Details for: ZNF165

Gene ID: 7718

Symbol: ZNF165

Ensembl ID: ENSG00000197279

Description: zinc finger protein 165

Associated with

  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Metal ion binding
    (GO:0046872)
  • Nucleus
    (GO:0005634)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 44.1994
    Cell Significance Index: -6.8800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 25.5871
    Cell Significance Index: -6.4900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 16.6769
    Cell Significance Index: -6.8700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 14.1536
    Cell Significance Index: -5.7500
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 12.2173
    Cell Significance Index: 46.7800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 6.0435
    Cell Significance Index: -5.7700
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 5.9703
    Cell Significance Index: 20.5000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.6835
    Cell Significance Index: -7.0100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.3047
    Cell Significance Index: 171.6700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.8747
    Cell Significance Index: 62.2800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.7316
    Cell Significance Index: 40.9300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.5347
    Cell Significance Index: -6.7900
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.2852
    Cell Significance Index: 24.2800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.9814
    Cell Significance Index: 32.6500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.5055
    Cell Significance Index: 9.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.3187
    Cell Significance Index: 98.2800
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 1.1866
    Cell Significance Index: 12.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9579
    Cell Significance Index: 27.6000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7687
    Cell Significance Index: 146.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.7351
    Cell Significance Index: 25.8300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6505
    Cell Significance Index: 84.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6302
    Cell Significance Index: 28.5700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6183
    Cell Significance Index: 16.8300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4947
    Cell Significance Index: 13.2100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.4650
    Cell Significance Index: 6.6200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4587
    Cell Significance Index: 27.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4294
    Cell Significance Index: 20.1800
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.3735
    Cell Significance Index: 2.4400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3371
    Cell Significance Index: 36.6700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2997
    Cell Significance Index: 2.7600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2745
    Cell Significance Index: 247.8800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2646
    Cell Significance Index: 3.6100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2276
    Cell Significance Index: 22.5100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2143
    Cell Significance Index: 34.8600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.2077
    Cell Significance Index: 6.5700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1723
    Cell Significance Index: 3.6700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1677
    Cell Significance Index: 11.6000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1426
    Cell Significance Index: 8.9900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1373
    Cell Significance Index: 15.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1314
    Cell Significance Index: 22.4300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1263
    Cell Significance Index: 15.5300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1055
    Cell Significance Index: 12.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1049
    Cell Significance Index: 57.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0975
    Cell Significance Index: 17.5800
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.0490
    Cell Significance Index: 0.4100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0479
    Cell Significance Index: 1.2300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0443
    Cell Significance Index: 8.8000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0362
    Cell Significance Index: 16.0000
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 0.0298
    Cell Significance Index: 0.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0293
    Cell Significance Index: 5.8800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0256
    Cell Significance Index: 0.2700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0089
    Cell Significance Index: 0.2500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0088
    Cell Significance Index: 0.6200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0055
    Cell Significance Index: 7.4200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0006
    Cell Significance Index: 0.0300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0004
    Cell Significance Index: 0.2600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0000
    Cell Significance Index: -0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0004
    Cell Significance Index: -0.7800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0010
    Cell Significance Index: -0.6200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0012
    Cell Significance Index: -1.8100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0020
    Cell Significance Index: -0.2500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0027
    Cell Significance Index: -1.6900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0028
    Cell Significance Index: -5.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0029
    Cell Significance Index: -1.6300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0035
    Cell Significance Index: -2.6600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0039
    Cell Significance Index: -2.8800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0041
    Cell Significance Index: -1.4600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0044
    Cell Significance Index: -0.6000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0047
    Cell Significance Index: -0.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0073
    Cell Significance Index: -0.8500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0077
    Cell Significance Index: -1.6200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0079
    Cell Significance Index: -1.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0083
    Cell Significance Index: -0.8500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0135
    Cell Significance Index: -6.1400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0148
    Cell Significance Index: -4.2700
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0186
    Cell Significance Index: -0.1200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0297
    Cell Significance Index: -3.5000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0339
    Cell Significance Index: -0.2300
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0404
    Cell Significance Index: -0.5600
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0411
    Cell Significance Index: -0.3900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0436
    Cell Significance Index: -1.0900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0532
    Cell Significance Index: -1.2300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0545
    Cell Significance Index: -1.1300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0581
    Cell Significance Index: -0.6600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0606
    Cell Significance Index: -0.7800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0644
    Cell Significance Index: -3.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0650
    Cell Significance Index: -6.7700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0687
    Cell Significance Index: -2.2000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0688
    Cell Significance Index: -5.4500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0715
    Cell Significance Index: -1.9200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0755
    Cell Significance Index: -2.7700
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0822
    Cell Significance Index: -0.9300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0860
    Cell Significance Index: -5.7800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0860
    Cell Significance Index: -6.6000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0877
    Cell Significance Index: -4.9200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0894
    Cell Significance Index: -1.2800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0930
    Cell Significance Index: -3.8100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0940
    Cell Significance Index: -2.7700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0943
    Cell Significance Index: -4.9500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0958
    Cell Significance Index: -4.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulation:** ZNF165 exhibits DNA-binding transcription factor activity, specifically targeting RNA polymerase II-specific cis-regulatory regions. This suggests its capacity to modulate gene expression by influencing transcriptional initiation and elongation. 2. **Metal Ion Binding:** The presence of metal ion binding capabilities in ZNF165 indicates its potential involvement in protein-protein interactions and redox-sensitive signaling pathways. 3. **Cellular Expression:** ZNF165 is expressed in a wide range of cell types, including those in the nervous system (cerebral cortex GABAergic interneuron, forebrain radial glial cell), epithelial tissues (glandular epithelial cell, absorptive cell), and urothelial tissues (bladder urothelial cell). This tissue-specific expression pattern suggests a diverse role in various biological processes. **Pathways and Functions:** 1. **Transcriptional Regulation by RNA Polymerase II:** ZNF165's involvement in RNA polymerase II-specific transcriptional regulation implies its role in the regulation of gene expression, particularly in the context of cellular differentiation and development. 2. **Cellular Differentiation and Development:** The expression of ZNF165 in progenitor cells of mammary luminal epithelium and forebrain radial glial cells suggests its potential involvement in cellular differentiation and development processes. 3. **Metal Ion-Sensitive Signaling:** The metal ion binding capabilities of ZNF165 may contribute to redox-sensitive signaling pathways, influencing cellular responses to environmental changes and stress. 4. **Tissue-Specific Functions:** The diverse expression patterns of ZNF165 across different tissues suggest specialized roles in various biological processes, including epithelial barrier function, immune response, and neural development. **Clinical Significance:** 1. **Cancer Research:** The expression of ZNF165 in various tumor types (e.g., bladder urothelial cell carcinoma) and its potential involvement in cancer progression make it an interesting target for future research. 2. **Neurological Disorders:** The expression of ZNF165 in the nervous system and its involvement in neuronal development and function suggest potential implications in neurological disorders, such as autism spectrum disorder and schizophrenia. 3. **Epithelial Barrier Function:** The expression of ZNF165 in epithelial tissues and its potential role in maintaining epithelial barrier function make it an interesting candidate for the study of epithelial disorders, such as inflammatory bowel disease and skin conditions. In conclusion, ZNF165 is a zinc finger protein with a complex expression pattern and diverse functional implications. Further research into its role in transcriptional regulation, cellular differentiation, and metal ion-sensitive signaling pathways is warranted to fully understand its significance in various biological processes and its potential applications in human disease.

