Details for: CUL4B

Gene ID: 8450

Symbol: CUL4B

Ensembl ID: ENSG00000158290

Description: cullin 4B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 163.6502
    Cell Significance Index: -25.4600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 99.9040
    Cell Significance Index: -25.3400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 67.2901
    Cell Significance Index: -27.7200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 52.7129
    Cell Significance Index: -21.4200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 22.5139
    Cell Significance Index: -21.5000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.1889
    Cell Significance Index: -26.1300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.4910
    Cell Significance Index: -25.4300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.7105
    Cell Significance Index: -26.4800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.2132
    Cell Significance Index: 257.9200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.6915
    Cell Significance Index: 1527.3400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.6690
    Cell Significance Index: 23.4100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3574
    Cell Significance Index: 18.5200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1981
    Cell Significance Index: 130.3200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1634
    Cell Significance Index: 189.2100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0068
    Cell Significance Index: 60.4400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7641
    Cell Significance Index: 153.2800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5907
    Cell Significance Index: 117.2300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5074
    Cell Significance Index: 181.9900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3926
    Cell Significance Index: 20.4500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3873
    Cell Significance Index: 38.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3658
    Cell Significance Index: 65.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2737
    Cell Significance Index: 7.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2640
    Cell Significance Index: 32.4600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2537
    Cell Significance Index: 175.4400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2084
    Cell Significance Index: 5.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2018
    Cell Significance Index: 27.7100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1984
    Cell Significance Index: 9.2500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1915
    Cell Significance Index: 84.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1881
    Cell Significance Index: 10.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1793
    Cell Significance Index: 13.7600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1782
    Cell Significance Index: 7.8800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1780
    Cell Significance Index: 10.9400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1720
    Cell Significance Index: 93.9200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1678
    Cell Significance Index: 31.9300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1524
    Cell Significance Index: 5.7700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1163
    Cell Significance Index: 2.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0953
    Cell Significance Index: 4.9500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0920
    Cell Significance Index: 5.8000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0885
    Cell Significance Index: 4.0100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0852
    Cell Significance Index: 10.0500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0842
    Cell Significance Index: 10.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0772
    Cell Significance Index: 13.1800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0601
    Cell Significance Index: 1.0300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0403
    Cell Significance Index: 1.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0317
    Cell Significance Index: 59.6000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0294
    Cell Significance Index: 1.9800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0292
    Cell Significance Index: 1.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0155
    Cell Significance Index: 9.8500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0129
    Cell Significance Index: 19.8600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0124
    Cell Significance Index: 22.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0016
    Cell Significance Index: -0.7100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0043
    Cell Significance Index: -5.8000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0073
    Cell Significance Index: -5.4200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0075
    Cell Significance Index: -0.2100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0085
    Cell Significance Index: -5.2800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0153
    Cell Significance Index: -11.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0267
    Cell Significance Index: -20.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0268
    Cell Significance Index: -3.9000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0286
    Cell Significance Index: -0.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0331
    Cell Significance Index: -18.6500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0401
    Cell Significance Index: -1.0700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0492
    Cell Significance Index: -0.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0534
    Cell Significance Index: -5.4500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0611
