Details for: ZNF18

Gene ID: 7566

Symbol: ZNF18

Ensembl ID: ENSG00000154957

Description: zinc finger protein 18

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 48.7961
    Cell Significance Index: -7.5900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 29.2537
    Cell Significance Index: -7.4200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 17.2305
    Cell Significance Index: -7.0000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 7.3449
    Cell Significance Index: -7.0100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.5290
    Cell Significance Index: -8.0500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.6354
    Cell Significance Index: -7.0600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.0806
    Cell Significance Index: -8.2100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.3616
    Cell Significance Index: -2.9800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7085
    Cell Significance Index: 70.0900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5518
    Cell Significance Index: 498.2300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4083
    Cell Significance Index: 44.4200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3766
    Cell Significance Index: 22.6100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3762
    Cell Significance Index: 61.1800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3471
    Cell Significance Index: 9.7000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2417
    Cell Significance Index: 48.4800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.2141
    Cell Significance Index: 3.0100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2014
    Cell Significance Index: 4.4100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1877
    Cell Significance Index: 12.9800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1565
    Cell Significance Index: 4.5100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1534
    Cell Significance Index: 106.1100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.1471
    Cell Significance Index: 2.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1256
    Cell Significance Index: 45.0700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1228
    Cell Significance Index: 22.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1151
    Cell Significance Index: 22.8500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1136
    Cell Significance Index: 5.1500
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: 0.0989
    Cell Significance Index: 1.5900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0677
    Cell Significance Index: 12.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0655
    Cell Significance Index: 5.0300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0637
    Cell Significance Index: 3.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0587
    Cell Significance Index: 6.8400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0559
    Cell Significance Index: 24.7200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0544
    Cell Significance Index: 3.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0530
    Cell Significance Index: 7.7000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0468
    Cell Significance Index: 1.1700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0322
    Cell Significance Index: 0.4400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0303
    Cell Significance Index: 2.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0300
    Cell Significance Index: 4.1200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0257
    Cell Significance Index: 14.0600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0166
    Cell Significance Index: 0.6300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0149
    Cell Significance Index: 0.6600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0139
    Cell Significance Index: 1.7100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0084
    Cell Significance Index: 0.2400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0033
    Cell Significance Index: 0.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0032
    Cell Significance Index: 6.0000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0012
    Cell Significance Index: 0.7600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0001
    Cell Significance Index: -0.0100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0005
    Cell Significance Index: -0.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0008
    Cell Significance Index: -1.5400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0018
    Cell Significance Index: -2.8400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0024
    Cell Significance Index: -3.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0044
    Cell Significance Index: -2.0000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0053
    Cell Significance Index: -0.3500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0061
    Cell Significance Index: -0.1000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0071
    Cell Significance Index: -0.3300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0084
    Cell Significance Index: -6.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0089
    Cell Significance Index: -1.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0099
    Cell Significance Index: -7.3700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0105
    Cell Significance Index: -7.9800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0136
    Cell Significance Index: -7.6700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0146
    Cell Significance Index: -9.1100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0156
    Cell Significance Index: -0.3100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0162
    Cell Significance Index: -0.5700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0168
    Cell Significance Index: -0.4500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0224
    Cell Significance Index: -6.4400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0225
    Cell Significance Index: -1.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0248
    Cell Significance Index: -2.5300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0282
    Cell Significance Index: -1.5800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0315
    Cell Significance Index: -2.2300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0325
    Cell Significance Index: -1.9900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0385
    Cell Significance Index: -4.4200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0397
    Cell Significance Index: -2.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0431
    Cell Significance Index: -9.0800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0495
    Cell Significance Index: -6.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0496
    Cell Significance Index: -1.5900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0503
    Cell Significance Index: -1.0800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0525
    Cell Significance Index: -1.0900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0714
    Cell Significance Index: -1.9100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0724
    Cell Significance Index: -7.5400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0724
    Cell Significance Index: -1.8600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0726
    Cell Significance Index: -5.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0770
    Cell Significance Index: -2.1000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0799
    Cell Significance Index: -2.0400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0834
    Cell Significance Index: -1.2500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0879
    Cell Significance Index: -1.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0890
    Cell Significance Index: -4.1900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0897
    Cell Significance Index: -4.7100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0908
    Cell Significance Index: -1.3000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0931
    Cell Significance Index: -7.3700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0996
    Cell Significance Index: -3.4600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1001
    Cell Significance Index: -2.9400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1013
    Cell Significance Index: -1.7000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1192
    Cell Significance Index: -2.5300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1237
    Cell Significance Index: -2.6800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1365
    Cell Significance Index: -2.3400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1391
    Cell Significance Index: -4.4300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1408
    Cell Significance Index: -4.6100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1567
    Cell Significance Index: -5.4900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1651
    Cell Significance Index: -4.3400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1679
    Cell Significance Index: -3.3200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1680
    Cell Significance Index: -4.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcription Factor:** ZNF18 is a transcription factor, which means it regulates gene expression by binding to specific DNA sequences and influencing the transcriptional machinery. 2. **RNA Polymerase II-Specific:** ZNF18 is specifically involved in the regulation of transcription by RNA polymerase II, a crucial enzyme responsible for transcribing protein-coding genes. 3. **Metal Ion Binding:** ZNF18 contains a metal ion-binding domain, which allows it to interact with metal ions and regulate its activity. 4. **Tissue-Specific Expression:** ZNF18 is highly expressed in the brain, particularly in GABAergic interneurons, and is also found in other tissues such as the intestinal epithelium and the small intestine. **Pathways and Functions:** 1. **Gene Expression Regulation:** ZNF18 regulates gene expression by binding to specific DNA sequences and influencing the transcriptional machinery. 2. **Transcriptional Regulation by RNA Polymerase II:** ZNF18 is specifically involved in the regulation of transcription by RNA polymerase II, which is responsible for transcribing protein-coding genes. 3. **Metal Ion Binding and Regulation:** ZNF18's metal ion-binding domain allows it to interact with metal ions and regulate its activity, which is essential for its function as a transcription factor. 4. **Cellular Context-Specific Function:** ZNF18's function is context-dependent, meaning its activity and regulation can vary depending on the cellular context and specific tissue type. **Clinical Significance:** 1. **Neurological Disorders:** Dysregulation of ZNF18 has been implicated in various neurological disorders, including epilepsy, schizophrenia, and autism spectrum disorder. 2. **Gastrointestinal Diseases:** ZNF18's role in regulating gene expression in the intestinal epithelium and small intestine makes it a potential target for the treatment of gastrointestinal diseases such as inflammatory bowel disease and colorectal cancer. 3. **Cancer:** ZNF18's involvement in the regulation of gene expression and its role in maintaining cellular homeostasis make it a potential biomarker for cancer diagnosis and treatment. 4. **Personalized Medicine:** Further research on ZNF18's function and regulation may lead to the development of personalized medicine strategies, where ZNF18's activity is tailored to an individual's specific genetic and environmental profile. In conclusion, ZNF18 is a transcription factor that plays a critical role in regulating gene expression in various tissues and cell types. Its involvement in neurological disorders, gastrointestinal diseases, and cancer makes it a potential target for the development of novel therapeutic strategies. Further research on ZNF18's function and regulation is necessary to fully understand its significance in human health and to explore its potential as a therapeutic target.

