Details for: SLC30A1

Gene ID: 7779

Symbol: SLC30A1

Ensembl ID: ENSG00000170385

Description: solute carrier family 30 member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 85.0556
    Cell Significance Index: -13.2300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 70.0294
    Cell Significance Index: -17.7600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 34.0115
    Cell Significance Index: -17.5000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.4798
    Cell Significance Index: -16.6200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.2340
    Cell Significance Index: -16.7000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.6097
    Cell Significance Index: -18.1900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.1055
    Cell Significance Index: -12.6100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.9185
    Cell Significance Index: 223.5800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.6979
    Cell Significance Index: 45.5000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.6833
    Cell Significance Index: 76.3000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.3743
    Cell Significance Index: 39.6000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3587
    Cell Significance Index: 134.4100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3484
    Cell Significance Index: 219.3000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.3227
    Cell Significance Index: 19.8200
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.1370
    Cell Significance Index: 12.0800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1279
    Cell Significance Index: 67.7100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9432
    Cell Significance Index: 102.6000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.7685
    Cell Significance Index: 8.7300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6768
    Cell Significance Index: 611.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6576
    Cell Significance Index: 359.1400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6504
    Cell Significance Index: 14.0900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.6196
    Cell Significance Index: 14.3200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5224
    Cell Significance Index: 36.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4283
    Cell Significance Index: 84.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4018
    Cell Significance Index: 20.8700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3686
    Cell Significance Index: 7.8500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3149
    Cell Significance Index: 8.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2934
    Cell Significance Index: 13.6800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2786
    Cell Significance Index: 50.2300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.2636
    Cell Significance Index: 4.4400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2487
    Cell Significance Index: 7.1300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2105
    Cell Significance Index: 93.0800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.1907
    Cell Significance Index: 3.0600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1903
    Cell Significance Index: 36.2200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1888
    Cell Significance Index: 24.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1762
    Cell Significance Index: 8.2800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1674
    Cell Significance Index: 20.5800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1656
    Cell Significance Index: 4.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1214
    Cell Significance Index: 16.6700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1087
    Cell Significance Index: 3.8200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0772
    Cell Significance Index: 1.9300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0746
    Cell Significance Index: 4.7000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0666
    Cell Significance Index: 4.7100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0568
    Cell Significance Index: 1.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0442
    Cell Significance Index: 15.8700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0307
    Cell Significance Index: 0.2500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0175
    Cell Significance Index: 3.5100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0153
    Cell Significance Index: 0.4900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0042
    Cell Significance Index: 3.0800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0013
    Cell Significance Index: -0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0032
    Cell Significance Index: -6.0300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0080
    Cell Significance Index: -1.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0103
    Cell Significance Index: -19.0800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0111
    Cell Significance Index: -0.8300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0111
    Cell Significance Index: -7.7100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0131
    Cell Significance Index: -20.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0147
    Cell Significance Index: -19.9400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0159
    Cell Significance Index: -12.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0180
    Cell Significance Index: -11.4200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0183
    Cell Significance Index: -0.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0211
    Cell Significance Index: -15.6400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0230
    Cell Significance Index: -3.9200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0275
    Cell Significance Index: -15.5000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0311
    Cell Significance Index: -14.1200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0317
    Cell Significance Index: -19.7800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0338
    Cell Significance Index: -3.4500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0417
    Cell Significance Index: -12.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0722
    Cell Significance Index: -10.5000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0861
    Cell Significance Index: -9.8700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0869
    Cell Significance Index: -5.6100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0943
    Cell Significance Index: -19.8700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0994
    Cell Significance Index: -7.6300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1260
    Cell Significance Index: -14.8600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1368
    Cell Significance Index: -9.2000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1373
    Cell Significance Index: -7.2100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1448
    Cell Significance Index: -2.2400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1504
    Cell Significance Index: -2.2200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1636
    Cell Significance Index: -10.0300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1666
    Cell Significance Index: -17.3500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1854
    Cell Significance Index: -7.0200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1874
    Cell Significance Index: -14.8400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1883
    Cell Significance Index: -9.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2033
    Cell Significance Index: -11.4100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2113
    Cell Significance Index: -8.6600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2134
    Cell Significance Index: -9.4400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2154
    Cell Significance Index: -6.0200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2420
    Cell Significance Index: -3.8400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2540
    Cell Significance Index: -15.6100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2817
    Cell Significance Index: -9.7900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2906
    Cell Significance Index: -7.6400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3035
    Cell Significance Index: -5.1100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3086
    Cell Significance Index: -11.3300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3571
    Cell Significance Index: -10.1900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3693
    Cell Significance Index: -7.6600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.3694
    Cell Significance Index: -5.1900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3874
    Cell Significance Index: -4.0100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4142
    Cell Significance Index: -12.2000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4273
    Cell Significance Index: -3.9400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4544
    Cell Significance Index: -8.0300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4598
    Cell Significance Index: -7.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane Transporter:** SLC30A1 is a transmembrane protein that spans the plasma membrane, allowing for the transport of metal ions across the cell membrane. 2. **Zinc Ion Efflux:** SLC30A1 is primarily responsible for the efflux of zinc ions from cells, which is crucial for maintaining zinc homeostasis and preventing zinc toxicity. 3. **Cadmium Ion Uptake:** SLC30A1 also facilitates the uptake of cadmium ions, which is essential for the detoxification of cadmium and its sequestration within cells. 4. **Regulatory Function:** SLC30A1 acts as a negative regulator of calcium ion import and neurotransmitter secretion, highlighting its role in modulating cellular excitability and synaptic transmission. **Pathways and Functions:** 1. **Intracellular Zinc Ion Homeostasis:** SLC30A1 plays a critical role in maintaining zinc ion homeostasis within cells, ensuring that zinc is not accumulated to toxic levels. 2. **Cadmium Detoxification:** By facilitating cadmium ion uptake, SLC30A1 contributes to the detoxification of cadmium and its sequestration within cells. 3. **Neurotransmitter Secretion:** SLC30A1's regulatory function on calcium ion import and neurotransmitter secretion highlights its involvement in modulating synaptic transmission and neural function. 4. **Cellular Development:** SLC30A1's expression in various cell types, including those involved in neural development, suggests its role in maintaining cellular homeostasis and development. **Clinical Significance:** 1. **Cadmium Toxicity:** Dysregulation of SLC30A1 has been implicated in cadmium toxicity, highlighting the importance of this gene in maintaining metal ion homeostasis. 2. **Neurodegenerative Diseases:** Alterations in SLC30A1 expression have been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, suggesting its potential role in disease pathogenesis. 3. **Immunological Disorders:** SLC30A1's involvement in immune response and development highlights its potential role in immunological disorders, such as autoimmune diseases and immunodeficiency syndromes. 4. **Cardiovascular Disease:** SLC30A1's expression in cardiac cells suggests its potential role in cardiovascular disease, including hypertension and cardiac dysfunction. In conclusion, SLC30A1 is a crucial gene that plays a pivotal role in maintaining metal ion homeostasis and regulating cellular function. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in human health and disease. Further research is necessary to fully elucidate the mechanisms by which SLC30A1 regulates metal ion homeostasis and its clinical significance.

