Details for: ACOX3

Gene ID: 8310

Symbol: ACOX3

Ensembl ID: ENSG00000087008

Description: acyl-CoA oxidase 3, pristanoyl

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 122.8582
    Cell Significance Index: -19.1100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 72.3851
    Cell Significance Index: -18.3600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 40.5654
    Cell Significance Index: -16.4800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.8075
    Cell Significance Index: -19.4900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.8835
    Cell Significance Index: -18.4400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.4053
    Cell Significance Index: -11.8300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.9670
    Cell Significance Index: -19.6000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.2219
    Cell Significance Index: 422.8500
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 1.4531
    Cell Significance Index: 1.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9509
    Cell Significance Index: 190.7500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8435
    Cell Significance Index: 64.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8250
    Cell Significance Index: 22.0300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8026
    Cell Significance Index: 10.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7712
    Cell Significance Index: 40.0600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.7646
    Cell Significance Index: 10.9500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7634
    Cell Significance Index: 689.3400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.7555
    Cell Significance Index: 12.4500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6028
    Cell Significance Index: 36.1900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5596
    Cell Significance Index: 60.8700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5140
    Cell Significance Index: 184.3500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5110
    Cell Significance Index: 101.4000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4914
    Cell Significance Index: 79.9300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4043
    Cell Significance Index: 11.3000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3850
    Cell Significance Index: 17.9500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3757
    Cell Significance Index: 3.4600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2937
    Cell Significance Index: 11.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2923
    Cell Significance Index: 12.9300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2829
    Cell Significance Index: 19.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2710
    Cell Significance Index: 16.6600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2497
    Cell Significance Index: 11.3200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2353
    Cell Significance Index: 162.7100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2294
    Cell Significance Index: 6.6100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2199
    Cell Significance Index: 21.7500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1918
    Cell Significance Index: 4.9300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1582
    Cell Significance Index: 28.5200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1545
    Cell Significance Index: 3.3500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1497
    Cell Significance Index: 81.7600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1424
    Cell Significance Index: 2.7800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1020
    Cell Significance Index: 2.5500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0934
    Cell Significance Index: 11.4900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0807
    Cell Significance Index: 124.2800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0680
    Cell Significance Index: 2.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0670
    Cell Significance Index: 3.7600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0612
    Cell Significance Index: 1.6400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0599
    Cell Significance Index: 112.7800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0547
    Cell Significance Index: 4.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0545
    Cell Significance Index: 100.4500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0438
    Cell Significance Index: 59.6200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0431
    Cell Significance Index: 19.5800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0351
    Cell Significance Index: 2.3600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0325
    Cell Significance Index: 14.3500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0304
    Cell Significance Index: 0.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0294
    Cell Significance Index: 1.3800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0247
    Cell Significance Index: 0.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0199
    Cell Significance Index: 3.4000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0128
    Cell Significance Index: 8.1600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0125
    Cell Significance Index: 0.1900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0074
    Cell Significance Index: 0.8700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0046
    Cell Significance Index: 0.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0106
    Cell Significance Index: -1.4600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0184
    Cell Significance Index: -13.5100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0216
    Cell Significance Index: -16.3300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0219
    Cell Significance Index: -2.8100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0231
    Cell Significance Index: -3.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0233
    Cell Significance Index: -17.2900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0343
    Cell Significance Index: -19.3500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0343
    Cell Significance Index: -21.4000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0432
    Cell Significance Index: -0.7400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0509
    Cell Significance Index: -1.3900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0528
    Cell Significance Index: -15.2000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0634
    Cell Significance Index: -7.3900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0703
    Cell Significance Index: -7.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0772
    Cell Significance Index: -8.8500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0981
    Cell Significance Index: -2.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0990
    Cell Significance Index: -20.8500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1083
    Cell Significance Index: -6.9900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1114
    Cell Significance Index: -7.8800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1121
    Cell Significance Index: -11.6700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1361
    Cell Significance Index: -1.9100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1390
    Cell Significance Index: -8.7600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1417
    Cell Significance Index: -8.6900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1503
    Cell Significance Index: -3.1900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1728
    Cell Significance Index: -3.6800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2197
    Cell Significance Index: -17.4000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2281
    Cell Significance Index: -6.5100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2331
    Cell Significance Index: -12.2400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2445
    Cell Significance Index: -7.8300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2475
    Cell Significance Index: -12.5100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2511
    Cell Significance Index: -13.0800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2556
    Cell Significance Index: -3.6700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2786
    Cell Significance Index: -7.3300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3212
    Cell Significance Index: -10.2300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3255
    Cell Significance Index: -3.8800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3398
    Cell Significance Index: -9.0900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3485
    Cell Significance Index: -11.4100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3566
    Cell Significance Index: -12.3900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3599
    Cell Significance Index: -10.5700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3717
    Cell Significance Index: -6.2200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3729
    Cell Significance Index: -5.6200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3828
    Cell Significance Index: -8.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Expression:** ACOX3 is located on the X chromosome and is highly expressed in various tissues, including cardiac myocytes, corneal epithelial cells, and neurons. 2. **Function:** ACOX3 catalyzes the oxidation of pristanoyl-CoA, a key intermediate in the fatty acid biosynthetic pathway. 3. **Pathways:** ACOX3 is involved in several cellular pathways, including beta-oxidation of pristanoyl-CoA, fatty acid binding, fatty acid metabolism, and lipid homeostasis. 4. **Proteins:** ACOX3 is a peroxisomal protein that exhibits pristanoyl-CoA oxidase activity. **Pathways and Functions:** 1. **Beta-oxidation of pristanoyl-CoA:** ACOX3 plays a crucial role in the beta-oxidation of pristanoyl-CoA, a key intermediate in the fatty acid biosynthetic pathway. This process involves the sequential removal of two-carbon units from pristanoyl-CoA, resulting in the production of acetyl-CoA and pristanoyl-CoA. 2. **Fatty acid binding:** ACOX3 is involved in the binding of fatty acids to their respective carriers, such as albumin and lipoproteins. 3. **Fatty acid metabolism:** ACOX3 regulates fatty acid metabolism by controlling the production and utilization of fatty acids in various tissues. 4. **Lipid homeostasis:** ACOX3 maintains lipid homeostasis by regulating the levels of fatty acids and phospholipids in cells. 5. **Peroxisomal lipid metabolism:** ACOX3 is involved in the peroxisomal metabolism of fatty acids, which is essential for the removal of toxic intermediates and the production of energy. **Clinical Significance:** 1. **Cardiovascular diseases:** ACOX3 has been implicated in the development of cardiovascular diseases, such as atherosclerosis and coronary artery disease, due to its role in fatty acid metabolism. 2. **Immunological disorders:** ACOX3 has been linked to immunological disorders, such as rheumatoid arthritis and multiple sclerosis, due to its involvement in lipid homeostasis and inflammation. 3. **Neurological disorders:** ACOX3 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, due to its role in fatty acid metabolism and neuronal function. 4. **Cancer:** ACOX3 has been associated with cancer, particularly in the context of fatty acid metabolism and energy production. In conclusion, ACOX3 is a critical gene involved in fatty acid metabolism, lipid homeostasis, and immunological processes. Its dysregulation has been implicated in various diseases, including cardiovascular, immunological, and neurological disorders. Further research is needed to fully elucidate the role of ACOX3 in human health and disease, and to explore its potential as a therapeutic target.

