Details for: WNT7B

Gene ID: 7477

Symbol: WNT7B

Ensembl ID: ENSG00000188064

Description: Wnt family member 7B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 8.7046
    Cell Significance Index: 190.6000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 5.7759
    Cell Significance Index: 300.0400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 5.2894
    Cell Significance Index: -5.0500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.5291
    Cell Significance Index: 48.1500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.3107
    Cell Significance Index: -6.1900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 2.0504
    Cell Significance Index: 51.2600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.0261
    Cell Significance Index: 55.1500
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.9941
    Cell Significance Index: 20.5700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.8100
    Cell Significance Index: 110.9700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.6234
    Cell Significance Index: 23.1100
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.5502
    Cell Significance Index: 3.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1556
    Cell Significance Index: 208.3100
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.1394
    Cell Significance Index: 9.0000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1207
    Cell Significance Index: 137.8000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.7123
    Cell Significance Index: 22.8200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.5242
    Cell Significance Index: 7.9000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5136
    Cell Significance Index: 97.7400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.5134
    Cell Significance Index: 8.4600
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.5077
    Cell Significance Index: 1.5100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.4583
    Cell Significance Index: 4.2200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3011
    Cell Significance Index: 29.7900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2801
    Cell Significance Index: 252.9400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2631
    Cell Significance Index: 94.3600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2451
    Cell Significance Index: 6.8500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1923
    Cell Significance Index: 85.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1672
    Cell Significance Index: 91.2900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1564
    Cell Significance Index: 25.4400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1312
    Cell Significance Index: 178.3400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1142
    Cell Significance Index: 12.4200
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.0973
    Cell Significance Index: 0.6000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0527
    Cell Significance Index: 3.6500
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.0516
    Cell Significance Index: 0.6000
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.0275
    Cell Significance Index: 0.1700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0162
    Cell Significance Index: 0.9700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0130
    Cell Significance Index: 20.0200
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.0092
    Cell Significance Index: 0.0500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0088
    Cell Significance Index: 0.4000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0063
    Cell Significance Index: 4.8000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0014
    Cell Significance Index: 0.1900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0007
    Cell Significance Index: 0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0035
    Cell Significance Index: -6.5600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0037
    Cell Significance Index: -6.7500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0044
    Cell Significance Index: -0.3200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0062
    Cell Significance Index: -4.5400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0065
    Cell Significance Index: -0.2300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0081
    Cell Significance Index: -0.5000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0087
    Cell Significance Index: -5.5100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0109
    Cell Significance Index: -8.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0133
    Cell Significance Index: -2.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0142
    Cell Significance Index: -8.0000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0151
    Cell Significance Index: -6.8400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0193
    Cell Significance Index: -5.5600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0248
    Cell Significance Index: -4.9200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0303
    Cell Significance Index: -3.4700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0314
    Cell Significance Index: -0.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0315
    Cell Significance Index: -3.6700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0318
    Cell Significance Index: -4.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0331
    Cell Significance Index: -4.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0359
    Cell Significance Index: -6.1300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0359
    Cell Significance Index: -0.5500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0393
    Cell Significance Index: -8.2800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0393
    Cell Significance Index: -1.0100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0443
    Cell Significance Index: -4.5300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0462
    Cell Significance Index: -1.0000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0486
    Cell Significance Index: -6.6700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0531
    Cell Significance Index: -6.2600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0555
    Cell Significance Index: -3.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0560
    Cell Significance Index: -2.6100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0709
    Cell Significance Index: -3.3300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0730
    Cell Significance Index: -5.7800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0856
    Cell Significance Index: -5.5200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0924
    Cell Significance Index: -4.8200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0927
    Cell Significance Index: -6.2300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0931
    Cell Significance Index: -2.3300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1018
    Cell Significance Index: -7.2000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1065
    Cell Significance Index: -2.2100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1137
    Cell Significance Index: -4.6600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1138
    Cell Significance Index: -1.9500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1161
    Cell Significance Index: -8.9100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1213
    Cell Significance Index: -0.7200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1232
    Cell Significance Index: -6.2200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1447
    Cell Significance Index: -4.2600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1479
    Cell Significance Index: -8.3000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1488
    Cell Significance Index: -3.1700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1511
    Cell Significance Index: -4.7800
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.1538
    Cell Significance Index: -2.1500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1616
    Cell Significance Index: -3.8800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1645
    Cell Significance Index: -6.0400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1692
    Cell Significance Index: -5.8800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1755
    Cell Significance Index: -4.6900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1824
    Cell Significance Index: -6.3900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1837
    Cell Significance Index: -3.1000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1837
    Cell Significance Index: -2.6100
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1847
    Cell Significance Index: -1.1600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1847
    Cell Significance Index: -9.7000
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.1850
    Cell Significance Index: -1.5900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1888
    Cell Significance Index: -8.3500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1900
    Cell Significance Index: -4.7400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1918
    Cell Significance Index: -6.2800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1996
    Cell Significance Index: -1.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Wnt family member**: WNT7B is a member of the Wnt family, which consists of a group of secreted proteins that signal through the Wnt/β-catenin pathway to regulate various cellular processes. 2. **Canonical Wnt signaling pathway**: WNT7B is a ligand that activates the canonical Wnt signaling pathway, which involves the binding of WNT7B to its receptor, Frizzled, and the subsequent activation of β-catenin. 3. **Multiple expression patterns**: WNT7B is expressed in various cell types, including Purkinje cells, cardiac endothelial cells, and intestinal crypt stem cells, highlighting its role in different tissues and organs. 4. **Regulation of cell fate commitment**: WNT7B has been shown to regulate cell fate commitment, particularly in the development of the central nervous system and the intestinal epithelium. **Pathways and Functions:** 1. **Canonical Wnt signaling pathway**: WNT7B activates the canonical Wnt signaling pathway, which is involved in the regulation of cell fate commitment, proliferation, and differentiation. 2. **Cell fate commitment**: WNT7B regulates cell fate commitment, particularly in the development of the central nervous system and the intestinal epithelium. 3. **Developmental growth involved in morphogenesis**: WNT7B is involved in the regulation of developmental growth and morphogenesis, particularly in the development of the central nervous system and the intestinal epithelium. 4. **Chemoattraction of dopaminergic neuron axon**: WNT7B has been shown to regulate the chemoattraction of dopaminergic neuron axon, highlighting its role in the development of the nervous system. 5. **Cytokine activity**: WNT7B has been shown to regulate cytokine activity, particularly in the regulation of the immune response. **Clinical Significance:** 1. **Neurodevelopmental disorders**: Mutations in the WNT7B gene have been associated with neurodevelopmental disorders, such as autism spectrum disorder and intellectual disability. 2. **Cancer**: WNT7B has been implicated in the development and progression of various cancers, including colorectal cancer and lung cancer. 3. **Inflammatory bowel disease**: WNT7B has been shown to regulate inflammation in the intestinal epithelium, and its dysregulation has been implicated in inflammatory bowel disease. 4. **Cardiovascular disease**: WNT7B has been shown to regulate the development of the cardiovascular system, and its dysregulation has been implicated in cardiovascular disease. In conclusion, the WNT7B gene plays a crucial role in the regulation of various cellular processes, including development, cell fate commitment, and tissue homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of further research in this area.

