Details for: TRIM26

Gene ID: 7726

Symbol: TRIM26

Ensembl ID: ENSG00000234127

Description: tripartite motif containing 26

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 154.4567
    Cell Significance Index: -24.0300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 91.8613
    Cell Significance Index: -23.3000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 55.5929
    Cell Significance Index: -22.5900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 23.7498
    Cell Significance Index: -22.6800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.5830
    Cell Significance Index: -24.1500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.4331
    Cell Significance Index: -25.2700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.1682
    Cell Significance Index: -24.3400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.6097
    Cell Significance Index: -17.2300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.0757
    Cell Significance Index: -8.9200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3978
    Cell Significance Index: 138.2700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.3719
    Cell Significance Index: 34.2100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.3322
    Cell Significance Index: 37.2300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.3123
    Cell Significance Index: 19.3700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.0775
    Cell Significance Index: 745.2300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9450
    Cell Significance Index: 56.7300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8722
    Cell Significance Index: 94.8700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8246
    Cell Significance Index: 163.6500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7783
    Cell Significance Index: 40.4300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7249
    Cell Significance Index: 117.9000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6008
    Cell Significance Index: 17.3100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5556
    Cell Significance Index: 501.6300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5248
    Cell Significance Index: 14.2900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4799
    Cell Significance Index: 56.6000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4729
    Cell Significance Index: 58.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4607
    Cell Significance Index: 83.0500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4293
    Cell Significance Index: 9.3000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4145
    Cell Significance Index: 28.6700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4003
    Cell Significance Index: 143.5900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.3688
    Cell Significance Index: 5.2500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3021
    Cell Significance Index: 19.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2780
    Cell Significance Index: 12.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2714
    Cell Significance Index: 12.3000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2248
    Cell Significance Index: 99.3800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1907
    Cell Significance Index: 104.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1759
    Cell Significance Index: 9.8700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1705
    Cell Significance Index: 106.5000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1654
    Cell Significance Index: 31.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1285
    Cell Significance Index: 6.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0812
    Cell Significance Index: 11.1500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0785
    Cell Significance Index: 5.5500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0615
    Cell Significance Index: 83.6600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0496
    Cell Significance Index: 0.8400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0459
    Cell Significance Index: 5.9400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0431
    Cell Significance Index: 27.3700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0351
    Cell Significance Index: 6.0000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0239
    Cell Significance Index: 0.5100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0212
    Cell Significance Index: 39.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0167
    Cell Significance Index: 3.3500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0153
    Cell Significance Index: 1.9600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0148
    Cell Significance Index: 0.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0100
    Cell Significance Index: 0.7700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0072
    Cell Significance Index: 13.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0013
    Cell Significance Index: 1.9800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0049
    Cell Significance Index: -0.1300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0078
    Cell Significance Index: -5.7100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0136
    Cell Significance Index: -6.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0148
    Cell Significance Index: -10.9400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0177
    Cell Significance Index: -13.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0217
    Cell Significance Index: -12.2300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0258
    Cell Significance Index: -1.9300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0357
    Cell Significance Index: -1.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0418
    Cell Significance Index: -6.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0572
    Cell Significance Index: -6.5500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0581
