Details for: ZNF180

Gene ID: 7733

Symbol: ZNF180

Ensembl ID: ENSG00000167384

Description: zinc finger protein 180

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 55.8037
    Cell Significance Index: -8.6800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 34.6944
    Cell Significance Index: -8.8000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 20.7150
    Cell Significance Index: -9.7800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 19.7412
    Cell Significance Index: -8.0200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 8.4211
    Cell Significance Index: -8.0400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.5266
    Cell Significance Index: -9.2800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.3783
    Cell Significance Index: -9.0500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.3897
    Cell Significance Index: -9.4300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.0739
    Cell Significance Index: -6.3700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8664
    Cell Significance Index: 85.7100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6585
    Cell Significance Index: 594.5500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6153
    Cell Significance Index: 36.9400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4453
    Cell Significance Index: 72.4300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3523
    Cell Significance Index: 69.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2669
    Cell Significance Index: 53.5300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2663
    Cell Significance Index: 31.0300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2661
    Cell Significance Index: 16.7700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2312
    Cell Significance Index: 5.7800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2215
    Cell Significance Index: 5.9400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2050
    Cell Significance Index: 14.1800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1994
    Cell Significance Index: 4.3200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1553
    Cell Significance Index: 3.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1541
    Cell Significance Index: 55.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1273
    Cell Significance Index: 7.1500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1237
    Cell Significance Index: 3.5700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1188
    Cell Significance Index: 5.3900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1061
    Cell Significance Index: 6.5200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1012
    Cell Significance Index: 19.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0985
    Cell Significance Index: 17.7600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0811
    Cell Significance Index: 56.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0768
    Cell Significance Index: 41.9300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0752
    Cell Significance Index: 33.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0727
    Cell Significance Index: 9.9900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0590
    Cell Significance Index: 2.6100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0581
    Cell Significance Index: 4.4600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0479
    Cell Significance Index: 1.8200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0393
    Cell Significance Index: 2.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0372
    Cell Significance Index: 4.5800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0365
    Cell Significance Index: 2.5800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0317
    Cell Significance Index: 1.4800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0261
    Cell Significance Index: 0.7300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0165
    Cell Significance Index: 2.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0121
    Cell Significance Index: 0.6300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0054
    Cell Significance Index: 0.0900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0054
    Cell Significance Index: 0.1900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0039
    Cell Significance Index: 0.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0001
    Cell Significance Index: 0.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0022
    Cell Significance Index: -1.4300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0023
    Cell Significance Index: -0.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0035
    Cell Significance Index: -6.4000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0042
    Cell Significance Index: -6.4700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0060
    Cell Significance Index: -4.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0060
    Cell Significance Index: -8.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0087
    Cell Significance Index: -3.9300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0101
    Cell Significance Index: -7.4600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0104
    Cell Significance Index: -0.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0104
    Cell Significance Index: -7.8600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0112
    Cell Significance Index: -1.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0144
    Cell Significance Index: -8.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0147
    Cell Significance Index: -2.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0174
    Cell Significance Index: -10.8500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0227
    Cell Significance Index: -3.8800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0235
    Cell Significance Index: -0.3200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0258
    Cell Significance Index: -7.4100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0338
    Cell Significance Index: -3.4500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0375
    Cell Significance Index: -1.2000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0427
    Cell Significance Index: -1.1400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0431
    Cell Significance Index: -5.5700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0451
    Cell Significance Index: -2.3500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0499
    Cell Significance Index: -10.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0627
    Cell Significance Index: -7.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0628
    Cell Significance Index: -4.0500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0635
    Cell Significance Index: -1.6700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0726
    Cell Significance Index: -1.7400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0732
    Cell Significance Index: -4.4900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0782
    Cell Significance Index: -1.3400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0801
    Cell Significance Index: -5.9700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0825
    Cell Significance Index: -1.6100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0854
    Cell Significance Index: -4.0200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0883
    Cell Significance Index: -9.1900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0902
    Cell Significance Index: -1.0800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0928
    Cell Significance Index: -2.5300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0995
    Cell Significance Index: -7.8800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1019
    Cell Significance Index: -1.0600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1019
    Cell Significance Index: -1.4600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1135
    Cell Significance Index: -3.0400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1179
    Cell Significance Index: -1.8700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1179
    Cell Significance Index: -6.1900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1210
    Cell Significance Index: -3.1100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1356
    Cell Significance Index: -3.8700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1695
    Cell Significance Index: -5.5500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1711
    Cell Significance Index: -5.4500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1863
    Cell Significance Index: -3.9000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1961
    Cell Significance Index: -6.8700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1962
    Cell Significance Index: -9.9200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2118
    Cell Significance Index: -1.8000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2133
    Cell Significance Index: -5.4500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2222
    Cell Significance Index: -8.1600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2251
    Cell Significance Index: -6.6100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2314
    Cell Significance Index: -5.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **DNA-binding domain**: ZNF180 contains a zinc finger domain, which is a conserved structural motif that allows it to bind to specific DNA sequences. 2. **Transcriptional regulation**: ZNF180 acts as a transcription factor, regulating the expression of target genes by interacting with RNA polymerase II and other transcriptional machinery components. 3. **Cell-type specificity**: ZNF180 is highly expressed in cells of the nervous system, including GABAergic interneurons, and in epithelial cells of the colon. 4. **Metal ion binding**: ZNF180 can bind to metal ions, which is essential for its DNA-binding activity. **Pathways and Functions:** 1. **Gene expression (transcription)**: ZNF180 regulates the transcription of target genes by interacting with RNA polymerase II and other transcriptional machinery components. 2. **Generic transcription pathway**: ZNF180 participates in the generic transcription pathway, which is a fundamental process by which cells express genes involved in various cellular processes. 3. **Regulation of transcription by RNA polymerase II**: ZNF180 modulates the activity of RNA polymerase II, a key enzyme responsible for transcribing protein-coding genes. 4. **Metal ion binding**: ZNF180's ability to bind metal ions is essential for its DNA-binding activity and transcriptional regulation. **Clinical Significance:** 1. **Cancer development**: ZNF180's dysregulation has been implicated in the development of various cancers, including colon cancer, where it may act as an oncogene. 2. **Neurological disorders**: ZNF180's expression in GABAergic interneurons suggests that it may play a role in regulating gene expression in the nervous system, potentially contributing to the development of neurological disorders such as epilepsy or schizophrenia. 3. **Epithelial dysregulation**: ZNF180's expression in epithelial cells of the colon implies that it may be involved in regulating gene expression in these cells, potentially contributing to the development of colon cancer or other epithelial disorders. 4. **Therapeutic targeting**: Understanding ZNF180's role in regulating gene expression may lead to the development of novel therapeutic strategies targeting its dysregulated expression in various diseases. In conclusion, ZNF180 is a transcription factor that plays a critical role in regulating gene expression in various cell types. Its dysregulation has been implicated in the development of various diseases, including cancer. Further research is needed to fully elucidate the mechanisms by which ZNF180 regulates gene expression and to explore its potential as a therapeutic target.

