Details for: CCDC6

Gene ID: 8030

Symbol: CCDC6

Ensembl ID: ENSG00000108091

Description: coiled-coil domain containing 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 277.5399
    Cell Significance Index: -43.1700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 164.5618
    Cell Significance Index: -41.7400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 91.8405
    Cell Significance Index: -43.3600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 90.0169
    Cell Significance Index: -36.5700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 64.5731
    Cell Significance Index: -43.3300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 38.5235
    Cell Significance Index: -36.7800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 35.8083
    Cell Significance Index: -44.1500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.4954
    Cell Significance Index: -41.5100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.7655
    Cell Significance Index: -42.2800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.2999
    Cell Significance Index: -44.5900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.5365
    Cell Significance Index: -23.0600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.5100
    Cell Significance Index: 57.9900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.1624
    Cell Significance Index: 57.7400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.1428
    Cell Significance Index: 429.8400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.1145
    Cell Significance Index: 230.0000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.1103
    Cell Significance Index: 1905.4200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.9341
    Cell Significance Index: 73.2400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.8095
    Cell Significance Index: 80.0400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.7429
    Cell Significance Index: 117.1900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.4206
    Cell Significance Index: 40.5400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.2900
    Cell Significance Index: 36.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.2819
    Cell Significance Index: 459.7900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2189
    Cell Significance Index: 55.2500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1943
    Cell Significance Index: 237.0100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1025
    Cell Significance Index: 31.7700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9646
    Cell Significance Index: 173.8800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9397
    Cell Significance Index: 20.3600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8450
    Cell Significance Index: 39.4000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8329
    Cell Significance Index: 63.9200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8204
    Cell Significance Index: 448.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8041
    Cell Significance Index: 37.7900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7890
    Cell Significance Index: 97.0200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7582
    Cell Significance Index: 52.4400
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.7165
    Cell Significance Index: 6.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6697
    Cell Significance Index: 41.1600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6418
    Cell Significance Index: 33.3400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5827
    Cell Significance Index: 30.3500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5479
    Cell Significance Index: 5.0500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5290
    Cell Significance Index: 233.8900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4679
    Cell Significance Index: 64.2600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4623
    Cell Significance Index: 25.9400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3332
    Cell Significance Index: 39.2900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2629
    Cell Significance Index: 18.6000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2389
    Cell Significance Index: 15.0600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2360
    Cell Significance Index: 5.6600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2118
    Cell Significance Index: 36.1700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2017
    Cell Significance Index: 5.4900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1728
    Cell Significance Index: 2.0600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1450
    Cell Significance Index: 27.5900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1435
    Cell Significance Index: 2.4600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1302
    Cell Significance Index: 16.8300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1281
    Cell Significance Index: 4.5000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1110
    Cell Significance Index: 209.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1058
    Cell Significance Index: 48.0000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0961
    Cell Significance Index: 130.6400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0801
    Cell Significance Index: 50.8900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0709
    Cell Significance Index: 130.8200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0582
    Cell Significance Index: 89.5500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0398
    Cell Significance Index: 6.4800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0333
    Cell Significance Index: 0.7100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0058
    Cell Significance Index: 0.5700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0131
    Cell Significance Index: -8.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0137
    Cell Significance Index: -10.1200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0139
    Cell Significance Index: -10.2200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0237
    Cell Significance Index: -3.4400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0267
    Cell Significance Index: -20.2200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0390
    Cell Significance Index: -2.9100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0392
    Cell Significance Index: -27.1000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0446
    Cell Significance Index: -0.8700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0580
    Cell Significance Index: -32.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0936
    Cell Significance Index: -9.5600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1140
    Cell Significance Index: -3.0600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1141
    Cell Significance Index: -24.0300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1202
    Cell Significance Index: -3.1600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1250
    Cell Significance Index: -16.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1342
    Cell Significance Index: -38.6100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1356
    Cell Significance Index: -1.8500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1759
    Cell Significance Index: -20.1500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2016
    Cell Significance Index: -5.0400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2059
    Cell Significance Index: -24.0000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2183
    Cell Significance Index: -14.0900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2820
    Cell Significance Index: -7.2500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3224
    Cell Significance Index: -7.0600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3288
    Cell Significance Index: -34.2400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3297
    Cell Significance Index: -37.6300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3471
    Cell Significance Index: -7.4200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3514
    Cell Significance Index: -18.4500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4044
    Cell Significance Index: -32.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4365
    Cell Significance Index: -13.9800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.4558
    Cell Significance Index: -2.8100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5256
    Cell Significance Index: -14.0600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.5578
    Cell Significance Index: -7.9400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5680
    Cell Significance Index: -8.3900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5885
    Cell Significance Index: -20.4500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6609
    Cell Significance Index: -21.0500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.6891
    Cell Significance Index: -11.6100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.6921
    Cell Significance Index: -8.6300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6935
    Cell Significance Index: -42.5200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7358
    Cell Significance Index: -24.0900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.7547
    Cell Significance Index: -12.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Coiled-Coil Domain:** The CCDC6 protein contains a coiled-coil domain, which is a structural motif composed of two or more alpha-helices that interact with each other through hydrophobic interactions. 2. **Widespread Expression:** CCDC6 is expressed in various cell types, including acinar cells of the salivary gland, conjunctival epithelial cells, astrocytes of the cerebral cortex, and neurons in the cerebral cortex and spinal cord. 3. **Protein Binding:** CCDC6 interacts with other proteins through protein binding, including Sh3 domain binding and identical protein binding. 4. **Cytoskeleton Organization:** CCDC6 has been implicated in cytoskeleton organization, suggesting a potential role in cell shape, movement, and division. **Pathways and Functions:** 1. **Cytoskeleton Organization:** CCDC6 is involved in the organization of the cytoskeleton, which is essential for maintaining cell shape, movement, and division. 2. **Protein Binding:** CCDC6 interacts with other proteins through protein binding, which may regulate protein-protein interactions and signal transduction. 3. **Structural Constituent of Cytoskeleton:** CCDC6 is a structural constituent of the cytoskeleton, suggesting a potential role in maintaining cell structure and organization. 4. **Immune Regulation:** CCDC6 is expressed in immune cells, including T cells and dendritic cells, suggesting a potential role in immune regulation and immune responses. **Clinical Significance:** 1. **Autoimmune Diseases:** CCDC6 has been implicated in autoimmune diseases, including rheumatoid arthritis and lupus, suggesting a potential role in immune regulation and autoimmunity. 2. **Neurological Disorders:** CCDC6 is expressed in neurons and has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease, suggesting a potential role in neurodegeneration. 3. **Cancer:** CCDC6 has been implicated in cancer, including breast cancer and lung cancer, suggesting a potential role in tumorigenesis and cancer progression. 4. **Infectious Diseases:** CCDC6 is expressed in immune cells and has been implicated in infectious diseases, including HIV and tuberculosis, suggesting a potential role in immune regulation and immune responses. In conclusion, CCDC6 is a protein-coding gene that has been implicated in various cellular processes, including cytoskeleton organization, protein binding, and structural constituent of the cytoskeleton. Further research is necessary to elucidate its role in immune regulation, cellular organization, and disease pathogenesis. The clinical significance of CCDC6 is significant, with potential implications for autoimmune diseases, neurological disorders, cancer, and infectious diseases.

