YWHAG | ENSG00000170027 | NCBI 7532

Details for: YWHAG

Gene ID: 7532

Symbol: YWHAG

Ensembl ID: ENSG00000170027

Description: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma

Associated with

Activation of bad and translocation to mitochondria
(R-HSA-111447)
Activation of bh3-only proteins
(R-HSA-114452)
Anchoring of the basal body to the plasma membrane
(R-HSA-5620912)
Apoptosis
(R-HSA-109581)
Aurka activation by tpx2
(R-HSA-8854518)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Centrosome maturation
(R-HSA-380287)
Chk1/chk2(cds1) mediated inactivation of cyclin b:cdk1 complex
(R-HSA-75035)
Cilium assembly
(R-HSA-5617833)
Disease
(R-HSA-1643685)
Foxo-mediated transcription
(R-HSA-9614085)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
G2/m transition
(R-HSA-69275)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Infectious disease
(R-HSA-5663205)
Intrinsic pathway for apoptosis
(R-HSA-109606)
Loss of nlp from mitotic centrosomes
(R-HSA-380259)
Loss of proteins required for interphase microtubule organization from the centrosome
(R-HSA-380284)
Membrane trafficking
(R-HSA-199991)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic prometaphase
(R-HSA-68877)
M phase
(R-HSA-68886)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Programmed cell death
(R-HSA-5357801)
Recruitment of mitotic centrosome proteins and complexes
(R-HSA-380270)
Recruitment of numa to mitotic centrosomes
(R-HSA-380320)
Regulation of localization of foxo transcription factors
(R-HSA-9614399)
Regulation of plk1 activity at g2/m transition
(R-HSA-2565942)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate pkns
(R-HSA-5625740)
Rna polymerase ii transcription
(R-HSA-73857)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1 targets host intracellular signalling and regulatory pathways
(R-HSA-9735871)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2 targets host intracellular signalling and regulatory pathways
(R-HSA-9755779)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Tp53 regulates metabolic genes
(R-HSA-5628897)
Transcriptional regulation by tp53
(R-HSA-3700989)
Translocation of slc2a4 (glut4) to the plasma membrane
(R-HSA-1445148)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Cellular response to glucose starvation
(GO:0042149)
Cellular response to insulin stimulus
(GO:0032869)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Extracellular exosome
(GO:0070062)
Focal adhesion
(GO:0005925)
Identical protein binding
(GO:0042802)
Insulin-like growth factor receptor binding
(GO:0005159)
Membrane
(GO:0016020)
Negative regulation of protein kinase activity
(GO:0006469)
Negative regulation of torc1 signaling
(GO:1904262)
Nucleus
(GO:0005634)
Phosphorylation-dependent protein binding
(GO:0140031)
Positive regulation of cell-cell adhesion
(GO:0022409)
Positive regulation of t cell activation
(GO:0050870)
Positive regulation of t cell mediated immune response to tumor cell
(GO:0002842)
Presynapse
(GO:0098793)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein kinase c binding
(GO:0005080)
Protein kinase c inhibitor activity
(GO:0008426)
Protein localization
(GO:0008104)
Protein sequestering activity
(GO:0140311)
Protein targeting
(GO:0006605)
Receptor tyrosine kinase binding
(GO:0030971)
Regulation of neuron differentiation
(GO:0045664)
Regulation of protein localization
(GO:0032880)
Regulation of signal transduction
(GO:0009966)
Regulation of synaptic plasticity
(GO:0048167)
Rna binding
(GO:0003723)
Signal transduction
(GO:0007165)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 435.3396
Cell Significance Index: -67.7200
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 255.1614
Cell Significance Index: -64.7200
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 178.2023
Cell Significance Index: -73.4100
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 148.3936
Cell Significance Index: -70.0600
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 127.7836
Cell Significance Index: -65.7300
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 58.0232
Cell Significance Index: -71.5400
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 24.5216
Cell Significance Index: -65.6900
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 23.9235
Cell Significance Index: -73.4800
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 18.3804
Cell Significance Index: -72.5300
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 10.1024
Cell Significance Index: -22.1100
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.2017
Cell Significance Index: 441.6600
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 2.0927
Cell Significance Index: 16.1300
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 1.9242
Cell Significance Index: 54.9100
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 1.6670
Cell Significance Index: 102.4600
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.3451
Cell Significance Index: 482.4600
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 1.2882
Cell Significance Index: 86.6200
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.2455
Cell Significance Index: 64.7000
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.2271
Cell Significance Index: 64.4300
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.1892
Cell Significance Index: 129.3500
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.1037
Cell Significance Index: 135.7100
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.0726
Cell Significance Index: 28.6400
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.0684
Cell Significance Index: 64.1400
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.0314
Cell Significance Index: 185.9300
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.0297
Cell Significance Index: 562.3300
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.9101
Cell Significance Index: 180.6200
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.8334
Cell Significance Index: 22.6900
Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.8089
Cell Significance Index: 19.4000
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.7034
Cell Significance Index: 20.2700
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.6870
Cell Significance Index: 303.7200
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.6304
Cell Significance Index: 48.3800
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.5416
Cell Significance Index: 37.4600
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.5158
Cell Significance Index: 24.2400
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.5107
Cell Significance Index: 70.1400
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.4551
Cell Significance Index: 33.9200
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4249
Cell Significance Index: 383.6300
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.4148
Cell Significance Index: 18.8000
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.3862
Cell Significance Index: 11.0700
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3823
Cell Significance Index: 72.7500
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3728
Cell Significance Index: 36.8800
Cell Name: lactocyte (CL0002325)
Fold Change: 0.3362
Cell Significance Index: 43.4300
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.2862
Cell Significance Index: 197.9400
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.2294
Cell Significance Index: 6.4100
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.1371
Cell Significance Index: 2.9700
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.1316
Cell Significance Index: 5.8200
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0808
Cell Significance Index: 109.9000
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0666
Cell Significance Index: 4.7100
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.0537
Cell Significance Index: 3.4700
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0537