Genular Protein ID: 3269634374

Symbol: ACOX3_HUMAN

Name: Peroxisomal acyl-coenzyme A oxidase 3

UniProtKB Accession Codes:

O15254 Q96AJ8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 21 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 1 EMBL 2 Ensembl 3 ExpressionAtlas 1 GO 10 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 5 Rhea 10 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9271077

Title: Evidence for the existence of a pristanoyl-CoA oxidase gene in man.

PubMed ID: 9271077

DOI: 10.1042/bj3250593

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 700
  • Mass: 77629
  • Checksum: 40D1CD3DC6A620C1
  • Sequence:
    • MASTVEGGDT ALLPEFPRGP LDAYRARASF SWKELALFTE GEGMLRFKKT IFSALENDPL 
FARSPGADLS LEKYRELNFL RCKRIFEYDF LSVEDMFKSP LKVPALIQCL GMYDSSLAAK 
YLLHSLVFGS AVYSSGSERH LTYIQKIFRM EIFGCFALTE LSHGSNTKAI RTTAHYDPAT 
EEFIIHSPDF EAAKFWVGNM GKTATHAVVF AKLCVPGDQC HGLHPFIVQI RDPKTLLPMP 
GVMVGDIGKK LGQNGLDNGF AMFHKVRVPR QSLLNRMGDV TPEGTYVSPF KDVRQRFGAS 
LGSLSSGRVS IVSLAILNLK LAVAIALRFS ATRRQFGPTE EEEIPVLEYP MQQWRLLPYL 
AAVYALDHFS KSLFLDLVEL QRGLASGDRS ARQAELGREI HALASASKPL ASWTTQQGIQ 
ECREACGGHG YLAMNRLGVL RDDNDPNCTY EGDNNILLQQ TSNYLLGLLA HQVHDGACFR 
SPLKSVDFLD AYPGILDQKF EVSSVADCLD SAVALAAYKW LVCYLLRETY QKLNQEKRSG 
SSDFEARNKC QVSHGRPLAL AFVELTVVQR FHEHVHQPSV PPSLRAVLGR LSALYALWSL 
SRHAALLYRG GYFSGEQAGE VLESAVLALC SQLKDDAVAL VDVIAPPDFV LDSPIGRADG 
ELYKNLWGAV LQESKVLERA SWWPEFSVNK PVIGSLKSKL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.