Details for: TRIM26

Gene ID: 7726

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: TRIM26

Ensembl ID: ENSG00000234127

Description: tripartite motif containing 26

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • lung ciliated cell CL1000271
    CSI 14.29
    rCSI 16.52%
    PRS 61.32
  • dendritic cell, human CL0001056
    CSI 9.61
    rCSI 14.76%
    PRS 79.71
  • VIP GABAergic cortical interneuron CL4023016
    CSI 7.3
    rCSI 8.72%
    PRS 51.37
  • glutamatergic neuron CL0000679
    CSI 6.38
    rCSI 13.11%
    PRS 59.13
  • GABAergic neuron CL0000617
    CSI 5.76
    rCSI 19.3%
    PRS 54.82
  • plasmacytoid dendritic cell, human CL0001058
    CSI 4.69
    rCSI 3.28%
    PRS 73.29
  • plasmablast CL0000980
    CSI 3.95
    rCSI 3.1%
    PRS 76.94
  • sst GABAergic cortical interneuron CL4023017
    CSI 3.9
    rCSI 5.02%
    PRS 52.91
  • effector CD8-positive, alpha-beta T cell CL0001050
    CSI 3.75
    rCSI 2.86%
    PRS 83.09
  • myeloid leukocyte CL0000766
    CSI 3.66
    rCSI 3.37%
    PRS 72.06
  • Kupffer cell CL0000091
    CSI 3.42
    rCSI 7.81%
    PRS 70.99
  • retinal rod cell CL0000604
    CSI 3.4
    rCSI 5.99%
    PRS 66.48
  • colonocyte CL1000347
    CSI 3.29
    rCSI 4.72%
    PRS 72.7
  • double negative thymocyte CL0002489
    CSI 3.2
    rCSI 2.23%
    PRS 81.87
  • enteroendocrine cell of small intestine CL0009006
    CSI 3.11
    rCSI 6.84%
    PRS 81.09
  • CD4-positive, alpha-beta memory T cell CL0000897
    CSI 3.1
    rCSI 2.23%
    PRS 83.87
  • lung secretory cell CL1000272
    CSI 2.93
    rCSI 7.25%
    PRS 69.15
  • central memory CD4-positive, alpha-beta T cell CL0000904
    CSI 2.87
    rCSI 1.7%
    PRS 86.65
  • duct epithelial cell CL0000068
    CSI 2.84
    rCSI 4.15%
    PRS 75.2
  • midzonal region hepatocyte CL0019028
    CSI 2.76
    rCSI 6.47%
    PRS 72.92
  • central memory CD8-positive, alpha-beta T cell CL0000907
    CSI 2.73
    rCSI 1.84%
    PRS 83.53
  • interneuron CL0000099
    CSI 2.72
    rCSI 5.45%
    PRS 59.57
  • group 3 innate lymphoid cell CL0001071
    CSI 2.7
    rCSI 2.03%
    PRS 76.25
  • naive T cell CL0000898
    CSI 2.67
    rCSI 1.86%
    PRS 84.99
  • CD4-positive helper T cell CL0000492
    CSI 2.63
    rCSI 1.99%
    PRS 83.54
  • conjunctival epithelial cell CL1000432
    CSI 2.49
    rCSI 3.8%
    PRS 71.05
  • T follicular helper cell CL0002038
    CSI 2.42
    rCSI 1.81%
    PRS 84.34
  • neural crest cell CL0011012
    CSI 2.41
    rCSI 1.91%
    PRS 57.55
  • choroid plexus epithelial cell CL0000706
    CSI 2.41
    rCSI 3.95%
    PRS 59.37
  • colon epithelial cell CL0011108
    CSI 2.3
    rCSI 2.41%
    PRS 67.29
  • astrocyte of the cerebral cortex CL0002605
    CSI 2.28
    rCSI 5.11%
    PRS 52.16
  • stem cell CL0000034
    CSI 2.23
    rCSI 2.15%
    PRS 62.08
  • cerebral cortex endothelial cell CL1001602
    CSI 2.22
    rCSI 3.84%
    PRS 60.76
  • keratinocyte CL0000312
    CSI 2.07
    rCSI 1.74%
    PRS 73.7
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 2.05
    rCSI 5.29%
    PRS 65.23
  • hepatocyte CL0000182
    CSI 2.02
    rCSI 3.62%
    PRS 69.83
  • epithelial cell of lung CL0000082
    CSI 2.02
    rCSI 1.67%
    PRS 70.34
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 1.99
    rCSI 2.82%
    PRS 66.52
  • granulocyte monocyte progenitor cell CL0000557
    CSI 1.99
    rCSI 1.72%
    PRS 75.09
  • hepatic stellate cell CL0000632
    CSI 1.98
    rCSI 7.42%
    PRS 62.28
