Details for: EPX

Gene ID: 8288

Symbol: EPX

Ensembl ID: ENSG00000121053

Description: eosinophil peroxidase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 21.2503
    Cell Significance Index: -5.3900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.1493
    Cell Significance Index: 27.8400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.5440
    Cell Significance Index: 7.7300
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.4175
    Cell Significance Index: 4.3300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.2910
    Cell Significance Index: 7.2600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2404
    Cell Significance Index: 4.1200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.2356
    Cell Significance Index: 3.4200
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.0338
    Cell Significance Index: 0.3000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0296
    Cell Significance Index: 0.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0229
    Cell Significance Index: 0.6400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0211
    Cell Significance Index: 4.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0084
    Cell Significance Index: 0.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0075
    Cell Significance Index: 1.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0068
    Cell Significance Index: 2.4500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0023
    Cell Significance Index: 4.1900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0018
    Cell Significance Index: 2.7000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0005
    Cell Significance Index: 0.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0031
    Cell Significance Index: -4.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0053
    Cell Significance Index: -3.3800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0072
    Cell Significance Index: -5.3400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0090
    Cell Significance Index: -4.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0093
    Cell Significance Index: -5.2500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0107
    Cell Significance Index: -3.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0125
    Cell Significance Index: -1.8200
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.0136
    Cell Significance Index: -0.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0138
    Cell Significance Index: -6.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0188
    Cell Significance Index: -3.3900
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0248
    Cell Significance Index: -0.3200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0253
    Cell Significance Index: -0.3600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0255
    Cell Significance Index: -5.3700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0255
    Cell Significance Index: -4.3600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0296
    Cell Significance Index: -0.7600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0363
    Cell Significance Index: -4.9800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0367
    Cell Significance Index: -4.5100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0390
    Cell Significance Index: -2.4000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0396
    Cell Significance Index: -2.6600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0398
    Cell Significance Index: -1.7600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0428
    Cell Significance Index: -4.9000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0492
    Cell Significance Index: -5.1200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0512
    Cell Significance Index: -1.0000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0599
    Cell Significance Index: -2.2700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0740
    Cell Significance Index: -5.6800
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.0766
    Cell Significance Index: -0.8900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0788
    Cell Significance Index: -1.6500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0846
    Cell Significance Index: -2.2600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0847
    Cell Significance Index: -1.0300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0847
    Cell Significance Index: -1.2500
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0862
    Cell Significance Index: -1.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0873
    Cell Significance Index: -4.9000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0962
    Cell Significance Index: -1.6200
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0989
    Cell Significance Index: -1.3000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0996
    Cell Significance Index: -3.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1013
    Cell Significance Index: -4.7600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1062
    Cell Significance Index: -1.8300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1077
    Cell Significance Index: -0.7300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1182
    Cell Significance Index: -1.1200
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.1191
    Cell Significance Index: -1.1400
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.1297
    Cell Significance Index: -1.6600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1306
    Cell Significance Index: -1.6900
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.1322
    Cell Significance Index: -0.8600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1344
    Cell Significance Index: -4.2800
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1345
    Cell Significance Index: -1.5600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1381
    Cell Significance Index: -4.5200
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.1422
    Cell Significance Index: -1.2300
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: -0.1429
    Cell Significance Index: -0.3300
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.1438
    Cell Significance Index: -1.5200
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.1547
    Cell Significance Index: -1.6000
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.1563
    Cell Significance Index: -1.6500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1566
    Cell Significance Index: -4.4700
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.1579
    Cell Significance Index: -1.5000
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: -0.1629
    Cell Significance Index: -1.3800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1699
    Cell Significance Index: -3.7200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1730
    Cell Significance Index: -2.5300
  • Cell Name: group 3 innate lymphoid cell, human (CL0001078)
    Fold Change: -0.1740
    Cell Significance Index: -1.6300
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1793
    Cell Significance Index: -2.5100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1813
    Cell Significance Index: -4.6200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1816
    Cell Significance Index: -4.8700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1838
    Cell Significance Index: -4.5900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1847
    Cell Significance Index: -3.9200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1869
    Cell Significance Index: -5.0000
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.1977
    Cell Significance Index: -1.8300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1982
    Cell Significance Index: -4.9500
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: -0.2029
    Cell Significance Index: -1.9100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2030
    Cell Significance Index: -2.4200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2090
    Cell Significance Index: -5.3400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2139
    Cell Significance Index: -5.1300
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.2179
    Cell Significance Index: -1.7200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2202
    Cell Significance Index: -4.4200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2236
    Cell Significance Index: -4.8300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2306
    Cell Significance Index: -4.5600
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.2393
    Cell Significance Index: -2.1200
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.2412
    Cell Significance Index: -2.7300
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.2424
    Cell Significance Index: -2.8900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2453
    Cell Significance Index: -5.1200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2462
    Cell Significance Index: -4.1200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2482
    Cell Significance Index: -5.0500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2484
    Cell Significance Index: -8.7300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2533
    Cell Significance Index: -4.3300
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -0.2571
    Cell Significance Index: -1.6100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2574
    Cell Significance Index: -3.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EPX is a heme-containing peroxidase enzyme that catalyzes the oxidation of hydrogen peroxide (H2O2) to reactive oxygen species (ROS), such as hydroxyl radicals (OH•) and superoxides (O2•-). This enzymatic activity is crucial for the antimicrobial and antiparasitic functions of eosinophils. EPX is also involved in the regulation of eosinophil degranulation, which is essential for the elimination of pathogens from the body. Furthermore, EPX has been shown to play a role in the regulation of cytokine production, including the suppression of interleukin-5 (IL-5) and IL-10 production, which are critical for the resolution of inflammation. **Pathways and Functions:** EPX is involved in various signaling pathways that regulate its expression and activity. These pathways include: 1. **Cellular oxidant detoxification:** EPX plays a crucial role in the detoxification of H2O2, which is a reactive oxygen species produced during the respiratory burst of immune cells. 2. **Defense response to bacterium:** EPX is involved in the defense against bacterial infections, particularly in the activation of eosinophils and the production of ROS. 3. **Defense response to nematode:** EPX has also been shown to play a role in the defense against nematode infections, which are caused by parasitic worms. 4. **Eosinophil migration:** EPX is involved in the regulation of eosinophil migration, which is essential for the elimination of pathogens from the body. 5. **Negative regulation of cytokine production:** EPX suppresses the production of IL-5 and IL-10, which are critical for the resolution of inflammation. **Clinical Significance:** EPX has been implicated in various diseases, including: 1. **Allergies:** EPX has been shown to play a role in the pathogenesis of allergic diseases, such as asthma and atopic dermatitis. 2. **Parasitic infections:** EPX has been implicated in the defense against parasitic infections, particularly those caused by nematodes. 3. **Autoimmune diseases:** EPX has been shown to play a role in the regulation of cytokine production and the resolution of inflammation in autoimmune diseases, such as multiple sclerosis. 4. **Cancer:** EPX has been implicated in the development and progression of certain types of cancer, particularly those caused by oxidative stress. In conclusion, EPX is a complex enzyme that plays a dual-edged role in the immune system and oxidative stress. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its mechanisms of action and regulation. Further research is needed to elucidate the full extent of EPX's role in human disease.

