H2BC8 | ENSG00000273802 | NCBI 8339

Details for: H2BC8

Gene ID: 8339

Symbol: H2BC8

Ensembl ID: ENSG00000273802

Description: H2B clustered histone 8

Associated with

Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Base-excision repair, ap site formation
(R-HSA-73929)
Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Chromosome maintenance
(R-HSA-73886)
Defective pyroptosis
(R-HSA-9710421)
Deposition of new cenpa-containing nucleosomes at the centromere
(R-HSA-606279)
Depurination
(R-HSA-73927)
Depyrimidination
(R-HSA-73928)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna double-strand break repair
(R-HSA-5693532)
Dna double strand break response
(R-HSA-5693606)
Dna methylation
(R-HSA-5334118)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
E3 ubiquitin ligases ubiquitinate target proteins
(R-HSA-8866654)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv infection
(R-HSA-9609646)
Hdacs deacetylate histones
(R-HSA-3214815)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Homology directed repair
(R-HSA-5693538)
Infectious disease
(R-HSA-5663205)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Meiotic synapsis
(R-HSA-1221632)
Metabolism of proteins
(R-HSA-392499)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Nonhomologous end-joining (nhej)
(R-HSA-5693571)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleosome assembly
(R-HSA-774815)
Oxidative stress induced senescence
(R-HSA-2559580)
Packaging of telomere ends
(R-HSA-171306)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Post-translational protein modification
(R-HSA-597592)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Protein ubiquitination
(R-HSA-8852135)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-HSA-5693565)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by piwi-interacting rnas (pirnas)
(R-HSA-9845323)
Regulation of endogenous retroelements by the human silencing hub (hush) complex
(R-HSA-9843970)
Replacement of protamines by nucleosomes in the male pronucleus
(R-HSA-9821993)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Telomere maintenance
(R-HSA-157579)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Ub-specific processing proteases
(R-HSA-5689880)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: embryonic stem cell (CL0002322)
Fold Change: 40.5391
Cell Significance Index: -16.7000
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 31.9409
Cell Significance Index: -15.0800
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 28.4417
Cell Significance Index: -14.6300
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 8.3849
Cell Significance Index: 86.8000
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 3.2200
Cell Significance Index: -9.8900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2.7394
Cell Significance Index: 124.1700
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.8156
Cell Significance Index: 117.1400
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 1.4482
Cell Significance Index: 21.7000
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.2211
Cell Significance Index: 1102.5900
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 1.1783
Cell Significance Index: 12.7700
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.9355
Cell Significance Index: 101.7600
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.9188
Cell Significance Index: 55.1600
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.8898
Cell Significance Index: 46.7200
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.8264
Cell Significance Index: 134.4100
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.7513
Cell Significance Index: 10.2500
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.6880
Cell Significance Index: 7.1200
Cell Name: sebaceous gland cell (CL2000021)
Fold Change: 0.6879
Cell Significance Index: 0.8900
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 0.6848
Cell Significance Index: 4.2300
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.6529
Cell Significance Index: 16.6800
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5962
Cell Significance Index: 58.9800
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.5011
Cell Significance Index: 34.6600
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.4721
Cell Significance Index: 12.8500
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.4247
Cell Significance Index: 11.8700
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3839
Cell Significance Index: 73.0600
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.3450
Cell Significance Index: 16.2200
Cell Name: thymocyte (CL0000893)
Fold Change: 0.3375
Cell Significance Index: 4.2700
Cell Name: kidney cell (CL1000497)
Fold Change: 0.3194
Cell Significance Index: 2.5500
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.3108
Cell Significance Index: 10.9200
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.2649
Cell Significance Index: 13.7600
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.2290
Cell Significance Index: 4.7500
Cell Name: odontoblast (CL0000060)
Fold Change: 0.2267
Cell Significance Index: 29.0600
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.2138
Cell Significance Index: 6.1600
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.2026
Cell Significance Index: 4.2400
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.1986
Cell Significance Index: 20.2900
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.1115
Cell Significance Index: 3.5700
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 0.1103
Cell Significance Index: 0.8500
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.1042
Cell Significance Index: 3.6200
Cell Name: lactocyte (CL0002325)
Fold Change: 0.1029
Cell Significance Index: 13.3000
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.0962
Cell Significance Index: 11.0200
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.0606
Cell Significance Index: 1.5100
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0559
Cell Significance Index: 1.1900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0548
Cell Significance Index: 7.5200
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0472
Cell Significance Index: 25.7800
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0380
Cell Significance Index: 16.7800
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0213
Cell Significance Index: 4.2200
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0016
Cell Significance Index: -0.3000
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0016
Cell Significance Index: -0.0800
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0048
Cell Significance Index: -0.1900
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0058
Cell Significance Index: -1.2200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0065
Cell Significance Index: -12.2400
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0123
Cell Significance Index: -22.6300
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0143
Cell Significance Index: -21.9800
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0163
Cell Significance Index: -12.3400
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0166
Cell Significance Index: -22.5600
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0166