Genular Protein ID: 3760468300

Symbol: ZNT1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9Y6M5 Q0VAK9 Q9BZF6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 6 ComplexPortal 4 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 6 EMDB 1 Ensembl 1 GO 35 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SASBDB 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18158319

Title: Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses.

PubMed ID: 18158319

DOI: 10.1084/jem.20071311

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 31471319

Title: Zinc transporter 1 (ZNT1) expression on the cell surface is elaborately controlled by cellular zinc levels.

PubMed ID: 31471319

DOI: 10.1074/jbc.ra119.010227

PubMed ID: 32441444

Title: Frontline Science: LPS-inducible SLC30A1 drives human macrophage-mediated zinc toxicity against intracellular Escherichia coli.

PubMed ID: 32441444

DOI: 10.1002/jlb.2hi0420-160r

PubMed ID: 36204728

Title: Transmembrane 163 (TMEM163) protein interacts with specific mammalian SLC30 zinc efflux transporter family members.

PubMed ID: 36204728

DOI: 10.1016/j.bbrep.2022.101362

Sequence Information:

  • Length: 507
  • Mass: 55300
  • Checksum: 2FC5B67F033AE457
  • Sequence:
    • MGCWGRNRGR LLCMLALTFM FMVLEVVVSR VTSSLAMLSD SFHMLSDVLA LVVALVAERF 
ARRTHATQKN TFGWIRAEVM GALVNAIFLT GLCFAILLEA IERFIEPHEM QQPLVVLGVG 
VAGLLVNVLG LCLFHHHSGF SQDSGHGHSH GGHGHGHGLP KGPRVKSTRP GSSDINVAPG 
EQGPDQEETN TLVANTSNSN GLKLDPADPE NPRSGDTVEV QVNGNLVREP DHMELEEDRA 
GQLNMRGVFL HVLGDALGSV IVVVNALVFY FSWKGCSEGD FCVNPCFPDP CKAFVEIINS 
THASVYEAGP CWVLYLDPTL CVVMVCILLY TTYPLLKESA LILLQTVPKQ IDIRNLIKEL 
RNVEGVEEVH ELHVWQLAGS RIIATAHIKC EDPTSYMEVA KTIKDVFHNH GIHATTIQPE 
FASVGSKSSV VPCELACRTQ CALKQCCGTL PQAPSGKDAE KTPAVSISCL ELSNNLEKKP 
RRTKAENIPA VVIEIKNMPN KQPESSL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.