Details for: XRCC3

Gene ID: 7517

Symbol: XRCC3

Ensembl ID: ENSG00000126215

Description: X-ray repair cross complementing 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 27.3875
    Cell Significance Index: -4.2600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 22.7485
    Cell Significance Index: -5.7700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 13.6244
    Cell Significance Index: -5.5400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 5.7974
    Cell Significance Index: -5.5400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.8907
    Cell Significance Index: -6.0300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.3928
    Cell Significance Index: -6.4100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.7271
    Cell Significance Index: 28.4600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.6168
    Cell Significance Index: -6.3800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0005
    Cell Significance Index: 98.9700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.5116
    Cell Significance Index: 7.1800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4843
    Cell Significance Index: 78.7700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4619
    Cell Significance Index: 50.2400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4471
    Cell Significance Index: 6.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3890
    Cell Significance Index: 77.2000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.3820
    Cell Significance Index: 5.3000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3779
    Cell Significance Index: 22.6900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3488
    Cell Significance Index: 314.9300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3464
    Cell Significance Index: 65.9300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3457
    Cell Significance Index: 9.6600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2796
    Cell Significance Index: 2.5800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2515
    Cell Significance Index: 11.4000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2308
    Cell Significance Index: 6.6500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2191
    Cell Significance Index: 12.3000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.2134
    Cell Significance Index: 6.7500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2004
    Cell Significance Index: 5.3700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1944
    Cell Significance Index: 10.1000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1777
    Cell Significance Index: 3.8500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1765
    Cell Significance Index: 31.8100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1639
    Cell Significance Index: 3.4000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1466
    Cell Significance Index: 10.1400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1428
    Cell Significance Index: 16.8400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1108
    Cell Significance Index: 22.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0967
    Cell Significance Index: 11.8900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0920
    Cell Significance Index: 1.0000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0788
    Cell Significance Index: 1.9700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0759
    Cell Significance Index: 2.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0680
    Cell Significance Index: 2.3900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0667
    Cell Significance Index: 7.7700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0474
    Cell Significance Index: 0.7100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.0399
    Cell Significance Index: 1.0200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0386
    Cell Significance Index: 2.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0369
    Cell Significance Index: 20.1500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0366
    Cell Significance Index: 25.2800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0303
    Cell Significance Index: 57.0300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0279
    Cell Significance Index: 1.3000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0273
    Cell Significance Index: 42.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0249
    Cell Significance Index: 0.6600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0246
    Cell Significance Index: 8.8200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0223
    Cell Significance Index: 1.4400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0202
    Cell Significance Index: 8.9300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0160
    Cell Significance Index: 0.3400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0155
    Cell Significance Index: 28.6100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0074
    Cell Significance Index: 10.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0014
    Cell Significance Index: -0.9000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0025
    Cell Significance Index: -0.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0028
    Cell Significance Index: -0.4100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0036
    Cell Significance Index: -0.0600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0043
    Cell Significance Index: -0.1900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0047
    Cell Significance Index: -0.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0060
    Cell Significance Index: -2.7400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0069
    Cell Significance Index: -0.8800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0076
    Cell Significance Index: -5.7200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0078
    Cell Significance Index: -5.7500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0085