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 1.98
    rCSI 2.46%
    PRS 49.63
  • retinal bipolar neuron CL0000748
    CSI 1.97
    rCSI 3.69%
    PRS 58.07
  • goblet cell CL0000160
    CSI 1.97
    rCSI 1.86%
    PRS 69.66
  • ependymal cell CL0000065
    CSI 1.96
    rCSI 3.97%
    PRS 48.62
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 1.96
    rCSI 1.51%
    PRS 72.15
  • kidney connecting tubule epithelial cell CL1000768
    CSI 1.95
    rCSI 4.94%
    PRS 59.94
  • ciliated epithelial cell CL0000067
    CSI 1.93
    rCSI 1.7%
    PRS 58.29
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 1.89
    rCSI 4.94%
    PRS 70.76
  • GABAergic interneuron CL0011005
    CSI 1.86
    rCSI 29.26%
    PRS 73.57
  • vascular leptomeningeal cell CL4023051
    CSI 1.74
    rCSI 3.05%
    PRS 62.79
  • renal principal cell CL0005009
    CSI 1.74
    rCSI 4.51%
    PRS 72.86
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 1.73
    rCSI 2.91%
    PRS 51.54
  • rod bipolar cell CL0000751
    CSI 1.72
    rCSI 3.09%
    PRS 63.41
  • multi-ciliated epithelial cell CL0005012
    CSI 1.69
    rCSI 1.69%
    PRS 63.82
  • Mueller cell CL0000636
    CSI 1.67
    rCSI 3.82%
    PRS 61.74
  • ciliated cell CL0000064
    CSI 1.65
    rCSI 2.67%
    PRS 65.99
  • renal beta-intercalated cell CL0002201
    CSI 1.6
    rCSI 3.82%
    PRS 70.76
  • extravillous trophoblast CL0008036
    CSI 1.59
    rCSI 1.96%
    PRS 67.37
  • BEST4+ enteroycte CL4030026
    CSI 1.55
    rCSI 1.93%
    PRS 72.18
  • effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062
    CSI 1.55
    rCSI 7.76%
    PRS 82.78
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 1.53
    rCSI 1.77%
    PRS 62.76
  • transit amplifying cell of colon CL0009011
    CSI 1.51
    rCSI 1.77%
    PRS 72.52
  • squamous epithelial cell CL0000076
    CSI 1.5
    rCSI 3.55%
    PRS 72.5
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 1.47
    rCSI 2.59%
    PRS 50.65
  • CD14-positive, CD16-positive monocyte CL0002397
    CSI 1.45
    rCSI 1.9%
    PRS 82.89
  • epithelial cell of proximal tubule CL0002306
    CSI 1.45
    rCSI 3.54%
    PRS 63.41
  • corneal epithelial cell CL0000575
    CSI 1.32
    rCSI 3.78%
    PRS 79.77
  • germinal center B cell CL0000844
    CSI 1.23
    rCSI 3.68%
    PRS 83.96
  • intestinal crypt stem cell of small intestine CL0009017
    CSI 1.21
    rCSI 3.26%
    PRS 76.69
  • indirect pathway medium spiny neuron CL4023029
    CSI 1.17
    rCSI 28.19%
    PRS 51.19
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 1.07
    rCSI 3.35%
    PRS 55.83
  • paneth cell of epithelium of small intestine CL1000343
    CSI 1.05
    rCSI 2.94%
    PRS 79.96
  • sncg GABAergic cortical interneuron CL4023015
    CSI 0.89
    rCSI 1.43%
    PRS 53.43
  • retinal cone cell CL0000573
    CSI 0.69
    rCSI 1.11%
    PRS 59.73
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 0.69
    rCSI 1.68%
    PRS 49.94
  • retinal ganglion cell CL0000740
    CSI 0.67
    rCSI 1.49%
    PRS 56.2
  • blood vessel smooth muscle cell CL0019018
    CSI 0.64
    rCSI 5.24%
    PRS 63.8
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 0.62
    rCSI 2.23%
    PRS 49.71
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 0.45
    rCSI 1.71%
    PRS 52.13
  • L6b glutamatergic cortical neuron CL4023038
    CSI 0.39
    rCSI 1.21%
    PRS 53.34
  • direct pathway medium spiny neuron CL4023026
    CSI 0.34
    rCSI 8.09%
    PRS 50.57

