Details for: ZNF135

Gene ID: 7694

Symbol: ZNF135

Ensembl ID: ENSG00000176293

Description: zinc finger protein 135

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 109.2930
    Cell Significance Index: -17.0000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 63.0807
    Cell Significance Index: -16.0000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.9150
    Cell Significance Index: -14.2400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.9786
    Cell Significance Index: -17.2400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.3816
    Cell Significance Index: -17.2900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0372
    Cell Significance Index: 197.3800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6848
    Cell Significance Index: 38.4300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.6708
    Cell Significance Index: 29.6700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.6597
    Cell Significance Index: 24.9800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.6462
    Cell Significance Index: 8.0200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.6147
    Cell Significance Index: 13.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5983
    Cell Significance Index: 120.0300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.5191
    Cell Significance Index: 7.3900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5012
    Cell Significance Index: 31.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4259
    Cell Significance Index: 152.7800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4018
    Cell Significance Index: 39.7500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3877
    Cell Significance Index: 23.8300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3487
    Cell Significance Index: 314.8100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3043
    Cell Significance Index: 15.8100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.2911
    Cell Significance Index: 4.6700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2723
    Cell Significance Index: 5.8000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2249
    Cell Significance Index: 36.5800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2235
    Cell Significance Index: 24.3100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1935
    Cell Significance Index: 14.8500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1855
    Cell Significance Index: 12.4700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1843
    Cell Significance Index: 4.4200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1779
    Cell Significance Index: 10.6800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1197
    Cell Significance Index: 3.4500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0908
    Cell Significance Index: 16.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0769
    Cell Significance Index: 144.8400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0755
    Cell Significance Index: 5.2200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0671
    Cell Significance Index: 9.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0593
    Cell Significance Index: 37.6300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0579
    Cell Significance Index: 0.6900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0522
    Cell Significance Index: 36.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0496
    Cell Significance Index: 91.5200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0424
    Cell Significance Index: 65.2200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0416
    Cell Significance Index: 1.0400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0315
    Cell Significance Index: 0.5400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0268
    Cell Significance Index: 0.9400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0254
    Cell Significance Index: 13.8500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0222
    Cell Significance Index: 9.8100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0203
    Cell Significance Index: 0.5800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0195
    Cell Significance Index: 2.5000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0189
    Cell Significance Index: 25.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0150
    Cell Significance Index: 1.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0083
    Cell Significance Index: 3.7600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0051
    Cell Significance Index: 0.1100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0013
    Cell Significance Index: -0.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0039
    Cell Significance Index: -0.5700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0050
    Cell Significance Index: -3.6900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0181
    Cell Significance Index: -0.8200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0206
    Cell Significance Index: -15.2900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0234
    Cell Significance Index: -17.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0288
    Cell Significance Index: -16.2700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0298
    Cell Significance Index: -18.6000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0411
    Cell Significance Index: -8.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0494
    Cell Significance Index: -14.2100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0769
    Cell Significance Index: -2.1500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0818
    Cell Significance Index: -13.9600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0878
    Cell Significance Index: -18.5000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0892
    Cell Significance Index: -5.4700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0909
    Cell Significance Index: -11.7400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0972
    Cell Significance Index: -9.9300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0991
    Cell Significance Index: -11.3500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1061
    Cell Significance Index: -2.2000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1117
    Cell Significance Index: -1.8700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1118
    Cell Significance Index: -7.9100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1192
    Cell Significance Index: -6.2600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1210
    Cell Significance Index: -14.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1304
    Cell Significance Index: -9.7200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1364
    Cell Significance Index: -14.2000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1460
    Cell Significance Index: -7.6100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1508
    Cell Significance Index: -5.2400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1531
    Cell Significance Index: -4.0300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1811
    Cell Significance Index: -14.3400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1883
    Cell Significance Index: -8.8500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1892
    Cell Significance Index: -6.0600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1977
    Cell Significance Index: -5.3800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2200
    Cell Significance Index: -1.8700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2378
    Cell Significance Index: -15.3400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2389
    Cell Significance Index: -7.8200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2470
    Cell Significance Index: -4.8200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2619
    Cell Significance Index: -8.3400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2660
    Cell Significance Index: -12.4000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2695
    Cell Significance Index: -6.8900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2737
    Cell Significance Index: -5.8100
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.2827
    Cell Significance Index: -3.9700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2995
    Cell Significance Index: -6.2700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3071
    Cell Significance Index: -3.8300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3486
    Cell Significance Index: -4.4000
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.3510
    Cell Significance Index: -4.9200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3537
    Cell Significance Index: -12.3900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3575
    Cell Significance Index: -9.5800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3591
    Cell Significance Index: -9.2300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3601
    Cell Significance Index: -7.1200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3651
    Cell Significance Index: -7.3300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3651
    Cell Significance Index: -5.3900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3854
    Cell Significance Index: -10.3100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.3876
    Cell Significance Index: -2.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Zinc Finger Domain**: ZNF135 contains a zinc finger domain, a conserved structural motif that allows for specific DNA binding and transcriptional regulation. 2. **RNA Polymerase II Specificity**: ZNF135 exhibits specificity for RNA polymerase II (RNAPII), a key enzyme responsible for transcribing protein-coding genes. 3. **Cytoskeleton Organization**: ZNF135 is involved in regulating cytoskeleton organization, which is essential for cell shape, movement, and division. 4. **Diverse Cell Types**: ZNF135 is expressed in various cell types, including mesenchymal cells, neurons, and epithelial cells, suggesting its broad functional significance. **Pathways and Functions** 1. **Transcriptional Regulation**: ZNF135 regulates transcription by binding to specific DNA sequences and recruiting RNAPII to initiate gene expression. 2. **Cytoskeleton Organization**: ZNF135 influences cytoskeleton organization by regulating the expression of genes involved in cytoskeletal dynamics. 3. **Metal Ion Binding**: ZNF135 binds to metal ions, which may influence its DNA-binding activity and transcriptional regulation. 4. **Cell Morphogenesis**: ZNF135 is involved in regulating cell morphogenesis, a process critical for cellular development and differentiation. **Clinical Significance** 1. **Neurological Disorders**: Aberrant expression or function of ZNF135 may contribute to neurological disorders, such as Parkinson's disease, Alzheimer's disease, and schizophrenia. 2. **Cancer**: ZNF135 has been implicated in cancer development and progression, particularly in mesenchymal cells and epithelial cells. 3. **Developmental Disorders**: ZNF135 may play a role in developmental disorders, such as neural tube defects and congenital heart defects. 4. **Neurodegenerative Diseases**: ZNF135 has been identified as a potential therapeutic target for neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). In conclusion, ZNF135 is a multifunctional transcription factor that plays a crucial role in regulating cellular processes, including transcription, cytoskeleton organization, and metal ion binding. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the molecular mechanisms underlying ZNF135 function and its clinical significance.

Genular Protein ID: 3963250018

Symbol: ZN135_HUMAN

Name: Zinc finger protein 135

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7557990

Title: Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders.

PubMed ID: 7557990

DOI: 10.1006/geno.1995.1040

PubMed ID: 21834987

Title: Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration.

PubMed ID: 21834987

DOI: 10.1186/1741-7007-9-54

Sequence Information:

  • Length: 658
  • Mass: 75261
  • Checksum: ED6A4FB042CB3CE5
  • Sequence:
  • MTPGVRVSTD PEQVTFEDVV VGFSQEEWGQ LKPAQRTLYR DVMLDTFRLL VSVGHWLPKP 
    NVISLLEQEA ELWAVESRLP QGVYPDLETR PKVKLSVLKQ GISEEISNSV ILVERFLWDG 
    LWYCRGEDTE GHWEWSCESL ESLAVPVAFT PVKTPVLEQW QRNGFGENIS LNPDLPHQPM 
    TPERQSPHTW GTRGKREKPD LNVLQKTCVK EKPYKCQECG KAFSHSSALI EHHRTHTGER 
    PYECHECLKG FRNSSALTKH QRIHTGEKPY KCTQCGRTFN QIAPLIQHQR THTGEKPYEC 
    SECGKSFSFR SSFSQHERTH TGEKPYECSE CGKAFRQSIH LTQHLRIHTG EKPYQCGECG 
    KAFSHSSSLT KHQRIHTGEK PYECHECGKA FTQITPLIQH QRTHTGEKPY ECGECGKAFS 
    QSTLLTEHRR IHTGEKPYGC NECGKTFSHS SSLSQHERTH TGEKPYECSQ CGKAFRQSTH 
    LTQHQRIHTG EKPYECNDCG KAFSHSSSLT KHQRIHTGEK PYECNQCGRA FSQLAPLIQH 
    QRIHTGEKPY ECNQCGRAFS QSSLLIEHQR IHTKEKPYGC NECGKSFSHS SSLSQHERTH 
    TGEKPYECHD CGKSFRQSTH LTQHRRIHTG EKPYACRDCG KAFTHSSSLT KHQRTHTG

