No CSI details found for gene ID: 7517
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3366522496
Symbol: XRCC3_HUMAN
Name: DNA repair protein XRCC3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9660962
Title: XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages.
PubMed ID: 9660962
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11751635
Title: Identification and purification of two distinct complexes containing the five RAD51 paralogs.
PubMed ID: 11751635
DOI: 10.1101/gad.947001
PubMed ID: 12023982
Title: Variants in DNA double-strand break repair genes and breast cancer susceptibility.
PubMed ID: 12023982
PubMed ID: 11744692
Title: RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51.
PubMed ID: 11744692
PubMed ID: 11842113
Title: Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells.
PubMed ID: 11842113
PubMed ID: 14704354
Title: Domain mapping of the Rad51 paralog protein complexes.
PubMed ID: 14704354
DOI: 10.1093/nar/gkg925
PubMed ID: 14716019
Title: RAD51C is required for Holliday junction processing in mammalian cells.
PubMed ID: 14716019
PubMed ID: 16215984
Title: Cellular localization of human Rad51C and regulation of ubiquitin-mediated proteolysis of Rad51.
PubMed ID: 16215984
DOI: 10.1002/jcb.20640
PubMed ID: 17525332
Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
PubMed ID: 17525332
PubMed ID: 20413593
Title: Discovery of a novel function for human Rad51: maintenance of the mitochondrial genome.
PubMed ID: 20413593
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21965664
Title: hSWS1.SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair.
PubMed ID: 21965664
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23108668
Title: The RAD51 paralogs ensure cellular protection against mitotic defects and aneuploidy.
PubMed ID: 23108668
DOI: 10.1242/jcs.114595
PubMed ID: 23149936
Title: Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway.
PubMed ID: 23149936
DOI: 10.1128/mcb.00465-12
PubMed ID: 24141787
Title: Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair.
PubMed ID: 24141787
DOI: 10.1038/onc.2013.421
PubMed ID: 20207730
Title: Ring-shaped Rad51 paralog protein complexes bind Holliday junctions and replication forks as visualized by electron microscopy.
PubMed ID: 20207730
PubMed ID: 11059748
Title: A variant within the DNA repair gene XRCC3 is associated with the development of melanoma skin cancer.
PubMed ID: 11059748
PubMed ID: 12376526
Title: DNA repair gene XRCC3 241Met variant is not associated with risk of cutaneous malignant melanoma.
PubMed ID: 12376526
PubMed ID: 12037675
Title: Variant XRCC3 implicated in cancer is functional in homology-directed repair of double-strand breaks.
PubMed ID: 12037675
PubMed ID: 26137085
Title: XRCC3 T241M polymorphism and melanoma skin cancer risk: A meta-analysis.
PubMed ID: 26137085
DOI: 10.3892/ol.2015.3040
PubMed ID: 26922354
Title: Quantitative assessment of the influence of X-ray repair cross-complementing group 3 rs861539 polymorphism and cutaneous melanoma susceptibility.
