Details for: MZF1

Gene ID: 7593

Symbol: MZF1

Ensembl ID: ENSG00000099326

Description: myeloid zinc finger 1

Associated with

  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Protein homodimerization activity
    (GO:0042803)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Transcription cis-regulatory region binding
    (GO:0000976)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 156.2247
    Cell Significance Index: -24.3000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 89.3380
    Cell Significance Index: -22.6600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.2359
    Cell Significance Index: -24.9500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.9623
    Cell Significance Index: -21.3300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.3988
    Cell Significance Index: -25.2500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.9445
    Cell Significance Index: -13.0100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.1018
    Cell Significance Index: -15.6700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6292
    Cell Significance Index: 161.1600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3989
    Cell Significance Index: 227.5200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.3608
    Cell Significance Index: 391.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8527
    Cell Significance Index: 171.0600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8439
    Cell Significance Index: 91.7900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8373
    Cell Significance Index: 24.1300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7257
    Cell Significance Index: 19.4500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7051
    Cell Significance Index: 9.6200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6719
    Cell Significance Index: 606.7000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6665
    Cell Significance Index: 42.0100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6510
    Cell Significance Index: 39.0800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6508
    Cell Significance Index: 14.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6442
    Cell Significance Index: 127.8400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6312
    Cell Significance Index: 17.6400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5867
    Cell Significance Index: 26.6000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4684
    Cell Significance Index: 24.3300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4502
    Cell Significance Index: 245.8900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4453
    Cell Significance Index: 30.8000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4440
    Cell Significance Index: 23.3100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4005
    Cell Significance Index: 30.7300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3943
    Cell Significance Index: 14.9300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3922
    Cell Significance Index: 74.6300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3830
    Cell Significance Index: 16.9400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3726
    Cell Significance Index: 133.6600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2972
    Cell Significance Index: 53.5800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.2774
    Cell Significance Index: 4.4500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2755
    Cell Significance Index: 9.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2661
    Cell Significance Index: 14.9300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2652
    Cell Significance Index: 183.3900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2587
    Cell Significance Index: 31.8100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2445
    Cell Significance Index: 11.4000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2148
    Cell Significance Index: 2.5600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1880
    Cell Significance Index: 4.7000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1582
    Cell Significance Index: 21.7200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1503
    Cell Significance Index: 9.7000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1462
    Cell Significance Index: 64.6600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0854
    Cell Significance Index: 2.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0758
    Cell Significance Index: 4.6600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0722
    Cell Significance Index: 4.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0486
    Cell Significance Index: 30.8500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0408
    Cell Significance Index: 76.7400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0383
    Cell Significance Index: 70.6900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0376
    Cell Significance Index: 57.8800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0260
    Cell Significance Index: 0.6000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0099
    Cell Significance Index: 1.1700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0098
    Cell Significance Index: 1.2700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0057
    Cell Significance Index: 7.7400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0017
    Cell Significance Index: 0.1200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0021
    Cell Significance Index: -0.1000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0088
    Cell Significance Index: -0.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0110
    Cell Significance Index: -5.0100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0119
    Cell Significance Index: -1.5200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0135
    Cell Significance Index: -9.8800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0188
    Cell Significance Index: -2.7400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0207
    Cell Significance Index: -15.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0240
    Cell Significance Index: -18.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0332
    Cell Significance Index: -18.7500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0437
    Cell Significance Index: -27.3100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0512
    Cell Significance Index: -8.7500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0522
    Cell Significance Index: -5.3300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0736
    Cell Significance Index: -1.8800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0813
    Cell Significance Index: -9.4800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0820
    Cell Significance Index: -1.6000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0865
    Cell Significance Index: -1.9000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0967
    Cell Significance Index: -2.0600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0974
    Cell Significance Index: -2.7800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0999
    Cell Significance Index: -0.7700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1165
    Cell Significance Index: -1.4500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1202
    Cell Significance Index: -25.3200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1261
    Cell Significance Index: -9.4000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1262
    Cell Significance Index: -3.3700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1292
    Cell Significance Index: -2.6800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1429
    Cell Significance Index: -16.3700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1609
    Cell Significance Index: -5.5900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2153
    Cell Significance Index: -22.4200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2239
    Cell Significance Index: -3.3600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2476
    Cell Significance Index: -3.7600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2652
    Cell Significance Index: -21.0000
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.2957
    Cell Significance Index: -3.9900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3421
    Cell Significance Index: -5.7200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3448
    Cell Significance Index: -8.2700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3529
    Cell Significance Index: -9.2800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3756
    Cell Significance Index: -12.0300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3868
    Cell Significance Index: -11.3600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3887
    Cell Significance Index: -8.2500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3941
    Cell Significance Index: -5.6600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3959
    Cell Significance Index: -24.2700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3991
    Cell Significance Index: -3.6800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4072
    Cell Significance Index: -12.9700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4166
    Cell Significance Index: -8.7200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4415
    Cell Significance Index: -14.4600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4721
    Cell Significance Index: -6.9700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4860
    Cell Significance Index: -6.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MZF1 is a DNA-binding transcription factor that exhibits both activating and repressive functions, depending on the context. Its zinc finger domain allows it to bind to specific DNA sequences, thereby regulating the expression of target genes. MZF1 has been shown to interact with RNA polymerase II, a key enzyme involved in transcriptional regulation, and influence its activity. This interaction enables MZF1 to modulate transcriptional processes, including the regulation of gene expression in response to environmental cues. **Pathways and Functions** MZF1 is involved in various signaling pathways, including: 1. **Transcriptional regulation**: MZF1 regulates gene expression by binding to specific DNA sequences and influencing the activity of RNA polymerase II. 2. **Cell differentiation**: MZF1 plays a crucial role in the differentiation of neurons, particularly in the development of glutamatergic and GABAergic neurons. 3. **Apoptosis**: MZF1 has been implicated in the regulation of apoptosis, a process of programmed cell death, in various cell types. 4. **Cell growth and proliferation**: MZF1 regulates cell growth and proliferation by modulating the expression of genes involved in these processes. **Clinical Significance** Dysregulation of MZF1 has been implicated in various diseases, including: 1. **Neurodegenerative disorders**: MZF1 has been associated with neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where its dysregulation may contribute to neuronal loss and degeneration. 2. **Cancer**: MZF1 has been found to be overexpressed in certain types of cancer, including lung cancer and leukemia, where it may contribute to tumorigenesis and cancer progression. 3. **Neurodevelopmental disorders**: MZF1 has been implicated in neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia, where its dysregulation may contribute to abnormalities in neuronal development and function. In conclusion, MZF1 is a transcription factor that plays a critical role in regulating gene expression in various cell types, including neurons and epithelial cells. Its dysregulation has been implicated in various diseases, highlighting the importance of MZF1 in maintaining normal cellular function and preventing disease. Further studies are needed to fully elucidate the functions and clinical significance of MZF1.

