Details for: CASP9

Gene ID: 842

Symbol: CASP9

Ensembl ID: ENSG00000132906

Description: caspase 9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 79.9767
    Cell Significance Index: -12.4400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 46.7586
    Cell Significance Index: -11.8600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 27.1011
    Cell Significance Index: -11.0100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 11.7623
    Cell Significance Index: -11.2300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.2599
    Cell Significance Index: -12.6500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 5.6176
    Cell Significance Index: 150.5300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.3470
    Cell Significance Index: -11.6500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 3.9657
    Cell Significance Index: 754.7000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.2361
    Cell Significance Index: -12.7700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.8114
    Cell Significance Index: -8.6400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0355
    Cell Significance Index: 29.8400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9421
    Cell Significance Index: 20.4100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6406
    Cell Significance Index: 38.4600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6128
    Cell Significance Index: 66.6600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5388
    Cell Significance Index: 27.9900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5092
    Cell Significance Index: 352.1900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4962
    Cell Significance Index: 80.7000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4478
    Cell Significance Index: 89.8300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.4240
    Cell Significance Index: 9.0600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4047
    Cell Significance Index: 40.0300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3215
    Cell Significance Index: 22.2400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2608
    Cell Significance Index: 11.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2577
    Cell Significance Index: 30.0300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2379
    Cell Significance Index: 12.3900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2376
    Cell Significance Index: 5.0600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2300
    Cell Significance Index: 5.7500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2240
    Cell Significance Index: 44.4600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1889
    Cell Significance Index: 67.7700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1625
    Cell Significance Index: 9.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1454
    Cell Significance Index: 6.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1340
    Cell Significance Index: 4.7100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1329
    Cell Significance Index: 10.2000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1252
    Cell Significance Index: 4.7400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1176
    Cell Significance Index: 221.4400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1166
    Cell Significance Index: 7.5200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1135
    Cell Significance Index: 61.9600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0990
    Cell Significance Index: 11.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0792
    Cell Significance Index: 10.8800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0608
    Cell Significance Index: 1.7000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0575
    Cell Significance Index: 10.3700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0501
    Cell Significance Index: 1.4700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0464
    Cell Significance Index: 20.5200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0446
    Cell Significance Index: 1.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0420
    Cell Significance Index: 26.6500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0379
    Cell Significance Index: 4.6600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0299
    Cell Significance Index: 55.1200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0275
    Cell Significance Index: 3.5200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0249
    Cell Significance Index: 38.3200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0161
    Cell Significance Index: 0.9900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0121
    Cell Significance Index: 0.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0067
    Cell Significance Index: 3.0500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0014
    Cell Significance Index: 0.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0009
    Cell Significance Index: -0.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0018
    Cell Significance Index: -2.4800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0022
    Cell Significance Index: -0.1500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0026
    Cell Significance Index: -0.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0107
    Cell Significance Index: -1.5600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0110
    Cell Significance Index: -0.2900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0116
    Cell Significance Index: -8.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0122
    Cell Significance Index: -9.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0124
    Cell Significance Index: -0.5800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0139
    Cell Significance Index: -10.5100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0152
    Cell Significance Index: -0.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0217
    Cell Significance Index: -12.2400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0224
    Cell Significance Index: -13.9900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0317
    Cell Significance Index: -4.0900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0377
    Cell Significance Index: -10.8500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0394
    Cell Significance Index: -4.0200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0420
    Cell Significance Index: -1.4600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0559
    Cell Significance Index: -0.8000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0644
    Cell Significance Index: -13.5700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0687
    Cell Significance Index: -1.1500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0709
    Cell Significance Index: -0.8500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0779
    Cell Significance Index: -8.9300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0802
    Cell Significance Index: -2.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0832
    Cell Significance Index: -3.9100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0905
    Cell Significance Index: -1.2700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0938
    Cell Significance Index: -2.4100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0962
    Cell Significance Index: -7.1700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0967
    Cell Significance Index: -1.3200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1103
    Cell Significance Index: -11.4900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1132
    Cell Significance Index: -3.2300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1254
    Cell Significance Index: -8.8700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1409
    Cell Significance Index: -11.1600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1505
    Cell Significance Index: -9.2300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1539
    Cell Significance Index: -3.6900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1550
    Cell Significance Index: -8.1400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1626
    Cell Significance Index: -8.2200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.1784
    Cell Significance Index: -2.3800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1788
    Cell Significance Index: -1.5200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1933
    Cell Significance Index: -1.7800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1994
    Cell Significance Index: -3.6900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2045
    Cell Significance Index: -4.3400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2047
    Cell Significance Index: -5.2300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2057
    Cell Significance Index: -3.1000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2059
    Cell Significance Index: -3.0400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2298
    Cell Significance Index: -7.3200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2344
    Cell Significance Index: -6.7200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2352
    Cell Significance Index: -4.6500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2550
    Cell Significance Index: -5.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Caspase 9 exhibits several distinct characteristics that enable it to execute its function in apoptosis: 1. **Specificity**: Caspase 9 is highly specific for its substrates, which are primarily pro-apoptotic proteins, such as BID, BAX, and BAK. 2. **Activation mechanism**: Caspase 9 is activated through the formation of the apoptosome, a protein complex that assembles in response to cytochrome c release from the mitochondria. 3. **Cleavage specificity**: Caspase 9 exhibits high specificity for its substrates, cleaving them at specific sites to activate downstream caspases. 4. **Effector function**: Caspase 9 plays a key role in the execution of cell death, activating downstream caspases that cleave and degrade cellular proteins. **Pathways and Functions** Caspase 9 is involved in various cellular pathways, including: 1. **Intrinsic apoptosis pathway**: Caspase 9 is activated through the formation of the apoptosome in response to cytochrome c release from the mitochondria, leading to the execution of cell death. 2. **Extrinsic apoptosis pathway**: Caspase 9 is activated through the extrinsic apoptotic signaling pathway, which involves the binding of death receptors to ligands, leading to the activation of caspase 8 and subsequent activation of caspase 9. 3. **Apoptosome formation**: Caspase 9 plays a key role in the formation of the apoptosome, a protein complex that assembles in response to cytochrome c release from the mitochondria. 4. **Regulation of apoptosis**: Caspase 9 regulates apoptosis by cleaving and activating downstream caspases, leading to the execution of cell death. **Clinical Significance** Caspase 9 has significant implications in various diseases, including: 1. **Cancer**: Dysregulation of caspase 9 has been implicated in various cancers, including breast, lung, and colon cancer. 2. **Autoimmune diseases**: Caspase 9 has been implicated in the regulation of apoptosis in immune cells, and dysregulation of caspase 9 has been linked to autoimmune diseases, such as rheumatoid arthritis. 3. **Neurological disorders**: Caspase 9 has been implicated in the regulation of apoptosis in neurons, and dysregulation of caspase 9 has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. In conclusion, caspase 9 is a crucial protein involved in the regulation of programmed cell death, and its dysregulation has significant implications in various diseases. Understanding the mechanisms of caspase 9 activation and function can provide valuable insights into the development of novel therapeutic strategies for the treatment of these diseases.