Genular Protein ID: 3581802780

Symbol: ZN180_HUMAN

Name: Zinc finger protein 180

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 12743021

Title: Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters.

PubMed ID: 12743021

DOI: 10.1101/gr.963903

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 692
  • Mass: 79040
  • Checksum: 301612919D30602D
  • Sequence:
  • MRACAGSTRE AGSGAQDLST LLCLEESMEE QDEKPPEPPK VCAQDSFLPQ EIIIKVEGED 
    TGSLTIPSQE GVNFKIVTVD FTREEQGTCN PAQRTLDRDV ILENHRDLVS WDLATAVGKK 
    DSTSKQRIFD EEPANGVKIE RFTRDDPWLS SCEEVDDCKD QLEKQQEKQE ILLQEVAFTQ 
    RKAVIHERVC KSDETGEKSG LNSSLFSSPV IPIRNHFHKH VSHAKKWHLN AAVNSHQKIN 
    ENETLYENNE CGKPPQSIHL IQFTRTQTKD KSYGFSDRIQ SFCHGTPLHI HEKIHGGGKT 
    FDFKECGQVL NPKISHNEQQ RIPFEESQYK CSETSHSSSL TQNMRNNSEE KPFECNQCGK 
    SFSWSSHLVA HQRTHTGEKP YECSECGKSF SRSSHLVSHQ RTHTGEKPYR CNQCGKSFSQ 
    SYVLVVHQRT HTGEKPYECN QCGKSFRQSY KLIAHQRTHT GEKPYECNQC GKSFIQSYKL 
    IAHQRIHTGE KPYECNQCGK SFSQSYKLVA HQRTHTGEKP FECNQCGKSF SWSSQLVAHQ 
    RTHTGEKPYE CSECGKSFNR SSHLVMHQRI HTGEKPYECN QCGKSFSQSY VLVVHQRTHT 
    GEKPYECSQC GKSFRQSSCL TQHQRTHTGE KPFECNQCGK TFSLSARLIV HQRTHTGEKP 
    FTCIQCGKAF INSYKLIRHQ ATHTEEKLYE CN

Genular Protein ID: 2122302701

Symbol: G5E9B8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 667
  • Mass: 76341
  • Checksum: 7E48C98BB0D955A4
  • Sequence:
  • MRACAGSTRE AGSGAQDLST LLCLEESMEE QDEKPPEPPK VCAQEGVNFK IVTVDFTREE 
    QGTCNPAQRT LDRDVILENH RDLVSWDLAT AVGKKDSTSK QRIFDEEPAN GVKIERFTRD 
    DPWLSSCEEV DDCKDQLEKQ QEKQEILLQE VAFTQRKAVI HERVCKSDET GEKSGLNSSL 
    FSSPVIPIRN HFHKHVSHAK KWHLNAAVNS HQKINENETL YENNECGKPP QSIHLIQFTR 
    TQTKDKSYGF SDRIQSFCHG TPLHIHEKIH GGGKTFDFKE CGQVLNPKIS HNEQQRIPFE 
    ESQYKCSETS HSSSLTQNMR NNSEEKPFEC NQCGKSFSWS SHLVAHQRTH TGEKPYECSE 
    CGKSFSRSSH LVSHQRTHTG EKPYRCNQCG KSFSQSYVLV VHQRTHTGEK PYECNQCGKS 
    FRQSYKLIAH QRTHTGEKPY ECNQCGKSFI QSYKLIAHQR IHTGEKPYEC NQCGKSFSQS 
    YKLVAHQRTH TGEKPFECNQ CGKSFSWSSQ LVAHQRTHTG EKPYECSECG KSFNRSSHLV 
    MHQRIHTGEK PYECNQCGKS FSQSYVLVVH QRTHTGEKPY ECSQCGKSFR QSSCLTQHQR 
    THTGEKPFEC NQCGKTFSLS ARLIVHQRTH TGEKPFTCIQ CGKAFINSYK LIRHQATHTE 
    EKLYECN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.