Cell Significance Index: 101.1200
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0395
Cell Significance Index: 1.8400
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0308
Cell Significance Index: 5.2600
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0302
Cell Significance Index: 1.0600
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0197
Cell Significance Index: -30.2700
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0237
Cell Significance Index: -43.6500
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0249
Cell Significance Index: -18.4600
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0261
Cell Significance Index: -3.3500
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0299
Cell Significance Index: -3.5300
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0448
Cell Significance Index: -32.8400
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0459
Cell Significance Index: -28.6500
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0466
Cell Significance Index: -29.6000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0595
Cell Significance Index: -45.0500
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0666
Cell Significance Index: -6.8000
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.0693
Cell Significance Index: -11.2700
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0695
Cell Significance Index: -2.6300
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0742
Cell Significance Index: -33.6800
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0773
Cell Significance Index: -43.5800
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0958
Cell Significance Index: -3.3300
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1119
Cell Significance Index: -6.2800
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.1275
Cell Significance Index: -3.1100
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.1543
Cell Significance Index: -4.1400
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1701
Cell Significance Index: -35.8300
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1731
Cell Significance Index: -19.7600
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2140
Cell Significance Index: -61.5600
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2232
Cell Significance Index: -5.8700
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.2346
Cell Significance Index: -4.0200
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.2662
Cell Significance Index: -5.6700
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2790
Cell Significance Index: -40.5600
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.3359
Cell Significance Index: -8.5800
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.3423
Cell Significance Index: -4.6700
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3695
Cell Significance Index: -42.3300
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.3735
Cell Significance Index: -43.5300
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.4921
Cell Significance Index: -10.7800
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.5198
Cell Significance Index: -32.7600
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.5700
Cell Significance Index: -9.5400
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.5942
Cell Significance Index: -3.5900
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.6087
Cell Significance Index: -5.6100
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.6545
Cell Significance Index: -68.1500
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.6953
Cell Significance Index: -55.0700
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.7935
Cell Significance Index: -16.4600
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.8010
Cell Significance Index: -11.8300
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.8824
Cell Significance Index: -16.3100
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.9373
Cell Significance Index: -30.0200
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -1.0601
Cell Significance Index: -18.7300
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.1250
Cell Significance Index: -68.9700
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -1.1572
Cell Significance Index: -24.5600
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -1.1652
Cell Significance Index: -29.9500
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -1.2547
Cell Significance Index: -36.8500
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -1.2654
Cell Significance Index: -25.0200
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.2939
Cell Significance Index: -41.2100
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -1.3129
Cell Significance Index: -18.6900
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -1.3152
Cell Significance Index: -43.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **14-3-3 protein family member**: YWHAG is a member of the 14-3-3 protein family, which is characterized by a conserved structural motif that allows for the binding of multiple protein partners. 2. **Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma**: YWHAG is specifically involved in the activation of TDO and TDO2, enzymes that are essential for the conversion of tryptophan to kynurenine. 3. **Cellular localization**: YWHAG is primarily localized to the cytosol and nucleus, where it interacts with various protein partners to regulate cellular processes. 4. **Expression in various cell types**: YWHAG has been detected in various cell types, including skeletal muscle satellite stem cells, inhibitory interneurons, and dopaminergic neurons. **Pathways and Functions** 1. **Activation of Bcl-2 family proteins**: YWHAG is involved in the activation of Bcl-2 family proteins, which are essential for the regulation of apoptosis and mitochondrial function. 2. **Anchoring of the basal body to the plasma membrane**: YWHAG is involved in the anchoring of the basal body to the plasma membrane, which is essential for the maintenance of cellular polarity and organization. 3. **Regulation of synaptic plasticity**: YWHAG is involved in the regulation of synaptic plasticity, which is essential for learning and memory. 4. **Regulation of cell cycle**: YWHAG is involved in the regulation of the cell cycle, including the G2/M checkpoint and the G2/M DNA damage checkpoint. 5. **Regulation of apoptosis**: YWHAG is involved in the regulation of apoptosis, including the activation of pro-apoptotic and anti-apoptotic proteins. **Clinical Significance** 1. **Immune disorders**: YWHAG has been implicated in various immune disorders, including multiple sclerosis and rheumatoid arthritis, where it is involved in the regulation of tryptophan metabolism and immune responses. 2. **Neurological disorders**: YWHAG has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease, where it is involved in the regulation of synaptic plasticity and neuronal survival. 3. **Cancer**: YWHAG has been implicated in various types of cancer, including breast cancer and lung cancer, where it is involved in the regulation of cell cycle and apoptosis. 4. **Infectious diseases**: YWHAG has been implicated in various infectious diseases, including SARS-CoV-1 and SARS-CoV-2, where it is involved in the regulation of host immune responses and signaling pathways. In conclusion, YWHAG is a multifunctional protein that plays a critical role in various cellular processes, including signal transduction, apoptosis, and cell cycle regulation. Its dysregulation has been implicated in various diseases, including immune disorders, neurological disorders, and cancer. Further research is needed to fully understand the mechanisms by which YWHAG regulates cellular processes and to develop therapeutic strategies to target its dysregulation in disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Protein kinase C inhibitor protein 1