Genular Protein ID: 1804076613

Symbol: WNT7B_HUMAN

Name: Protein Wnt-7b

UniProtKB Accession Codes:

P56706 B8A596 Q96Q12

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 49 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11562755

Title: Molecular cloning and characterization of human WNT7B.

PubMed ID: 11562755

DOI: 10.3892/ijo.19.4.779

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8168088

Title: Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue.

PubMed ID: 8168088

PubMed ID: 16227623

Title: Processing by convertases is not required for glypican-3-induced stimulation of hepatocellular carcinoma growth.

PubMed ID: 16227623

DOI: 10.1074/jbc.m507004200

PubMed ID: 26902720

Title: Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/alpha-albumin.

PubMed ID: 26902720

DOI: 10.7554/elife.11621

PubMed ID: 30026314

Title: A molecular mechanism for Wnt ligand-specific signaling.

PubMed ID: 30026314

DOI: 10.1126/science.aat1178

Sequence Information:

  • Length: 349
  • Mass: 39327
  • Checksum: D114C329118C7CB1
  • Sequence:
    • MHRNFRKWIF YVFLCFGVLY VKLGALSSVV ALGANIICNK IPGLAPRQRA ICQSRPDAII 
VIGEGAQMGI NECQYQFRFG RWNCSALGEK TVFGQELRVG SREAAFTYAI TAAGVAHAVT 
AACSQGNLSN CGCDREKQGY YNQAEGWKWG GCSADVRYGI DFSRRFVDAR EIKKNARRLM 
NLHNNEAGRK VLEDRMQLEC KCHGVSGSCT TKTCWTTLPK FREVGHLLKE KYNAAVQVEV 
VRASRLRQPT FLRIKQLRSY QKPMETDLVY IEKSPNYCEE DAATGSVGTQ GRLCNRTSPG 
ADGCDTMCCG RGYNTHQYTK VWQCNCKFHW CCFVKCNTCS ERTEVFTCK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.