Details for: RND2

Gene ID: 8153

Symbol: RND2

Ensembl ID: ENSG00000108830

Description: Rho family GTPase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 68.7903
    Cell Significance Index: -10.7000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 42.0669
    Cell Significance Index: -10.6700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 21.2868
    Cell Significance Index: -10.0500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.7189
    Cell Significance Index: -10.7500
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 2.0496
    Cell Significance Index: 11.6500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4173
    Cell Significance Index: 13.3700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.1930
    Cell Significance Index: 4.6800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1545
    Cell Significance Index: 25.1200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1312
    Cell Significance Index: 1.7900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1092
    Cell Significance Index: 7.7200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1008
    Cell Significance Index: 2.1100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0958
    Cell Significance Index: 34.3600
  • Cell Name: glioblast (CL0000030)
    Fold Change: 0.0796
    Cell Significance Index: 0.5000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0765
    Cell Significance Index: 10.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0706
    Cell Significance Index: 14.0100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0687
    Cell Significance Index: 30.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0543
    Cell Significance Index: 10.3300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0511
    Cell Significance Index: 10.2500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0451
    Cell Significance Index: 2.7100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0362
    Cell Significance Index: 3.5800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0251
    Cell Significance Index: 0.5500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0137
    Cell Significance Index: 1.7600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0109
    Cell Significance Index: 0.5700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0089
    Cell Significance Index: 6.1300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0057
    Cell Significance Index: 0.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0006
    Cell Significance Index: -1.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0053
    Cell Significance Index: -2.8800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0065
    Cell Significance Index: -0.4000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0067
    Cell Significance Index: -12.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0083
    Cell Significance Index: -12.7900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0100
    Cell Significance Index: -7.3000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0100
    Cell Significance Index: -13.5900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0115
    Cell Significance Index: -7.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0126
    Cell Significance Index: -9.3400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0134
    Cell Significance Index: -10.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0177
    Cell Significance Index: -2.5700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0179
    Cell Significance Index: -10.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0196
    Cell Significance Index: -3.5400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0217
    Cell Significance Index: -9.8600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0223
    Cell Significance Index: -0.4800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0243
    Cell Significance Index: -2.6500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0245
    Cell Significance Index: -7.0600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0294
    Cell Significance Index: -1.8600
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0341
    Cell Significance Index: -0.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0346
    Cell Significance Index: -4.0300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0349
    Cell Significance Index: -1.9600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0357
    Cell Significance Index: -1.0300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0417
    Cell Significance Index: -1.4500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0463
    Cell Significance Index: -3.2100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0512
    Cell Significance Index: -6.3000
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0553
    Cell Significance Index: -0.3600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0559
    Cell Significance Index: -7.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0572
    Cell Significance Index: -12.0600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0601
    Cell Significance Index: -1.2800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0601
    Cell Significance Index: -10.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0690
    Cell Significance Index: -7.9000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0697
    Cell Significance Index: -1.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0700
    Cell Significance Index: -7.1500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0762
    Cell Significance Index: -1.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0774
    Cell Significance Index: -5.7700
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0843
    Cell Significance Index: -0.5000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0855
    Cell Significance Index: -10.0900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0856
    Cell Significance Index: -1.2000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0928
    Cell Significance Index: -2.3200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0933
    Cell Significance Index: -4.3500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0955
    Cell Significance Index: -9.9400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1092
    Cell Significance Index: -4.9500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1116
    Cell Significance Index: -8.8400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1302
    Cell Significance Index: -1.8700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1304
    Cell Significance Index: -8.4100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1330
    Cell Significance Index: -2.1100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1363
    Cell Significance Index: -1.9400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1388
    Cell Significance Index: -10.6500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1411
    Cell Significance Index: -6.2400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1446
    Cell Significance Index: -9.7200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1524
    Cell Significance Index: -3.6600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1623
    Cell Significance Index: -8.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1664
    Cell Significance Index: -7.8200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1665
    Cell Significance Index: -4.2800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1683
    Cell Significance Index: -10.3200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1724
    Cell Significance Index: -2.4500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1832
    Cell Significance Index: -2.3200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1996
    Cell Significance Index: -7.5600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2119
    Cell Significance Index: -6.2400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2290
    Cell Significance Index: -2.4900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2297
    Cell Significance Index: -3.8500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2304
    Cell Significance Index: -8.0700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2402
    Cell Significance Index: -8.4400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2445
    Cell Significance Index: -6.1000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2546
    Cell Significance Index: -6.9300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2581
    Cell Significance Index: -8.4500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2629
    Cell Significance Index: -3.9600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2750
    Cell Significance Index: -5.5200
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.2782
    Cell Significance Index: -2.1400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2792
    Cell Significance Index: -5.5200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2800
    Cell Significance Index: -2.3800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2911
    Cell Significance Index: -9.2700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2999
    Cell Significance Index: -6.4800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3115
    Cell Significance Index: -8.9300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3141
    Cell Significance Index: -11.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RND2 is a small GTPase that belongs to the Rho family, which consists of seven members (RhoA, RhoB, RhoC, Rac1, Rac2, Cdc42, and Rnd1-3). RND2 is characterized by its ability to bind and hydrolyze GTP, which regulates its activity and interaction with downstream effectors. RND2 is also known as RhoN, and its expression is restricted to specific cell types, including epithelial cells, neurons, and endothelial cells. **Pathways and Functions** RND2 is involved in various signaling pathways, including: 1. **Actin filament organization**: RND2 regulates the organization of actin filaments, which is essential for cell migration, shape changes, and cell division. 2. **Cell migration**: RND2 is involved in the regulation of cell migration, which is critical for development, tissue repair, and immune responses. 3. **Regulation of actin cytoskeleton organization**: RND2 regulates the organization of the actin cytoskeleton, which is essential for maintaining cellular shape and structure. 4. **Rho GTPase cycle**: RND2 is involved in the Rho GTPase cycle, which regulates the activity of downstream effectors and modulates cellular processes. 5. **Signaling by Rho GTPases**: RND2 is involved in the signaling pathways of Rho GTPases, which regulate various cellular processes, including cell migration, cytoskeleton organization, and gene expression. **Clinical Significance** Dysregulation of RND2 has been implicated in various diseases, including: 1. **Cancer**: RND2 is overexpressed in various types of cancer, including colon, breast, and lung cancer, and its dysregulation is associated with tumor progression and metastasis. 2. **Neurological disorders**: RND2 is involved in the regulation of neuronal development and function, and its dysregulation is associated with neurological disorders, including Alzheimer's disease, Parkinson's disease, and autism spectrum disorder. 3. **Cardiovascular disease**: RND2 is involved in the regulation of endothelial cell function and vascular tone, and its dysregulation is associated with cardiovascular disease. In conclusion, RND2 is a critical regulator of cellular processes, including cell migration, cytoskeleton organization, and signaling pathways. Its dysregulation has been implicated in various diseases, including cancer, neurological disorders, and cardiovascular disease. Further research is needed to fully understand the mechanisms of RND2 and its role in human disease.

