Details for: SLC30A4

Gene ID: 7782

Symbol: SLC30A4

Ensembl ID: ENSG00000104154

Description: solute carrier family 30 member 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 78.8195
    Cell Significance Index: -12.2600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 47.9216
    Cell Significance Index: -12.1600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 26.2642
    Cell Significance Index: -10.6700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.9355
    Cell Significance Index: -12.2500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.5168
    Cell Significance Index: -12.1000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.1018
    Cell Significance Index: -12.2400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.9425
    Cell Significance Index: -6.4400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.0154
    Cell Significance Index: 383.5500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.6778
    Cell Significance Index: 116.0300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.3266
    Cell Significance Index: 58.6800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.2229
    Cell Significance Index: 46.3100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.2075
    Cell Significance Index: 26.4400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0447
    Cell Significance Index: 169.9200
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.9355
    Cell Significance Index: 4.5500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.8301
    Cell Significance Index: 8.5900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8069
    Cell Significance Index: 161.8600
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.7415
    Cell Significance Index: 1.7300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7024
    Cell Significance Index: 42.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6910
    Cell Significance Index: 14.9700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6815
    Cell Significance Index: 74.1300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.6052
    Cell Significance Index: 9.7100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4874
    Cell Significance Index: 440.0800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3898
    Cell Significance Index: 11.2300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3143
    Cell Significance Index: 112.7200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3104
    Cell Significance Index: 30.7100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2573
    Cell Significance Index: 30.3400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2542
    Cell Significance Index: 11.5200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2032
    Cell Significance Index: 5.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1939
    Cell Significance Index: 28.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1392
    Cell Significance Index: 4.8900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1351
    Cell Significance Index: 1.9400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1348
    Cell Significance Index: 2.0200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1332
    Cell Significance Index: 2.6000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0988
    Cell Significance Index: 68.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0903
    Cell Significance Index: 6.9300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0602
    Cell Significance Index: 8.2700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0474
    Cell Significance Index: 2.9900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0362
    Cell Significance Index: 0.7700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0342
    Cell Significance Index: 4.3900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0239
    Cell Significance Index: 0.4100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0222
    Cell Significance Index: 9.8000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0161
    Cell Significance Index: 30.2400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0109
    Cell Significance Index: 0.1800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0043
    Cell Significance Index: 2.7500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0023
    Cell Significance Index: 1.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0003
    Cell Significance Index: 0.1400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0016
    Cell Significance Index: -2.9300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0028
    Cell Significance Index: -4.3300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0039
    Cell Significance Index: -0.7100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0040
    Cell Significance Index: -5.4300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0115
    Cell Significance Index: -8.5500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0127
    Cell Significance Index: -9.3000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0158
    Cell Significance Index: -11.9600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0186
    Cell Significance Index: -10.5100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0210
    Cell Significance Index: -0.2800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0224
    Cell Significance Index: -14.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0246
    Cell Significance Index: -2.8700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0293
    Cell Significance Index: -5.8100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0293
    Cell Significance Index: -1.9700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0341
    Cell Significance Index: -9.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0357
    Cell Significance Index: -6.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0359
    Cell Significance Index: -4.4200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0420
    Cell Significance Index: -2.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0487
    Cell Significance Index: -4.9700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0512
    Cell Significance Index: -6.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0605
    Cell Significance Index: -6.9300
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0612
    Cell Significance Index: -0.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0640
    Cell Significance Index: -13.4900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0698
    Cell Significance Index: -3.6300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0784
    Cell Significance Index: -2.1900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0881
    Cell Significance Index: -2.3600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0894
    Cell Significance Index: -2.3500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0988
    Cell Significance Index: -2.8200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0995
    Cell Significance Index: -6.4200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1017
    Cell Significance Index: -5.3400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1041
    Cell Significance Index: -10.8400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1046
    Cell Significance Index: -6.4100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1051
    Cell Significance Index: -7.4300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1107
    Cell Significance Index: -8.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1201
    Cell Significance Index: -5.6500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1211
    Cell Significance Index: -6.3100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1275
    Cell Significance Index: -1.0400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1289
    Cell Significance Index: -2.7600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1441
    Cell Significance Index: -11.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1486
    Cell Significance Index: -6.9300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1526
    Cell Significance Index: -2.5200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1552
    Cell Significance Index: -4.9700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1594
    Cell Significance Index: -4.3400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1617
    Cell Significance Index: -2.0100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1678
    Cell Significance Index: -2.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1723
    Cell Significance Index: -4.6000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1736
    Cell Significance Index: -5.5300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2035
    Cell Significance Index: -12.5100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2053
    Cell Significance Index: -6.7200
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.2154
    Cell Significance Index: -1.4300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2187
    Cell Significance Index: -3.4700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2334
    Cell Significance Index: -6.6900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2389
    Cell Significance Index: -5.0700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2486
    Cell Significance Index: -8.7100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2507
    Cell Significance Index: -8.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SLC30A4 is a transmembrane transporter belonging to the solute carrier family 30. It is characterized by its ability to transport zinc ions across cellular membranes, with a preference for the plasma membrane and late endosome membranes. The transporter is also involved in the uptake of zinc ions into lysosomes and the export of zinc ions across the plasma membrane. SLC30A4 is highly expressed in various cell types, including mural cells, luminal cells of prostate epithelium, ovarian surface epithelial cells, and pancreatic A cells. **Pathways and Functions:** The zinc transporter encoded by SLC30A4 is involved in several cellular pathways, including: 1. **Zinc homeostasis:** SLC30A4 plays a crucial role in maintaining zinc balance within cells by regulating the transport of zinc ions across cellular membranes. 2. **Cell signaling:** Zinc ions are essential for various signaling pathways, including those involved in immune response, cell proliferation, and differentiation. SLC30A4 is involved in the regulation of these pathways by controlling the availability of zinc ions. 3. **Immune response:** SLC30A4 is expressed in immune cells, including granulocyte monocyte progenitor cells, and is involved in the regulation of immune responses, including the response to toxic substances and zinc ions. 4. **Neurotransmission:** SLC30A4 is also expressed in the nervous system, where it plays a role in the regulation of GABAergic neurotransmission. **Clinical Significance:** Dysregulation of SLC30A4 has been implicated in various diseases, including: 1. **Zinc deficiency:** Impaired zinc transport by SLC30A4 can lead to zinc deficiency, which is associated with impaired immune function, growth retardation, and increased risk of infections. 2. **Neurodegenerative diseases:** SLC30A4 has been implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, where zinc dysregulation is thought to contribute to disease progression. 3. **Cancer:** SLC30A4 has been shown to be overexpressed in certain types of cancer, including prostate cancer, where it is thought to contribute to tumorigenesis and metastasis. 4. **Autoimmune diseases:** SLC30A4 has been implicated in autoimmune diseases, including rheumatoid arthritis, where zinc dysregulation is thought to contribute to disease progression. In conclusion, SLC30A4 is a zinc transporter with multifaceted roles in various physiological processes, including zinc homeostasis, cell signaling, and immune response. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the clinical significance of this gene.