    Cell Significance Index: -6.3300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0105
    Cell Significance Index: -0.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0115
    Cell Significance Index: -6.4600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0156
    Cell Significance Index: -1.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0162
    Cell Significance Index: -4.6800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0162
    Cell Significance Index: -1.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0189
    Cell Significance Index: -2.1700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0250
    Cell Significance Index: -3.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0259
    Cell Significance Index: -4.4300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0265
    Cell Significance Index: -0.3800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0283
    Cell Significance Index: -0.9900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0291
    Cell Significance Index: -0.6100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0336
    Cell Significance Index: -7.0800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0343
    Cell Significance Index: -3.5000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0413
    Cell Significance Index: -2.5300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0437
    Cell Significance Index: -1.1700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0478
    Cell Significance Index: -1.3000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0523
    Cell Significance Index: -5.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0584
    Cell Significance Index: -2.7500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0610
    Cell Significance Index: -2.3100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0611
    Cell Significance Index: -4.1100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0644
    Cell Significance Index: -2.8500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0662
    Cell Significance Index: -1.4500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0688
    Cell Significance Index: -3.6100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0710
    Cell Significance Index: -5.2900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0770
    Cell Significance Index: -6.1000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0877
    Cell Significance Index: -4.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1044
    Cell Significance Index: -6.4200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1059
    Cell Significance Index: -2.6400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1068
    Cell Significance Index: -1.5300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1174
    Cell Significance Index: -1.2200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1189
    Cell Significance Index: -2.3200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1279
    Cell Significance Index: -4.4800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1295
    Cell Significance Index: -4.2400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1298
    Cell Significance Index: -0.7700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1316
    Cell Significance Index: -3.4600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1330
    Cell Significance Index: -3.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **DNA repair function**: XRCC3 is an essential component of the DNA repair machinery, specifically involved in the repair of DSBs through HR and SSA pathways. 2. **Homologous recombination**: XRCC3 interacts with Rad51c to facilitate the exchange of genetic information between homologous DNA strands, allowing for the repair of DSBs. 3. **Synthesis-dependent strand annealing**: XRCC3 also participates in the SSA pathway, where it facilitates the annealing of complementary strands during DNA replication. 4. **Cell-type specific expression**: XRCC3 is highly expressed in cells with high proliferative capacities, such as cardiac endothelial cells and lymphoid lineage-restricted progenitor cells. 5. **Tissue-specific expression**: XRCC3 is also expressed in kidney proximal convoluted tubule epithelial cells and cardiac muscle myoblasts, highlighting its importance in maintaining tissue-specific genome stability. **Pathways and Functions** 1. **DNA double-strand break repair**: XRCC3 is involved in the repair of DSBs through HR and SSA pathways, ensuring genome stability and preventing mutations. 2. **DNA recombination**: XRCC3 facilitates the exchange of genetic information between homologous DNA strands, allowing for the repair of DSBs and the maintenance of genome integrity. 3. **Telomere maintenance**: XRCC3 is also involved in the maintenance of telomeres through recombination and SSA pathways, preventing telomere shortening and associated genomic instability. 4. **Interstrand cross-link repair**: XRCC3 participates in the repair of interstrand cross-links, which are lesions that can cause DNA damage and genomic instability. **Clinical Significance** 1. **Cancer susceptibility**: Mutations in XRCC3 have been associated with an increased risk of cancer, particularly in the context of homologous recombination deficiency (HRD). 2. **Genetic instability**: XRCC3 dysfunction can lead to genetic instability, resulting in an increased risk of mutations and genomic alterations. 3. **Neurological disorders**: XRCC3 mutations have been implicated in neurological disorders, such as ataxia-telangiectasia and ataxia with oculocerebroelopathy, due to its role in maintaining genome stability. 4. **Radiosensitivity**: XRCC3 plays a crucial role in the response to ionizing radiation, and its dysfunction can lead to increased radiosensitivity and genomic instability. In conclusion, XRCC3 is a critical gene involved in the repair of DNA double-strand breaks and the maintenance of genome stability. Its dysfunction can lead to genetic instability, cancer susceptibility, and neurological disorders, highlighting the importance of XRCC3 in maintaining genome integrity.