PubMed ID: 26922354
Sequence Information:
- Length: 346
- Mass: 37850
- Checksum: 4DDF3B163C3B3332
- Sequence:
MDLDLLDLNP RIIAAIKKAK LKSVKEVLHF SGPDLKRLTN LSSPEVWHLL RTASLHLRGS SILTALQLHQ QKERFPTQHQ RLSLGCPVLD ALLRGGLPLD GITELAGRSS AGKTQLALQL CLAVQFPRQH GGLEAGAVYI CTEDAFPHKR LQQLMAQQPR LRTDVPGELL QKLRFGSQIF IEHVADVDTL LECVNKKVPV LLSRGMARLV VIDSVAAPFR CEFDSQASAP RARHLQSLGA TLRELSSAFQ SPVLCINQVT EAMEEQGAAH GPLGFWDERV SPALGITWAN QLLVRLLADR LREEEAALGC PARTLRVLSA PHLPPSSCSY TISAEGVRGT PGTQSH
Details Unavailable
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{
"geneID": 7517,
"tax": {
"id": 9606,
"name": [
{
"name": "Homo sapiens Linnaeus 1758"
},
{
"name": "Homo sapiens",
"type": 0
},
{
"name": "human",
"type": 4
}
]
},
"accession": {
"gene": [
"AL049840.8"
]
},
"genePos": {
"start": 103697617,
"end": 103715451
},
"orientation": true,
"symbol": "XRCC3",
"created": {
"$date": {
"$numberLong": "1738333349260"
}
},
"crossReference": {
"enseGeneID": "ENSG00000126215",
"enseRnaID": [
"ENST00000352127.11"
],
"enseProtID": [
"ENSP00000343392.7"
]
},
"chrom": {
"pos": "14",
"type": 1,
"loc": "14q32.33"
},
"desc": "X-ray repair cross complementing 3",
"geneType": 5,
"mim": [
{
"id": 600675,
"relation": 0
}
],
"ontology": [
{
"id": "R-HSA-73894",
"term": "DNA Repair",
"cat": 10
},
{
"id": "R-HSA-5693532",
"term": "DNA Double-Strand Break Repair",
"cat": 11
},
{
"id": "R-HSA-5693538",
"term": "Homology Directed Repair",
"cat": 12
},
{
"id": "R-HSA-5693567",
"term": "HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)",
"cat": 13
},
{
"id": "R-HSA-5685942",
"term": "HDR through Homologous Recombination (HRR)",
"cat": 14
},
{
"id": "R-HSA-5693537",
"term": "Resolution of D-Loop Structures",
"cat": 15
},
{
"id": "R-HSA-5693579",
"term": "Homologous DNA Pairing and Strand Exchange",
"cat": 15
},
{
"id": "R-HSA-5693554",
"term": "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)",
"cat": 16
},
{
"id": "R-HSA-5693568",
"term": "Resolution of D-loop Structures through Holliday Junction Intermediates",
"cat": 16
},
{
"id": "GO:0000400",
"term": "four-way junction DNA binding",
"cat": 0
},
{
"id": "GO:0000400",
"term": "four-way junction DNA binding",
"pubMed": [
20207730
],
"cat": 0
},
{
"id": "GO:0005515",
"term": "protein binding",
"pubMed": [
9469824,
9660962,
11751635,
11842113,
21965664,
24005329,
24141787,
26496610,
28864920,
34591612
],
"cat": 0
},
{
"id": "GO:0005524",
"term": "ATP binding",
"cat": 0
},
{
"id": "GO:0008821",
"term": "crossover junction DNA endonuclease activity",
"pubMed": [
14716019,
23108668
],
"cat": 0
},
{
"id": "GO:0140664",
"term": "ATP-dependent DNA damage sensor activity",
"cat": 0
},
{
"id": "GO:0000722",
"term": "telomere maintenance via recombination",
"cat": 1
},
{
"id": "GO:0000722",
"term": "telomere maintenance via recombination",
"pubMed": [
15507207
],
"cat": 1
},
{
"id": "GO:0000724",
"term": "double-strand break repair via homologous recombination",
"pubMed": [
23149936
],
"cat": 1
},
{
"id": "GO:0006281",
"term": "DNA repair",
"pubMed": [