Genular Protein ID: 3851290402

Symbol: 1433G_HUMAN

Name: Protein kinase C inhibitor protein 1

UniProtKB Accession Codes:

P61981 O70457 P35214 Q6FH52 Q9UDP2 Q9UN99

Database IDs:

Citations:

PubMed ID: 10433554

Title: 14-3-3gamma interacts with and is phosphorylated by multiple protein kinase C isoforms in PDGF-stimulated human vascular smooth muscle cells.

PubMed ID: 10433554

DOI: 10.1089/104454999315105

PubMed ID: 10486217

Title: Cloning, expression, and chromosomal mapping of the human 14-3-3gamma gene (YWHAG) to 7q11.23.

PubMed ID: 10486217

DOI: 10.1006/geno.1999.5887

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23572552

Title: ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding.

PubMed ID: 23572552

DOI: 10.1128/mbio.00098-13

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 11427721

Title: Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis.

PubMed ID: 11427721

DOI: 10.1073/pnas.141118798

PubMed ID: 14534293

Title: Proteomics-based target identification: bengamides as a new class of methionine aminopeptidase inhibitors.

PubMed ID: 14534293

DOI: 10.1074/jbc.m309039200

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15454081

Title: The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector.

PubMed ID: 15454081

DOI: 10.1016/j.cell.2004.09.015

PubMed ID: 15159416

Title: A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia.

PubMed ID: 15159416

DOI: 10.1083/jcb.200401136

PubMed ID: 15696159

Title: JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage.

PubMed ID: 15696159

DOI: 10.1038/ncb1228

PubMed ID: 16511572

Title: 14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation.

PubMed ID: 16511572

DOI: 10.1038/sj.emboj.7601010

PubMed ID: 16959763

Title: Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.

PubMed ID: 16959763

DOI: 10.1074/mcp.m600147-mcp200

PubMed ID: 18249187

Title: Sirt2 interacts with 14-3-3 beta/gamma and down-regulates the activity of p53.

PubMed ID: 18249187

DOI: 10.1016/j.bbrc.2008.01.114

PubMed ID: 19172738

Title: Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein.

