Details for: ZNF35

Gene ID: 7584

Symbol: ZNF35

Ensembl ID: ENSG00000169981

Description: zinc finger protein 35

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 73.3549
    Cell Significance Index: -11.4100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 43.3286
    Cell Significance Index: -10.9900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 25.2057
    Cell Significance Index: -10.2400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.4083
    Cell Significance Index: -11.6000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 4.4039
    Cell Significance Index: 72.5700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.9422
    Cell Significance Index: -11.6100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.7317
    Cell Significance Index: -3.7900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.6761
    Cell Significance Index: 16.8600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5388
    Cell Significance Index: 53.3000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5020
    Cell Significance Index: 30.1400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4641
    Cell Significance Index: 419.0900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.4380
    Cell Significance Index: 15.3900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4122
    Cell Significance Index: 44.8300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3158
    Cell Significance Index: 51.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3023
    Cell Significance Index: 8.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2976
    Cell Significance Index: 15.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2424
    Cell Significance Index: 48.6200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2188
    Cell Significance Index: 13.7900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2131
    Cell Significance Index: 14.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2019
    Cell Significance Index: 11.3300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1832
    Cell Significance Index: 21.3500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1659
    Cell Significance Index: 7.5200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1478
    Cell Significance Index: 11.3400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1360
    Cell Significance Index: 48.7900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1352
    Cell Significance Index: 2.9300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.1229
    Cell Significance Index: 1.7300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1199
    Cell Significance Index: 23.7900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1150
    Cell Significance Index: 5.9900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1020
    Cell Significance Index: 18.4000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.1019
    Cell Significance Index: 1.4600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1005
    Cell Significance Index: 69.5100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0855
    Cell Significance Index: 16.2700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0781
    Cell Significance Index: 42.6300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0751
    Cell Significance Index: 3.8000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0717
    Cell Significance Index: 31.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0631
    Cell Significance Index: 7.7600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0511
    Cell Significance Index: 1.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0307
    Cell Significance Index: 1.4300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0226
    Cell Significance Index: 1.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0137
    Cell Significance Index: 21.0800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0102
    Cell Significance Index: 0.4500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0090
    Cell Significance Index: 16.6100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0060
    Cell Significance Index: 11.3000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0030
    Cell Significance Index: 0.4100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0010
    Cell Significance Index: 1.3700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0007
    Cell Significance Index: -0.4300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0009
    Cell Significance Index: -0.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0033
    Cell Significance Index: -1.4800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0061
    Cell Significance Index: -0.2300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0081
    Cell Significance Index: -6.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0092
    Cell Significance Index: -6.7500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0111
    Cell Significance Index: -8.4400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0171
    Cell Significance Index: -9.6300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0182
    Cell Significance Index: -2.3300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0206
    Cell Significance Index: -3.0000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0217
    Cell Significance Index: -2.8000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0230
    Cell Significance Index: -0.4900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0235
    Cell Significance Index: -1.7500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0238
    Cell Significance Index: -14.8900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0286
    Cell Significance Index: -4.8800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0298
    Cell Significance Index: -8.5800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0337
    Cell Significance Index: -3.9800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0374
    Cell Significance Index: -1.0000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0380
    Cell Significance Index: -0.4500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0397
    Cell Significance Index: -1.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0477
    Cell Significance Index: -5.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0531
    Cell Significance Index: -5.4200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0605
    Cell Significance Index: -12.7500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0747
    Cell Significance Index: -1.2500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0792
    Cell Significance Index: -1.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0860
    Cell Significance Index: -4.0400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0959
    Cell Significance Index: -2.5700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0992
    Cell Significance Index: -1.7000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0999
    Cell Significance Index: -1.4800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1053
    Cell Significance Index: -10.9600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1100
    Cell Significance Index: -2.7500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1113
    Cell Significance Index: -2.3300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1163
    Cell Significance Index: -4.0400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1171
    Cell Significance Index: -3.7500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1247
    Cell Significance Index: -2.6700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1260
    Cell Significance Index: -8.1300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1288
    Cell Significance Index: -10.2000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1324
    Cell Significance Index: -6.9500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1404
    Cell Significance Index: -8.6100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1435
    Cell Significance Index: -2.8000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1700
    Cell Significance Index: -2.1800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1790
    Cell Significance Index: -5.8600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1890
    Cell Significance Index: -6.6200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1894
    Cell Significance Index: -4.0200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1900
    Cell Significance Index: -6.0500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1949
    Cell Significance Index: -5.0100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2130
    Cell Significance Index: -3.2100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2160
    Cell Significance Index: -5.6800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2557
    Cell Significance Index: -10.4800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2561
    Cell Significance Index: -3.5900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2568
    Cell Significance Index: -4.4400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2603
    Cell Significance Index: -2.8300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2606
    Cell Significance Index: -6.5000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2620
    Cell Significance Index: -7.5100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2781
    Cell Significance Index: -10.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZNF35 is a member of the zinc finger protein family, characterized by its unique DNA-binding domain, which enables it to regulate gene expression by interacting with specific DNA sequences. This protein is highly expressed in various cell types, including cerebral cortex GABAergic interneurons, forebrain radial glial cells, and intestinal epithelial cells. ZNF35 exhibits a high degree of specificity in its binding to DNA, allowing it to modulate the expression of target genes. **Pathways and Functions:** ZNF35 is involved in several key pathways, including: 1. **Cellular response to retinoic acid**: ZNF35 regulates the expression of genes involved in retinoic acid signaling, which is crucial for cell differentiation and development. 2. **DNA-binding transcription factor activity**: ZNF35 acts as a transcription factor, binding to specific DNA sequences and recruiting RNA polymerase II to initiate transcription. 3. **RNA polymerase II-specific transcription regulation**: ZNF35 regulates the expression of genes involved in transcription by RNA polymerase II, a key enzyme responsible for transcribing DNA into RNA. 4. **Spermatogenesis**: ZNF35 plays a critical role in the development of sperm cells, regulating the expression of genes involved in spermatogenesis. **Clinical Significance:** ZNF35 has significant implications in human disease, particularly in the context of immunological disorders. Aberrant expression of ZNF35 has been linked to various diseases, including: 1. **Cancer**: ZNF35 has been implicated in the development and progression of cancer, including leukemia and lymphoma. 2. **Neurological disorders**: ZNF35 has been linked to various neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Immune system dysregulation**: ZNF35 may play a role in immune system dysregulation, contributing to autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. In conclusion, ZNF35 is a multifunctional transcription factor that plays a critical role in various cellular processes, including spermatogenesis, regulation of transcription by RNA polymerase II, and response to retinoic acid. Its aberrant expression has significant implications in human disease, particularly in the context of immunological disorders. Further research is necessary to fully elucidate the functions and significance of ZNF35 in human health and disease. **Recommendations:** 1. **Further research**: Investigate the role of ZNF35 in various diseases, including cancer, neurological disorders, and immune system dysregulation. 2. **Therapeutic applications**: Explore the potential therapeutic applications of ZNF35 in the treatment of human diseases. 3. **Gene editing**: Investigate the use of gene editing technologies, such as CRISPR-Cas9, to modulate ZNF35 expression and its impact on disease. By advancing our understanding of ZNF35, we can uncover new avenues for therapeutic intervention and improve our ability to diagnose and treat human diseases.

