Details for: ZBTB25

Gene ID: 7597

Symbol: ZBTB25

Ensembl ID: ENSG00000089775

Description: zinc finger and BTB domain containing 25

Associated with

  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Protein binding
    (GO:0005515)
  • Regulation of cytokine production
    (GO:0001817)
  • Regulation of immune system process
    (GO:0002682)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 143.2381
    Cell Significance Index: -22.2800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 84.7253
    Cell Significance Index: -21.4900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 50.0791
    Cell Significance Index: -20.3500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.3218
    Cell Significance Index: -22.5900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.2834
    Cell Significance Index: -22.1900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.8404
    Cell Significance Index: -21.0100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.7703
    Cell Significance Index: -22.7700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.2607
    Cell Significance Index: -9.3300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0652
    Cell Significance Index: 213.6700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9072
    Cell Significance Index: 89.7400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6542
    Cell Significance Index: 590.7000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.6103
    Cell Significance Index: 23.1100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.5896
    Cell Significance Index: 26.0800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5728
    Cell Significance Index: 43.9600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5512
    Cell Significance Index: 11.7400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5029
    Cell Significance Index: 347.7900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4908
    Cell Significance Index: 53.3900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4897
    Cell Significance Index: 79.6400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4502
    Cell Significance Index: 27.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4430
    Cell Significance Index: 158.8900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.4164
    Cell Significance Index: 6.6800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3966
    Cell Significance Index: 78.7100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3360
    Cell Significance Index: 22.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2303
    Cell Significance Index: 27.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2182
    Cell Significance Index: 39.3400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2010
    Cell Significance Index: 13.9000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2001
    Cell Significance Index: 109.2900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1800
    Cell Significance Index: 5.0300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1390
    Cell Significance Index: 8.7600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1255
    Cell Significance Index: 17.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1246
    Cell Significance Index: 6.9900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1186
    Cell Significance Index: 52.4500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1072
    Cell Significance Index: 1.3300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0813
    Cell Significance Index: 5.2500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0809
    Cell Significance Index: 2.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0702
    Cell Significance Index: 132.1200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0668
    Cell Significance Index: 1.6700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0570
    Cell Significance Index: 87.7800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0525
    Cell Significance Index: 0.8800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0460
    Cell Significance Index: 84.8200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0405
    Cell Significance Index: 55.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0361
    Cell Significance Index: 16.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0330
    Cell Significance Index: 20.9900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0298
    Cell Significance Index: 0.5100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0203
    Cell Significance Index: 2.5000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0143
    Cell Significance Index: 1.0100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0065
    Cell Significance Index: -0.3400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0083
    Cell Significance Index: -0.4300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0187
    Cell Significance Index: -13.6900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0208
    Cell Significance Index: -3.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0229
    Cell Significance Index: -17.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0242
    Cell Significance Index: -17.9000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0268
    Cell Significance Index: -0.4000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0358
    Cell Significance Index: -4.5900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0367
    Cell Significance Index: -20.7200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0420
    Cell Significance Index: -26.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0438
    Cell Significance Index: -7.4800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0455
    Cell Significance Index: -1.1700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0495
    Cell Significance Index: -14.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0516
    Cell Significance Index: -2.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0557
    Cell Significance Index: -5.6900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0862
    Cell Significance Index: -2.4600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0868
    Cell Significance Index: -2.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1084
    Cell Significance Index: -12.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1157
    Cell Significance Index: -5.4400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1168
    Cell Significance Index: -15.0900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1174
    Cell Significance Index: -24.7200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1204
    Cell Significance Index: -4.2300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1255
    Cell Significance Index: -2.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1257
    Cell Significance Index: -5.8600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1289
    Cell Significance Index: -15.0200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1328
    Cell Significance Index: -13.8300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1352
    Cell Significance Index: -2.9600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1392
    Cell Significance Index: -2.3300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1720
    Cell Significance Index: -4.6100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1732
    Cell Significance Index: -3.3800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1749
    Cell Significance Index: -2.0900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1760
    Cell Significance Index: -10.7900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2090
    Cell Significance Index: -5.5800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2102
    Cell Significance Index: -4.3600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2137
    Cell Significance Index: -15.9300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2209
    Cell Significance Index: -3.2600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2223
    Cell Significance Index: -6.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2312
    Cell Significance Index: -7.4100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2391
    Cell Significance Index: -1.9500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2612
    Cell Significance Index: -20.6900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2807
    Cell Significance Index: -4.0200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3432
    Cell Significance Index: -4.2800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3529
    Cell Significance Index: -18.3800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3654
    Cell Significance Index: -9.7800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3684
    Cell Significance Index: -7.8800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3701
    Cell Significance Index: -22.7500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3803
    Cell Significance Index: -9.2800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3841
    Cell Significance Index: -19.4100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3953
    Cell Significance Index: -8.3900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4016
    Cell Significance Index: -12.7900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4062
    Cell Significance Index: -14.1200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4068
    Cell Significance Index: -13.3200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4284
    Cell Significance Index: -11.2700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.4366
    Cell Significance Index: -5.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Repressor:** ZBTB25 acts as a transcriptional repressor, binding to specific DNA sequences and inhibiting the recruitment of RNA polymerase II, thereby reducing gene expression. 2. **Zinc Finger and BTB Domain:** The zinc finger and BTB domains of ZBTB25 are essential for its DNA-binding activity and ability to regulate transcription. 3. **Cellular Expression:** ZBTB25 is expressed in various cell types, including immune cells, suggesting its role in immune regulation. 4. **Pathway Involvement:** ZBTB25 is involved in negative regulation of transcription by RNA polymerase II, metal ion binding, and regulation of cytokine production. **Pathways and Functions:** 1. **Negative Regulation of Transcription:** ZBTB25 represses the expression of genes involved in cytokine production, immune response, and immune system processes by binding to specific DNA sequences and inhibiting RNA polymerase II recruitment. 2. **Metal Ion Binding:** ZBTB25 binds to metal ions, which may play a role in its DNA-binding activity and transcriptional regulation. 3. **Regulation of Cytokine Production:** ZBTB25 regulates cytokine production by modulating the expression of cytokine genes, thereby influencing the immune response. 4. **Regulation of Immune System Processes:** ZBTB25 regulates immune system processes by modulating the expression of genes involved in immune cell function and immune response. **Clinical Significance:** 1. **Immune-Related Disorders:** Dysregulation of ZBTB25 may contribute to immune-related disorders, such as autoimmune diseases, where immune system dysregulation is a hallmark. 2. **Cancer:** ZBTB25 may play a role in cancer development and progression by regulating gene expression in cancer cells. 3. **Neurological Disorders:** ZBTB25 may be involved in neurological disorders, such as epilepsy, where immune system dysregulation is a contributing factor. 4. **Immunotherapy:** Understanding the role of ZBTB25 in immune regulation may provide insights into the development of immunotherapies for immune-related disorders. In conclusion, ZBTB25 plays a critical role in regulating the immune system by modulating transcriptional activity. Its dysregulation may contribute to immune-related disorders, cancer, and neurological disorders. Further research is needed to fully understand the mechanisms of ZBTB25 and its clinical significance in human diseases.

