Details for: NELFA

Gene ID: 7469

Symbol: NELFA

Ensembl ID: ENSG00000185049

Description: negative elongation factor complex member A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 189.7197
    Cell Significance Index: -29.5100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 113.4664
    Cell Significance Index: -28.7800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 68.1179
    Cell Significance Index: -32.1600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 63.7773
    Cell Significance Index: -25.9100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 27.2744
    Cell Significance Index: -26.0400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 25.5565
    Cell Significance Index: -31.5100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.9599
    Cell Significance Index: -29.3600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.0916
    Cell Significance Index: -31.9300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.9438
    Cell Significance Index: -10.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.1530
    Cell Significance Index: 250.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.9692
    Cell Significance Index: 395.0100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.1883
    Cell Significance Index: 26.0200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.1516
    Cell Significance Index: 43.6100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.1453
    Cell Significance Index: 50.6600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9985
    Cell Significance Index: 358.1600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9235
    Cell Significance Index: 100.4500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8933
    Cell Significance Index: 53.6300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8291
    Cell Significance Index: 134.8500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.6712
    Cell Significance Index: 19.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6601
    Cell Significance Index: 131.0000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6266
    Cell Significance Index: 32.5500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6072
    Cell Significance Index: 16.9700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5961
    Cell Significance Index: 538.2400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5755
    Cell Significance Index: 38.7000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.5566
    Cell Significance Index: 8.9300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5348
    Cell Significance Index: 15.4100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4768
    Cell Significance Index: 10.3300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4640
    Cell Significance Index: 12.6300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4552
    Cell Significance Index: 82.0600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4472
    Cell Significance Index: 30.9300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4293
    Cell Significance Index: 52.7900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4280
    Cell Significance Index: 26.3100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4033
    Cell Significance Index: 18.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3708
    Cell Significance Index: 202.4900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3705
    Cell Significance Index: 20.7900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2518
    Cell Significance Index: 11.7400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.2514
    Cell Significance Index: 3.2200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2420
    Cell Significance Index: 33.2400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2418
    Cell Significance Index: 6.0500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2307
    Cell Significance Index: 159.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2303
    Cell Significance Index: 101.8300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1999
    Cell Significance Index: 19.7700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1622
    Cell Significance Index: 8.4500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1605
    Cell Significance Index: 3.8500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1427
    Cell Significance Index: 16.8300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1423
    Cell Significance Index: 8.9700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1050
    Cell Significance Index: 8.0600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0801
    Cell Significance Index: 2.0600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0726
    Cell Significance Index: 1.9100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0712
    Cell Significance Index: 4.6000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0665
    Cell Significance Index: 3.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0595
    Cell Significance Index: 112.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0544
    Cell Significance Index: 10.3600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0504
    Cell Significance Index: 6.5100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0449
    Cell Significance Index: 0.7700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0313
    Cell Significance Index: 1.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0241
    Cell Significance Index: 37.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0170
    Cell Significance Index: 31.2900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0051
    Cell Significance Index: 6.9200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0037
    Cell Significance Index: 0.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0023
    Cell Significance Index: -1.4600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0049
    Cell Significance Index: -2.2400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0066