Genular Protein ID: 642215863

Symbol: PERE_HUMAN

Name: Eosinophil peroxidase

UniProtKB Accession Codes:

P11678 Q4TVP3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 15 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 12 Ensembl 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PeroxiBase 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2550461

Title: Molecular cloning and characterization of a chromosomal gene for human eosinophil peroxidase.

PubMed ID: 2550461

DOI: 10.1016/s0021-9258(19)84781-6

PubMed ID: 2541222

Title: Molecular cloning of the human eosinophil peroxidase. Evidence for the existence of a peroxidase multigene family.

PubMed ID: 2541222

DOI: 10.1084/jem.169.5.1757

PubMed ID: 10358043

Title: Biochemical evidence for heme linkage through esters with Asp-93 and Glu-241 in human eosinophil peroxidase. The ester with Asp-93 is only partially formed in vivo.

PubMed ID: 10358043

DOI: 10.1074/jbc.274.24.16953

PubMed ID: 12540536

Title: Human eosinophil peroxidase induces surface alteration, killing, and lysis of Mycobacterium tuberculosis.

PubMed ID: 12540536

DOI: 10.1128/iai.71.2.605-613.2003

PubMed ID: 18694936

Title: Post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase.

PubMed ID: 18694936

DOI: 10.1074/jbc.m801196200

PubMed ID: 7809065

Title: Hereditary eosinophil peroxidase deficiency: immunochemical and spectroscopic studies and evidence for a compound heterozygosity of the defect.

PubMed ID: 7809065

DOI: 10.1073/pnas.91.26.12496

PubMed ID: 14657871

Title: High contribution contrast between the genes of eosinophil peroxidase and IL-4 receptor alpha-chain in Japanese cedar pollinosis.

PubMed ID: 14657871

DOI: 10.1016/j.jaci.2003.08.051

Sequence Information:

  • Length: 715
  • Mass: 81040
  • Checksum: CEB4E689A6C46374
  • Sequence:
    • MHLLPALAGV LATLVLAQPC EGTDPASPGA VETSVLRDCI AEAKLLVDAA YNWTQKSIKQ 
RLRSGSASPM DLLSYFKQPV AATRTVVRAA DYMHVALGLL EEKLQPQRSG PFNVTDVLTE 
PQLRLLSQAS GCALRDQAER CSDKYRTITG RCNNKRRPLL GASNQALARW LPAEYEDGLS 
LPFGWTPSRR RNGFLLPLVR AVSNQIVRFP NERLTSDRGR ALMFMQWGQF IDHDLDFSPE 
SPARVAFTAG VDCERTCAQL PPCFPIKIPP NDPRIKNQRD CIPFFRSAPS CPQNKNRVRN 
QINALTSFVD ASMVYGSEVS LSLRLRNRTN YLGLLAINQR FQDNGRALLP FDNLHDDPCL 
LTNRSARIPC FLAGDTRSTE TPKLAAMHTL FMREHNRLAT ELRRLNPRWN GDKLYNEARK 
IMGAMVQIIT YRDFLPLVLG KARARRTLGH YRGYCSNVDP RVANVFTLAF RFGHTMLQPF 
MFRLDSQYRA SAPNSHVPLS SAFFASWRIV YEGGIDPILR GLMATPAKLN RQDAMLVDEL 
RDRLFRQVRR IGLDLAALNM QRSRDHGLPG YNAWRRFCGL SQPRNLAQLS RVLKNQDLAR 
KFLNLYGTPD NIDIWIGAIA EPLLPGARVG PLLACLFENQ FRRARDGDRF WWQKRGVFTK 
RQRKALSRIS LSRIICDNTG ITTVSRDIFR ANIYPRGFVN CSRIPRLNLS AWRGT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.