Details for: PUDP

Gene ID: 8226

Symbol: PUDP

Ensembl ID: ENSG00000130021

Description: pseudouridine 5'-phosphatase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 52.7009
    Cell Significance Index: -21.7100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 49.8176
    Cell Significance Index: -23.5200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.1303
    Cell Significance Index: -21.7800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.8306
    Cell Significance Index: -20.9800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.4157
    Cell Significance Index: 459.7200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6326
    Cell Significance Index: 161.5100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.3156
    Cell Significance Index: 58.1900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.2425
    Cell Significance Index: 69.7200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.1573
    Cell Significance Index: 43.8300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8868
    Cell Significance Index: 175.9900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8472
    Cell Significance Index: 98.7300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7892
    Cell Significance Index: 22.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7799
    Cell Significance Index: 279.7300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7053
    Cell Significance Index: 42.3400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6209
    Cell Significance Index: 47.6500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6084
    Cell Significance Index: 66.1700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.5886
    Cell Significance Index: 85.5600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5617
    Cell Significance Index: 112.6700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5421
    Cell Significance Index: 13.5500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4887
    Cell Significance Index: 79.4800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4223
    Cell Significance Index: 9.1500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3955
    Cell Significance Index: 24.3100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3260
    Cell Significance Index: 178.0200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3115
    Cell Significance Index: 36.7300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3001
    Cell Significance Index: 270.9800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2948
    Cell Significance Index: 20.3900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2798
    Cell Significance Index: 6.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2228
    Cell Significance Index: 27.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2137
    Cell Significance Index: 38.5300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1969
    Cell Significance Index: 136.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1921
    Cell Significance Index: 9.9800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1685
    Cell Significance Index: 4.3300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1484
    Cell Significance Index: 7.5000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0964
    Cell Significance Index: 43.7400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0964
    Cell Significance Index: 177.8100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0757
    Cell Significance Index: 2.1800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0632
    Cell Significance Index: 97.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0622
    Cell Significance Index: 117.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0614
    Cell Significance Index: 39.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0614
    Cell Significance Index: 2.7900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0607
    Cell Significance Index: 82.5000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0473
    Cell Significance Index: 0.8100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0310
    Cell Significance Index: 0.9800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0272
    Cell Significance Index: 1.2700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0262
    Cell Significance Index: 11.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0223
    Cell Significance Index: 3.0600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0114
    Cell Significance Index: 0.4000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0097
    Cell Significance Index: -0.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0177
    Cell Significance Index: -13.4300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0226
    Cell Significance Index: -16.5700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0245
    Cell Significance Index: -18.1700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0245
    Cell Significance Index: -4.1900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0254
    Cell Significance Index: -0.3800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0315
    Cell Significance Index: -0.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0370
    Cell Significance Index: -20.8900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0376
    Cell Significance Index: -23.4900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0453
    Cell Significance Index: -5.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0552
    Cell Significance Index: -3.7100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0627
    Cell Significance Index: -18.0400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0735
    Cell Significance Index: -7.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1174
    Cell Significance Index: -24.7200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1181
    Cell Significance Index: -1.7700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1200
    Cell Significance Index: -7.7400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1261
    Cell Significance Index: -4.0400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1291
    Cell Significance Index: -16.5500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1356
    Cell Significance Index: -17.5300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1482
    Cell Significance Index: -6.9700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1701
    Cell Significance Index: -17.7100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2174
    Cell Significance Index: -3.2100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2219
    Cell Significance Index: -4.7100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2250
    Cell Significance Index: -16.7700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2290
    Cell Significance Index: -2.7300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2397
    Cell Significance Index: -16.9500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2479
    Cell Significance Index: -7.2800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2479
    Cell Significance Index: -15.2000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2532
    Cell Significance Index: -1.5300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2535
    Cell Significance Index: -20.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2566
    Cell Significance Index: -13.4700
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.2934
    Cell Significance Index: -2.2200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.3442
    Cell Significance Index: -4.9000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3481
    Cell Significance Index: -5.8300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3548
    Cell Significance Index: -9.3300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3687
    Cell Significance Index: -7.2900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3696
    Cell Significance Index: -12.1000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3715
    Cell Significance Index: -19.3500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3809
    Cell Significance Index: -12.1300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3833
    Cell Significance Index: -5.2300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4158
    Cell Significance Index: -5.9600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4168
    Cell Significance Index: -4.3200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4311
    Cell Significance Index: -14.9800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.4363
    Cell Significance Index: -7.1900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.4399
    Cell Significance Index: -7.4100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.4411
    Cell Significance Index: -5.5000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4488
    Cell Significance Index: -9.0100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4572
    Cell Significance Index: -4.2100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4636
    Cell Significance Index: -16.2400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4787
    Cell Significance Index: -13.0300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4796
    Cell Significance Index: -9.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PUDP exhibits the following key characteristics: 1. **Phosphatase activity:** PUDP possesses phosphatase activity, which is necessary for its role in regulating pseudouridine levels. 2. **Pseudouridine 5'-phosphatase activity:** PUDP specifically catalyzes the hydrolysis of pseudouridine 5'-phosphate, a key step in pseudouridine metabolism. 3. **Metal ion binding:** PUDP binds metal ions, such as zinc, which is essential for its enzymatic activity. 4. **Protein binding:** PUDP interacts with various proteins, including other enzymes and transcription factors, to regulate its activity and target specificity. **Pathways and Functions:** PUDP is involved in several metabolic and signaling pathways, including: 1. **Nucleotide metabolism:** PUDP plays a critical role in the regulation of pseudouridine levels, which is essential for maintaining RNA stability and translation efficiency. 2. **Pyrimidine salvage:** PUDP is involved in the salvage pathway of pyrimidine nucleotides, which is responsible for the regeneration of nucleotides from their deoxyribonucleotide precursors. 3. **Metal ion homeostasis:** PUDP helps regulate metal ion levels in the cell, which is essential for maintaining proper enzymatic activity and cellular function. 4. **Transcriptional regulation:** PUDP interacts with transcription factors and other proteins to regulate gene expression and cellular differentiation. **Clinical Significance:** Dysregulation of PUDP activity has been implicated in various diseases, including: 1. **Neurological disorders:** Alterations in PUDP activity have been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 2. **Cardiovascular disease:** PUDP dysregulation has been implicated in cardiac arrhythmias and other cardiovascular disorders. 3. **Cancer:** PUDP activity has been linked to cancer development and progression, particularly in the context of DNA repair and replication. 4. **Metabolic disorders:** PUDP dysregulation has been implicated in metabolic disorders, such as diabetes and obesity. In conclusion, PUDP is a critical enzyme that plays a central role in nucleotide metabolism, transcriptional regulation, and metal ion homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of PUDP in maintaining cellular homeostasis and overall health. Further research is necessary to fully elucidate the functions and dysregulations of PUDP in human disease.