    Cell Significance Index: -1.1200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0174
    Cell Significance Index: -1.3000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0275
    Cell Significance Index: -20.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0300
    Cell Significance Index: -22.7400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0338
    Cell Significance Index: -25.0300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0342
    Cell Significance Index: -1.1900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0369
    Cell Significance Index: -1.9400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0481
    Cell Significance Index: -6.1600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0488
    Cell Significance Index: -3.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0491
    Cell Significance Index: -7.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0511
    Cell Significance Index: -28.8100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0536
    Cell Significance Index: -0.6600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0543
    Cell Significance Index: -33.9000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0671
    Cell Significance Index: -1.4300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0702
    Cell Significance Index: -7.1700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0847
    Cell Significance Index: -24.3600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1378
    Cell Significance Index: -1.8800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1586
    Cell Significance Index: -33.4100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1615
    Cell Significance Index: -18.5000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1670
    Cell Significance Index: -3.4700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1915
    Cell Significance Index: -2.8700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2007
    Cell Significance Index: -4.2000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2023
    Cell Significance Index: -3.3900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2657
    Cell Significance Index: -27.6700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2666
    Cell Significance Index: -7.8300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2829
    Cell Significance Index: -9.0600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3073
    Cell Significance Index: -8.2400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3467
    Cell Significance Index: -27.4600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3616
    Cell Significance Index: -3.3300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3616
    Cell Significance Index: -10.3700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3835
    Cell Significance Index: -8.1400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.4078
    Cell Significance Index: -5.7200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4264
    Cell Significance Index: -13.5800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4356
    Cell Significance Index: -14.2600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4385
    Cell Significance Index: -8.6700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4968
    Cell Significance Index: -7.1200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5055
    Cell Significance Index: -30.9900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5250
    Cell Significance Index: -10.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** NELFA is a protein that belongs to the negative elongation factor complex (NEF-C) family. The NEF-C complex is composed of multiple subunits, including NELFA, which is responsible for binding to the RNA polymerase II (RNAPII) complex and regulating its activity. NELFA is a highly conserved protein across different species, suggesting its essential role in various cellular processes. The gene expression profile of NELFA is widespread, with high expression levels in various cell types, including neurons, fibroblasts, and immune cells. **Pathways and Functions** NELFA is involved in several key pathways, including: 1. **Transcription Elongation**: NELFA works to slow down the transcription process by binding to the RNAPII complex and inhibiting its activity. This ensures that the transcription process is accurate and efficient. 2. **Gene Expression**: NELFA plays a critical role in regulating gene expression by controlling the transcription of genetic information. 3. **Viral Replication**: NELFA is involved in the regulation of viral replication, particularly in the context of HIV-1. The NEF-C complex is essential for the proper regulation of transcription elongation, allowing for the efficient transcription of viral genetic material. 4. **Cellular Signaling**: NELFA is also involved in cellular signaling pathways, including the regulation of protein modification processes and the positive regulation of transcription by RNAPII. **Clinical Significance** NELFA has been implicated in various diseases, including: 1. **HIV-1 Infection**: NELFA plays a critical role in the regulation of viral replication, making it an important target for the development of HIV-1 therapies. 2. **Cancer**: NELFA has been shown to be overexpressed in certain types of cancer, suggesting its potential role in tumorigenesis. 3. **Neurological Disorders**: NELFA has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease, suggesting its potential role in neurodegenerative diseases. In conclusion, NELFA is an essential protein that plays a critical role in regulating transcription elongation and gene expression. Its involvement in various diseases, including HIV-1 infection, cancer, and neurological disorders, highlights its potential as a therapeutic target and a biomarker for disease diagnosis. Further research is needed to fully elucidate the role of NELFA in these diseases and to explore its potential as a therapeutic agent.

