Gene H2BC6 - ENSG00000274290 | NCBI Gene ID: 8344

Details for: H2BC6

Gene ID: 8344

Symbol: H2BC6

Ensembl ID: ENSG00000274290

Description: H2B clustered histone 6

Associated with

Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Base-excision repair, ap site formation
(R-HSA-73929)
Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Chromosome maintenance
(R-HSA-73886)
Cleavage of the damaged purine
(R-HSA-110331)
Cleavage of the damaged pyrimidine
(R-HSA-110329)
Condensation of prophase chromosomes
(R-HSA-2299718)
Defective pyroptosis
(R-HSA-9710421)
Deposition of new cenpa-containing nucleosomes at the centromere
(R-HSA-606279)
Depurination
(R-HSA-73927)
Depyrimidination
(R-HSA-73928)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna double-strand break repair
(R-HSA-5693532)
Dna double strand break response
(R-HSA-5693606)
Dna methylation
(R-HSA-5334118)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
E3 ubiquitin ligases ubiquitinate target proteins
(R-HSA-8866654)
Epigenetic regulation of gene expression
(R-HSA-212165)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv infection
(R-HSA-9609646)
Hdacs deacetylate histones
(R-HSA-3214815)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Homology directed repair
(R-HSA-5693538)
Infectious disease
(R-HSA-5663205)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Meiotic synapsis
(R-HSA-1221632)
Metabolism of proteins
(R-HSA-392499)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Nonhomologous end-joining (nhej)
(R-HSA-5693571)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleosome assembly
(R-HSA-774815)
Oxidative stress induced senescence
(R-HSA-2559580)
Packaging of telomere ends
(R-HSA-171306)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Post-translational protein modification
(R-HSA-597592)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Protein ubiquitination
(R-HSA-8852135)
Recognition and association of dna glycosylase with site containing an affected purine
(R-HSA-110330)
Recognition and association of dna glycosylase with site containing an affected pyrimidine
(R-HSA-110328)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-HSA-5693565)
Replacement of protamines by nucleosomes in the male pronucleus
(R-HSA-9821993)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate pkns
(R-HSA-5625740)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Telomere maintenance
(R-HSA-157579)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Ub-specific processing proteases
(R-HSA-5689880)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 1.68
Marker Score: 3472
Cell Name: goblet cell (CL0000160)
Fold Change: 1.14
Marker Score: 7555
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30408
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 499
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.96
Marker Score: 452
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.92
Marker Score: 5255
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2736
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.88
Marker Score: 317
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5283
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.84
Marker Score: 567.5
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1267
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 703
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.77
Marker Score: 576
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.72
Marker Score: 233
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.71
Marker Score: 539
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.67
Marker Score: 172
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.65
Marker Score: 262
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.64
Marker Score: 2696
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.61
Marker Score: 1430
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.6
Marker Score: 187.5
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 439
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.49
Marker Score: 155
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.48
Marker Score: 305
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.43
Marker Score: 287
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.42
Marker Score: 4249
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 0.38
Marker Score: 280
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.37
Marker Score: 368
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.35
Marker Score: 90
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.35
Marker Score: 534
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.34
Marker Score: 89
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 0.33
Marker Score: 130
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.33
Marker Score: 353
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.32
Marker Score: 227
Cell Name: gut endothelial cell (CL0000131)
Fold Change: 0.32
Marker Score: 114
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.31
Marker Score: 286
Cell Name: melanocyte (CL0000148)
Fold Change: 0.29
Marker Score: 118
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.29
Marker Score: 197
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.28
Marker Score: 273
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.27
Marker Score: 2330
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.27
Marker Score: 16590
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.26
Marker Score: 254
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.26
Marker Score: 256
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.26
Marker Score: 1549
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.25
Marker Score: 3330
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.23
Marker Score: 233
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.23
Marker Score: 2149
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.22
Marker Score: 130
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 0.22
Marker Score: 606.5
Cell Name: mature B cell (CL0000785)
Fold Change: 0.22
Marker Score: 160
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.21
Marker Score: 61
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.21
Marker Score: 71
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.21
Marker Score: 104
Cell Name: proerythroblast (CL0000547)
Fold Change: 0.21
Marker Score: 141
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.21
Marker Score: 278
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 0.2
Marker Score: 53
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 0.19
Marker Score: 83
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.19
Marker Score: 109
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.18
Marker Score: 115
Cell Name: plasmablast (CL0000980)
Fold Change: 0.17
Marker Score: 229
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.17
Marker Score: 103
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 0.17
Marker Score: 84
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.17
Marker Score: 123
Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.16
Marker Score: 52
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.16
Marker Score: 56
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 0.16
Marker Score: 404
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.16
Marker Score: 235
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.16
Marker Score: 2349
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.16
Marker Score: 91
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.16
Marker Score: 651
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.16
Marker Score: 49
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.15
Marker Score: 375.5
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.15
Marker Score: 75
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.15
Marker Score: 153
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.15
Marker Score: 64
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.15
Marker Score: 101
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.15
Marker Score: 1415
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 0.15
Marker Score: 155
Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 0.14
Marker Score: 47
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.14
Marker Score: 1076
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.14
Marker Score: 270
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.14
Marker Score: 57
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.14
Marker Score: 173.5
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.14
Marker Score: 50
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.14
Marker Score: 534
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.14
Marker Score: 110
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.14
Marker Score: 166
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.14
Marker Score: 93
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.14
Marker Score: 4982
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.13
Marker Score: 5120
Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 0.13
Marker Score: 30
Cell Name: interneuron (CL0000099)
Fold Change: 0.13
Marker Score: 61
Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 0.13
Marker Score: 29
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 0.13
Marker Score: 145
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.13
Marker Score: 42
Cell Name: germ cell (CL0000586)
Fold Change: 0.13
Marker Score: 232
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 0.13
Marker Score: 65
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.13
Marker Score: 211
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 0.13
Marker Score: 362
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.13
Marker Score: 53