Genular Protein ID: 830779879

Symbol: HDHD1_HUMAN

Name: Haloacid dehalogenase-like hydrolase domain-containing protein 1

UniProtKB Accession Codes:

Q08623 B2R7X6 B4DV93 B7Z6Q3 E9PAV8 F5GWZ2 Q53F84 Q96EB8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChEBI 7 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 9 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 Rhea 1 SABIO-RK 1 SFLD 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1284467

Title: Isolation of a new gene from the distal short arm of the human X chromosome that escapes X-inactivation.

PubMed ID: 1284467

DOI: 10.1093/hmg/1.1.47

PubMed ID: 20722631

Title: HDHD1, which is often deleted in X-linked ichthyosis, encodes a pseudouridine-5'-phosphatase.

PubMed ID: 20722631

DOI: 10.1042/bj20100174

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 228
  • Mass: 25249
  • Checksum: EF9B8CC51C122924
  • Sequence:
    • MAAPPQPVTH LIFDMDGLLL DTERLYSVVF QEICNRYDKK YSWDVKSLVM GKKALEAAQI 
IIDVLQLPMS KEELVEESQT KLKEVFPTAA LMPGAEKLII HLRKHGIPFA LATSSGSASF 
DMKTSRHKEF FSLFSHIVLG DDPEVQHGKP DPDIFLACAK RFSPPPAMEK CLVFEDAPNG 
VEAALAAGMQ VVMVPDGNLS RDLTTKATLV LNSLQDFQPE LFGLPSYE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.