Genular Protein ID: 1978674921

Symbol: CASP9_HUMAN

Name: Caspase-9

UniProtKB Accession Codes:

P55211 B4E1A3 O95348 Q53Y70 Q5JRU9 Q5UGI1 Q92852 Q9BQ62 Q9UEQ3 Q9UIJ8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 EC 1 ELM 1 EMBL 16 EMDB 2 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 39 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 9 RefSeq 4 SABIO-RK 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8663294

Title: ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B.

PubMed ID: 8663294

DOI: 10.1074/jbc.271.28.16720

PubMed ID: 8900201

Title: The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32.

PubMed ID: 8900201

DOI: 10.1074/jbc.271.43.27099

PubMed ID: 10384055

Title: Genomic organization of the human caspase-9 gene on chromosome 1p36.1-p36.3.

PubMed ID: 10384055

DOI: 10.1007/s003359901086

PubMed ID: 10070954

Title: Identification of an endogenous dominant-negative short isoform of caspase-9 that can regulate apoptosis.

PubMed ID: 10070954

PubMed ID: 9890966

Title: A caspase-9 variant missing the catalytic site is an endogenous inhibitor of apoptosis.

PubMed ID: 9890966

DOI: 10.1074/jbc.274.4.2072

PubMed ID: 16780893

Title: Cloning of a novel human caspase-9 splice variant containing only the CARD domain.

PubMed ID: 16780893

DOI: 10.1016/j.lfs.2006.04.026

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12792650

Title: Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK.

PubMed ID: 12792650

DOI: 10.1038/ncb1005

PubMed ID: 15200957

Title: Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase.

PubMed ID: 15200957

DOI: 10.1016/j.molcel.2004.05.018

PubMed ID: 15657060

Title: c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage.

PubMed ID: 15657060

DOI: 10.1074/jbc.m413787200

PubMed ID: 16857965

Title: Overexpression of HAX-1 protects cardiac myocytes from apoptosis through caspase-9 inhibition.

PubMed ID: 16857965

DOI: 10.1161/01.res.0000237387.05259.a5

PubMed ID: 16352606

Title: Caspase-7 is directly activated by the approximately 700-kDa apoptosome complex and is released as a stable XIAP-caspase-7 approximately 200-kDa complex.

PubMed ID: 16352606

DOI: 10.1074/jbc.m507393200

PubMed ID: 16916640

Title: Engineered hybrid dimers: tracking the activation pathway of caspase-7.

