Details for: IFT88

Gene ID: 8100

Symbol: IFT88

Ensembl ID: ENSG00000032742

Description: intraflagellar transport 88

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 245.4592
    Cell Significance Index: -38.1800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 150.8811
    Cell Significance Index: -38.2700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 91.2252
    Cell Significance Index: -37.5800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 84.4272
    Cell Significance Index: -39.8600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 79.6540
    Cell Significance Index: -32.3600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 33.8416
    Cell Significance Index: -32.3100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 32.2153
    Cell Significance Index: -39.7200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.1403
    Cell Significance Index: -37.8800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.1272
    Cell Significance Index: -39.9600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.6723
    Cell Significance Index: -18.9800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.9277
    Cell Significance Index: 46.8200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.0329
    Cell Significance Index: 128.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.5969
    Cell Significance Index: 316.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4066
    Cell Significance Index: 282.1600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2245
    Cell Significance Index: 1105.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.2092
    Cell Significance Index: 53.4900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.1387
    Cell Significance Index: 43.1200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.9764
    Cell Significance Index: 54.7900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9707
    Cell Significance Index: 348.1600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8356
    Cell Significance Index: 90.8900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7708
    Cell Significance Index: 125.3600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7457
    Cell Significance Index: 44.7700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7124
    Cell Significance Index: 492.6900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.7014
    Cell Significance Index: 13.6900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6182
    Cell Significance Index: 61.1500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6049
    Cell Significance Index: 330.3400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5935
    Cell Significance Index: 36.4800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5485
    Cell Significance Index: 13.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5396
    Cell Significance Index: 11.6900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4899
    Cell Significance Index: 22.2100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.4381
    Cell Significance Index: 7.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4070
    Cell Significance Index: 55.8900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3978
    Cell Significance Index: 27.5100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3539
    Cell Significance Index: 27.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3359
    Cell Significance Index: 632.3700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3174
    Cell Significance Index: 8.8700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.2793
    Cell Significance Index: 5.9700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2569
    Cell Significance Index: 6.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2532
    Cell Significance Index: 45.6500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2122
    Cell Significance Index: 391.4000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2037
    Cell Significance Index: 313.6000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1713
    Cell Significance Index: 11.5200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1708
    Cell Significance Index: 108.4800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1530
    Cell Significance Index: 67.6400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1318
    Cell Significance Index: 179.2300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1126
    Cell Significance Index: 14.4300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1082
    Cell Significance Index: 20.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0868
    Cell Significance Index: 3.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0800
    Cell Significance Index: 9.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0754
    Cell Significance Index: 34.2200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0175
    Cell Significance Index: 0.3000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0040
    Cell Significance Index: -2.9500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0122
    Cell Significance Index: -1.7800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0400
    Cell Significance Index: -29.6400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0452
    Cell Significance Index: -34.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0641
    Cell Significance Index: -36.1700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0719
    Cell Significance Index: -44.9100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1011
    Cell Significance Index: -2.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1202
    Cell Significance Index: -34.5900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1242
    Cell Significance Index: -21.2000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1359
    Cell Significance Index: -15.8400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1713
    Cell Significance Index: -17.5000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1822
    Cell Significance Index: -21.4900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1822
    Cell Significance Index: -3.8800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1960
    Cell Significance Index: -10.2100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2022
    Cell Significance Index: -21.0600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2038
    Cell Significance Index: -42.9200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2068
    Cell Significance Index: -9.7200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2144
    Cell Significance Index: -27.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2209
    Cell Significance Index: -10.3000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2242
    Cell Significance Index: -16.7100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2299
    Cell Significance Index: -6.6300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2350
    Cell Significance Index: -15.1600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2428
    Cell Significance Index: -27.8200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2555
    Cell Significance Index: -18.0700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2694
    Cell Significance Index: -8.6300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2764
    Cell Significance Index: -4.0800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2970
    Cell Significance Index: -15.4300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3520
    Cell Significance Index: -5.0600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3580
    Cell Significance Index: -9.5600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3785
    Cell Significance Index: -10.8000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.3797
    Cell Significance Index: -4.7100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3812
    Cell Significance Index: -30.2000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3924
    Cell Significance Index: -6.5700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4556
    Cell Significance Index: -23.9200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.4741
    Cell Significance Index: -4.0300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4891
    Cell Significance Index: -10.3800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4910
    Cell Significance Index: -13.3700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5345
    Cell Significance Index: -32.7700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5891
    Cell Significance Index: -12.9000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5922
    Cell Significance Index: -20.5800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.6191
    Cell Significance Index: -7.7200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.6272
    Cell Significance Index: -14.4900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6634
    Cell Significance Index: -21.1300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6858
    Cell Significance Index: -13.5600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6979
    Cell Significance Index: -18.3500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6988
    Cell Significance Index: -22.8800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.7187
    Cell Significance Index: -10.6100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.7212
    Cell Significance Index: -14.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** IFT88 is a cytoplasmic protein that belongs to the IFT complex, which is responsible for transporting proteins and ribosomes along the length of cilia. IFT88 interacts with other IFT complex components, such as IFT27, IFT57, and KIF3A, to facilitate anterograde and retrograde transport of cargo along the cilium. The protein has a long N-terminus domain, which is thought to be involved in the binding of IFT complex components, while the C-terminus domain contains a kinesin binding motif, which facilitates interactions with kinesin motors. **Pathways and Functions** IFT88 is involved in several cellular pathways, including: 1. **Intraflagellar transport**: IFT88 plays a critical role in the assembly and maintenance of cilia by facilitating the transport of proteins and ribosomes along the cilium. 2. **Autophagy**: IFT88 has been implicated in the regulation of autophagy, a process by which cells recycle damaged or dysfunctional organelles and proteins. 3. **Ciliary assembly**: IFT88 is essential for the assembly of cilia, particularly in the inner ear and kidney, where cilia play a critical role in sensing the environment and maintaining tissue homeostasis. 4. **Regulation of cilium assembly**: IFT88 has been shown to regulate the assembly of cilia by interacting with other IFT complex components and kinesin motors. **Clinical Significance** Dysfunction of IFT88 has been implicated in various diseases, including: 1. **Primary ciliary dyskinesia (PCD)**: PCD is a condition characterized by impaired ciliary function, leading to respiratory and reproductive issues. 2. **Kartagener syndrome**: A rare genetic disorder characterized by situs inversus, chronic sinusitis, and bronchiectasis. 3. **Polycystic kidney disease**: IFT88 dysfunction has been implicated in the development of polycystic kidney disease, a condition characterized by the growth of numerous cysts in the kidneys. In conclusion, IFT88 is a critical component of the IFT complex, essential for the assembly, maintenance, and function of cilia in various tissues. Dysfunction of IFT88 has been implicated in various diseases, highlighting the importance of this protein in maintaining cellular homeostasis and tissue function.