Genular Protein ID: 534809557

Symbol: ZNF35_HUMAN

Name: Zinc finger protein 35

UniProtKB Accession Codes:

P13682 B2RBU6 Q53Y54 Q96D01

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 4 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3380682

Title: Isolation of cDNAs encoding finger proteins and measurement of the corresponding mRNA levels during myeloid terminal differentiation.

PubMed ID: 3380682

DOI: 10.1093/nar/16.10.4227

PubMed ID: 1572646

Title: Structural and functional organization of the HF.10 human zinc finger gene (ZNF35) located on chromosome 3p21-p22.

PubMed ID: 1572646

DOI: 10.1016/0888-7543(92)90301-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 527
  • Mass: 59089
  • Checksum: 9E7099A290ED938B
  • Sequence:
    • MTAELREAMA LAPWGPVKVK KEEEEEENFP GQASSQQVHS ENIKVWAPVQ GLQTGLDGSE 
EEEKGQNISW DMAVVLKATQ EAPAASTLGS YSLPGTLAKS EILETHGTMN FLGAETKNLQ 
LLVPKTEICE EAEKPLIISE RIQKADPQGP ELGEACEKGN MLKRQRIKRE KKDFRQVIVN 
DCHLPESFKE EENQKCKKSG GKYSLNSGAV KNPKTQLGQK PFTCSVCGKG FSQSANLVVH 
QRIHTGEKPF ECHECGKAFI QSANLVVHQR IHTGQKPYVC SKCGKAFTQS SNLTVHQKIH 
SLEKTFKCNE CEKAFSYSSQ LARHQKVHIT EKCYECNECG KTFTRSSNLI VHQRIHTGEK 
PFACNDCGKA FTQSANLIVH QRSHTGEKPY ECKECGKAFS CFSHLIVHQR IHTAEKPYDC 
SECGKAFSQL SCLIVHQRIH SGDLPYVCNE CGKAFTCSSY LLIHQRIHNG EKPYTCNECG 
KAFRQRSSLT VHQRTHTGEK PYECEKCGAA FISNSHLMRH HRTHLVE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.