    Cell Significance Index: -3.9500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0615
    Cell Significance Index: -12.9600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0648
    Cell Significance Index: -1.3800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0716
    Cell Significance Index: -20.6100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0792
    Cell Significance Index: -5.6000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0984
    Cell Significance Index: -11.2300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0994
    Cell Significance Index: -1.9400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1105
    Cell Significance Index: -14.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1185
    Cell Significance Index: -13.5800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1353
    Cell Significance Index: -6.3600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1407
    Cell Significance Index: -3.8300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1568
    Cell Significance Index: -4.0300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1730
    Cell Significance Index: -4.1500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1973
    Cell Significance Index: -5.6300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2037
    Cell Significance Index: -15.1800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2192
    Cell Significance Index: -7.0200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2225
    Cell Significance Index: -23.1700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2407
    Cell Significance Index: -5.5600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2651
    Cell Significance Index: -13.9200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2668
    Cell Significance Index: -21.1300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2860
    Cell Significance Index: -7.6500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3256
    Cell Significance Index: -16.4600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3645
    Cell Significance Index: -22.3500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3902
    Cell Significance Index: -13.5600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4110
    Cell Significance Index: -9.0000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4447
    Cell Significance Index: -9.5100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4601
    Cell Significance Index: -13.1900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4619
    Cell Significance Index: -7.7300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4697
    Cell Significance Index: -11.7400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.4836
    Cell Significance Index: -4.1100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4980
    Cell Significance Index: -16.3100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5119
    Cell Significance Index: -16.3100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5155
    Cell Significance Index: -10.9400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.5232
    Cell Significance Index: -6.7000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5364
    Cell Significance Index: -19.6900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5569
    Cell Significance Index: -19.5100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5604
    Cell Significance Index: -11.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Ring E3 ubiquitin ligase**: CUL4B is a member of the Cullin family, which forms a ring E3 ubiquitin ligase complex. This complex is responsible for the ubiquitination of target proteins, leading to their degradation or modification. 2. **DNA damage response**: CUL4B has been implicated in the response to DNA damage, including the recognition of damaged DNA and the activation of DNA repair pathways. 3. **Cell cycle regulation**: CUL4B is involved in the regulation of the cell cycle, particularly in the G1/S transition, which is a critical checkpoint in the cell cycle. 4. **Transcriptional control**: CUL4B has been shown to regulate gene expression by interacting with transcriptional regulators and influencing the activity of transcription factors. **Pathways and Functions** CUL4B is involved in several cellular pathways, including: 1. **DNA damage response**: CUL4B recognizes damaged DNA and recruits other proteins to form a complex that activates DNA repair pathways. 2. **Cell cycle regulation**: CUL4B regulates the G1/S transition by ubiquitinating and degrading proteins that inhibit cell cycle progression. 3. **Transcriptional control**: CUL4B regulates gene expression by interacting with transcriptional regulators and influencing the activity of transcription factors. 4. **Protein degradation**: CUL4B is involved in the ubiquitination and degradation of proteins, which is critical for maintaining protein homeostasis. **Clinical Significance** CUL4B has been implicated in several diseases and disorders, including: 1. **Cancer**: CUL4B has been shown to be overexpressed in several types of cancer, including breast, lung, and colon cancer. Its role in cancer is thought to be related to its ability to regulate cell cycle progression and DNA damage response. 2. **Neurodegenerative diseases**: CUL4B has been implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Its role in these diseases is thought to be related to its ability to regulate protein degradation and transcriptional control. 3. **Genetic disorders**: CUL4B has been associated with genetic disorders, including X-linked mental retardation and X-linked ichthyosis. Its role in these disorders is thought to be related to its ability to regulate gene expression and protein degradation. In summary, CUL4B is a critical protein that plays a key role in various cellular processes, including DNA damage response, cell cycle regulation, and transcriptional control. Its dysregulation has been implicated in several diseases and disorders, highlighting its importance as a therapeutic target.