10422536
],
"cat": 1
},
{
"id": "GO:0006310",
"term": "DNA recombination",
"pubMed": [
9660962
],
"cat": 1
},
{
"id": "GO:0006974",
"term": "DNA damage response",
"pubMed": [
7603995
],
"cat": 1
},
{
"id": "GO:0010824",
"term": "regulation of centrosome duplication",
"pubMed": [
23108668
],
"cat": 1
},
{
"id": "GO:0036297",
"term": "interstrand cross-link repair",
"pubMed": [
26323318
],
"cat": 1
},
{
"id": "GO:0045003",
"term": "double-strand break repair via synthesis-dependent strand annealing",
"cat": 1
},
{
"id": "GO:0071140",
"term": "resolution of mitotic recombination intermediates",
"cat": 1
},
{
"id": "GO:0071140",
"term": "resolution of mitotic recombination intermediates",
"pubMed": [
23108668
],
"cat": 1
},
{
"id": "GO:0090267",
"term": "positive regulation of mitotic cell cycle spindle assembly checkpoint",
"pubMed": [
23108668
],
"cat": 1
},
{
"id": "GO:0090656",
"term": "t-circle formation",
"cat": 1
},
{
"id": "GO:0090656",
"term": "t-circle formation",
"pubMed": [
15507207
],
"cat": 1
},
{
"id": "GO:0090656",
"term": "t-circle formation",
"pubMed": [
21903669
],
"cat": 1
},
{
"id": "GO:0090657",
"term": "telomeric loop disassembly",
"pubMed": [
27918544
],
"cat": 1
},
{
"id": "GO:0090737",
"term": "telomere maintenance via telomere trimming",
"pubMed": [
27918544
],
"cat": 1
},
{
"id": "GO:0000781",
"term": "chromosome, telomeric region",
"pubMed": [
15507207
],
"cat": 2
},
{
"id": "GO:0005634",
"term": "nucleus",
"pubMed": [
16215984,
26323318
],
"cat": 2
},
{
"id": "GO:0005654",
"term": "nucleoplasm",
"cat": 2
},
{
"id": "GO:0005657",
"term": "replication fork",
"cat": 2
},
{
"id": "GO:0005657",
"term": "replication fork",
"pubMed": [
20207730
],
"cat": 2
},
{
"id": "GO:0005737",
"term": "cytoplasm",
"pubMed": [
16215984
],
"cat": 2
},
{
"id": "GO:0005739",
"term": "mitochondrion",
"pubMed": [
20413593
],
"cat": 2
},
{
"id": "GO:0005829",
"term": "cytosol",
"cat": 2
},
{
"id": "GO:0033065",
"term": "Rad51C-XRCC3 complex",
"cat": 2
},
{
"id": "GO:0033065",
"term": "Rad51C-XRCC3 complex",
"pubMed": [
11751635
],
"cat": 2
},
{
"id": "GO:0048471",
"term": "perinuclear region of cytoplasm",
"pubMed": [
16215984
],
"cat": 2
}
],
"protein": [
{
"symbol": "XRCC3_HUMAN",
"name": "DNA repair protein XRCC3",
"accession": [
"O43542",
"O43568",
"Q9BU18"
],
"databaseIDs": {
"NCBI Taxonomy": [
"9606"
],
"MIM": [
"114480",
"613972",
"114480",
"600675",
"613972"
],
"EMBL": [
"AF035586",
"AF037222",
"AF508041",
"BC001036",
"BC002949",
"BC011725"
],
"CCDS": [
"CCDS9984.1"
],
"RefSeq": [
"NP_001093588.1",
"NP_001093589.1",
"NP_005423.1",
"XP_005268103.1",
"XP_011535440.1"
],
"AlphaFoldDB": [
"O43542"
],
"SASBDB": [
"O43542"
],
"SMR": [
"O43542"
],
"BioGRID": [
"113351"
],
"ComplexPortal": [
"CPX-2182"
],
"CORUM": [
"O43542"
],
"DIP": [
"DIP-42016N"
],
"IntAct": [
"O43542"
],
"MINT": [
"O43542"
],
"STRING": [
"9606.ENSP00000451974"
],
"iPTMnet": [
"O43542"
],
"PhosphoSitePlus": [
"O43542"
],
"BioMuta": [
"XRCC3"
],
"jPOST": [
"O43542"
],
"MassIVE": [
"O43542"
],
"PaxDb": [
