Details for: ZP3
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 42.6243
Cell Significance Index: -6.6300 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 21.0926
Cell Significance Index: -5.3500 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 5.7910
Cell Significance Index: -7.1400 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 2.6466
Cell Significance Index: -7.0900 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 1.8322
Cell Significance Index: -7.2300 - Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 1.1798
Cell Significance Index: 16.3700 - Cell Name: germ cell (CL0000586)
Fold Change: 1.1575
Cell Significance Index: 8.7400 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.9235
Cell Significance Index: 91.3500 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.8189
Cell Significance Index: 49.1600 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7327
Cell Significance Index: 661.5300 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.6867
Cell Significance Index: 74.7000 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.5342
Cell Significance Index: 27.7500 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5072
Cell Significance Index: 82.4900 - Cell Name: proerythroblast (CL0000547)
Fold Change: 0.4745
Cell Significance Index: 6.8000 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.3941
Cell Significance Index: 10.5600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.3918
Cell Significance Index: 77.7600 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.3643
Cell Significance Index: 4.9700 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.3609
Cell Significance Index: 103.8300 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3558
Cell Significance Index: 24.6100 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.3349
Cell Significance Index: 9.3600 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.3135
Cell Significance Index: 11.8700 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.2765
Cell Significance Index: 12.2300 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.2629
Cell Significance Index: 3.7700 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.2417
Cell Significance Index: 6.5800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2369
Cell Significance Index: 10.7400 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.2284
Cell Significance Index: 6.5800 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.2152
Cell Significance Index: 15.2200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.2009
Cell Significance Index: 40.3000 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1790
Cell Significance Index: 79.1600 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.1755
Cell Significance Index: 11.0600 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.1398
Cell Significance Index: 18.0600 - Cell Name: decidual cell (CL2000002)
Fold Change: 0.1078
Cell Significance Index: 1.7300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0922
Cell Significance Index: 17.5400 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0808
Cell Significance Index: 1.7500 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.0737
Cell Significance Index: 1.1100 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.0717
Cell Significance Index: 10.4200 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0662
Cell Significance Index: 3.1100 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0564
Cell Significance Index: 10.1600 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0523
Cell Significance Index: 18.7700 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0444
Cell Significance Index: 24.2400 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0385
Cell Significance Index: 0.8200 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0317
Cell Significance Index: 5.4100 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.0298
Cell Significance Index: 0.9500 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.0256
Cell Significance Index: 1.9100 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0256
Cell Significance Index: 0.6400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0225
Cell Significance Index: 42.3800 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0205
Cell Significance Index: 2.5300 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.0174
Cell Significance Index: 1.1200 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0168
Cell Significance Index: 30.9800 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0167
Cell Significance Index: 25.6600 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0073
Cell Significance Index: 0.3400 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0059
Cell Significance Index: 0.3600 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0041
Cell Significance Index: 0.0700 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0041
Cell Significance Index: 5.5900 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0026
Cell Significance Index: 1.6800 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0021
Cell Significance Index: 0.2900 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0007
Cell Significance Index: 0.0200 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.0023
Cell Significance Index: -0.0500 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0049
Cell Significance Index: -3.7000 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0063
Cell Significance Index: -2.8600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0067
Cell Significance Index: -4.9900 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0081
Cell Significance Index: -5.9700 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0104
Cell Significance Index: -5.8600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0120
Cell Significance Index: -7.4800 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0151
Cell Significance Index: -1.7600 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0202
Cell Significance Index: -2.3100 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0216
Cell Significance Index: -2.2100 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0238
Cell Significance Index: -1.4600 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0247
Cell Significance Index: -3.1600 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0272
Cell Significance Index: -2.0900 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0324
Cell Significance Index: -2.1800 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0359
Cell Significance Index: -7.5600 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0391
Cell Significance Index: -1.0000 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0415
Cell Significance Index: -1.4600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0440
Cell Significance Index: -2.4700 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.0459
Cell Significance Index: -1.1200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0501
Cell Significance Index: -2.6300 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0548
Cell Significance Index: -1.4400 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0588
Cell Significance Index: -6.1200 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0595
Cell Significance Index: -7.0200 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.0613
Cell Significance Index: -0.5000 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0673
Cell Significance Index: -1.7300 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0866
Cell Significance Index: -6.8600 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.0871
Cell Significance Index: -1.2400 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.0958
Cell Significance Index: -1.1900 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0961
Cell Significance Index: -2.5700 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: -0.1059
Cell Significance Index: -0.9400 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.1117
Cell Significance Index: -1.3900 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.1211
Cell Significance Index: -3.8300 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.1216
Cell Significance Index: -3.4700 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.1261
Cell Significance Index: -2.6400 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.1302
Cell Significance Index: -1.3500 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.1307
Cell Significance Index: -1.9700 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.1312
Cell Significance Index: -2.5600 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1390
Cell Significance Index: -4.8700 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1397
Cell Significance Index: -4.4500 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.1406
Cell Significance Index: -4.1400 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1413
Cell Significance Index: -2.3700 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1423
Cell Significance Index: -4.6600 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: -0.1561
Cell Significance Index: -2.0100
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3987241440
Symbol: ZP3_HUMAN
Name: Zona pellucida sperm-binding protein 3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2385582
PubMed ID: 1478648
Title: Cloning and characterization of the human sperm receptor ligand ZP3: evidence for a second polymorphic allele with a different frequency in the Caucasian and Japanese populations.
PubMed ID: 1478648
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 12853948
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15379548
Title: Mass spectrometry analysis of recombinant human ZP3 expressed in glycosylation-deficient CHO cells.
PubMed ID: 15379548
DOI: 10.1021/bi048958k
PubMed ID: 28886344
Title: A recurrent missense mutation in ZP3 causes empty follicle syndrome and female infertility.
PubMed ID: 28886344
PubMed ID: 29895852
Title: ZP2 pathogenic variants cause in vitro fertilization failure and female infertility.
PubMed ID: 29895852
Sequence Information:
- Length: 424
- Mass: 47018
- Checksum: 0F3CCDA2427C0E3A
- Sequence:
MELSYRLFIC LLLWGSTELC YPQPLWLLQG GASHPETSVQ PVLVECQEAT LMVMVSKDLF GTGKLIRAAD LTLGPEACEP LVSMDTEDVV RFEVGLHECG NSMQVTDDAL VYSTFLLHDP RPVGNLSIVR TNRAEIPIEC RYPRQGNVSS QAILPTWLPF RTTVFSEEKL TFSLRLMEEN WNAEKRSPTF HLGDAAHLQA EIHTGSHVPL RLFVDHCVAT PTPDQNASPY HTIVDFHGCL VDGLTDASSA FKVPRPGPDT LQFTVDVFHF ANDSRNMIYI TCHLKVTLAE QDPDELNKAC SFSKPSNSWF PVEGSADICQ CCNKGDCGTP SHSRRQPHVM SQWSRSASRN RRHVTEEADV TVGPLIFLDR RGDHEVEQWA LPSDTSVVLL GVGLAVVVSL TLTAVILVLT RRCRTASHPV SASE
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.