Genular Protein ID: 1160417290

Symbol: IFT88_HUMAN

Name: Intraflagellar transport protein 88 homolog

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7633404

Title: Characterization of the human homologue of the mouse Tg737 candidate polycystic kidney disease gene.

PubMed ID: 7633404

DOI: 10.1093/hmg/4.4.559

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17604723

Title: HEF1-dependent Aurora A activation induces disassembly of the primary cilium.

PubMed ID: 17604723

DOI: 10.1016/j.cell.2007.04.035

PubMed ID: 28625565

Title: The CEP19-RABL2 GTPase complex binds IFT-B to initiate intraflagellar transport at the ciliary base.

PubMed ID: 28625565

DOI: 10.1016/j.devcel.2017.05.016

PubMed ID: 28428259

Title: RABL2 interacts with the intraflagellar transport-B complex and CEP19 and participates in ciliary assembly.

PubMed ID: 28428259

DOI: 10.1091/mbc.e17-01-0017

PubMed ID: 27767179

Title: The serologically defined colon cancer antigen-3 (SDCCAG3) is involved in the regulation of ciliogenesis.

PubMed ID: 27767179

DOI: 10.1038/srep35399

PubMed ID: 30388400

Title: Biallelic mutations in LRRC56, encoding a protein associated with intraflagellar transport, cause mucociliary clearance and laterality defects.

