Details for: MZF1

Gene ID: 7593

Symbol: MZF1

Ensembl ID: ENSG00000099326

Description: myeloid zinc finger 1

Associated with

  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Protein homodimerization activity
    (GO:0042803)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Transcription cis-regulatory region binding
    (GO:0000976)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.19
    Marker Score: 1830
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.18
    Marker Score: 11170
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.09
    Marker Score: 9381
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.08
    Marker Score: 2540
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.06
    Marker Score: 10938
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.06
    Marker Score: 65103
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.06
    Marker Score: 4403
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.05
    Marker Score: 9106
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.04
    Marker Score: 437
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71735
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47960
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.99
    Marker Score: 318
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30398
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.96
    Marker Score: 35572
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.96
    Marker Score: 9055
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.95
    Marker Score: 297
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2403
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 480
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 437
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2714
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.88
    Marker Score: 418
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4959
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.86
    Marker Score: 18439
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.85
    Marker Score: 249
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.82
    Marker Score: 1104
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.82
    Marker Score: 3325
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.81
    Marker Score: 28171
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.81
    Marker Score: 3351
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.8
    Marker Score: 886
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.8
    Marker Score: 467
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.79
    Marker Score: 3064
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.79
    Marker Score: 3058
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.79
    Marker Score: 215
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.78
    Marker Score: 15614
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.77
    Marker Score: 929
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.77
    Marker Score: 29121
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.76
    Marker Score: 857.5
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.76
    Marker Score: 1538
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 570
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.75
    Marker Score: 1251
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 374
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.72
    Marker Score: 287
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2986
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.71
    Marker Score: 765
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.7
    Marker Score: 2936
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.7
    Marker Score: 10429
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.69
    Marker Score: 2381
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.69
    Marker Score: 797
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.68
    Marker Score: 766
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.67
    Marker Score: 811
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.67
    Marker Score: 1173
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.67
    Marker Score: 369
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.66
    Marker Score: 605
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.66
    Marker Score: 367
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.65
    Marker Score: 1227
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.65
    Marker Score: 559
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.64
    Marker Score: 495
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.64
    Marker Score: 603
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.64
    Marker Score: 4878
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.63
    Marker Score: 644
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.62
    Marker Score: 300
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.62
    Marker Score: 301
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.62
    Marker Score: 231
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.62
    Marker Score: 913
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.61
    Marker Score: 159
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.6
    Marker Score: 353
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.6
    Marker Score: 317
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6
    Marker Score: 9645
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.6
    Marker Score: 190
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6
    Marker Score: 10654
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.6
    Marker Score: 313
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.6
    Marker Score: 201
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.59
    Marker Score: 222
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.59
    Marker Score: 510
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.59
    Marker Score: 393
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.59
    Marker Score: 1444
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.59
    Marker Score: 186
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.59
    Marker Score: 631
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.58
    Marker Score: 215
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.58
    Marker Score: 1112
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.57
    Marker Score: 171
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.57
    Marker Score: 1525.5
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.57
    Marker Score: 801
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.56
    Marker Score: 1179
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.56
    Marker Score: 677.5
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.55
    Marker Score: 713
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.55
    Marker Score: 124
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.55
    Marker Score: 250
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.54
    Marker Score: 500
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.54
    Marker Score: 143
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.54
    Marker Score: 576
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.54
    Marker Score: 183
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.54
    Marker Score: 1222
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.54
    Marker Score: 108
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.53
    Marker Score: 426
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.53
    Marker Score: 124