Genular Protein ID: 2891996643

Symbol: B4DLZ7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 588
  • Mass: 67672
  • Checksum: 13DB4C05F6EB18ED
  • Sequence:
  • MELGSRRRSV GCRCRGLCLA VRRDIGYRSR MSSPCWSKRQ SCGRWSLDFP KACTQRLRDI 
    SSFCFFQTWK LNPLHMCWYC RGEDTEGHWE WSCESLESLA VPVAFTPVKT PVLEQWQRNG 
    FGENISLNPD LPHQPMTPER QSPHTWGTRG KREKPDLNVL QKTCVKEKPY KCQECGKAFS 
    HSSALIEHHR THTGERPYEC HECLKGFRNS SALTKHQRIH TGEKPYKCTQ CGRTFNQIAP 
    LIQHQRTHTG EKPYECSECG KSFSFRSSFS QHERTHTGEK PYECSECGKA FRQSIHLTQH 
    LRIHTGEKPY QCGECGKAFS HSSSLTKHQR IHTGEKPYEC HECGKAFTQI TPLIQHQRTH 
    TGEKPYECGE CGKAFSQSTL LTEHRRIHTG EKPYGCNECG KTFSHSSSLS QHERTHTGEK 
    PYECSQCGKA FRQSTHLTQH QRIHTGEKPY ECNDCGKAFS HSSSLTKHQR IHTGEKPYEC 
    NQCGRAFSQL APLIQHQRIH TGEKPYECNQ CGRAFSQSSL LIEHQRIHTK EKPYGCNECG 
    KSFSHSSSLS QHERTHTGEK PYECHDCGKS FRQSTHLTQH RRIHIGRP

Genular Protein ID: 1560160083

Symbol: Q8N9M3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 616
  • Mass: 70483
  • Checksum: 22946EDC09BE2EA9
  • Sequence:
  • MLDTFRLLVS VGHWLPKPNV ISLLEQEAEL WAVESRLPQG VYPDLETRPK VKLSVLKQGI 
    SEEISNSVIL VERFLWDGLW YCRGEDTEGH WEWSCESLES LAVPVAFTPV KTPVLEQWQR 
    NGFGENISLN PDLPHQPMTP ERQSPHTWGT RGKREKPDLN VLQKTCVKEK PYKCQECGKA 
    FSHSSALIEH HRTHTGERPY ECHECLKGFR NSSALTKHQR IHTGEKPYKC TQCGRTFNQI 
    APLIQHQRTH TGEKPYECSE CGKSFSFRSS FSQHERTHTG EKPYECSECG KAFRQSIHLT 
    QHLRIHTGEK PYQCGECGKA FSHSSSLTKH QRIHTGEKPY ECHECGKAFT QITPLIQHQR 
    THTGEKPYEC GECGKAFSQS TLLTEHRRIH TGEKPYGCNE CGKTFSHSSS LSQHERTHTG 
    EKPYECSQCG KAFRQSTHLT QHQRIHTGEK PYECNDCGKA FSHSSSLTKH QRIHTGEKPY 
    ECNQCGRAFS QLAPLIQHQR IHTGEKPYEC NQCGRAFSQS SLLIEHQRIH TKEKPYGCNE 
    CGKSFSHSSS LSQHERTHTG EKPYECHDCG KSFRQSTHLT QHRRIHTGEK PYACRDCGKA 
    FTHSSSLTKH QRTHTG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.