Genular Protein ID: 1229941921

Symbol: CCDC6_HUMAN

Name: Coiled-coil domain-containing protein 6

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8058316

Title: Cloning and characterization of H4 (D10S170), a gene involved in RET rearrangements in vivo.

PubMed ID: 8058316

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2406025

Title: PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas.

PubMed ID: 2406025

DOI: 10.1016/0092-8674(90)90659-3

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 474
  • Mass: 53291
  • Checksum: DF055DBF20304D26
  • Sequence:
  • MADSASESDT DGAGGNSSSS AAMQSSCSST SGGGGGGGGG GGGGKSGGIV ISPFRLEELT 
    NRLASLQQEN KVLKIELETY KLKCKALQEE NRDLRKASVT IQARAEQEEE FISNTLFKKI 
    QALQKEKETL AVNYEKEEEF LTNELSRKLM QLQHEKAELE QHLEQEQEFQ VNKLMKKIKK 
    LENDTISKQL TLEQLRREKI DLENTLEQEQ EALVNRLWKR MDKLEAEKRI LQEKLDQPVS 
    APPSPRDISM EIDSPENMMR HIRFLKNEVE RLKKQLRAAQ LQHSEKMAQY LEEERHMREE 
    NLRLQRKLQR EMERREALCR QLSESESSLE MDDERYFNEM SAQGLRPRTV SSPIPYTPSP 
    SSSRPISPGL SYASHTVGFT PPTSLTRAGM SYYNSPGLHV QHMGTSHGIT RPSPRRSNSP 
    DKFKRPTPPP SPNTQTPVQP PPPPPPPPMQ PTVPSAATSQ PTPSQHSAHP SSQP

Genular Protein ID: 3020438770

Symbol: Q05CP8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 334
  • Mass: 38164
  • Checksum: 4DA022DF2550140D
  • Sequence:
  • MADSASESDT DGAGGNSSSS AAMQSSCSST SGGGGGGGGG GGGGKSGGIV ISPFRLEELT 
    NRLASLQQEN KVLKIELETY KLKCKALQEE NRDLRKASVT IQARAEQEEE FISNTLFKKI 
    QALQKEKETL AVNYEKEEEF LTNELSRKLM QLQHEKAELE QHLEQEQEFQ VNKLMKKIKK 
    LENDTISKQL TLEQLRREKI DLENTLEQEQ EALVNRLWKR MDKLEAEKRI LQEKLDQPVS 
    APPSPRDISM EIDSPENMMR HIRFLKNEVE RLKKQLRAAQ LQHSEKMAQY LEEERHMREE 
    RGRRGKMAAT KRKRRGGFAV QAKKPKKKKK KKKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.