Details for: ZNF35

Gene ID: 7584

Symbol: ZNF35

Ensembl ID: ENSG00000169981

Description: zinc finger protein 35

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71803
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48027
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.96
    Marker Score: 345
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 494
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 447
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2731
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5171
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5276
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 313
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.79
    Marker Score: 1226
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1247
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.75
    Marker Score: 1310
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 383
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 658
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2987
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.71
    Marker Score: 2001.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.71
    Marker Score: 540
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.68
    Marker Score: 273
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.65
    Marker Score: 491
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.63
    Marker Score: 1072.5
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.62
    Marker Score: 610
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.61
    Marker Score: 6291
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.55
    Marker Score: 509
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 436
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.54
    Marker Score: 4638
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.49
    Marker Score: 312
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.48
    Marker Score: 589
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.45
    Marker Score: 27825
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.44
    Marker Score: 4179
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.43
    Marker Score: 15692
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.4
    Marker Score: 3753
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.39
    Marker Score: 1428
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.37
    Marker Score: 1429
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.37
    Marker Score: 106
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.37
    Marker Score: 527
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.36
    Marker Score: 7786
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.36
    Marker Score: 361
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.36
    Marker Score: 1462
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.35
    Marker Score: 441
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.34
    Marker Score: 223
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.33
    Marker Score: 208.5
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.32
    Marker Score: 388
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.32
    Marker Score: 1315
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.32
    Marker Score: 156
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.31
    Marker Score: 11841
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.31
    Marker Score: 4596
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.31
    Marker Score: 183
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.3
    Marker Score: 5985
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.3
    Marker Score: 126
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.3
    Marker Score: 374.5
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.3
    Marker Score: 203
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.3
    Marker Score: 174
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.29
    Marker Score: 100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.29
    Marker Score: 605
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.28
    Marker Score: 89
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.28
    Marker Score: 189
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.27
    Marker Score: 6138
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.27
    Marker Score: 2077
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.27
    Marker Score: 594
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.27
    Marker Score: 232
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.26
    Marker Score: 140
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.26
    Marker Score: 352
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.25
    Marker Score: 228
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.25
    Marker Score: 170
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.25
    Marker Score: 61
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.25
    Marker Score: 80
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.25
    Marker Score: 880
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.24
    Marker Score: 2121
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.24
    Marker Score: 100
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.24
    Marker Score: 269
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.24
    Marker Score: 116
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.23
    Marker Score: 340
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.23
    Marker Score: 245
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.23
    Marker Score: 61
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.23
    Marker Score: 105
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.23
    Marker Score: 92
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.23
    Marker Score: 181
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.22
    Marker Score: 97
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.22
    Marker Score: 91
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.22
    Marker Score: 234
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.22
    Marker Score: 523
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.22
    Marker Score: 125
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.22
    Marker Score: 106
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.22
    Marker Score: 438
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.22
    Marker Score: 91
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.22
    Marker Score: 286
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.21
    Marker Score: 106
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.21
    Marker Score: 230
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 72
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.2
    Marker Score: 852
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.2
    Marker Score: 942
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.2
    Marker Score: 46
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.2
    Marker Score: 99
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.2
    Marker Score: 86
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.2
    Marker Score: 79
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.2
    Marker Score: 177