PubMed ID: 19172738

DOI: 10.1038/emboj.2008.159

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19640509

Title: SLITRK1 binds 14-3-3 and regulates neurite outgrowth in a phosphorylation-dependent manner.

PubMed ID: 19640509

DOI: 10.1016/j.biopsych.2009.05.033

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26047703

Title: Suppression of death-associated protein kinase 2 by interaction with 14-3-3 proteins.

PubMed ID: 26047703

DOI: 10.1016/j.bbrc.2015.05.105

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27030597

Title: Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation.

PubMed ID: 27030597

DOI: 10.1126/scitranslmed.aaf1471

PubMed ID: 28202711

Title: Structural interface between LRRK2 and 14-3-3 protein.

PubMed ID: 28202711

DOI: 10.1042/bcj20161078

PubMed ID: 29121962

Title: Direct interaction with 14-3-3gamma promotes surface expression of Best1 channel in astrocyte.

PubMed ID: 29121962

DOI: 10.1186/s13041-017-0331-x

PubMed ID: 33473107

Title: Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response.

PubMed ID: 33473107

DOI: 10.1038/s41467-020-20780-2

PubMed ID: 36732624

Title: AMPK-dependent phosphorylation of the GATOR2 component WDR24 suppresses glucose-mediated mTORC1 activation.

PubMed ID: 36732624

DOI: 10.1038/s42255-022-00732-4

PubMed ID: 28777935

Title: De novo mutations in YWHAG cause early-onset epilepsy.

PubMed ID: 28777935

DOI: 10.1016/j.ajhg.2017.07.004

PubMed ID: 17085597

Title: Structural basis for protein-protein interactions in the 14-3-3 protein family.

PubMed ID: 17085597

DOI: 10.1073/pnas.0605779103

Sequence Information:

Length: 247
Mass: 28303
Checksum: B0D16C6DE1F4455D
Sequence:

MVDREQLVQK ARLAEQAERY DDMAAAMKNV TELNEPLSNE ERNLLSVAYK NVVGARRSSW 
RVISSIEQKT SADGNEKKIE MVRAYREKIE KELEAVCQDV LSLLDNYLIK NCSETQYESK 
VFYLKMKGDY YRYLAEVATG EKRATVVESS EKAYSEAHEI SKEHMQPTHP IRLGLALNYS 
VFYYEIQNAP EQACHLAKTA FDDAIAELDT LNEDSYKDST LIMQLLRDNL TLWTSDQQDD 
DGGEGNN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: YWHAG

Associated with

Cells (max top 100)

Other Information

14-3-3gamma interacts with and is phosphorylated by multiple protein kinase C isoforms in PDGF-stimulated human vascular smooth muscle cells. PubMed ID: 10433554

Cloning, expression, and chromosomal mapping of the human 14-3-3gamma gene (YWHAG) to 7q11.23. PubMed ID: 10486217

The DNA sequence of human chromosome 7. PubMed ID: 12853948

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding. PubMed ID: 23572552

Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. PubMed ID: 12665801

Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis. PubMed ID: 11427721

Proteomics-based target identification: bengamides as a new class of methionine aminopeptidase inhibitors. PubMed ID: 14534293

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. PubMed ID: 15454081

A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. PubMed ID: 15159416

JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. PubMed ID: 15696159

14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation. PubMed ID: 16511572

Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling. PubMed ID: 16959763

Sirt2 interacts with 14-3-3 beta/gamma and down-regulates the activity of p53. PubMed ID: 18249187

Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. PubMed ID: 19172738

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

SLITRK1 binds 14-3-3 and regulates neurite outgrowth in a phosphorylation-dependent manner. PubMed ID: 19640509

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Suppression of death-associated protein kinase 2 by interaction with 14-3-3 proteins. PubMed ID: 26047703

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation. PubMed ID: 27030597

Structural interface between LRRK2 and 14-3-3 protein. PubMed ID: 28202711

Direct interaction with 14-3-3gamma promotes surface expression of Best1 channel in astrocyte. PubMed ID: 29121962

Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response. PubMed ID: 33473107

AMPK-dependent phosphorylation of the GATOR2 component WDR24 suppresses glucose-mediated mTORC1 activation. PubMed ID: 36732624

De novo mutations in YWHAG cause early-onset epilepsy. PubMed ID: 28777935

Structural basis for protein-protein interactions in the 14-3-3 protein family. PubMed ID: 17085597