Genular Protein ID: 2528289934

Symbol: ZNT4_HUMAN

Name: N/A

UniProtKB Accession Codes:

O14863 Q8TC39

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 6 ChiTaRS 1 ComplexPortal 5 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 4 Ensembl 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 3 Rhea 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9354792

Title: A novel gene involved in zinc transport is deficient in the lethal milk mouse.

PubMed ID: 9354792

DOI: 10.1038/ng1197-292

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19521526

Title: SLC30A3 (ZnT3) oligomerization by dityrosine bonds regulates its subcellular localization and metal transport capacity.

PubMed ID: 19521526

DOI: 10.1371/journal.pone.0005896

PubMed ID: 17349999

Title: Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect of adaptor protein 3-depleted fibroblasts by promoting zinc accumulation in lysosomes.

PubMed ID: 17349999

DOI: 10.1016/j.yexcr.2007.02.006

PubMed ID: 36204728

Title: Transmembrane 163 (TMEM163) protein interacts with specific mammalian SLC30 zinc efflux transporter family members.

PubMed ID: 36204728

DOI: 10.1016/j.bbrep.2022.101362

Sequence Information:

  • Length: 429
  • Mass: 47483
  • Checksum: 97B7FCBE881C8C32
  • Sequence:
    • MAGSGAWKRL KSMLRKDDAP LFLNDTSAFD FSDEAGDEGL SRFNKLRVVV ADDGSEAPER 
PVNGAHPTLQ ADDDSLLDQD LPLTNSQLSL KVDSCDNCSK QREILKQRKV KARLTIAAVL 
YLLFMIGELV GGYIANSLAI MTDALHMLTD LSAIILTLLA LWLSSKSPTK RFTFGFHRLE 
VLSAMISVLL VYILMGFLLY EAVQRTIHMN YEINGDIMLI TAAVGVAVNV IMGFLLNQSG 
HRHSHSHSLP SNSPTRGSGC ERNHGQDSLA VRAAFVHALG DLVQSVGVLI AAYIIRFKPE 
YKIADPICTY VFSLLVAFTT FRIIWDTVVI ILEGVPSHLN VDYIKEALMK IEDVYSVEDL 
NIWSLTSGKS TAIVHIQLIP GSSSKWEEVQ SKANHLLLNT FGMYRCTIQL QSYRQEVDRT 
CANCQSSSP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.