Genular Protein ID: 2812006415

Symbol: ZNF18_HUMAN

Name: Zinc finger protein 18

UniProtKB Accession Codes:

P17022 Q5QHQ3 Q8IYC4 Q8NAH6

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 4 ExpressionAtlas 1 GO 5 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 10 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16120570

Title: Molecular cloning and expression analysis of a novel human gene ZNF18.

PubMed ID: 16120570

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2288909

Title: Multiple genes encoding zinc finger domains are expressed in human T cells.

PubMed ID: 2288909

Sequence Information:

  • Length: 549
  • Mass: 62288
  • Checksum: 5468BA67A459174D
  • Sequence:
    • MPVDLGQALG LLPSLAKAED SQFSESDAAL QEELSSPETA RQLFRQFRYQ VMSGPHETLK 
QLRKLCFQWL QPEVHTKEQI LEILMLEQFL TILPGEIQMW VRKQCPGSGE EAVTLVESLK 
GDPQRLWQWI SIQVLGQDIL SEKMESPSCQ VGEVEPHLEV VPQELGLENS SSGPGELLSH 
IVKEESDTEA ELALAASQPA RLEERLIRDQ DLGASLLPAA PQEQWRQLDS TQKEQYWDLM 
LETYGKMVSG AGISHPKSDL TNSIEFGEEL AGIYLHVNEK IPRPTCIGDR QENDKENLNL 
ENHRDQELLH ASCQASGEVP SQASLRGFFT EDEPGCFGEG ENLPEALQNI QDEGTGEQLS 
PQERISEKQL GQHLPNPHSG EMSTMWLEEK RETSQKGQPR APMAQKLPTC RECGKTFYRN 
SQLIFHQRTH TGETYFQCTI CKKAFLRSSD FVKHQRTHTG EKPCKCDYCG KGFSDFSGLR 
HHEKIHTGEK PYKCPICEKS FIQRSNFNRH QRVHTGEKPY KCSHCGKSFS WSSSLDKHQR 
SHLGKKPFQ

Genular Protein ID: 566921911

Symbol: B3KXT5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KXT5

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 3 InterPro 7 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 7 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 3 RefSeq 1 SMART 3 SUPFAM 3

Sequence Information:

  • Length: 549
  • Mass: 62279
  • Checksum: 07F9C835AB362ABD
  • Sequence:
    • MPVDLGQALG LLPSLAKAED SQFSESDAAL QEELSSPETA RQLFRQFRYQ VMSGPHETLK 
QLRKLCFQWL QPEVHTKEQI LEILMLEQFL TILPGEIQMW VRKQCPGSGE EAVTLVESLK 
GDPQRLWQWI SIQVLGQDIL SEKMESPSCQ VGEVEPHLEV VPQELGLENS SSGPGELLSH 
IVKEESDTEA ELALAASQPA RLEERLIRDQ DLGASLLSAA PQEQWRQLDS TQKEQYWDLM 
LETYGKMVSG AGISHPKSDL TNSIEFGEEL AGIYLHVNEK IPRPTCIGDR QENDKENLNL 
ENHRDQELLH ASCQASGEVP SQASLRGFFT EDEPGCFGEG ENLPEALQNI QDEGTGEQLS 
PQERISEKQL GQHLPNPHSG EMSTMWLEEK RETSQKGQPR APMAQKLPTC RECGKTFYRN 
SQLIFHQRTH TGETYFQCTI CKKAFLRSSD FVKHQRTHTG EKPCKCDYCG KGFSDFSGLR 
HHEKIHTGEE PYKCPICEKS FIQRSNFNRH QRVHTGEKPY KCSHCGKSFS WSSSLDKHQR 
SHLGKKPFQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.