Details for: H2BC6

Gene ID: 8344

Symbol: H2BC6

Ensembl ID: ENSG00000274290

Description: H2B clustered histone 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 14.4030
    Cell Significance Index: -6.8000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9852
    Cell Significance Index: 187.4800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6574
    Cell Significance Index: 29.8000
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.6339
    Cell Significance Index: 5.1400
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.5016
    Cell Significance Index: 6.9600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4508
    Cell Significance Index: 44.6000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4073
    Cell Significance Index: 21.1600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.3983
    Cell Significance Index: 3.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3915
    Cell Significance Index: 11.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3741
    Cell Significance Index: 24.1400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3473
    Cell Significance Index: 313.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3250
    Cell Significance Index: 7.0400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3074
    Cell Significance Index: 18.4600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.3072
    Cell Significance Index: 3.1800
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.3062
    Cell Significance Index: 3.0700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3009
    Cell Significance Index: 32.7300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2625
    Cell Significance Index: 42.7000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.1635
    Cell Significance Index: 1.3900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1384
    Cell Significance Index: 2.8700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1377
    Cell Significance Index: 9.5200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1250
    Cell Significance Index: 22.5300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1238
    Cell Significance Index: 3.1000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1048
    Cell Significance Index: 1.5800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.1019
    Cell Significance Index: 1.4300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0966
    Cell Significance Index: 2.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0844
    Cell Significance Index: 16.7500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0831
    Cell Significance Index: 2.9200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0617
    Cell Significance Index: 0.7800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0472
    Cell Significance Index: 16.9500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0413
    Cell Significance Index: 0.3800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0369
    Cell Significance Index: 2.0700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0318
    Cell Significance Index: 1.0200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0313
    Cell Significance Index: 4.0100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0197
    Cell Significance Index: 1.5100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0176
    Cell Significance Index: 2.1700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0160
    Cell Significance Index: 7.0600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0154
    Cell Significance Index: 0.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0129
    Cell Significance Index: 1.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0127
    Cell Significance Index: 1.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0106
    Cell Significance Index: 5.8000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0097
    Cell Significance Index: 0.6100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0094
    Cell Significance Index: 1.6100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0088
    Cell Significance Index: 16.3200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0075
    Cell Significance Index: 0.3800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0071
    Cell Significance Index: 13.4000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0055
    Cell Significance Index: 0.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0046
    Cell Significance Index: 7.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0029
    Cell Significance Index: 0.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0003
    Cell Significance Index: 0.4600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0013
    Cell Significance Index: -0.9600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0019
    Cell Significance Index: -0.3800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0043
    Cell Significance Index: -2.7400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0074
    Cell Significance Index: -5.4400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0077
    Cell Significance Index: -4.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0080
    Cell Significance Index: -0.4900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0080
    Cell Significance Index: -6.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0086
    Cell Significance Index: -3.9100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0089
    Cell Significance Index: -1.0600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0109
    Cell Significance Index: -0.5700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0117
    Cell Significance Index: -0.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0142
    Cell Significance Index: -2.9900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0173
    Cell Significance Index: -2.5200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0181
    Cell Significance Index: -0.7900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0205
    Cell Significance Index: -0.5100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0252
    Cell Significance Index: -0.6800
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.0304
    Cell Significance Index: -0.3300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0324
    Cell Significance Index: -1.5100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0420