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Other Information

Description

**Key Characteristics** The H2BC6 gene has several key characteristics that distinguish it from other histone genes. These include: 1. **Histone H2B family**: The H2BC6 gene belongs to the histone H2B family, which is one of the five major histone families in eukaryotic cells. Histone H2B is a highly conserved protein that plays a central role in chromatin structure and gene regulation. 2. **Clustered histone 6**: The H2BC6 gene is a member of the clustered histone 6 family, which is characterized by the presence of a histone H2B protein with a unique N-terminal tail. 3. **Significant expression in various cell types**: The H2BC6 gene is significantly expressed in various cell types, including kidney proximal convoluted tubule epithelial cells, goblet cells, and intestinal epithelial cells. 4. **Involvement in DNA replication and repair**: The H2BC6 gene has been implicated in the regulation of DNA replication and repair, including the formation of the pre-replicative complex and the assembly of the orc complex at the origin of replication. **Pathways and Functions** The H2BC6 gene is involved in several cellular pathways and functions, including: 1. **DNA replication**: The H2BC6 gene plays a role in the regulation of DNA replication, including the formation of the pre-replicative complex and the assembly of the orc complex at the origin of replication. 2. **DNA repair**: The H2BC6 gene has been implicated in the regulation of DNA repair, including the recognition and association of DNA glycosylase with sites containing affected purines and pyrimidines. 3. **Gene expression**: The H2BC6 gene regulates gene expression by interacting with other chromatin-modifying enzymes, such as histone acetyltransferases and histone deacetylases. 4. **Cell cycle regulation**: The H2BC6 gene regulates the cell cycle by interacting with other proteins involved in cell cycle progression, such as cyclin-dependent kinases and cyclin-dependent phosphatases. 5. **Chromatin modifications**: The H2BC6 gene regulates chromatin modifications, including histone acetylation and histone deacetylation, which are essential for gene expression and chromatin structure. **Clinical Significance** The H2BC6 gene has significant clinical implications, including: 1. **Cancer**: The H2BC6 gene has been implicated in the development of cancer, including colorectal cancer, where it is often overexpressed. 2. **Neurological disorders**: The H2BC6 gene has been implicated in neurological disorders, including Alzheimer's disease, where it is often underexpressed. 3. **Immune system dysfunction**: The H2BC6 gene has been implicated in immune system dysfunction, including autoimmune diseases, where it is often overexpressed. 4. **Telomere maintenance**: The H2BC6 gene regulates telomere maintenance, which is essential for cellular aging and cancer development. In conclusion, the H2BC6 gene is a critical component of the histone H2B family, which plays a central role in chromatin structure and gene regulation. Its involvement in DNA replication, repair, and transcription makes it a key player in various cellular pathways and functions. The clinical significance of the H2BC6 gene is evident in its association with cancer, neurological disorders, immune system dysfunction, and telomere maintenance. Further studies are necessary to fully understand the role of the H2BC6 gene in human disease and to develop therapeutic strategies to target this gene.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.