    Cell Significance Index: -5.9300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0749
    Cell Significance Index: -4.8300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0773
    Cell Significance Index: -4.7500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0780
    Cell Significance Index: -3.4500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0818
    Cell Significance Index: -17.2300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0883
    Cell Significance Index: -25.4100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0963
    Cell Significance Index: -10.9900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1239
    Cell Significance Index: -1.6900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1454
    Cell Significance Index: -2.6900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1511
    Cell Significance Index: -2.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1556
    Cell Significance Index: -18.1300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1606
    Cell Significance Index: -3.7100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1644
    Cell Significance Index: -5.2700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1889
    Cell Significance Index: -9.9200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2267
    Cell Significance Index: -23.6000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2324
    Cell Significance Index: -2.1400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2561
    Cell Significance Index: -7.5200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2609
    Cell Significance Index: -20.6600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2668
    Cell Significance Index: -3.1800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2780
    Cell Significance Index: -7.4400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3136
    Cell Significance Index: -6.1200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3414
    Cell Significance Index: -20.9300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3884
    Cell Significance Index: -6.5000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.4053
    Cell Significance Index: -12.8200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4123
    Cell Significance Index: -11.8200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4170
    Cell Significance Index: -3.4000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4377
    Cell Significance Index: -11.2500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4414
    Cell Significance Index: -15.3400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4902
    Cell Significance Index: -7.3500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5097
    Cell Significance Index: -11.1600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5220
    Cell Significance Index: -12.5200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5486
    Cell Significance Index: -20.1400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5509
    Cell Significance Index: -13.7700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5585
    Cell Significance Index: -16.4500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5680
    Cell Significance Index: -14.9400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5772
    Cell Significance Index: -12.2500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5858
    Cell Significance Index: -19.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TRIM26 is a 396-amino acid protein that belongs to the TRIM family of proteins. The protein contains three distinct domains: a RING (Ring finger) domain, a B-box domain, and a coiled-coil domain. The RING domain is responsible for the protein's ubiquitin ligase activity, while the B-box domain regulates the protein's interaction with other proteins. The coiled-coil domain mediates protein-protein interactions and oligomerization. TRIM26 is highly conserved across species, suggesting its importance in maintaining cellular homeostasis. **Pathways and Functions** TRIM26 is involved in several signaling pathways, including: 1. **Negative regulation of viral entry into host cells**: TRIM26 acts as a restriction factor that inhibits the entry of viruses into host cells, thereby preventing viral replication. 2. **Suppression of viral release by host**: TRIM26 regulates the release of viruses from infected cells, preventing the spread of infection. 3. **Cytokine signaling in immune system**: TRIM26 modulates the activity of cytokines, which are signaling molecules that regulate immune responses. 4. **Interferon signaling**: TRIM26 interacts with interferon signaling pathways, regulating the production of interferons and other antiviral proteins. 5. **Proteasome-mediated ubiquitin-dependent protein catabolic process**: TRIM26 regulates the degradation of proteins through the ubiquitin-proteasome pathway. TRIM26's functions include: 1. **Regulation of protein degradation**: TRIM26 targets proteins for degradation through the ubiquitin-proteasome pathway. 2. **Modulation of immune responses**: TRIM26 regulates the activity of immune cells and cytokines, influencing the immune response to viral infections. 3. **Maintenance of cellular homeostasis**: TRIM26 maintains cellular homeostasis by regulating protein degradation and immune responses. **Clinical Significance** Dysregulation of TRIM26 has been implicated in various diseases, including: 1. **Viral infections**: TRIM26's role in regulating viral entry and release makes it a target for antiviral therapies. 2. **Autoimmune diseases**: TRIM26's involvement in immune responses suggests its potential role in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Cancer**: TRIM26's regulation of protein degradation and immune responses may influence cancer development and progression. 4. **Neurological disorders**: TRIM26's expression in neurons suggests its potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, TRIM26 is a critical regulator of viral entry, immune responses, and cellular homeostasis. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms of TRIM26 and its potential therapeutic applications.