Genular Protein ID: 1684685166

Symbol: RND2_HUMAN

Name: Rho-related GTP-binding protein RhoN

UniProtKB Accession Codes:

P52198 A8K2D4 O00690 O00734 Q5U0P6 Q99535

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 3 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9531558

Title: A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion.

PubMed ID: 9531558

DOI: 10.1083/jcb.141.1.187

PubMed ID: 8938427

Title: Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1.

PubMed ID: 8938427

DOI: 10.1101/gr.6.11.1029

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12590651

Title: Rho family GTPase Rnd2 interacts and co-localizes with MgcRacGAP in male germ cells.

PubMed ID: 12590651

DOI: 10.1042/bj20021652

PubMed ID: 11940653

Title: Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers.

PubMed ID: 11940653

DOI: 10.1128/mcb.22.9.2952-2964.2002

Sequence Information:

  • Length: 227
  • Mass: 25369
  • Checksum: DB2127B97B468F86
  • Sequence:
    • MEGQSGRCKI VVVGDAECGK TALLQVFAKD AYPGSYVPTV FENYTASFEI DKRRIELNMW 
DTSGSSYYDN VRPLAYPDSD AVLICFDISR PETLDSVLKK WQGETQEFCP NAKVVLVGCK 
LDMRTDLATL RELSKQRLIP VTHEQGTVLA KQVGAVSYVE CSSRSSERSV RDVFHVATVA 
SLGRGHRQLR RTDSRRGMQR SAQLSGRPDR GNEGEIHKDR AKSCNLM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.