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [TRIM26](/details-gene/7726) (Tripartite Motif Containing 26) is a protein-coding gene located on chromosome 6 within the major histocompatibility complex (MHC) class I region ([Link](https://doi.org/10.1006/geno.1995.1236)). As a member of the TRIM family, it functions as an E3 ubiquitin ligase ([GO:0061630](https://www.ebi.ac.uk/QuickGO/term/GO:0061630)), playing a pivotal role in the post-translational modification of proteins. Functionally, [TRIM26](/details-gene/7726) is deeply integrated into the [innate immune response](/details-ontologies/GO:0045087), particularly through its involvement in [interferon signaling](/details-ontologies/R-HSA-913531) and the regulation of NF-kappaB pathways ([GO:1901224](https://www.ebi.ac.uk/QuickGO/term/GO:1901224)). Expression data indicates its significance across a surprisingly diverse range of cell types, with high expression in [lung ciliated cell](/details-cell/CL1000271), various immune cells such as [dendritic cell, human](/details-cell/CL0001056), and several neuronal subtypes. This broad expression profile suggests that its regulatory functions extend beyond immunity to include roles in mucosal defense, neuronal homeostasis, and cellular stress responses. ## Cellular Roles and Expression Landscape The expression profile of [TRIM26](/details-gene/7726) reveals a multifaceted role across distinct physiological systems. **Overall**, its most significant expression is observed in [lung ciliated cell](/details-cell/CL1000271) (CSI: 14.29), suggesting a primary function in the respiratory mucosa, potentially related to host defense against airborne pathogens. Beyond the epithelium, [TRIM26](/details-gene/7726) is a significant marker in key cells of the innate and adaptive immune systems. It shows high significance in antigen-presenting cells like [dendritic cell, human](/details-cell/CL0001056) (CSI: 9.61) and [plasmacytoid dendritic cell, human](/details-cell/CL0001058) (CSI: 4.69), as well as in other [myeloid leukocyte](/details-cell/CL0000766) populations like [Kupffer cell](/details-cell/CL0000091) (CSI: 3.42). Its expression extends to the lymphoid lineage, with notable significance in [plasmablast](/details-cell/CL0000980) (CSI: 3.95), [effector CD8-positive, alpha-beta T cell](/details-cell/CL0001050) (CSI: 3.75), and developing [double negative thymocyte](/details-cell/CL0002489) (CSI: 3.20). This pattern is consistent with its established role in modulating immune signaling pathways. Intriguingly, [TRIM26](/details-gene/7726) also demonstrates a prominent signature within the central nervous system. It is highly expressed in neuronal subtypes, including [VIP GABAergic cortical interneuron](/details-cell/CL4023016) (CSI: 7.30), [glutamatergic neuron](/details-cell/CL0000679) (CSI: 6.38), and [GABAergic neuron](/details-cell/CL0000617) (CSI: 5.76). This suggests a previously underappreciated role in neuronal function or maintenance, separate from its immunological activities. The diverse cellular landscape underscores [TRIM26](/details-gene/7726)'s function as a fundamental regulator involved in specialized cellular processes across epithelial, immune, and neural tissues. ## Pathways and Molecular Function The primary molecular function of [TRIM26](/details-gene/7726) is its E3 [ubiquitin protein ligase activity](/details-ontologies/GO:0061630), enabling it to target specific proteins for proteasome-mediated degradation ([GO:0043161](https://www.ebi.ac.uk/QuickGO/term/GO:0043161)) or to modify their function through ubiquitination. Its activity is central to the [immune system](/details-ontologies/R-HSA-168256), particularly in regulating [cytokine signaling](/details-ontologies/R-HSA-1280215) and the [interferon gamma signaling](/details-ontologies/R-HSA-877300) pathway. [TRIM26](/details-gene/7726) exhibits a dual regulatory role in antiviral immunity. It can negatively regulate interferon-beta production by promoting the degradation of nuclear IRF3, which may facilitate certain viral infections ([Link](https://doi.org/10.1371/journal.ppat.1004726), [Link](https://doi.org/10.3390/v13010070)). Conversely, it also participates in the RLR-mediated antiviral response by linking TBK1 to NEMO through