Genular Protein ID: 2326021498

Symbol: CUL4B_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q13620 B1APK5 B3KVX4 B7Z5K8 Q6PIE4 Q6UP07 Q7Z673 Q9BY37 Q9UEB7 Q9UED7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 20 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 9 RefSeq 3 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14578910

Title: Radiation-mediated proteolysis of CDT1 by CUL4-ROC1 and CSN complexes constitutes a new checkpoint.

PubMed ID: 14578910

DOI: 10.1038/ncb1061

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9734811

Title: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9734811

DOI: 10.1093/dnares/5.3.169

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 8681378

Title: cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family.

PubMed ID: 8681378

DOI: 10.1016/s0092-8674(00)81267-2

PubMed ID: 10597293

Title: Covalent modification of all members of human cullin family proteins by NEDD8.

PubMed ID: 10597293

DOI: 10.1038/sj.onc.1203093

PubMed ID: 10230407

Title: ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity.

PubMed ID: 10230407

DOI: 10.1016/s1097-2765(00)80482-7

PubMed ID: 12609982

Title: TIP120A associates with cullins and modulates ubiquitin ligase activity.

PubMed ID: 12609982

DOI: 10.1074/jbc.m213070200

PubMed ID: 16322693

Title: Involvement of CUL4 ubiquitin E3 ligases in regulating CDK inhibitors Dacapo/p27Kip1 and cyclin E degradation.

PubMed ID: 16322693

DOI: 10.4161/cc.5.1.2266

PubMed ID: 16678110

Title: Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage.

PubMed ID: 16678110

DOI: 10.1016/j.molcel.2006.03.035

PubMed ID: 16949367

Title: A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1.

PubMed ID: 16949367

DOI: 10.1016/j.molcel.2006.08.010

PubMed ID: 17041588

Title: CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation.

PubMed ID: 17041588

DOI: 10.1038/ncb1490

PubMed ID: 17273978

Title: Mutation in CUL4B, which encodes a member of cullin-RING ubiquitin ligase complex, causes X-linked mental retardation.

PubMed ID: 17273978

DOI: 10.1086/512489

PubMed ID: 18593899

Title: The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2A.

PubMed ID: 18593899

DOI: 10.1158/0008-5472.can-07-6162

PubMed ID: 18235224

Title: mTORC1 signaling requires proteasomal function and the involvement of CUL4-DDB1 ubiquitin E3 ligase.

PubMed ID: 18235224

DOI: 10.4161/cc.7.3.5267

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19801544

Title: Characterization of nuclear localization signal in the N terminus of CUL4B and its essential role in cyclin E degradation and cell cycle progression.

PubMed ID: 19801544

DOI: 10.1074/jbc.m109.050427

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20002452

Title: A novel nonsense mutation in CUL4B gene in three brothers with X-linked mental retardation syndrome.

PubMed ID: 20002452

DOI: 10.1111/j.1399-0004.2009.01331.x

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23201271

Title: Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes.

PubMed ID: 23201271

DOI: 10.1016/j.str.2012.10.013

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26711351

Title: Genome-wide RNAi Screening Identifies Protein Modules Required for 40S Subunit Synthesis in Human Cells.

PubMed ID: 26711351

DOI: 10.1016/j.celrep.2015.11.061

PubMed ID: 26906416

Title: Characterization of the mammalian family of DCN-type NEDD8 E3 ligases.

PubMed ID: 26906416

DOI: 10.1242/jcs.181784

PubMed ID: 29779948

Title: The eukaryotic proteome is shaped by E3 ubiquitin ligases targeting C-terminal degrons.

PubMed ID: 29779948

DOI: 10.1016/j.cell.2018.04.028

PubMed ID: 30166453

Title: CRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling.

PubMed ID: 30166453

DOI: 10.15252/embj.201797508

PubMed ID: 33854232

Title: AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity.

PubMed ID: 33854232

DOI: 10.1038/s41586-021-03422-5

PubMed ID: 33854239

Title: The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D.

PubMed ID: 33854239

DOI: 10.1038/s41586-021-03474-7

PubMed ID: 22118460

Title: The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation.

PubMed ID: 22118460

DOI: 10.1016/j.cell.2011.10.035

PubMed ID: 17236139

Title: Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor.

PubMed ID: 17236139

DOI: 10.1086/511134

PubMed ID: 19377476

Title: A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation.

PubMed ID: 19377476

DOI: 10.1038/ng.367

Sequence Information:

  • Length: 913
  • Mass: 103982
  • Checksum: 3E58C5868FDF0700
  • Sequence:
    • MMSQSSGSGD GNDDEATTSK DGGFSSPSPS AAAAAQEVRS ATDGNTSTTP PTSAKKRKLN 
SSSSSSSNSS NEREDFDSTS SSSSTPPLQP RDSASPSTSS FCLGVSVAAS SHVPIQKKLR 
FEDTLEFVGF DAKMAEESSS SSSSSSPTAA TSQQQQLKNK SILISSVASV HHANGLAKSS 
TTVSSFANSK PGSAKKLVIK NFKDKPKLPE NYTDETWQKL KEAVEAIQNS TSIKYNLEEL 
YQAVENLCSY KISANLYKQL RQICEDHIKA QIHQFREDSL DSVLFLKKID RCWQNHCRQM 
IMIRSIFLFL DRTYVLQNSM LPSIWDMGLE LFRAHIISDQ KVQNKTIDGI LLLIERERNG 
EAIDRSLLRS LLSMLSDLQI YQDSFEQRFL EETNRLYAAE GQKLMQEREV PEYLHHVNKR 
LEEEADRLIT YLDQTTQKSL IATVEKQLLG EHLTAILQKG LNNLLDENRI QDLSLLYQLF 
SRVRGGVQVL LQQWIEYIKA FGSTIVINPE KDKTMVQELL DFKDKVDHII DICFLKNEKF 
INAMKEAFET FINKRPNKPA ELIAKYVDSK LRAGNKEATD EELEKMLDKI MIIFRFIYGK 
DVFEAFYKKD LAKRLLVGKS ASVDAEKSML SKLKHECGAA FTSKLEGMFK DMELSKDIMI 
QFKQYMQNQN VPGNIELTVN ILTMGYWPTY VPMEVHLPPE MVKLQEIFKT FYLGKHSGRK 
LQWQSTLGHC VLKAEFKEGK KELQVSLFQT LVLLMFNEGE EFSLEEIKQA TGIEDGELRR 
TLQSLACGKA RVLAKNPKGK DIEDGDKFIC NDDFKHKLFR IKINQIQMKE TVEEQASTTE 
RVFQDRQYQI DAAIVRIMKM RKTLSHNLLV SEVYNQLKFP VKPADLKKRI ESLIDRDYME 
RDKENPNQYN YIA

Genular Protein ID: 2630183099

Symbol: K4DI93_HUMAN

Name: N/A

UniProtKB Accession Codes:

K4DI93

Database IDs:

ARBA 5 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 GO 6 Gene3D 2 GeneTree 1 HGNC 1 IntAct 1 InterPro 9 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SUPFAM 3 UCSC 1 UniPathway 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 900
  • Mass: 102756
  • Checksum: 791179F3BA23E10F
  • Sequence:
    • MKSVCPVTSG FSSPSPSAAA AAQEVRSATD GNTSTTPPTS AKKRKLNSSS SSSSNSSNER 
EDFDSTSSSS STPPLQPRDS ASPSTSSFCL GVSVAASSHV PIQKKLRFED TLEFVGFDAK 
MAEESSSSSS SSSPTAATSQ QQQLKNKSIL ISSVASVHHA NGLAKSSTTV SSFANSKPGS 
AKKLVIKNFK DKPKLPENYT DETWQKLKEA VEAIQNSTSI KYNLEELYQA VENLCSYKIS 
ANLYKQLRQI CEDHIKAQIH QFREDSLDSV LFLKKIDRCW QNHCRQMIMI RSIFLFLDRT 
YVLQNSMLPS IWDMGLELFR AHIISDQKVQ NKTIDGILLL IERERNGEAI DRSLLRSLLS 
MLSDLQIYQD SFEQRFLEET NRLYAAEGQK LMQEREVPEY LHHVNKRLEE EADRLITYLD 
QTTQKSLIAT VEKQLLGEHL TAILQKGLNN LLDENRIQDL SLLYQLFSRV RGGVQVLLQQ 
WIEYIKAFGS TIVINPEKDK TMVQELLDFK DKVDHIIDIC FLKNEKFINA MKEAFETFIN 
KRPNKPAELI AKYVDSKLRA GNKEATDEEL EKMLDKIMII FRFIYGKDVF EAFYKKDLAK 
RLLVGKSASV DAEKSMLSKL KHECGAAFTS KLEGMFKDME LSKDIMIQFK QYMQNQNVPG 
NIELTVNILT MGYWPTYVPM EVHLPPEMVK LQEIFKTFYL GKHSGRKLQW QSTLGHCVLK 
AEFKEGKKEL QVSLFQTLVL LMFNEGEEFS LEEIKQATGI EDGELRRTLQ SLACGKARVL 
AKNPKGKDIE DGDKFICNDD FKHKLFRIKI NQIQMKETVE EQASTTERVF QDRQYQIDAA 
IVRIMKMRKT LSHNLLVSEV YNQLKFPVKP ADLKKRIESL IDRDYMERDK ENPNQYNYIA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.