Genular Protein ID: 3521000853

Symbol: MZF1_HUMAN

Name: Myeloid zinc finger 1

UniProtKB Accession Codes:

P28698 M0QXU0 Q7Z729 Q96I71 Q9NRY0 Q9UBW2

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 10 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 3 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1860835

Title: A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells.

PubMed ID: 1860835

DOI: 10.1016/s0021-9258(18)98664-3

PubMed ID: 10974541

Title: Human myeloid zinc finger gene MZF produces multiple transcripts and encodes a SCAN box protein.

PubMed ID: 10974541

DOI: 10.1016/s0378-1119(00)00281-x

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15541732

Title: Sp1/Sp3 and the myeloid zinc finger gene MZF1 regulate the human N-cadherin promoter in osteoblasts.

PubMed ID: 15541732

DOI: 10.1016/j.yexcr.2004.08.028

PubMed ID: 17851584

Title: Crucial roles of MZF1 and Sp1 in the transcriptional regulation of the peptidylarginine deiminase type I gene (PADI1) in human keratinocytes.

PubMed ID: 17851584

DOI: 10.1038/sj.jid.5701048

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 16950398

Title: Structure of the SCAN domain from the tumor suppressor protein MZF1.

PubMed ID: 16950398

DOI: 10.1016/j.jmb.2006.07.063

Sequence Information:

  • Length: 734
  • Mass: 82055
  • Checksum: B804766A0B008048
  • Sequence:
    • MRPAVLGSPD RAPPEDEGPV MVKLEDSEEE GEAALWDPGP EAARLRFRCF RYEEATGPQE 
ALAQLRELCR QWLRPEVRSK EQMLELLVLE QFLGALPPEI QARVQGQRPG SPEEAAALVD 
GLRREPGGPR RWVTVQVQGQ EVLSEKMEPS SFQPLPETEP PTPEPGPKTP PRTMQESPLG 
LQVKEESEVT EDSDFLESGP LAATQESVPT LLPEEAQRCG TVLDQIFPHS KTGPEGPSWR 
EHPRALWHEE AGGIFSPGFA LQLGSISAGP GSVSPHLHVP WDLGMAGLSG QIQSPSREGG 
FAHALLLPSD LRSEQDPTDE DPCRGVGPAL ITTRWRSPRG RSRGRPSTGG GVVRGGRCDV 
CGKVFSQRSN LLRHQKIHTG ERPFVCSECG RSFSRSSHLL RHQLTHTEER PFVCGDCGQG 
FVRSARLEEH RRVHTGEQPF RCAECGQSFR QRSNLLQHQR IHGDPPGPGA KPPAPPGAPE 
PPGPFPCSEC RESFARRAVL LEHQAVHTGD KSFGCVECGE RFGRRSVLLQ HRRVHSGERP 
FACAECGQSF RQRSNLTQHR RIHTGERPFA CAECGKAFRQ RPTLTQHLRV HTGEKPFACP 
ECGQRFSQRL KLTRHQRTHT GEKPYHCGEC GLGFTQVSRL TEHQRIHTGE RPFACPECGQ 
SFRQHANLTQ HRRIHTGERP YACPECGKAF RQRPTLTQHL RTHRREKPFA CQDCGRRFHQ 
STKLIQHQRV HSAE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.