Genular Protein ID: 661206609

Symbol: ZBT25_HUMAN

Name: Zinc finger and BTB domain-containing protein 25

UniProtKB Accession Codes:

P24278 B3KUX6 Q8IYH9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 9 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2027750

Title: The KUP gene, located on human chromosome 14, encodes a protein with two distant zinc fingers.

PubMed ID: 2027750

DOI: 10.1093/nar/19.7.1431

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 435
  • Mass: 48990
  • Checksum: 5994E14B735AA0AE
  • Sequence:
    • MDTASHSLVL LQQLNMQREF GFLCDCTVAI GDVYFKAHRA VLAAFSNYFK MIFIHQTSEC 
IKIQPTDIQP DIFSYLLHIM YTGKGPKQIV DHSRLEEGIR FLHADYLSHI ATEMNQVFSP 
ETVQSSNLYG IQISTTQKTV VKQGLEVKEA PSSNSGNRAA VQGDHPQLQL SLAIGLDDGT 
ADQQRACPAT QALEEHQKPP VSIKQERCDP ESVISQSHPS PSSEVTGPTF TENSVKIHLC 
HYCGERFDSR SNLRQHLHTH VSGSLPFGVP ASILESNDLG EVHPLNENSE ALECRRLSSF 
IVKENEQQPD HTNRGTTEPL QISQVSLISK DTEPVELNCN FSFSRKRKMS CTICGHKFPR 
KSQLLEHMYT HKGKSYRYNR CQRFGNALAQ RFQPYCDSWS DVSLKSSRLS QEHLDLPCAL 
ESELTQENVD TILVE

Genular Protein ID: 287854671

Symbol: G3V2K3_HUMAN

Name: N/A

UniProtKB Accession Codes:

G3V2K3

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 2 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 2 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 2 Pfam 1 Proteomes 2 RefSeq 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 86
  • Mass: 9640
  • Checksum: DDEAEDC961745DCA
  • Sequence:
    • MDTASHSLVL LQQLNMQREF GFLCDCTVAI GDVYFKAHRA VLAAFSNYFK MIFIHQTRQQ 
ITHLEVIKEL EAAGCLCCSL DGLSQG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.