LGFSKSSSPS ASLTENEVSD SPGDEPSESP YESADETQTE VSVSSKKSER GVTAKKEYVC QLCEKPGSLL LCEGPCCGAF HLACLGLSRR PEGRFTCSEC ASGIHSCFVC KESKTDVKRC VVTQCGKFYH EACVKKYPLT VFESRGFRCP LHSCVSCHAS NPSNPRPSKG KMMRCVRCPV AYHSGDACLA AGCSVIASNS IICTAHFTAR KGKRHHAHVN VSWCFVCSKG GSLLCCESCP AAFHPDCLNI EMPDGSWFCN DCRAGKKLHF QDIIWVKLGN YRWWPAEVCH PKNVPPNIQK MKHEIGEFPV FFFGSKDYYW THQARVFPYM EGDRGSRYQG VRGIGRVFKN ALQEAEARFR EIKLQREARE TQESERKPPP YKHIKVNKPY GKVQIYTADI SEIPKCNCKP TDENPCGFDS ECLNRMLMFE CHPQVCPAGE FCQNQCFTKR QYPETKIIKT DGKGWGLVAK RDIRKGEFVN EYVGELIDEE ECMARIKHAH ENDITHFYML TIDKDRIIDA GPKGNYSRFM NHSCQPNCET LKWTVNGDTR VGLFAVCDIP AGTELTFNYN LDCLGNEKTV CRCGASNCSG FLGDRPKTST TLSSEEKGKK TKKKTRRRRA KGEGKRQSED ECFRCGDGGQ LVLCDRKFCT KAYHLSCLGL GKRPFGKWEC PWHHCDVCGK PSTSFCHLCP NSFCKEHQDG TAFSCTPDGR SYCCEHDLGA ASVRSTKTEK PPPEPGKPKG KRRRRRGWRR VTEGK