Genular Protein ID: 4281688024

Symbol: NELFA_HUMAN

Name: Negative elongation factor A

UniProtKB Accession Codes:

Q9H3P2 A2A2T1 O95392

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 7 EMDB 11 Ensembl 1 ExpressionAtlas 1 GO 10 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 11 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 14 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10409432

Title: Comparative analysis of a novel gene from the Wolf-Hirschhorn/Pitt-Rogers-Danks syndrome critical region.

PubMed ID: 10409432

DOI: 10.1006/geno.1999.5871

PubMed ID: 11280764

Title: Molecular basis of T cell-mediated recognition of pancreatic cancer cells.

PubMed ID: 11280764

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11387440

Title: Stimulation of RNA polymerase II elongation by hepatitis delta antigen.

PubMed ID: 11387440

DOI: 10.1126/science.1057925

PubMed ID: 10199401

Title: NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation.

PubMed ID: 10199401

DOI: 10.1016/s0092-8674(00)80713-8

PubMed ID: 11150502

Title: Modulation of WHSC2 expression in human endothelial cells.

PubMed ID: 11150502

DOI: 10.1016/s0014-5793(00)02335-8

PubMed ID: 12563561

Title: Mapping the Wolf-Hirschhorn syndrome phenotype outside the currently accepted WHS critical region and defining a new critical region, WHSCR-2.

PubMed ID: 12563561

DOI: 10.1086/367925

PubMed ID: 12612062

Title: Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex.

PubMed ID: 12612062

DOI: 10.1128/mcb.23.6.1863-1873.2003

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23884411

Title: Negative elongation factor (NELF) coordinates RNA polymerase II pausing, premature termination, and chromatin remodeling to regulate HIV transcription.

PubMed ID: 23884411

DOI: 10.1074/jbc.m113.496489

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27282391

Title: Architecture and RNA binding of the human negative elongation factor.

PubMed ID: 27282391

DOI: 10.7554/elife.14981

Sequence Information:

  • Length: 528
  • Mass: 57277
  • Checksum: 4F33C3BC68BDC798
  • Sequence:
    • MASMRESDTG LWLHNKLGAT DELWAPPSIA SLLTAAVIDN IRLCFHGLSS AVKLKLLLGT 
LHLPRRTVDE MKGALMEIIQ LASLDSDPWV LMVADILKSF PDTGSLNLEL EEQNPNVQDI 
LGELREKVGE CEASAMLPLE CQYLNKNALT TLAGPLTPPV KHFQLKRKPK SATLRAELLQ 
KSTETAQQLK RSAGVPFHAK GRGLLRKMDT TTPLKGIPKQ APFRSPTAPS VFSPTGNRTP 
IPPSRTLLRK ERGVKLLDIS ELDMVGAGRE AKRRRKTLDA EVVEKPAKEE TVVENATPDY 
AAGLVSTQKL GSLNNEPALP STSYLPSTPS VVPASSYIPS SETPPAPSSR EASRPPEEPS 
APSPTLPAQF KQRAPMYNSG LSPATPTPAA PTSPLTPTTP PAVAPTTQTP PVAMVAPQTQ 
APAQQQPKKN LSLTREQMFA AQEMFKTANK VTRPEKALIL GFMAGSRENP CQEQGDVIQI 
KLSEHTEDLP KADGQGSTTM LVDTVFEMNY ATGQWTRFKK YKPMTNVS

Genular Protein ID: 3849663971

Symbol: A0A0C4DFX9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0C4DFX9

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 3 GeneTree 1 HGNC 1 IntAct 1 InterPro 2 KEGG 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 PhylomeDB 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMR 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 539
  • Mass: 58499
  • Checksum: 6A2F0080991B2271
  • Sequence:
    • MPGQRRALSP KMASMRESDT GLWLHNKLGA TDELWAPPSI ASLLTAAVID NIRLCFHGLS 
SAVKLKLLLG TLHLPRRTVD EMKGALMEII QLASLDSDPW VLMVADILKS FPDTGSLNLE 
LEEQNPNVQD ILGELREKVG ECEASAMLPL ECQYLNKNAL TTLAGPLTPP VKHFQLKRKP 
KSATLRAELL QKSTETAQQL KRSAGVPFHA KGRGLLRKMD TTTPLKGIPK QAPFRSPTAP 
SVFSPTGNRT PIPPSRTLLR KERGVKLLDI SELDMVGAGR EAKRRRKTLD AEVVEKPAKE 
ETVVENATPD YAAGLVSTQK LGSLNNEPAL PSTSYLPSTP SVVPASSYIP SSETPPAPSS 
REASRPPEEP SAPSPTLPAQ FKQRAPMYNS GLSPATPTPA APTSPLTPTT PPAVAPTTQT 
PPVAMVAPQT QAPAQQQPKK NLSLTREQMF AAQEMFKTAN KVTRPEKALI LGFMAGSREN 
PCQEQGDVIQ IKLSEHTEDL PKADGQGSTT MLVDTVFEMN YATGQWTRFK KYKPMTNVS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.