    Cell Significance Index: -0.6300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0425
    Cell Significance Index: -0.9300
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0446
    Cell Significance Index: -0.2900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0450
    Cell Significance Index: -3.1800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0469
    Cell Significance Index: -6.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0486
    Cell Significance Index: -2.1500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0491
    Cell Significance Index: -5.1100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0512
    Cell Significance Index: -1.9400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0521
    Cell Significance Index: -2.4500
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.0527
    Cell Significance Index: -0.5500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0566
    Cell Significance Index: -1.5100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0597
    Cell Significance Index: -0.8500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0630
    Cell Significance Index: -2.5800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0684
    Cell Significance Index: -0.9800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0734
    Cell Significance Index: -0.7600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0761
    Cell Significance Index: -6.0300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0810
    Cell Significance Index: -6.0400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0832
    Cell Significance Index: -2.6300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0959
    Cell Significance Index: -0.6500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1030
    Cell Significance Index: -1.1700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1096
    Cell Significance Index: -2.8000
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.1128
    Cell Significance Index: -1.2000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1264
    Cell Significance Index: -3.2500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1408
    Cell Significance Index: -4.6100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1456
    Cell Significance Index: -1.3800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1553
    Cell Significance Index: -5.4400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1608
    Cell Significance Index: -2.0000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1624
    Cell Significance Index: -5.1700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1626
    Cell Significance Index: -5.9700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1629
    Cell Significance Index: -3.4100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1631
    Cell Significance Index: -3.9800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1632
    Cell Significance Index: -5.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The H2BC6 gene has several key characteristics that distinguish it from other histone genes. These include: 1. **Histone H2B family**: The H2BC6 gene belongs to the histone H2B family, which is one of the five major histone families in eukaryotic cells. Histone H2B is a highly conserved protein that plays a central role in chromatin structure and gene regulation. 2. **Clustered histone 6**: The H2BC6 gene is a member of the clustered histone 6 family, which is characterized by the presence of a histone H2B protein with a unique N-terminal tail. 3. **Significant expression in various cell types**: The H2BC6 gene is significantly expressed in various cell types, including kidney proximal convoluted tubule epithelial cells, goblet cells, and intestinal epithelial cells. 4. **Involvement in DNA replication and repair**: The H2BC6 gene has been implicated in the regulation of DNA replication and repair, including the formation of the pre-replicative complex and the assembly of the orc complex at the origin of replication. **Pathways and Functions** The H2BC6 gene is involved in several cellular pathways and functions, including: 1. **DNA replication**: The H2BC6 gene plays a role in the regulation of DNA replication, including the formation of the pre-replicative complex and the assembly of the orc complex at the origin of replication. 2. **DNA repair**: The H2BC6 gene has been implicated in the regulation of DNA repair, including the recognition and association of DNA glycosylase with sites containing affected purines and pyrimidines. 3. **Gene expression**: The H2BC6 gene regulates gene expression by interacting with other chromatin-modifying enzymes, such as histone acetyltransferases and histone deacetylases. 4. **Cell cycle regulation**: The H2BC6 gene regulates the cell cycle by interacting with other proteins involved in cell cycle progression, such as cyclin-dependent kinases and cyclin-dependent phosphatases. 5. **Chromatin modifications**: The H2BC6 gene regulates chromatin modifications, including histone acetylation and histone deacetylation, which are essential for gene expression and chromatin structure. **Clinical Significance** The H2BC6 gene has significant clinical implications, including: 1. **Cancer**: The H2BC6 gene has been implicated in the development of cancer, including colorectal cancer, where it is often overexpressed. 2. **Neurological disorders**: The H2BC6 gene has been implicated in neurological disorders, including Alzheimer's disease, where it is often underexpressed. 3. **Immune system dysfunction**: The H2BC6 gene has been implicated in immune system dysfunction, including autoimmune diseases, where it is often overexpressed. 4. **Telomere maintenance**: The H2BC6 gene regulates telomere maintenance, which is essential for cellular aging and cancer development. In conclusion, the H2BC6 gene is a critical component of the histone H2B family, which plays a central role in chromatin structure and gene regulation. Its involvement in DNA replication, repair, and transcription makes it a key player in various cellular pathways and functions. The clinical significance of the H2BC6 gene is evident in its association with cancer, neurological disorders, immune system dysfunction, and telomere maintenance. Further studies are necessary to fully understand the role of the H2BC6 gene in human disease and to develop therapeutic strategies to target this gene.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.