PubMed ID: 30388400

DOI: 10.1016/j.ajhg.2018.10.003

Sequence Information:

  • Length: 824
  • Mass: 93192
  • Checksum: 12E30169CFC5476B
  • Sequence:
  • MMQNVHLAPE TDEDDLYSGY NDYNPIYDIE ELENDAAFQQ AVRTSHGRRP PITAKISSTA 
    VTRPIATGYG SKTSLASSIG RPMTGAIQDG VTRPMTAVRA AGFTKAALRG SAFDPLSQSR 
    GPASPLEAKK KDSPEEKIKQ LEKEVNELVE ESCIANSCGD LKLALEKAKD AGRKERVLVR 
    QREQVTTPEN INLDLTYSVL FNLASQYSVN EMYAEALNTY QVIVKNKMFS NAGILKMNMG 
    NIYLKQRNYS KAIKFYRMAL DQVPSVNKQM RIKIMQNIGV TFIQAGQYSD AINSYEHIMS 
    MAPNLKAGYN LTICYFAIGD REKMKKAFQK LITVPLEIDE DKYISPSDDP HTNLVTEAIK 
    NDHLRQMERE RKAMAEKYIM TSAKLIAPVI ETSFAAGYDW CVEVVKASQY VELANDLEIN 
    KAVTYLRQKD YNQAVEILKV LEKKDSRVKS AAATNLSALY YMGKDFAQAS SYADIAVNSD 
    RYNPAALTNK GNTVFANGDY EKAAEFYKEA LRNDSSCTEA LYNIGLTYEK LNRLDEALDC 
    FLKLHAILRN SAEVLYQIAN IYELMENPSQ AIEWLMQVVS VIPTDPQVLS KLGELYDREG 
    DKSQAFQYYY ESYRYFPCNI EVIEWLGAYY IDTQFWEKAI QYFERASLIQ PTQVKWQLMV 
    ASCFRRSGNY QKALDTYKDT HRKFPENVEC LRFLVRLCTD LGLKDAQEYA RKLKRLEKMK 
    EIREQRIKSG RDGSGGSRGK REGSASGDSG QNYSASSKGE RLSARLRALP GTNEPYESSS 
    NKEIDASYVD PLGPQIERPK TAAKKRIDED DFADEELGDD LLPE

Genular Protein ID: 810550981

Symbol: B3KX42_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 795
  • Mass: 90800
  • Checksum: 341FE49A2472A610
  • Sequence:
  • MKFTNTKVQM MQNVHLAPET DEDDLYSGYN DYNPIYDIEE LENDAAFQQA VRTSHGRRPP 
    ITAKISSTAV TRPIATGYGS KTSLASSIGR PMTGAIQDGV TRPMTAVRAA GFTKAALRGS 
    AFDPLSQSRG PASPLEAKKK DSPEEKIKQL EKEVNELVEE SCIANSCGDL KLALEKAKDA 
    GRKERVLVRQ REQVTTPENI NLDLTYSVLF NLASQYSVNE MYAEALNTYQ VIVKNKMFSN 
    AGILKMNMGN IYLKQRNYSK AIKFYRMALD QVPSVNKQMR IKIMQNIGVT FIQAGQYSDA 
    INSYEHIMSM APNLKAGYNL TICYFAIGDR EKMKKAFQKL ITVPLEIDED KYISPSDDPH 
    TNLVTEAIKN DHLRQMERER KAMAEKYIMT SAKLIAPVIE TSFAAGYDWC VEVVKASQYV 
    ELANDLEINK AVTYLRQKDY NQAVEFLKVL EKKDNRVKSA AATNLSALYY MGKDFAQASS 
    YADIAVNSDR YNLAALTNKG NTVFANGDYE KAAEFYKEAL RNDSSCTEAL YNIGLTYEKL 
    NRLDEALDCF LKLHAILRNS AEVLYQIANI YELMENPSQA IEWLMQVVSV IPTDPQVLSK 
    LGELYDREGD KSQAFQYYYE SYRYFPCNIE VIEWLGAYYI DTQFWEKAIQ YFERASLIQP 
    TQVKWQLMVA SCFRRSGNYQ KALDTYKDTH RKFPENVECS GSVRTGHMER DPLNLLPRKS 
    VLPGPEIAKR NYFSGEKYYL SAFLSSSLHR SWIKRCSRIC QKTEEVGKNE RNKGTAHKVR 
    QRWQWGLPWQ KRRKC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.