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key Characteristics** MZF1 is a DNA-binding transcription factor that exhibits both activating and repressive functions, depending on the context. Its zinc finger domain allows it to bind to specific DNA sequences, thereby regulating the expression of target genes. MZF1 has been shown to interact with RNA polymerase II, a key enzyme involved in transcriptional regulation, and influence its activity. This interaction enables MZF1 to modulate transcriptional processes, including the regulation of gene expression in response to environmental cues. **Pathways and Functions** MZF1 is involved in various signaling pathways, including: 1. **Transcriptional regulation**: MZF1 regulates gene expression by binding to specific DNA sequences and influencing the activity of RNA polymerase II. 2. **Cell differentiation**: MZF1 plays a crucial role in the differentiation of neurons, particularly in the development of glutamatergic and GABAergic neurons. 3. **Apoptosis**: MZF1 has been implicated in the regulation of apoptosis, a process of programmed cell death, in various cell types. 4. **Cell growth and proliferation**: MZF1 regulates cell growth and proliferation by modulating the expression of genes involved in these processes. **Clinical Significance** Dysregulation of MZF1 has been implicated in various diseases, including: 1. **Neurodegenerative disorders**: MZF1 has been associated with neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where its dysregulation may contribute to neuronal loss and degeneration. 2. **Cancer**: MZF1 has been found to be overexpressed in certain types of cancer, including lung cancer and leukemia, where it may contribute to tumorigenesis and cancer progression. 3. **Neurodevelopmental disorders**: MZF1 has been implicated in neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia, where its dysregulation may contribute to abnormalities in neuronal development and function. In conclusion, MZF1 is a transcription factor that plays a critical role in regulating gene expression in various cell types, including neurons and epithelial cells. Its dysregulation has been implicated in various diseases, highlighting the importance of MZF1 in maintaining normal cellular function and preventing disease. Further studies are needed to fully elucidate the functions and clinical significance of MZF1.

Genular Protein ID: 3521000853

Symbol: MZF1_HUMAN

Name: Myeloid zinc finger 1

UniProtKB Accession Codes:

P28698 M0QXU0 Q7Z729 Q96I71 Q9NRY0 Q9UBW2

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 10 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 3 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1860835

Title: A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells.

PubMed ID: 1860835

DOI: 10.1016/s0021-9258(18)98664-3

PubMed ID: 10974541

Title: Human myeloid zinc finger gene MZF produces multiple transcripts and encodes a SCAN box protein.

PubMed ID: 10974541

DOI: 10.1016/s0378-1119(00)00281-x

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15541732

Title: Sp1/Sp3 and the myeloid zinc finger gene MZF1 regulate the human N-cadherin promoter in osteoblasts.

PubMed ID: 15541732

DOI: 10.1016/j.yexcr.2004.08.028

PubMed ID: 17851584

Title: Crucial roles of MZF1 and Sp1 in the transcriptional regulation of the peptidylarginine deiminase type I gene (PADI1) in human keratinocytes.

PubMed ID: 17851584

DOI: 10.1038/sj.jid.5701048

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 16950398

Title: Structure of the SCAN domain from the tumor suppressor protein MZF1.

PubMed ID: 16950398

DOI: 10.1016/j.jmb.2006.07.063

Sequence Information:

  • Length: 734
  • Mass: 82055
  • Checksum: B804766A0B008048
  • Sequence:
    • MRPAVLGSPD RAPPEDEGPV MVKLEDSEEE GEAALWDPGP EAARLRFRCF RYEEATGPQE 
ALAQLRELCR QWLRPEVRSK EQMLELLVLE QFLGALPPEI QARVQGQRPG SPEEAAALVD 
GLRREPGGPR RWVTVQVQGQ EVLSEKMEPS SFQPLPETEP PTPEPGPKTP PRTMQESPLG 
LQVKEESEVT EDSDFLESGP LAATQESVPT LLPEEAQRCG TVLDQIFPHS KTGPEGPSWR 
EHPRALWHEE AGGIFSPGFA LQLGSISAGP GSVSPHLHVP WDLGMAGLSG QIQSPSREGG 
FAHALLLPSD LRSEQDPTDE DPCRGVGPAL ITTRWRSPRG RSRGRPSTGG GVVRGGRCDV 
CGKVFSQRSN LLRHQKIHTG ERPFVCSECG RSFSRSSHLL RHQLTHTEER PFVCGDCGQG 
FVRSARLEEH RRVHTGEQPF RCAECGQSFR QRSNLLQHQR IHGDPPGPGA KPPAPPGAPE 
PPGPFPCSEC RESFARRAVL LEHQAVHTGD KSFGCVECGE RFGRRSVLLQ HRRVHSGERP 
FACAECGQSF RQRSNLTQHR RIHTGERPFA CAECGKAFRQ RPTLTQHLRV HTGEKPFACP 
ECGQRFSQRL KLTRHQRTHT GEKPYHCGEC GLGFTQVSRL TEHQRIHTGE RPFACPECGQ 
SFRQHANLTQ HRRIHTGERP YACPECGKAF RQRPTLTQHL RTHRREKPFA CQDCGRRFHQ 
STKLIQHQRV HSAE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.