autoubiquitination ([Link](https://doi.org/10.1093/jmcb/mjv068)) and can positively regulate inflammatory responses through K11-linked ubiquitination of TAB1 ([GO:0070979](https://www.ebi.ac.uk/QuickGO/term/GO:0070979), [Link](https://doi.org/10.1038/s41418-021-00803-1)). Beyond immunity, [TRIM26](/details-gene/7726) is involved in fundamental cellular processes such as cell cycle control and stress responses. It can mediate TGF-beta-induced proliferative arrest by targeting TAF7 for degradation ([Link](https://doi.org/10.1128/mcb.00449-17)). It also contributes to the cellular response to oxidative stress by regulating the stability of the DNA glycosylase NTH1, thereby maintaining genome integrity ([Link](https://doi.org/10.1128/mcb.00616-17), [Link](https://doi.org/10.3390/ijms231911613)). In glioblastoma, it has been shown to act as a tumor suppressor by promoting the degradation of the stem cell factor SOX2 ([Link](https://doi.org/10.1038/s41467-021-26653-6)). ## Research Directions The diverse expression profile and dual-function nature of [TRIM26](/details-gene/7726) present several avenues for future investigation. Its context-dependent roles in immunity, cancer, and cellular stress suggest it is a key regulatory hub with significant therapeutic potential. **Proposed Hypotheses:** 1. Given its exceptionally high significance in [lung ciliated cell](/details-cell/CL1000271) and its known role in modulating interferon pathways, we hypothesize that **[TRIM26](/details-gene/7726) acts as a critical rheostat in the airway epithelium, fine-tuning the innate immune response to respiratory viruses to prevent both uncontrolled viral replication and excessive immunopathology.** 2. Based on its prominent expression in multiple neuronal subtypes ([VIP GABAergic cortical interneuron](/details-cell/CL4023016), [glutamatergic neuron](/details-cell/CL0000679)), we hypothesize that **[TRIM26](/details-gene/7726) regulates synaptic plasticity or neuronal survival by targeting key synaptic or structural proteins for ubiquitination-dependent degradation, thereby playing a role in neural circuit maintenance.** 3. Considering its demonstrated ability to target the oncogenic factor SOX2 for degradation in glioblastoma ([Link](https://doi.org/10.1038/s41467-021-26653-6)), we hypothesize that **the loss of [TRIM26](/details-gene/7726) expression or function is a key event in the pathogenesis of certain cancers, leading to the stabilization of oncogenic transcription factors and promoting a cancer stem cell phenotype.** **Key Experimental Approach:** To test the first hypothesis regarding the role of [TRIM26](/details-gene/7726) in respiratory viral defense, a robust *in vitro* model could be employed. Primary human bronchial epithelial cells would be cultured at an air-liquid interface to generate a differentiated, pseudostratified epithelium containing ciliated cells. [TRIM26](/details-gene/7726) expression would be silenced using CRISPR-Cas9 or shRNA lentiviral vectors. These knockdown and control cultures would then be infected with a relevant respiratory pathogen, such as Influenza A virus or SARS-CoV-2. The impact of [TRIM26](/details-gene/7726) loss would be assessed by quantifying viral titers, measuring the secretion of type I and III interferons and pro-inflammatory cytokines using ELISA, and performing RNA-sequencing to analyze global changes in the expression of interferon-stimulated genes and other host defense pathways. **Therapeutic Potential:** [TRIM26](/details-gene/7726) represents a complex but promising therapeutic target. Its therapeutic utility is highly context-dependent. In certain viral infections where [TRIM26](/details-gene/7726) dampens the antiviral IRF3 response (e.g., HBV, HSV-2), **inhibition** of its E3 ligase activity via small molecules could enhance the host's innate immune response and promote viral clearance. Conversely, in cancers like glioblastoma where [TRIM26](/details-gene/7726) acts as a tumor suppressor by degrading oncoproteins like SOX2, a strategy aimed at **activation** or stabilization of [TRIM26](/details-gene/7726) could be beneficial. This could involve developing molecules that enhance its ligase activity or therapies that restore its expression in tumors where it is silenced.