"9606-ENSP00000451974"
],
"PeptideAtlas": [
"O43542"
],
"ProteomicsDB": [
"49041"
],
"Pumba": [
"O43542"
],
"Antibodypedia": [
"14778"
],
"DNASU": [
"7517"
],
"Ensembl": [
"ENST00000352127.11",
"ENST00000553264.5",
"ENST00000554913.5",
"ENST00000555055.6"
],
"KEGG": [
"hsa:7517"
],
"MANE-Select": [
"ENST00000555055.6"
],
"AGR": [
"HGNC:12830"
],
"CTD": [
"7517"
],
"DisGeNET": [
"7517"
],
"GeneCards": [
"XRCC3"
],
"HGNC": [
"HGNC:12830"
],
"HPA": [
"ENSG00000126215"
],
"MalaCards": [
"XRCC3"
],
"neXtProt": [
"NX_O43542"
],
"OpenTargets": [
"ENSG00000126215"
],
"PharmGKB": [
"PA37422"
],
"VEuPathDB": [
"HostDB:ENSG00000126215"
],
"eggNOG": [
"KOG1564"
],
"GeneTree": [
"ENSGT00930000151053"
],
"HOGENOM": [
"CLU_041732_1_0_1"
],
"InParanoid": [
"O43542"
],
"OMA": [
"PCLGLQW"
],
"OrthoDB": [
"3177495at2759"
],
"PhylomeDB": [
"O43542"
],
"TreeFam": [
"TF101203"
],
"PathwayCommons": [
"O43542"
],
"Reactome": [
"R-HSA-5685942",
"R-HSA-5693554",
"R-HSA-5693568",
"R-HSA-5693579"
],
"SignaLink": [
"O43542"
],
"SIGNOR": [
"O43542"
],
"BioGRID-ORCS": [
"7517"
],
"ChiTaRS": [
"XRCC3"
],
"GeneWiki": [
"XRCC3"
],
"GenomeRNAi": [
"7517"
],
"Pharos": [
"O43542"
],
"PRO": [
"PR:O43542"
],
"Proteomes": [
"UP000005640"
],
"RNAct": [
"O43542"
],
"Bgee": [
"ENSG00000126215"
],
"ExpressionAtlas": [
"O43542"
],
"GO": [
"GO:0000781",
"GO:0005737",
"GO:0005829",
"GO:0005739",
"GO:0005654",
"GO:0005634",
"GO:0048471",
"GO:0033065",
"GO:0005657",
"GO:0005524",
"GO:0140664",
"GO:0003677",
"GO:0006974",
"GO:0006310",
"GO:0006281",
"GO:0000724",
"GO:0045003",
"GO:0036297",
"GO:0090267",
"GO:0010824",
"GO:0071140",
"GO:0090656",
"GO:0000722",
"GO:0090737",
"GO:0090657"
],
"CDD": [
"cd19491"
],
"Gene3D": [
"3.40.50.300"
],
"InterPro": [
"IPR013632",
"IPR016467",
"IPR027417",
"IPR020588",
"IPR047348"
],
"PANTHER": [
"PTHR46487",
"PTHR46487:SF1"
],
"Pfam": [
"PF08423"
],
"PIRSF": [
"PIRSF005856"
],
"SUPFAM": [
"SSF47789",
"SSF52540"
],
"PROSITE": [
"PS50162"
],
"ChEBI": [
"CHEBI:30616"
]
},
"citations": [
{
"title": "XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages.",
"pubmedID": "9660962",
"doi": "10.1016\/s1097-2765(00)80078-7"
},
{
"title": "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).",
"pubmedID": "15489334",
"doi": "10.1101\/gr.2596504"
},
{
"title": "Identification and purification of two distinct complexes containing the five RAD51 paralogs.",
"pubmedID": "11751635",
"doi": "10.1101\/gad.947001"
},
{
"title": "Variants in DNA double-strand break repair genes and breast cancer susceptibility.",
"pubmedID": "12023982",
"doi": "10.1093\/hmg\/11.12.1399"
},
{
"title": "RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51.",
"pubmedID": "11744692",
"doi": "10.1074\/jbc.m108306200"
},
{
"title": "Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells.",
"pubmedID": "11842113",
"doi": "10.1093\/nar\/30.4.1009"
},
{
"title": "Domain mapping of the Rad51 paralog protein complexes.",
"pubmedID": "14704354",
"doi": "10.1093\/nar\/gkg925"
},
{
"title": "RAD51C is required for Holliday junction processing in mammalian cells.",