Cell Significance Index: -12.2800
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0177
Cell Significance Index: -11.2500
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0179
Cell Significance Index: -0.4800
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0184
Cell Significance Index: -13.4700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0210
Cell Significance Index: -0.9800
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0254
Cell Significance Index: -11.5500
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0270
Cell Significance Index: -9.7000
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0272
Cell Significance Index: -15.3500
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0358
Cell Significance Index: -0.9200
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0482
Cell Significance Index: -5.6900
Cell Name: helper T cell (CL0000912)
Fold Change: -0.0535
Cell Significance Index: -0.7600
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0553
Cell Significance Index: -6.8000
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0612
Cell Significance Index: -10.4500
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0666
Cell Significance Index: -13.3500
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0678
Cell Significance Index: -0.7700
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: -0.0809
Cell Significance Index: -0.8600
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: -0.0826
Cell Significance Index: -1.0400
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: -0.0980
Cell Significance Index: -0.8700
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.0993
Cell Significance Index: -0.8100
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1021
Cell Significance Index: -7.2200
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1029
Cell Significance Index: -14.9600
Cell Name: PP cell (CL0000696)
Fold Change: -0.1043
Cell Significance Index: -1.0600
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1055
Cell Significance Index: -7.8600
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1271
Cell Significance Index: -7.1300
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1364
Cell Significance Index: -14.2000
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1380
Cell Significance Index: -3.6300
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1471
Cell Significance Index: -9.0200
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1573
Cell Significance Index: -12.0700
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.1623
Cell Significance Index: -1.1000
Cell Name: pancreatic epsilon cell (CL0005019)
Fold Change: -0.1630
Cell Significance Index: -1.5100
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1730
Cell Significance Index: -13.7000
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.1895
Cell Significance Index: -2.0600
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1925
Cell Significance Index: -5.1400
Cell Name: epidermal cell (CL0000362)
Fold Change: -0.1996
Cell Significance Index: -0.4500
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.2012
Cell Significance Index: -5.0300
Cell Name: immature alpha-beta T cell (CL0000790)
Fold Change: -0.2054
Cell Significance Index: -1.5300
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: -0.2184
Cell Significance Index: -2.2000
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: -0.2201
Cell Significance Index: -1.4400
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2366
Cell Significance Index: -14.9100
Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
Fold Change: -0.2597
Cell Significance Index: -1.3600
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: -0.2660
Cell Significance Index: -3.6900
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.3038
Cell Significance Index: -4.7000
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.3153
Cell Significance Index: -6.8300
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.3442
Cell Significance Index: -5.7600
Cell Name: ON-bipolar cell (CL0000749)
Fold Change: -0.3452
Cell Significance Index: -3.9000
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.3674
Cell Significance Index: -16.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** H2BC8 is a member of the histone H2B family, which is characterized by its ability to form dimers with histone H2A and H2A.Z. H2BC8 is specifically involved in the assembly of nucleosomes, where it interacts with histone H2A, histone H2A.Z, and histone H4 to form a nucleosome core. This protein is also known for its ability to bind to DNA and interact with other chromatin-modifying enzymes, such as histone acetyltransferases and histone methyltransferases. **Pathways and Functions** H2BC8 is involved in a wide range of biological pathways, including: 1. **DNA Replication and Repair**: H2BC8 plays a crucial role in the assembly of nucleosomes and the regulation of DNA replication and repair. 2. **Epigenetic Regulation**: H2BC8 is involved in the regulation of gene expression by modifying the chromatin landscape through histone modifications, such as acetylation and methylation. 3. **Cell Cycle Regulation**: H2BC8 is involved in the regulation of the cell cycle, particularly during the G2/M phase, where it interacts with cyclin-dependent kinases and other cell cycle regulators. 4. **DNA Damage Response**: H2BC8 is involved in the response to DNA damage, where it interacts with DNA repair enzymes and other signaling proteins to regulate the repair of double-strand breaks. 5. **Immune Response**: H2BC8 is highly expressed in immune cells, where it plays a role in the regulation of immune responses, including the activation of T cells and the regulation of cytokine production. **Clinical Significance** Dysregulation of H2BC8 has been implicated in various diseases, including: 1. **Cancer**: H2BC8 is often downregulated in cancer cells, where it is thought to contribute to the silencing of tumor suppressor genes. 2. **Autoimmune Diseases**: H2BC8 is highly expressed in autoimmune cells, where it may play a role in the regulation of immune responses and the development of autoimmune diseases. 3. **Neurodegenerative Diseases**: H2BC8 has been implicated in the regulation of gene expression in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 4. **Reproductive Disorders**: H2BC8 is involved in the regulation of gene expression in reproductive cells, where it may contribute to the development of reproductive disorders, such as infertility. In conclusion, H2BC8 is a critical protein involved in various cellular processes, including DNA replication, repair, and transcription. Its dysregulation has been implicated in various diseases, highlighting the importance of this protein in maintaining genome stability and regulating gene expression.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

B2R4S9_HUMAN

Genular Protein ID: 3317916460

Symbol: B2R4S9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2R4S9

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

Length: 126
Mass: 13906
Checksum: FAE1479F44BE703D
Sequence:

MPEPAKSAPA PKKGSKKAVT KAQKKDGKKR KRSRKESYSV YVYKVLKQVH PDTGISSKAM 
GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR LLLPGELAKH AVSEGTKAVT 
KYTSSK

Database document: