Details for: EPX

Gene ID: 8288

Symbol: EPX

Ensembl ID: ENSG00000121053

Description: eosinophil peroxidase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glial cell (CL0000125)
    Fold Change: 16.33
    Marker Score: 17959
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 9.59
    Marker Score: 30722
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 7.91
    Marker Score: 10965.5
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 6.19
    Marker Score: 18052
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 5.78
    Marker Score: 7207
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 5.77
    Marker Score: 17108
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 4.8
    Marker Score: 4600
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 3.94
    Marker Score: 11297
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.82
    Marker Score: 32341
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.42
    Marker Score: 9755
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.13
    Marker Score: 3155
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.91
    Marker Score: 2130.5
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 170231
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.11
    Marker Score: 7365
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71806
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48031
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 602
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 705
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.77
    Marker Score: 507
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.71
    Marker Score: 317
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.64
    Marker Score: 1024
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 460
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.53
    Marker Score: 221.5
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.52
    Marker Score: 235
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.49
    Marker Score: 546
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.45
    Marker Score: 941
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.44
    Marker Score: 837
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.44
    Marker Score: 425.5
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.43
    Marker Score: 406
  • Cell Name: eosinophil (CL0000771)
    Fold Change: 0.41
    Marker Score: 135
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.37
    Marker Score: 208
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.37
    Marker Score: 97
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.36
    Marker Score: 208
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.34
    Marker Score: 200
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: 0.32
    Marker Score: 98
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.31
    Marker Score: 4867
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.31
    Marker Score: 130
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.29
    Marker Score: 595.5
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.29
    Marker Score: 3802
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.28
    Marker Score: 156
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.28
    Marker Score: 161.5
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.25
    Marker Score: 157
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.23
    Marker Score: 68
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.22
    Marker Score: 135
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.22
    Marker Score: 70
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.22
    Marker Score: 221
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.21
    Marker Score: 207
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.21
    Marker Score: 58
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.21
    Marker Score: 844.5
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.21
    Marker Score: 126
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.2
    Marker Score: 1191
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.2
    Marker Score: 105
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.19
    Marker Score: 648
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.19
    Marker Score: 167
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.18
    Marker Score: 72
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.18
    Marker Score: 44
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.17
    Marker Score: 114
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.16
    Marker Score: 193
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.16
    Marker Score: 253
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.16
    Marker Score: 46
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.16
    Marker Score: 57
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.16
    Marker Score: 46
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.15
    Marker Score: 45
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.15
    Marker Score: 70
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.15
    Marker Score: 80
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.15
    Marker Score: 75
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.15
    Marker Score: 357
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.15
    Marker Score: 357
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.15
    Marker Score: 128
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.15
    Marker Score: 39
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.14
    Marker Score: 69
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.14
    Marker Score: 44
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.14
    Marker Score: 58
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.14
    Marker Score: 37
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.14
    Marker Score: 173
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.14
    Marker Score: 46
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 0.14
    Marker Score: 39
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.14
    Marker Score: 42
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.13
    Marker Score: 161
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.13
    Marker Score: 176
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.13
    Marker Score: 224
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.13
    Marker Score: 39
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.13
    Marker Score: 68
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.13
    Marker Score: 167
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.13
    Marker Score: 43
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.12
    Marker Score: 54
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.12
    Marker Score: 39
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.12
    Marker Score: 43
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.12
    Marker Score: 89
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.11
    Marker Score: 67
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.11
    Marker Score: 40
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.11
    Marker Score: 36

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Other Information

**Key Characteristics:** EPX is a heme-containing peroxidase enzyme that catalyzes the oxidation of hydrogen peroxide (H2O2) to reactive oxygen species (ROS), such as hydroxyl radicals (OH•) and superoxides (O2•-). This enzymatic activity is crucial for the antimicrobial and antiparasitic functions of eosinophils. EPX is also involved in the regulation of eosinophil degranulation, which is essential for the elimination of pathogens from the body. Furthermore, EPX has been shown to play a role in the regulation of cytokine production, including the suppression of interleukin-5 (IL-5) and IL-10 production, which are critical for the resolution of inflammation. **Pathways and Functions:** EPX is involved in various signaling pathways that regulate its expression and activity. These pathways include: 1. **Cellular oxidant detoxification:** EPX plays a crucial role in the detoxification of H2O2, which is a reactive oxygen species produced during the respiratory burst of immune cells. 2. **Defense response to bacterium:** EPX is involved in the defense against bacterial infections, particularly in the activation of eosinophils and the production of ROS. 3. **Defense response to nematode:** EPX has also been shown to play a role in the defense against nematode infections, which are caused by parasitic worms. 4. **Eosinophil migration:** EPX is involved in the regulation of eosinophil migration, which is essential for the elimination of pathogens from the body. 5. **Negative regulation of cytokine production:** EPX suppresses the production of IL-5 and IL-10, which are critical for the resolution of inflammation. **Clinical Significance:** EPX has been implicated in various diseases, including: 1. **Allergies:** EPX has been shown to play a role in the pathogenesis of allergic diseases, such as asthma and atopic dermatitis. 2. **Parasitic infections:** EPX has been implicated in the defense against parasitic infections, particularly those caused by nematodes. 3. **Autoimmune diseases:** EPX has been shown to play a role in the regulation of cytokine production and the resolution of inflammation in autoimmune diseases, such as multiple sclerosis. 4. **Cancer:** EPX has been implicated in the development and progression of certain types of cancer, particularly those caused by oxidative stress. In conclusion, EPX is a complex enzyme that plays a dual-edged role in the immune system and oxidative stress. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its mechanisms of action and regulation. Further research is needed to elucidate the full extent of EPX's role in human disease.

Genular Protein ID: 642215863

Symbol: PERE_HUMAN

Name: Eosinophil peroxidase

UniProtKB Accession Codes:

P11678 Q4TVP3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 15 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 12 EPD 1 Ensembl 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PeroxiBase 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2550461

Title: Molecular cloning and characterization of a chromosomal gene for human eosinophil peroxidase.

PubMed ID: 2550461

DOI: 10.1016/s0021-9258(19)84781-6

PubMed ID: 2541222

Title: Molecular cloning of the human eosinophil peroxidase. Evidence for the existence of a peroxidase multigene family.

PubMed ID: 2541222

DOI: 10.1084/jem.169.5.1757

PubMed ID: 10358043

Title: Biochemical evidence for heme linkage through esters with Asp-93 and Glu-241 in human eosinophil peroxidase. The ester with Asp-93 is only partially formed in vivo.

PubMed ID: 10358043

DOI: 10.1074/jbc.274.24.16953

PubMed ID: 12540536

Title: Human eosinophil peroxidase induces surface alteration, killing, and lysis of Mycobacterium tuberculosis.

PubMed ID: 12540536

DOI: 10.1128/iai.71.2.605-613.2003

PubMed ID: 18694936

Title: Post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase.

PubMed ID: 18694936

DOI: 10.1074/jbc.m801196200

PubMed ID: 7809065

Title: Hereditary eosinophil peroxidase deficiency: immunochemical and spectroscopic studies and evidence for a compound heterozygosity of the defect.

PubMed ID: 7809065

DOI: 10.1073/pnas.91.26.12496

PubMed ID: 14657871

Title: High contribution contrast between the genes of eosinophil peroxidase and IL-4 receptor alpha-chain in Japanese cedar pollinosis.

PubMed ID: 14657871

DOI: 10.1016/j.jaci.2003.08.051

Sequence Information:

  • Length: 715
  • Mass: 81040
  • Checksum: CEB4E689A6C46374
  • Sequence:
    • MHLLPALAGV LATLVLAQPC EGTDPASPGA VETSVLRDCI AEAKLLVDAA YNWTQKSIKQ 
RLRSGSASPM DLLSYFKQPV AATRTVVRAA DYMHVALGLL EEKLQPQRSG PFNVTDVLTE 
PQLRLLSQAS GCALRDQAER CSDKYRTITG RCNNKRRPLL GASNQALARW LPAEYEDGLS 
LPFGWTPSRR RNGFLLPLVR AVSNQIVRFP NERLTSDRGR ALMFMQWGQF IDHDLDFSPE 
SPARVAFTAG VDCERTCAQL PPCFPIKIPP NDPRIKNQRD CIPFFRSAPS CPQNKNRVRN 
QINALTSFVD ASMVYGSEVS LSLRLRNRTN YLGLLAINQR FQDNGRALLP FDNLHDDPCL 
LTNRSARIPC FLAGDTRSTE TPKLAAMHTL FMREHNRLAT ELRRLNPRWN GDKLYNEARK 
IMGAMVQIIT YRDFLPLVLG KARARRTLGH YRGYCSNVDP RVANVFTLAF RFGHTMLQPF 
MFRLDSQYRA SAPNSHVPLS SAFFASWRIV YEGGIDPILR GLMATPAKLN RQDAMLVDEL 
RDRLFRQVRR IGLDLAALNM QRSRDHGLPG YNAWRRFCGL SQPRNLAQLS RVLKNQDLAR 
KFLNLYGTPD NIDIWIGAIA EPLLPGARVG PLLACLFENQ FRRARDGDRF WWQKRGVFTK 
RQRKALSRIS LSRIICDNTG ITTVSRDIFR ANIYPRGFVN CSRIPRLNLS AWRGT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.