"pubmedID": "14716019",
"doi": "10.1126\/science.1093037"
},
{
"title": "Cellular localization of human Rad51C and regulation of ubiquitin-mediated proteolysis of Rad51.",
"pubmedID": "16215984",
"doi": "10.1002\/jcb.20640"
},
{
"title": "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.",
"pubmedID": "17525332",
"doi": "10.1126\/science.1140321"
},
{
"title": "Discovery of a novel function for human Rad51: maintenance of the mitochondrial genome.",
"pubmedID": "20413593",
"doi": "10.1074\/jbc.m109.099846"
},
{
"title": "Initial characterization of the human central proteome.",
"pubmedID": "21269460",
"doi": "10.1186\/1752-0509-5-17"
},
{
"title": "hSWS1.SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair.",
"pubmedID": "21965664",
"doi": "10.1074\/jbc.m111.271080"
},
{
"title": "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.",
"pubmedID": "22814378",
"doi": "10.1073\/pnas.1210303109"
},
{
"title": "The RAD51 paralogs ensure cellular protection against mitotic defects and aneuploidy.",
"pubmedID": "23108668",
"doi": "10.1242\/jcs.114595"
},
{
"title": "Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway.",
"pubmedID": "23149936",
"doi": "10.1128\/mcb.00465-12"
},
{
"title": "Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair.",
"pubmedID": "24141787",
"doi": "10.1038\/onc.2013.421"
},
{
"title": "Ring-shaped Rad51 paralog protein complexes bind Holliday junctions and replication forks as visualized by electron microscopy.",
"pubmedID": "20207730",
"doi": "10.1074\/jbc.m109.074286"
},
{
"title": "A variant within the DNA repair gene XRCC3 is associated with the development of melanoma skin cancer.",
"pubmedID": "11059748"
},
{
"title": "DNA repair gene XRCC3 241Met variant is not associated with risk of cutaneous malignant melanoma.",
"pubmedID": "12376526"
},
{
"title": "Variant XRCC3 implicated in cancer is functional in homology-directed repair of double-strand breaks.",
"pubmedID": "12037675",
"doi": "10.1038\/sj.onc.1205539"
},
{
"title": "XRCC3 T241M polymorphism and melanoma skin cancer risk: A meta-analysis.",
"pubmedID": "26137085",
"doi": "10.3892\/ol.2015.3040"
},
{
"title": "Quantitative assessment of the influence of X-ray repair cross-complementing group 3 rs861539 polymorphism and cutaneous melanoma susceptibility.",
"pubmedID": "26922354",
"doi": "10.1007\/s00403-016-1629-8"
}
],
"sequence": {
"length": 346,
"mass": 37850,
"checksum": "4DDF3B163C3B3332",
"modified": {
"$date": {
"$numberLong": "896659200000"
}
},
"version": 1,
"sequence": "MDLDLLDLNPRIIAAIKKAKLKSVKEVLHFSGPDLKRLTNLSSPEVWHLLRTASLHLRGSSILTALQLHQQKERFPTQHQRLSLGCPVLDALLRGGLPLDGITELAGRSSAGKTQLALQLCLAVQFPRQHGGLEAGAVYICTEDAFPHKRLQQLMAQQPRLRTDVPGELLQKLRFGSQIFIEHVADVDTLLECVNKKVPVLLSRGMARLVVIDSVAAPFRCEFDSQASAPRARHLQSLGATLRELSSAFQSPVLCINQVTEAMEEQGAAHGPLGFWDERVSPALGITWANQLLVRLLADRLREEEAALGCPARTLRVLSAPHLPPSSCSYTISAEGVRGTPGTQSH"
},
"existence": 0,
"relevance": 1,
"proteinID": 3366522496
}
],
"singleCellExpressions": {
"cellSignificanceIndex": []
}
}