Genular Protein ID: 3366522496

Symbol: XRCC3_HUMAN

Name: DNA repair protein XRCC3

UniProtKB Accession Codes:

O43542 O43568 Q9BU18

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 4 ExpressionAtlas 1 GO 25 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 5 SASBDB 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9660962

Title: XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages.

PubMed ID: 9660962

DOI: 10.1016/s1097-2765(00)80078-7

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11751635

Title: Identification and purification of two distinct complexes containing the five RAD51 paralogs.

PubMed ID: 11751635

DOI: 10.1101/gad.947001

PubMed ID: 12023982

Title: Variants in DNA double-strand break repair genes and breast cancer susceptibility.

PubMed ID: 12023982

DOI: 10.1093/hmg/11.12.1399

PubMed ID: 11744692

Title: RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51.

PubMed ID: 11744692

DOI: 10.1074/jbc.m108306200

PubMed ID: 11842113

Title: Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells.

PubMed ID: 11842113

DOI: 10.1093/nar/30.4.1009

PubMed ID: 14704354

Title: Domain mapping of the Rad51 paralog protein complexes.

PubMed ID: 14704354

DOI: 10.1093/nar/gkg925

PubMed ID: 14716019

Title: RAD51C is required for Holliday junction processing in mammalian cells.

PubMed ID: 14716019

DOI: 10.1126/science.1093037

PubMed ID: 16215984

Title: Cellular localization of human Rad51C and regulation of ubiquitin-mediated proteolysis of Rad51.

PubMed ID: 16215984

DOI: 10.1002/jcb.20640

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 20413593

Title: Discovery of a novel function for human Rad51: maintenance of the mitochondrial genome.

PubMed ID: 20413593

DOI: 10.1074/jbc.m109.099846

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21965664

Title: hSWS1.SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair.

PubMed ID: 21965664

DOI: 10.1074/jbc.m111.271080

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23108668

Title: The RAD51 paralogs ensure cellular protection against mitotic defects and aneuploidy.

PubMed ID: 23108668

DOI: 10.1242/jcs.114595

PubMed ID: 23149936

Title: Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway.

PubMed ID: 23149936

DOI: 10.1128/mcb.00465-12

PubMed ID: 24141787

Title: Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair.

PubMed ID: 24141787

DOI: 10.1038/onc.2013.421

PubMed ID: 20207730

Title: Ring-shaped Rad51 paralog protein complexes bind Holliday junctions and replication forks as visualized by electron microscopy.

PubMed ID: 20207730

DOI: 10.1074/jbc.m109.074286

PubMed ID: 11059748

Title: A variant within the DNA repair gene XRCC3 is associated with the development of melanoma skin cancer.

PubMed ID: 11059748

PubMed ID: 12376526

Title: DNA repair gene XRCC3 241Met variant is not associated with risk of cutaneous malignant melanoma.

PubMed ID: 12376526

PubMed ID: 12037675

Title: Variant XRCC3 implicated in cancer is functional in homology-directed repair of double-strand breaks.

PubMed ID: 12037675

DOI: 10.1038/sj.onc.1205539

PubMed ID: 26137085

Title: XRCC3 T241M polymorphism and melanoma skin cancer risk: A meta-analysis.

PubMed ID: 26137085

DOI: 10.3892/ol.2015.3040

PubMed ID: 26922354

Title: Quantitative assessment of the influence of X-ray repair cross-complementing group 3 rs861539 polymorphism and cutaneous melanoma susceptibility.

PubMed ID: 26922354

DOI: 10.1007/s00403-016-1629-8

Sequence Information:

  • Length: 346
  • Mass: 37850
  • Checksum: 4DDF3B163C3B3332
  • Sequence:
    • MDLDLLDLNP RIIAAIKKAK LKSVKEVLHF SGPDLKRLTN LSSPEVWHLL RTASLHLRGS 
SILTALQLHQ QKERFPTQHQ RLSLGCPVLD ALLRGGLPLD GITELAGRSS AGKTQLALQL 
CLAVQFPRQH GGLEAGAVYI CTEDAFPHKR LQQLMAQQPR LRTDVPGELL QKLRFGSQIF 
IEHVADVDTL LECVNKKVPV LLSRGMARLV VIDSVAAPFR CEFDSQASAP RARHLQSLGA 
TLRELSSAFQ SPVLCINQVT EAMEEQGAAH GPLGFWDERV SPALGITWAN QLLVRLLADR 
LREEEAALGC PARTLRVLSA PHLPPSSCSY TISAEGVRGT PGTQSH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.