Genular Protein ID: 2354779545

Symbol: ZN165_HUMAN

Name: Zinc finger protein 165

UniProtKB Accession Codes:

P49910

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 4 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7490084

Title: Characterization of a novel zinc finger gene (ZNF165) mapping to 6p21 that is expressed specifically in testis.

PubMed ID: 7490084

DOI: 10.1006/geno.1995.1178

PubMed ID: 9244436

Title: Three genes encoding zinc finger proteins on human chromosome 6p21.3: members of a new subclass of the Kruppel gene family containing the conserved SCAN box domain.

PubMed ID: 9244436

DOI: 10.1006/geno.1997.4806

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 485
  • Mass: 55771
  • Checksum: 1265D859D1713AE8
  • Sequence:
    • MATEPKKAAA QNSPEDEGLL IVKIEEEEFI HGQDTCLQRS ELLKQELCRQ LFRQFCYQDS 
PGPREALSRL RELCCQWLKP EIHTKEQILE LLVLEQFLTI LPGDLQAWVH EHYPESGEEA 
VTILEDLERG TDEAVLQVQA HEHGQEIFQK KVSPPGPALN VKLQPVETKA HFDSSEPQLL 
WDCDNESENS RSMPKLEIFE KIESQRIISG RISGYISEAS GESQDICKSA GRVKRQWEKE 
SGESQRLSSA QDEGFGKILT HKNTVRGEII SHDGCERRLN LNSNEFTHQK SCKHGTCDQS 
FKWNSDFINH QIIYAGEKNH QYGKSFKSPK LAKHAAVFSG DKTHQCNECG KAFRHSSKLA 
RHQRIHTGER CYECNECGKS FAESSDLTRH RRIHTGERPF GCKECGRAFN LNSHLIRHQR 
IHTREKPYEC SECGKTFRVS SHLIRHFRIH TGEKPYECSE CGRAFSQSSN LSQHQRIHMR 
ENLLM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.