PubMed ID: 16916640

DOI: 10.1016/j.molcel.2006.06.020

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19255499

Title: HIP1R interacts with a member of Bcl-2 family, BCL2L10, and induces BAK-dependent cell death.

PubMed ID: 19255499

DOI: 10.1159/000204088

PubMed ID: 19118655

Title: Comparative proteomics analysis of caspase-9-protein complexes in untreated and cytochrome c/dATP stimulated lysates of NSCLC cells.

PubMed ID: 19118655

DOI: 10.1016/j.jprot.2008.11.016

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 27889207

Title: Dual site phosphorylation of caspase-7 by PAK2 blocks apoptotic activity by two distinct mechanisms.

PubMed ID: 27889207

DOI: 10.1016/j.str.2016.11.001

PubMed ID: 35446120

Title: Calmodulin binding activates chromobacterium CopC effector to ADP-riboxanate host apoptotic caspases.

PubMed ID: 35446120

DOI: 10.1128/mbio.00690-22

PubMed ID: 35338844

Title: Pathogen hijacks programmed cell death signaling by arginine ADPR-deacylization of caspases.

PubMed ID: 35338844

DOI: 10.1016/j.molcel.2022.03.010

PubMed ID: 36758106

Title: Structural basis for SMAC-mediated antagonism of caspase inhibition by the giant ubiquitin ligase BIRC6.

PubMed ID: 36758106

DOI: 10.1126/science.ade8840

PubMed ID: 36758105

Title: Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex.

PubMed ID: 36758105

DOI: 10.1126/science.ade8873

PubMed ID: 11734640

Title: Dimer formation drives the activation of the cell death protease caspase 9.

PubMed ID: 11734640

DOI: 10.1073/pnas.231465798

PubMed ID: 12620238

Title: Mechanism of XIAP-mediated inhibition of caspase-9.

PubMed ID: 12620238

DOI: 10.1016/s1097-2765(03)00054-6

PubMed ID: 23516580

Title: The E. coli effector protein NleF is a caspase inhibitor.

PubMed ID: 23516580

DOI: 10.1371/journal.pone.0058937

Sequence Information:

  • Length: 416
  • Mass: 46281
  • Checksum: 78E0180DF2A3BDD2
  • Sequence:
    • MDEADRRLLR RCRLRLVEEL QVDQLWDALL SRELFRPHMI EDIQRAGSGS RRDQARQLII 
DLETRGSQAL PLFISCLEDT GQDMLASFLR TNRQAAKLSK PTLENLTPVV LRPEIRKPEV 
LRPETPRPVD IGSGGFGDVG ALESLRGNAD LAYILSMEPC GHCLIINNVN FCRESGLRTR 
TGSNIDCEKL RRRFSSLHFM VEVKGDLTAK KMVLALLELA QQDHGALDCC VVVILSHGCQ 
ASHLQFPGAV YGTDGCPVSV EKIVNIFNGT SCPSLGGKPK LFFIQACGGE QKDHGFEVAS 
TSPEDESPGS NPEPDATPFQ EGLRTFDQLD AISSLPTPSD IFVSYSTFPG FVSWRDPKSG 
SWYVETLDDI FEQWAHSEDL QSLLLRVANA VSVKGIYKQM PGCFNFLRKK LFFKTS

Genular Protein ID: 2218277359

Symbol: F8VVS7_HUMAN

Name: N/A

UniProtKB Accession Codes:

F8VVS7

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 2 GeneTree 1 HGNC 1 InterPro 10 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 1 PRINTS 1 PROSITE 8 PeptideAtlas 2 Pfam 2 PhylomeDB 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 421
  • Mass: 46453
  • Checksum: 6B5EC6A06494125F
  • Sequence:
    • MDEADRRLLR RCRLRLVEEL QVDQLWDALL SRELFRPHMI EDIQRAGSGS RRDQARQLII 
DLETRGSQAL PLFISCLEDT GQDMLASFLR TNRQAAKLSK PTLENLTPVV LRPEIRKPEV 
LRPETPRPVD IGSGGFGDVG ALESLRGNAD LAYILSMEPC GHCLIINNVN FCRESGLRTR 
TGSNIDCEKL RRRFSSLHFM VEVKGDLTAK KMVLALLELA QQDHGALDCC VVVILSHGCQ 
ASHLQFPGAV YGTDGCPVSV EKIVNIFNGT SCPSLGGKPK LFFIQACGGE QKDHGFEVAS 
TSPEDESPGS NPEPDATPFQ EGLRTFDQLD AISSLPTPSD IFVSYSTFPG FVSWRDPKSG 
SWYVETLDDI FEQWAHSEDL QSLLLRVSAA FLCKGEGRLL RGSVSSWGWG FGVSRAGPNQ 
G

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.