Genular Protein ID: 3304251429

Symbol: TRI26_HUMAN

Name: Tripartite motif-containing protein 26

UniProtKB Accession Codes:

Q12899 A6NG96 Q5SRL2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChEBI 4 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 15 Ensembl 24 ExpressionAtlas 1 GO 15 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 8 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8530076

Title: Cloning of a new 'finger' protein gene (ZNF173) within the class I region of the human MHC.

PubMed ID: 8530076

DOI: 10.1006/geno.1995.1236

PubMed ID: 16702430

Title: Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity.

PubMed ID: 16702430

DOI: 10.1534/genetics.106.057034

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21750715

Title: The inhibitor of growth protein 5 (ING5) depends on INCA1 as a co-factor for its antiproliferative effects.

PubMed ID: 21750715

DOI: 10.1371/journal.pone.0021505

PubMed ID: 23452852

Title: Jmjd3 inhibits reprogramming by upregulating expression of INK4a/Arf and targeting PHF20 for ubiquitination.

PubMed ID: 23452852

DOI: 10.1016/j.cell.2013.02.006

PubMed ID: 25763818

Title: TRIM26 negatively regulates interferon-beta production and antiviral response through polyubiquitination and degradation of nuclear IRF3.

PubMed ID: 25763818

DOI: 10.1371/journal.ppat.1004726

PubMed ID: 26611359

Title: Autoubiquitination of TRIM26 links TBK1 to NEMO in RLR-mediated innate antiviral immune response.

PubMed ID: 26611359

DOI: 10.1093/jmcb/mjv068

PubMed ID: 29203640

Title: Transforming Growth Factor beta-Induced Proliferative Arrest Mediated by TRIM26-Dependent TAF7 Degradation and Its Antagonism by MYC.

PubMed ID: 29203640

DOI: 10.1128/mcb.00449-17

PubMed ID: 29610152

Title: NTH1 Is a New Target for Ubiquitylation-Dependent Regulation by TRIM26 Required for the Cellular Response to Oxidative Stress.

PubMed ID: 29610152

DOI: 10.1128/mcb.00616-17

PubMed ID: 33419081

Title: TRIM26 Facilitates HSV-2 Infection by Downregulating Antiviral Responses through the IRF3 Pathway.

PubMed ID: 33419081

DOI: 10.3390/v13010070

PubMed ID: 34017102

Title: TRIM26 positively regulates the inflammatory immune response through K11-linked ubiquitination of TAB1.

PubMed ID: 34017102

DOI: 10.1038/s41418-021-00803-1

PubMed ID: 34732716

Title: Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.

PubMed ID: 34732716

DOI: 10.1038/s41467-021-26653-6

PubMed ID: 36232914

Title: TRIM26 Maintains Cell Survival in Response to Oxidative Stress through Regulating DNA Glycosylase Stability.

PubMed ID: 36232914

DOI: 10.3390/ijms231911613

PubMed ID: 35872575

Title: TRIM26 inhibits hepatitis B virus replication by promoting HBx degradation and TRIM26 genetic polymorphism predicts PegIFNalpha treatment response of HBeAg-positive chronic hepatitis B Patients.

PubMed ID: 35872575

DOI: 10.1111/apt.17124

Sequence Information:

  • Length: 539
  • Mass: 62166
  • Checksum: 842A71C41F2E2348
  • Sequence:
    • MATSAPLRSL EEEVTCSICL DYLRDPVTID CGHVFCRSCT TDVRPISGSR PVCPLCKKPF 
KKENIRPVWQ LASLVENIER LKVDKGRQPG EVTREQQDAK LCERHREKLH YYCEDDGKLL 
CVMCRESREH RPHTAVLMEK AAQPHREKIL NHLSTLRRDR DKIQGFQAKG EADILAALKK 
LQDQRQYIVA EFEQGHQFLR EREEHLLEQL AKLEQELTEG REKFKSRGVG ELARLALVIS 
ELEGKAQQPA AELMQDTRDF LNRYPRKKFW VGKPIARVVK KKTGEFSDKL LSLQRGLREF 
QGKLLRDLEY KTVSVTLDPQ SASGYLQLSE DWKCVTYTSL YKSAYLHPQQ FDCEPGVLGS 
KGFTWGKVYW EVEVEREGWS EDEEEGDEEE EGEEEEEEEE AGYGDGYDDW ETDEDEESLG 
DEEEEEEEEE EEVLESCMVG VARDSVKRKG DLSLRPEDGV WALRLSSSGI WANTSPEAEL 
FPALRPRRVG IALDYEGGTV TFTNAESQEL IYTFTATFTR RLVPFLWLKW PGTRLLLRP