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Other Information

**Key Characteristics:** ZNF35 is a member of the zinc finger protein family, characterized by its unique DNA-binding domain, which enables it to regulate gene expression by interacting with specific DNA sequences. This protein is highly expressed in various cell types, including cerebral cortex GABAergic interneurons, forebrain radial glial cells, and intestinal epithelial cells. ZNF35 exhibits a high degree of specificity in its binding to DNA, allowing it to modulate the expression of target genes. **Pathways and Functions:** ZNF35 is involved in several key pathways, including: 1. **Cellular response to retinoic acid**: ZNF35 regulates the expression of genes involved in retinoic acid signaling, which is crucial for cell differentiation and development. 2. **DNA-binding transcription factor activity**: ZNF35 acts as a transcription factor, binding to specific DNA sequences and recruiting RNA polymerase II to initiate transcription. 3. **RNA polymerase II-specific transcription regulation**: ZNF35 regulates the expression of genes involved in transcription by RNA polymerase II, a key enzyme responsible for transcribing DNA into RNA. 4. **Spermatogenesis**: ZNF35 plays a critical role in the development of sperm cells, regulating the expression of genes involved in spermatogenesis. **Clinical Significance:** ZNF35 has significant implications in human disease, particularly in the context of immunological disorders. Aberrant expression of ZNF35 has been linked to various diseases, including: 1. **Cancer**: ZNF35 has been implicated in the development and progression of cancer, including leukemia and lymphoma. 2. **Neurological disorders**: ZNF35 has been linked to various neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Immune system dysregulation**: ZNF35 may play a role in immune system dysregulation, contributing to autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. In conclusion, ZNF35 is a multifunctional transcription factor that plays a critical role in various cellular processes, including spermatogenesis, regulation of transcription by RNA polymerase II, and response to retinoic acid. Its aberrant expression has significant implications in human disease, particularly in the context of immunological disorders. Further research is necessary to fully elucidate the functions and significance of ZNF35 in human health and disease. **Recommendations:** 1. **Further research**: Investigate the role of ZNF35 in various diseases, including cancer, neurological disorders, and immune system dysregulation. 2. **Therapeutic applications**: Explore the potential therapeutic applications of ZNF35 in the treatment of human diseases. 3. **Gene editing**: Investigate the use of gene editing technologies, such as CRISPR-Cas9, to modulate ZNF35 expression and its impact on disease. By advancing our understanding of ZNF35, we can uncover new avenues for therapeutic intervention and improve our ability to diagnose and treat human diseases.

Genular Protein ID: 534809557

Symbol: ZNF35_HUMAN

Name: Zinc finger protein 35

UniProtKB Accession Codes:

P13682 B2RBU6 Q53Y54 Q96D01

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 4 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3380682

Title: Isolation of cDNAs encoding finger proteins and measurement of the corresponding mRNA levels during myeloid terminal differentiation.

PubMed ID: 3380682

DOI: 10.1093/nar/16.10.4227

PubMed ID: 1572646

Title: Structural and functional organization of the HF.10 human zinc finger gene (ZNF35) located on chromosome 3p21-p22.

PubMed ID: 1572646

DOI: 10.1016/0888-7543(92)90301-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 527
  • Mass: 59089
  • Checksum: 9E7099A290ED938B
  • Sequence:
    • MTAELREAMA LAPWGPVKVK KEEEEEENFP GQASSQQVHS ENIKVWAPVQ GLQTGLDGSE 
EEEKGQNISW DMAVVLKATQ EAPAASTLGS YSLPGTLAKS EILETHGTMN FLGAETKNLQ 
LLVPKTEICE EAEKPLIISE RIQKADPQGP ELGEACEKGN MLKRQRIKRE KKDFRQVIVN 
DCHLPESFKE EENQKCKKSG GKYSLNSGAV KNPKTQLGQK PFTCSVCGKG FSQSANLVVH 
QRIHTGEKPF ECHECGKAFI QSANLVVHQR IHTGQKPYVC SKCGKAFTQS SNLTVHQKIH 
SLEKTFKCNE CEKAFSYSSQ LARHQKVHIT EKCYECNECG KTFTRSSNLI VHQRIHTGEK 
PFACNDCGKA FTQSANLIVH QRSHTGEKPY ECKECGKAFS CFSHLIVHQR IHTAEKPYDC 
SECGKAFSQL SCLIVHQRIH SGDLPYVCNE CGKAFTCSSY LLIHQRIHNG EKPYTCNECG 
KAFRQRSSLT VHQRTHTGEK PYECEKCGAA FISNSHLMRH HRTHLVE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.