Details for: ZP3

Gene ID: 7784

Symbol: ZP3

Ensembl ID: ENSG00000188372

Description: zona pellucida glycoprotein 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 42.6243
    Cell Significance Index: -6.6300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 21.0926
    Cell Significance Index: -5.3500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.7910
    Cell Significance Index: -7.1400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.6466
    Cell Significance Index: -7.0900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.8322
    Cell Significance Index: -7.2300
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.1798
    Cell Significance Index: 16.3700
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.1575
    Cell Significance Index: 8.7400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9235
    Cell Significance Index: 91.3500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8189
    Cell Significance Index: 49.1600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7327
    Cell Significance Index: 661.5300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6867
    Cell Significance Index: 74.7000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5342
    Cell Significance Index: 27.7500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5072
    Cell Significance Index: 82.4900
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.4745
    Cell Significance Index: 6.8000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3941
    Cell Significance Index: 10.5600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3918
    Cell Significance Index: 77.7600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3643
    Cell Significance Index: 4.9700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.3609
    Cell Significance Index: 103.8300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3558
    Cell Significance Index: 24.6100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3349
    Cell Significance Index: 9.3600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3135
    Cell Significance Index: 11.8700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2765
    Cell Significance Index: 12.2300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2629
    Cell Significance Index: 3.7700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2417
    Cell Significance Index: 6.5800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2369
    Cell Significance Index: 10.7400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2284
    Cell Significance Index: 6.5800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2152
    Cell Significance Index: 15.2200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2009
    Cell Significance Index: 40.3000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1790
    Cell Significance Index: 79.1600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1755
    Cell Significance Index: 11.0600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1398
    Cell Significance Index: 18.0600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.1078
    Cell Significance Index: 1.7300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0922
    Cell Significance Index: 17.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0808
    Cell Significance Index: 1.7500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0737
    Cell Significance Index: 1.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0717
    Cell Significance Index: 10.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0662
    Cell Significance Index: 3.1100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0564
    Cell Significance Index: 10.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0523
    Cell Significance Index: 18.7700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0444
    Cell Significance Index: 24.2400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0385
    Cell Significance Index: 0.8200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0317
    Cell Significance Index: 5.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0298
    Cell Significance Index: 0.9500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0256
    Cell Significance Index: 1.9100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0256
    Cell Significance Index: 0.6400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0225
    Cell Significance Index: 42.3800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0205
    Cell Significance Index: 2.5300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0174
    Cell Significance Index: 1.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0168
    Cell Significance Index: 30.9800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0167
    Cell Significance Index: 25.6600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0073
    Cell Significance Index: 0.3400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0059
    Cell Significance Index: 0.3600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0041
    Cell Significance Index: 0.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0041
    Cell Significance Index: 5.5900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0026
    Cell Significance Index: 1.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0021
    Cell Significance Index: 0.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0007
    Cell Significance Index: 0.0200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0023
    Cell Significance Index: -0.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0049
    Cell Significance Index: -3.7000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0063
    Cell Significance Index: -2.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0067
    Cell Significance Index: -4.9900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0081
    Cell Significance Index: -5.9700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0104
    Cell Significance Index: -5.8600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0120
    Cell Significance Index: -7.4800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0151
    Cell Significance Index: -1.7600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0202
    Cell Significance Index: -2.3100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0216
    Cell Significance Index: -2.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0238
    Cell Significance Index: -1.4600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0247
    Cell Significance Index: -3.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0272
    Cell Significance Index: -2.0900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0324
    Cell Significance Index: -2.1800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0359
    Cell Significance Index: -7.5600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0391
    Cell Significance Index: -1.0000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0415
    Cell Significance Index: -1.4600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0440
    Cell Significance Index: -2.4700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0459
    Cell Significance Index: -1.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0501
    Cell Significance Index: -2.6300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0548
    Cell Significance Index: -1.4400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0588
    Cell Significance Index: -6.1200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0595
    Cell Significance Index: -7.0200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0613
    Cell Significance Index: -0.5000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0673
    Cell Significance Index: -1.7300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0866
    Cell Significance Index: -6.8600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0871
    Cell Significance Index: -1.2400
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0958
    Cell Significance Index: -1.1900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0961
    Cell Significance Index: -2.5700
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.1059
    Cell Significance Index: -0.9400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1117
    Cell Significance Index: -1.3900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1211
    Cell Significance Index: -3.8300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1216
    Cell Significance Index: -3.4700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1261
    Cell Significance Index: -2.6400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1302
    Cell Significance Index: -1.3500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1307
    Cell Significance Index: -1.9700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1312
    Cell Significance Index: -2.5600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1390
    Cell Significance Index: -4.8700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1397
    Cell Significance Index: -4.4500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1406
    Cell Significance Index: -4.1400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1413
    Cell Significance Index: -2.3700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1423
    Cell Significance Index: -4.6600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1561
    Cell Significance Index: -2.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ZP3 is a type II transmembrane glycoprotein, consisting of 10 exons and 9 introns. Its primary structure is characterized by a hydrophobic transmembrane domain, a cytoplasmic tail, and a large extracellular domain containing multiple carbohydrate-binding motifs. The protein's carbohydrate-binding properties are essential for its interaction with sperm and other molecules. ZP3 has been shown to undergo alternative splicing, resulting in multiple isoforms with distinct functions. **Pathways and Functions** ZP3 is involved in several critical cellular processes, including: 1. **Fertilization**: ZP3 binds to sperm, facilitating their penetration of the zona pellucida and enabling fertilization to occur. 2. **Immune Response**: ZP3 has been shown to modulate immune responses, including humoral immunity, by interacting with immune cells and influencing cytokine production. 3. **Inflammation**: ZP3 can regulate inflammatory responses by interacting with pro-inflammatory cytokines and modulating the activity of immune cells. 4. **Cell Development**: ZP3 is expressed in various cell types, including oocytes, neurons, and epithelial cells, suggesting its involvement in cell development and differentiation. 5. **Signal Transduction**: ZP3 can regulate signal transduction pathways, including those involved in cell proliferation, differentiation, and survival. **Clinical Significance** Dysregulation of ZP3 has been implicated in various reproductive and non-reproductive disorders, including: 1. **Infertility**: Abnormalities in ZP3 expression or function have been linked to infertility in both males and females. 2. **Autoimmune Disorders**: ZP3 has been implicated in autoimmune diseases, such as lupus and rheumatoid arthritis, where it is thought to modulate immune responses. 3. **Cancer**: ZP3 has been found to be overexpressed in certain types of cancer, including breast and ovarian cancer, suggesting its potential role in tumorigenesis. 4. **Neurological Disorders**: ZP3 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it is thought to play a role in neuroinflammation and neurodegeneration. In conclusion, ZP3 is a multifunctional protein with critical roles in reproduction, immune response, inflammation, and cell development. Its dysregulation has been implicated in various disorders, highlighting the need for further research into the molecular mechanisms underlying its functions.