Genular Protein ID: 3304251429

Symbol: TRI26_HUMAN

Name: Tripartite motif-containing protein 26

UniProtKB Accession Codes:

Q12899 A6NG96 Q5SRL2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChEBI 4 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 15 Ensembl 24 ExpressionAtlas 1 GO 15 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 8 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8530076

Title: Cloning of a new 'finger' protein gene (ZNF173) within the class I region of the human MHC.

PubMed ID: 8530076

DOI: 10.1006/geno.1995.1236

PubMed ID: 16702430

Title: Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity.

PubMed ID: 16702430

DOI: 10.1534/genetics.106.057034

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21750715

Title: The inhibitor of growth protein 5 (ING5) depends on INCA1 as a co-factor for its antiproliferative effects.

PubMed ID: 21750715

DOI: 10.1371/journal.pone.0021505

PubMed ID: 23452852

Title: Jmjd3 inhibits reprogramming by upregulating expression of INK4a/Arf and targeting PHF20 for ubiquitination.

PubMed ID: 23452852

DOI: 10.1016/j.cell.2013.02.006

PubMed ID: 25763818

Title: TRIM26 negatively regulates interferon-beta production and antiviral response through polyubiquitination and degradation of nuclear IRF3.

PubMed ID: 25763818

DOI: 10.1371/journal.ppat.1004726

PubMed ID: 26611359

Title: Autoubiquitination of TRIM26 links TBK1 to NEMO in RLR-mediated innate antiviral immune response.

PubMed ID: 26611359

DOI: 10.1093/jmcb/mjv068

PubMed ID: 29203640

Title: Transforming Growth Factor beta-Induced Proliferative Arrest Mediated by TRIM26-Dependent TAF7 Degradation and Its Antagonism by MYC.

PubMed ID: 29203640

DOI: 10.1128/mcb.00449-17

PubMed ID: 29610152

Title: NTH1 Is a New Target for Ubiquitylation-Dependent Regulation by TRIM26 Required for the Cellular Response to Oxidative Stress.

PubMed ID: 29610152

DOI: 10.1128/mcb.00616-17

PubMed ID: 33419081

Title: TRIM26 Facilitates HSV-2 Infection by Downregulating Antiviral Responses through the IRF3 Pathway.

PubMed ID: 33419081

DOI: 10.3390/v13010070

PubMed ID: 34017102

Title: TRIM26 positively regulates the inflammatory immune response through K11-linked ubiquitination of TAB1.

PubMed ID: 34017102

DOI: 10.1038/s41418-021-00803-1

PubMed ID: 34732716

Title: Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.

PubMed ID: 34732716

DOI: 10.1038/s41467-021-26653-6

PubMed ID: 36232914

Title: TRIM26 Maintains Cell Survival in Response to Oxidative Stress through Regulating DNA Glycosylase Stability.

PubMed ID: 36232914

DOI: 10.3390/ijms231911613

PubMed ID: 35872575

Title: TRIM26 inhibits hepatitis B virus replication by promoting HBx degradation and TRIM26 genetic polymorphism predicts PegIFNalpha treatment response of HBeAg-positive chronic hepatitis B Patients.

PubMed ID: 35872575

DOI: 10.1111/apt.17124

Sequence Information:

  • Length: 539
  • Mass: 62166
  • Checksum: 842A71C41F2E2348
  • Sequence:
    • MATSAPLRSL EEEVTCSICL DYLRDPVTID CGHVFCRSCT TDVRPISGSR PVCPLCKKPF 
KKENIRPVWQ LASLVENIER LKVDKGRQPG EVTREQQDAK LCERHREKLH YYCEDDGKLL 
CVMCRESREH RPHTAVLMEK AAQPHREKIL NHLSTLRRDR DKIQGFQAKG EADILAALKK 
LQDQRQYIVA EFEQGHQFLR EREEHLLEQL AKLEQELTEG REKFKSRGVG ELARLALVIS 
ELEGKAQQPA AELMQDTRDF LNRYPRKKFW VGKPIARVVK KKTGEFSDKL LSLQRGLREF 
QGKLLRDLEY KTVSVTLDPQ SASGYLQLSE DWKCVTYTSL YKSAYLHPQQ FDCEPGVLGS 
KGFTWGKVYW EVEVEREGWS EDEEEGDEEE EGEEEEEEEE AGYGDGYDDW ETDEDEESLG 
DEEEEEEEEE EEVLESCMVG VARDSVKRKG DLSLRPEDGV WALRLSSSGI WANTSPEAEL 
FPALRPRRVG IALDYEGGTV TFTNAESQEL IYTFTATFTR RLVPFLWLKW PGTRLLLRP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.