Genular Protein ID: 3987241440

Symbol: ZP3_HUMAN

Name: Zona pellucida sperm-binding protein 3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2385582

Title: Human homolog of the mouse sperm receptor.

PubMed ID: 2385582

DOI: 10.1073/pnas.87.16.6014

PubMed ID: 1478648

Title: Cloning and characterization of the human sperm receptor ligand ZP3: evidence for a second polymorphic allele with a different frequency in the Caucasian and Japanese populations.

PubMed ID: 1478648

DOI: 10.1016/s0888-7543(05)80130-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15379548

Title: Mass spectrometry analysis of recombinant human ZP3 expressed in glycosylation-deficient CHO cells.

PubMed ID: 15379548

DOI: 10.1021/bi048958k

PubMed ID: 28886344

Title: A recurrent missense mutation in ZP3 causes empty follicle syndrome and female infertility.

PubMed ID: 28886344

DOI: 10.1016/j.ajhg.2017.08.001

PubMed ID: 29895852

Title: ZP2 pathogenic variants cause in vitro fertilization failure and female infertility.

PubMed ID: 29895852

DOI: 10.1038/s41436-018-0064-y

Sequence Information:

  • Length: 424
  • Mass: 47018
  • Checksum: 0F3CCDA2427C0E3A
  • Sequence:
  • MELSYRLFIC LLLWGSTELC YPQPLWLLQG GASHPETSVQ PVLVECQEAT LMVMVSKDLF 
    GTGKLIRAAD LTLGPEACEP LVSMDTEDVV RFEVGLHECG NSMQVTDDAL VYSTFLLHDP 
    RPVGNLSIVR TNRAEIPIEC RYPRQGNVSS QAILPTWLPF RTTVFSEEKL TFSLRLMEEN 
    WNAEKRSPTF HLGDAAHLQA EIHTGSHVPL RLFVDHCVAT PTPDQNASPY HTIVDFHGCL 
    VDGLTDASSA FKVPRPGPDT LQFTVDVFHF ANDSRNMIYI TCHLKVTLAE QDPDELNKAC 
    SFSKPSNSWF PVEGSADICQ CCNKGDCGTP SHSRRQPHVM SQWSRSASRN RRHVTEEADV 
    TVGPLIFLDR RGDHEVEQWA LPSDTSVVLL GVGLAVVVSL TLTAVILVLT RRCRTASHPV 
    SASE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.